August 1999 PMID 10444630

Immune changes in humans during cold exposure: effects of prior heating and exercise.

I K Brenner, J W Castellani, C Gabaree, A J Young, J Zamecnik, R J Shephard, P N Shek

Full text PDF Download social card

Mentions

Peak: 4 in Jan 2020

across 5 sources since Jan 2020

Extended reach

447,782

potential audience

Total likes

2,444

Video views

149,069

Mentions per month

Jan 2020 – Nov 2025

Where it's discussed

X / Twitter33 posts
News17 articles
Facebook4 posts
Blogs3 articles
YouTube2 videos

AI synopsis

What people are saying

Discussions frequently reference scientific studies, such as the one by Brenner et al., and mention mechanisms like increased white blood cells and cytokines, highlighting active engagement and interest. The tone combines curiosity, referencing research, and opinions on health benefits, reflecting a moderate but meaningful collective evaluation of the article’s significance.

AgreementModerate agreement

Most discussions acknowledge the findings that cold exposure activates immune responses and benefits health, indicating moderate agreement with the publication’s conclusions.

InterestHigh interest

The majority of posts show high curiosity about the subject, often referencing specific studies, mechanisms, and potential health benefits.

EngagementModerate engagement

Users engage by sharing related research, personal experiences, and scientific opinions, suggesting a moderate depth of involvement.

ImpactModerate impact

Among the comments, there is a recognition that the findings could have implications for health practices and scientific understanding, though not overwhelmingly revolutionary.

Abstract in brief

This study investigated how cold exposure affects the immune system in humans and whether pre-treatments like heating or exercise influence this response, finding that cold exposure generally stimulates immune activity, such as increasing white blood cells and natural killer cells.
The research found that exercise in cold water (18°C) before cold exposure enhanced immune responses more than passive heating, suggesting physical activity can boost immunity during cold stress, especially when core temperature is maintained with thermal clamping.
The immune changes observed, including increased cytokines and immune cells, may be driven by heightened norepinephrine levels, which are affected by initial body temperature and pre-treatment methods, highlighting how the body's stress response modulates immunity in cold conditions.]

Read the full abstract

All mentions

Enhancing Health with Sauna and Cold Water Immersion Techniques

Immerse yourself in the benefits of sauna and cold exposure. This video explores how immersion in different water temperatures affects heart rate, blood pressure, and metabolic responses. Discover effective strategies…

Tom Merrick · Nov 20, 2022 148,562 views

Exploring the Impact of Cold Water Immersion on Health Benefits

Lang zal je Leven · Oct 7, 2025 507 views

Dmitriy Tomatin

@Itachi261092 · X

@Bazanlazan @jechanceux 3. Исследование с доказательствами https://t.co/EgS1F8Licz https://t.co/VuceWyQFk6 4. Исследование с доказательствами https://t.co/hA9CbOHXvY https://t.co/j7iJ06CfI4 5. Нет. Именно холодная вода улучшает работу пор. https://t.co/ek5tK2sNtv https://t.co/1Ac8xwjLE5

Nov 13, 2025 · 168 followers View post →

Roger Seheult, MD

@RogerSeheult · X

@chipmcdonald @KenLawler9 @PGC1a_RB Cold weather seems to actually improve immunity https://t.co/SDbVS9HfRy

Jan 11, 2025 · 28,284 followers View post →

ΛRIΛ

@ItaliaSvb · X

@FonsiLoaiza Pensaba que tu tweet sobre Llorente y @Alvise_oficial_ era puro sarcasmo, y no pura ignorancia científica con sesgos sectarios.

Dec 11, 2024 · 951 followers View post →

Roger Seheult, MD

@RogerSeheult · X

@BharadSrini https://t.co/p1oZCfh3Su

Sep 26, 2024 · 1 like · 28,284 followers View post →

Dr. Philip Eckardt, MD

@MedEckardt · X

Dec 29, 2023 · 3 likes · 1,164 followers View post →

Roger Seheult, MD

@RogerSeheult · X

@Medical_Nemesis @sean_bernstein https://t.co/SDbVS9HfRy

Dec 31, 2022 · 28,284 followers View post →

GainsEveryday

@GainseverydayFA · X

How To Improve Training Results Without Exercising More? https://t.co/fxdsVmF4mN

Nov 21, 2022 · 201 followers View post →

Lee G

@ThaP0werCosmic · X

How To Improve Training Results Without Exercising More? https://t.co/7ORP4iBhEX via @YouTube

Nov 21, 2022 · 259 followers View post →

A Rooted Life

@TheRootCauseCo · X

Furthermore, cold exposure may increase the numbers of white blood cells, including cytotoxic T lymphocytes, a specialized type of immune cell that can kill cancer cells. https://t.co/JS3WQpyMna

Aug 18, 2022 · 23 likes · 1 share · 41,724 followers View post →

ENDALA klinika zdraví

@endalaclinic · X

Immune changes in humans during cold exposure: effects of prior heating and exercise | Journal of Applied Physiology https://t.co/mnB1xNAfXm

May 24, 2022 · 254 followers View post →

londo

@londo402 · X

@DBelardoMD i don't know much about it but I had this convo recently with my physio, so I did googling. My antivax "natural" neighbour sends her kids out in the snow each morning so that doesn't exactly sell it for me But there's this, brrrrr

Jan 23, 2022 · 669 followers View post →

Thomas P Seager, PhD

@seagertp · X

RT @drkohilathas: https://t.co/aZfxLszaor.

Jan 18, 2022 · 3 shares · 13,184 followers View post →

libmbr

@libmbr · X

RT @drkohilathas: https://t.co/aZfxLszaor.

Jan 18, 2022 · 3 shares · 2,374 followers View post →

L ❤ V E

@drkohilathas · X

https://t.co/aZfxLszaor.

Jan 18, 2022 · 3 likes · 3 shares · 47,836 followers View post →

Maarten De Cock

@mdc_martinus · X

@TWenseleers @jdceulaer @drWouterArrazol U verwijst naar die ene studie uit 2015 met muizen? Er zijn andere studies met mensen waarin men tot andere conclusies komt. Bv. https://t.co/lVGxhLi9K8

Dec 18, 2021 · 1 like · 6,681 followers View post →

أبو عقيل

@QallamQ · X

بالنسبة لي انا لا اصدق اي دراسة او تجربة اقرأها، لكني احلل وادقق وابذل جهدي في اثبات خطئها او صوابها، لكني وضعت الرابط هنا حتى يستفيد من اراد ان يتعمق او ان يبحث عن المنطق المنشود بين الايات وبين الواقع https://t.co/gyTz402EYR

Nov 4, 2021 · 1 like · 6,564 followers View post →

Harvia

@harviaglobal · X

@InvestingSnake Please see these links: https://t.co/yezaTEdoWm https://t.co/Accrs16pN3

Aug 2, 2021 · 1 like · 959 followers View post →

Federico Baldomá

@fedebaldoma · X

Adicionalmente ya hace años existe evidencia de cambios beneficiosos en la inmunidad mediados por complejos mecanismos https://t.co/1x0ynDJ35i

May 6, 2021 · 4 likes · 757 followers View post →

Ethan Hays

@ethanhays · X

Feb 20, 2021 · 2,672 followers View post →

crc traceur

@TraceurPac · X

@OUIYAMZ @Upb_92i @_belzepute_ @LeMonke_SP https://t.co/Zwo1NVU61o https://t.co/bBtwM3I5jK pas vraiment la peau etc, mais bon effets contre depression + améliorer le système immun

Feb 7, 2021 · 641 followers View post →

afolabi timothy

@micorazon941 · X

@djschuett @JonBLivesHere @thecheckdown @packers https://t.co/LIPfP59WsW. Maybe not directly but I think you'll agree cold temperatures especially if extreme can lead to stress to the body system, - effect on immune system. E.g in cases of hypothermia or can trigger conditions like CAD

Dec 28, 2020 · 147 followers View post →

plainAnn

@plain_annn · X

@grahamman43 @RAVGallegos @GovMLG @NMDOH https://t.co/AHeXi5aVtH

Dec 22, 2020 · 26 followers View post →

Maarten De Cock

@mdc_martinus · X

Sep 26, 2020 · 3 likes · 6,681 followers View post →

Tekn. dr Johan

@TeknDrJohan · X

@EgorPutilov @Lobuz1 https://t.co/Lmum6t3uFK https://t.co/TlC2LVz3iW https://t.co/hiCC3W9onR https://t.co/s58CUorLBn https://t.co/ClI4lxZOJ3

Apr 13, 2020 · 2,063 followers View post →

Yuji Marutani | The Exiled Emperor

@YujiMarutani · X

Immune changes in humans during cold exposure: effects of prior heating and exercise | Journal of Applied Physiology https://t.co/nAaoVZVgHK

Apr 6, 2020 · 1,571 followers View post →

Toomas Laasik

@ToomasLaasik · X

7/9 Hyperthermia combined with sudden cooling down mobilizes your first response immune system cells that are especially important because this virus is suppressing these. This is basically sauna (koos "karastamisega") https://t.co/CQVvkDHyPO #COVID19

Apr 2, 2020 · 1 like · 98 followers View post →

Kareem Medhat

@kareem_medhat · X

@p9alma Check this paper https://t.co/Yg9IsKTA4A

Apr 1, 2020 · 67,948 followers View post →

Cyrus Crook

@CyrusCrook · X

Looks like a score for cold exposure. It increases the innate immune response. @Iceman_Hof check out this paper! https://t.co/5u2Y3jNEu4 #wimhofmethod #cold #health

Mar 31, 2020 · 28 followers View post →

عبدالعزيز سعود العمار

@Aziz_LMR · X

https://t.co/HCJqj2LJqe

Mar 30, 2020 · 1 like · 1,268 followers View post →

Fer_For

@en_FER_mero · X

RT @rgtfisio: @chuletadeosler Sobre frío y respuesta inmune: https://t.co/Wqa1bRVtzc

Jan 11, 2020 · 4 shares · 182 followers View post →

Fer_For

@en_FER_mero · X

@Guillamon_ @svqcity @PauMatalap Sobre el tema de la respuesta inmune es interesante este estudio, si es cierto que añaden el componente del ejercicio con la exposición al frío, pero parece ser que provoca una aumento de la respuesta inmune. https://t.co/0VA6NpnnYC

Jan 11, 2020 · 2 likes · 182 followers View post →

GCinfecciosas

@GCinfecciosas · X

RT @rgtfisio: @chuletadeosler Sobre frío y respuesta inmune: https://t.co/Wqa1bRVtzc

Jan 11, 2020 · 4 shares · 778 followers View post →

Hidle Sol

@Solana_Hide · X

@chuletadeosler Sobre frío y respuesta inmune: https://t.co/Wqa1bRVtzc

Jan 10, 2020 · 11 likes · 4 shares · 5,788 followers View post →

Immune changes in humans during cold exposure: effects of prior heating and exercise.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Enhancing Health with Sauna and Cold Water Immersion Techniques

Exploring the Impact of Cold Water Immersion on Health Benefits