Publications by authors named "Zhefu Que"

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Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids.
Jiaxiang Wu, Jingliang Zhang, Xiaoling Chen, Kyle Wettschurack, Zhefu Que, Brody A Deming, Maria I Olivero-Acosta, Ningren Cui, Muriel Eaton, Yuanrui Zhao

Mol Psychiatry· August 2024

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Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids.
Maria I Olivero-Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Hope Elizabeth Harlow

bioRxiv· August 2025

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Autism-associated deficiency disrupts cortico-striatal circuitry in human brain assembloids.
Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, Morgan J Robinson, Harish Kothandaraman, Zhefu Que

bioRxiv· June 2025

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Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying mutation: Microglial diversity and response in assembloids.
Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Zhefu Que

bioRxiv· June 2025

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Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated deficiency.
Jingliang Zhang, Muriel Eaton, Xiaoling Chen, Yuanrui Zhao, Shivam Kant, Zhefu Que

bioRxiv· March 2025

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Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated -L1342P mutation.
Zhefu Que, Maria I Olivero-Acosta, Morgan Robinson, Ian Chen, Jingliang Zhang

J Neurosci· November 2024

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Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.
Zhefu Que, Maria I Olivero-Acosta, Ian Chen, Jingliang Zhang, Kyle Wettschurack

bioRxiv· October 2023

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Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids.
Yang Yang, Jiaxiang Wu, Jingliang Zhang, Xiaoling Chen, Zhefu Que

Res Sq· September 2023

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Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms.
Zhixiong Ma, Muriel Eaton, Yushuang Liu, Jingliang Zhang, Xiaoling Chen, Zhefu Que

Neurobiol Dis· June 2022

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Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant.
Zhefu Que, Maria I Olivero-Acosta, Jingliang Zhang, Muriel Eaton, Anke M Tukker

J Neurosci· December 2021

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Severe deficiency of the voltage-gated sodium channel Na1.2 elevates neuronal excitability in adult mice.
Jingliang Zhang, Xiaoling Chen, Muriel Eaton, Jiaxiang Wu, Zhixiong Ma, Zhefu Que

Cell Rep· August 2021

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Multi-Electrode Array of Sensory Neurons as an In Vitro Platform to Identify the Nociceptive Response to Pharmaceutical Buffer Systems of Injectable Biologics.
Muriel Eaton, Zhefu Que, Jingliang Zhang, Kaethe Beck, Riyi Shi

Pharm Res· July 2021

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Generation and basic characterization of a gene-trap knockout mouse model of Scn2a with a substantial reduction of voltage-gated sodium channel Na 1.2 expression.
Muriel Eaton, Jingliang Zhang, Zhixiong Ma, Anthony C Park, Emma Lietzke, Zhefu Que

Genes Brain Behav· April 2021

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