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The group expresses a general agreement with the rule's significance, citing examples such as the molecular weight of magnesium chloride and the limitations of compounds like rapamycin, which exceeds 500 Daltons. The tone varies from supportive to skeptical, with some participants referencing scientific sources or challenging claims, indicating both curiosity and critical engagement with the topic.
Most discussions acknowledge the importance of the 500 Dalton rule and support its relevance to recent debates on transdermal drug delivery.
The discussions show moderate interest, focusing on specific applications like cosmetics and topical treatments.
Many comments delve into explanations of the rule, critique of claims, and references to scientific literature, indicating a deeper engagement.
The conversations reflect awareness of the regulatory and practical implications of the rule, affecting both scientific understanding and industry practices.
https://t.co/umeGcp98r7 From what I understand, g/mol = dalton = molecular weight. For topical / transdermal absorption, a molecule has to be less than 500 daltons. For example magnesium chloride is 95, which makes sense because it is absorbed well through the skin
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It's always an honor to be blocked by crooks. In this case some guy selling topical rapamycin (MW 914) cream against skin aging. Many people don't know, but there is an upper limit (MW 500) for the size of molecules able to diffuse across skin. https://t.co/jCuhj8mbyW https://t.co/BEls64ju5u
What is the 500 Dalton rule and what does it mean for #cosmeticchemists? The linked publication provides a good discussion of the topic. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. #cosmeticscience #skincare #allergens https://t.co/5pdNTee4Qh https://t.co/1uDarzA0Rm
The company is @healthspanmed of which @dantawfik is a "founder, developer and CEO". Nothing against #rapamycin, but smearing it on your skin doesn't make sense. https://t.co/jCuhj8mbyW
@shreddy_kruger @Meow_Mermaid @Futurismprimo @DanceSafe So, I’m not sure if you’ve ever done a research paper in a science class, but this is exactly why your teacher told you to not write based off of the abstract. Here’s the full text. Good luck with whatever the hell you’re doing. https://t.co/YrlYgSByAE
The 500 Dalton rule states that chemical compounds need to have a molecular weight under 500 Dalton to effectively penetrate human skin, as larger molecules are prevented by the skin's corneal layer.
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The 500 Dalton rule states that chemical compounds need a molecular weight under 500 Dalton to penetrate human skin effectively. Most contact allergens and topical drugs are below this threshold, guiding pharmaceutical…
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@Bobsdplissken @LA_citizenz @bryan_johnson @xtbot https://t.co/54Wwv67INe… https://t.co/G1Kztn6qxU it doesn’t need to penetrate the blood brain barrier to elicit systemic decreases in DHT . There are 5AR receptors all over your whole body.
The classic literature "The 500 Dalton rule for the skin penetration of chemical compounds and drugs" in "Experimental Dermatology" points out that the molecular weight dividing line of compounds absorbed by normal skin (NS) through the stratum corneum is 500Da.
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RT @kellydobos: What is the 500 Dalton rule and what does it mean for #cosmeticchemists? The linked publication provides a good discussion…
RT @kellydobos: What is the 500 Dalton rule and what does it mean for #cosmeticchemists? The linked publication provides a good discussion…
What is the 500 Dalton rule and what does it mean for #cosmeticchemists? The linked publication provides a good discussion of the topic. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. #cosmeticscience #skincare #allergens https://t.co/5pdNTee4Qh https://t.co/1uDarzA0Rm
The company is @healthspanmed of which @dantawfik is a "founder, developer and CEO". Nothing against #rapamycin, but smearing it on your skin doesn't make sense. https://t.co/jCuhj8mbyW
It's always an honor to be blocked by crooks. In this case some guy selling topical rapamycin (MW 914) cream against skin aging. Many people don't know, but there is an upper limit (MW 500) for the size of molecules able to diffuse across skin. https://t.co/jCuhj8mbyW https://t.co/BEls64ju5u
@RapaNews @healthspanmed Sure, feel free to believe these small scale positive reports with all their COIs and biases.There is an infinite supply of these. They don't change the laws of physics. Rapamycin MW = 914. Transdermal limit ~500. Might as well believe in time travel. https://t.co/jCuhj8mbyW
The 500 Dalton rule for the skin penetration of chemical compounds and drugs https://t.co/UoGbxjSo3g
@shreddy_kruger @Meow_Mermaid @Futurismprimo @DanceSafe So, I’m not sure if you’ve ever done a research paper in a science class, but this is exactly why your teacher told you to not write based off of the abstract. Here’s the full text. Good luck with whatever the hell you’re doing. https://t.co/YrlYgSByAE
@kitteyandkat @Meow_Mermaid @Futurismprimo @DanceSafe Its literally called the dalton rule. https://t.co/AUqcdm8n7z
RT @Mithreu: https://t.co/umeGcp98r7 From what I understand, g/mol = dalton = molecular weight. For topical / transdermal absorption, a mo…
https://t.co/umeGcp98r7 From what I understand, g/mol = dalton = molecular weight. For topical / transdermal absorption, a molecule has to be less than 500 daltons. For example magnesium chloride is 95, which makes sense because it is absorbed well through the skin
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