Am J Physiol December 1999 PMID 10600804

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss.

D E Kelley, B Goodpaster, R R Wing, J A Simoneau

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What people are saying

The discussions show strong engagement with technical aspects, such as fatty acid uptake versus oxidation differences and implications for obesity, reflected in phrases like 'impaired ability to use FA for energy' and references to muscle enzyme activity. The toneOverall emphasizes curiosity and relevance, suggesting the article contributes meaningful insights into muscle metabolism, especially in the context of weight loss and insulin resistance.

AgreementModerate agreement

Most discussions acknowledge the findings and see them as consistent with current understanding of muscle metabolism in obesity.

InterestHigh interest

Participants demonstrate high interest, mentioning specific metabolic processes and implications for obesity treatment.

EngagementHigh engagement

Comments include references to detailed mechanisms and research insights, indicating deep involvement.

ImpactModerate impact

The discourse suggests the findings could influence future research directions and clinical approaches, although some see it as confirmatory rather than groundbreaking.

Abstract in brief

The study investigated how skeletal muscle processes fatty acids in lean versus obese individuals, finding that obesity is associated with decreased muscle enzyme activity and reduced fat oxidation, especially during fasting.
Obese subjects showed a higher respiratory quotient (RQ), indicating less fat burning and more reliance on carbohydrate metabolism, and didn't suppress fat oxidation effectively during insulin infusion, unlike lean individuals.
After weight loss, insulin sensitivity improved, but muscle enzyme activity and fat oxidation capacity didn't significantly change, suggesting that muscle triglyceride buildup in obesity is more related to a reduced ability to burn fat rather than increased fatty acid uptake.]

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Andrew Wyman

@Drago631 · X

@hjluks @simplavida https://t.co/kbmUNMzQG0

Sep 28, 2023 · 57 followers View post →

siobhan_huggins

@siobhan_huggins · X

@nicknorwitz @realDaveFeldman @Ad_SotoMota See also this interesting difference in fatty acid handling: https://t.co/gSt5deHb3U

Feb 11, 2022 · 1 like · 14,735 followers View post →

siobhan_huggins

@siobhan_huggins · X

Jan 31, 2022 · 14,735 followers View post →

Nick Krontiris

@nick_krontiris · X

Refs: https://t.co/ZigMRtKBiW https://t.co/gL7HSJu8sy https://t.co/wrOawnXFAD https://t.co/rjoXqPjIdi

Oct 11, 2020 · 19,386 followers View post →