Br J Clin Pharmacol January 1999 PMID 10073740

The pharmacokinetic modelling of GI198745 (dutasteride), a compound with parallel linear and nonlinear elimination.

P O Gisleskog, D Hermann, M Hammarlund-Udenaes, M O Karlsson

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Peak: 3 in Dec 2022
across 2 sources since Dec 2022

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The discussion highlights specific pharmacokinetic details, such as the fast half-life at low doses, showing modest curiosity and basic engagement, with no strong reactions or calls to action, reflecting a neutral overall response to the publication.

AgreementNeither agree nor disagree

The only comment made acknowledges the question but doesn't express strong support or disagreement with the publication.

InterestModerate interest

The discussion indicates some curiosity about pharmacokinetics but doesn't show deep engagement or enthusiasm.

EngagementNeutral engagement

The post mentions specific details like half-life and dosage but remains at a moderate level of detail without extensive discussion.

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The exchange offers informational value but does not suggest a significant influence or transformative impact stemming from the publication.

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Kyle Gillett MD
@GillettHealth · X

@HLcure2020 @hubermanlab @DrBevinBhoyrul Good question. Dutasteride has linear and non linear pharmacokinetics (similar to acetaminophen). At a dose of 0.01mg a day, half life so fast it’s below LCMS quant limit after 30mins. 0.1mg: hours. 0.5mg: days. https://t.co/Xs7kQBpQun

Dec 25, 2022 · 5 likes · 2 shares · 2,006 followers View post →
HairLossCure2020 (Hair Loss News)
@HLcure2020 · X

RT @GillettHealth: @HLcure2020 @hubermanlab @DrBevinBhoyrul Good question. Dutasteride has linear and non linear pharmacokinetics (similar…

Dec 25, 2022 · 2 shares · 3,196 followers View post →

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microsmart
@microsmart7 · X

RT @GillettHealth: @HLcure2020 @hubermanlab @DrBevinBhoyrul Good question. Dutasteride has linear and non linear pharmacokinetics (similar…

Dec 26, 2022 · 2 shares · 92 followers View post →
HairLossCure2020 (Hair Loss News)
@HLcure2020 · X

RT @GillettHealth: @HLcure2020 @hubermanlab @DrBevinBhoyrul Good question. Dutasteride has linear and non linear pharmacokinetics (similar…

Dec 25, 2022 · 2 shares · 3,196 followers View post →
Kyle Gillett MD
@GillettHealth · X

@HLcure2020 @hubermanlab @DrBevinBhoyrul Good question. Dutasteride has linear and non linear pharmacokinetics (similar to acetaminophen). At a dose of 0.01mg a day, half life so fast it’s below LCMS quant limit after 30mins. 0.1mg: hours. 0.5mg: days. https://t.co/Xs7kQBpQun

Dec 25, 2022 · 5 likes · 2 shares · 2,006 followers View post →