April 2001 PMID 11287972

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

B J Druker, M Talpaz, D J Resta, B Peng, E Buchdunger, J M Ford, N B Lydon, H Kantarjian, R Capdeville, S Ohno-Jones, C L Sawyers

Mentions

26
Peak: 8 in Jun 2025
across 4 sources since May 2020

Extended reach

47,133
potential audience

Total likes

33

Video views

617

Mentions per month

May 2020 – Jun 2025

Where it's discussed

  • YouTube8 videos
  • News8 articles
  • Blogs6 articles
  • X / Twitter4 posts

AI synopsis

What people are saying

The discussion collectively conveys strong approval and high interest, with posts describing the drug Gleevec's success in achieving remission for CML patients and noting its potential to revolutionize treatment, using words like 'breakthrough' and 'full remission' to underscore its importance and influence.

AgreementStrong agreement

Most discussions highlight the groundbreaking effectiveness of the drug in treating CML, with phrases like 'result in full remission' and 'breakthrough' indicating strong support.

InterestHigh interest

Participants show high curiosity and admiration for the research, referencing the drug's success and potential, signaling a deep interest in the topic.

EngagementHigh engagement

Some comments discuss specific mechanisms, trial phases, and broader implications, reflecting thoughtful and detailed engagement.

ImpactHigh impact

Numerous posts emphasize the potential for this drug to change cancer treatment paradigms, describing it as a 'game changer' and discussing its significance for patient outcomes.

Abstract in brief

  • The study tested STI571, a targeted drug that inhibits BCR-ABL tyrosine kinase, in patients with chronic myeloid leukemia (CML) who did not respond to interferon treatment, and found it to be generally safe with minimal side effects.
  • Most patients who received at least 300 mg of STI571 daily showed complete hematologic responses within the first four weeks, and some also experienced cytogenetic responses, including complete remissions in a subset of patients.
  • These findings highlight the crucial role of BCR-ABL kinase activity in CML and suggest that drugs targeting this specific abnormality can be effective and safe options for treatment.

Top posts

Most liked on X and Bluesky
Dr. Abdurahman Alloghbi د.عبدالرحمن اللغبي
@AAlloghbi · X

يسميه البعض الدواء المعجزة!(imatinib) حوّل المرض الذي كان قاتلا يوم من الأيام (CML) إلى مرض سهل التحكّم به الدراسة الأولى التي اثبتت فعالية الدواء (الرابط) كانت مدعومة من شركة أدوية مما يعكس دور شركات الأدوية في دعم البحث العلمي في تخصص حساس مثل الأورام https://t.co/dDXGosvabo

Apr 21, 2021 · 3 likes · 1 share · 12,653 followers View post →
Anirban Maitra
@Aiims1742 · X

@leslievosshall The phase 1 in CML patients is a #Singleplot in and of itself. https://t.co/I2LPFfeIWX https://t.co/QVviMqkY0g

Jun 17, 2022 · 2 likes · 31,211 followers View post →
Joe Matthews
@JosephMatthews_ · X

The hunt for a specific anti-cancer drug continued. Then, a breakthrough: CGP57148B (aka Gleevec) was shown to result in full remission for nearly all chronic myeloid leukaemia patients

Dec 30, 2022 · 1 like · 1,407 followers View post →
Ramya Ramaswami
@ramya_ramaswami · X

@DrKateLurain @adamcifu ...RCTs have to start somewhere https://t.co/ze9bsk9HeT

May 18, 2020 · 1 like · 1,245 followers View post →

All mentions

Joe Matthews
@JosephMatthews_ · X

The hunt for a specific anti-cancer drug continued. Then, a breakthrough: CGP57148B (aka Gleevec) was shown to result in full remission for nearly all chronic myeloid leukaemia patients

Dec 30, 2022 · 1 like · 1,407 followers View post →
Anirban Maitra
@Aiims1742 · X

@leslievosshall The phase 1 in CML patients is a #Singleplot in and of itself. https://t.co/I2LPFfeIWX https://t.co/QVviMqkY0g

Jun 17, 2022 · 2 likes · 31,211 followers View post →
Dr. Abdurahman Alloghbi د.عبدالرحمن اللغبي
@AAlloghbi · X

يسميه البعض الدواء المعجزة!(imatinib) حوّل المرض الذي كان قاتلا يوم من الأيام (CML) إلى مرض سهل التحكّم به الدراسة الأولى التي اثبتت فعالية الدواء (الرابط) كانت مدعومة من شركة أدوية مما يعكس دور شركات الأدوية في دعم البحث العلمي في تخصص حساس مثل الأورام https://t.co/dDXGosvabo

Apr 21, 2021 · 3 likes · 1 share · 12,653 followers View post →
Ramya Ramaswami
@ramya_ramaswami · X

@DrKateLurain @adamcifu ...RCTs have to start somewhere https://t.co/ze9bsk9HeT

May 18, 2020 · 1 like · 1,245 followers View post →