Am J Physiol Endocrinol Metab December 2001 PMID 11701428

Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet.

S J Peters, R A Harris, P Wu, T L Pehleman, G J Heigenhauser, L L Spriet

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Mentions

Peak: 2 in Jun 2022

across 3 sources since Mar 2021

Extended reach

431,071

potential audience

Total likes

7,450

Video views

405,597

Mentions per month

Mar 2021 – Jun 2022

Where it's discussed

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YouTube2 videos
Blogs2 articles

AI synopsis

What people are saying

The discussions demonstrate high interest and moderate engagement through references to prior research, such as mentions of Sandy Peters' work on PDH kinase activity and its time course after low-carb diets. The tone is analytical, emphasizing the metabolic significance of the enzyme activity changes and their implications for understanding high-fat/low-carbohydrate diet effects.

AgreementModerate agreement

Most discussions acknowledge the validity of the research, referencing prior work to support findings about PDH kinase activity changes.

InterestHigh interest

Participants show strong interest, engaging with specifics of enzyme activity, diet response timing, and metabolic implications.

EngagementModerate engagement

Posts cite specific studies and detail how PDH kinase levels change over days, demonstrating moderate to deep engagement.

ImpactModerate impact

The discussions highlight the significance of these findings for understanding metabolic shifts, which may influence dietary and exercise strategies.

Abstract in brief

The study found that after switching to a high-fat, low-carbohydrate diet, the activity of pyruvate dehydrogenase kinase (PDK) in skeletal muscle increased linearly over three days, indicating a metabolic shift toward fat utilization.
PDK4 protein and mRNA levels peaked after one day of the diet, while PDK2 remained unchanged, suggesting that PDK4 plays a more prominent role in this adaptation.
The decrease in respiratory exchange ratios and increased blood markers like glycerol and ketone bodies support a rapid switch to fat burning, although the sustained rise in PDK activity beyond day one might involve other PDK isoforms or increased enzyme activity.]

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Trent Stellingwerff, PhD / CSEP-CEP / FACSM / ChPC

@TStellingwerff · X

RT @jwhitfie: @NanciGuestRDPhD @theproof @BioLayne @Veganella_ @TStellingwerff Classic work from Sandy Peters and @lspriet showed PDH kinas…

Jun 5, 2022 · 1 share · 23,127 followers View post →

Jamie Whitfield, PhD

@jwhitfie · X

Jun 5, 2022 · 7 likes · 1 share · 2,344 followers View post →