N Engl J Med December 2001 PMID 11759645

A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure.

J N Cohn, G Tognoni

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Mentions

41
Peak: 8 in Sep 2024
across 4 sources since Jul 2020

Extended reach

157,372
potential audience

Total likes

225

Video views

11,304

Mentions per month

Jul 2020 – Sep 2024

Where it's discussed

  • X / Twitter32 posts
  • News4 articles
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reveal a nuanced debate about the effectiveness of valsartan, with posts referencing historical trials like Val-HeFT and highlighting conflicting evidence—such as one post mentioning that valsartan did not reduce mortality, while others focus on reduced hospitalizations. The tone varies from critical to analytical, showing both skepticism and engagement in interpreting trial outcomes, which supports the assigned scores.

AgreementNeither agree nor disagree

Discussions reflect mixed opinions about the study's findings, especially regarding valsartan's efficacy in reducing mortality, with some posts challenging or questioning its conclusions.

InterestModerate interest

Posts show moderate to high interest, as users discuss specific trials, compare drugs, and analyze implications for treatment decisions.

EngagementHigh engagement

Many posters deeply analyze trial results, cite studies, and engage in detailed debates, indicating a high level of intellectual engagement.

ImpactModerate impact

Discussions highlight the significance of the study in shaping treatment choices and understanding drug effects, although some debate about the overall benefits reduces perceived universal impact.

Abstract in brief

  • The study tested whether adding the drug valsartan, an angiotensin receptor blocker, to standard heart failure treatments could improve patient outcomes, focusing on effects like death rates and hospitalizations.
  • Results showed that while overall death rates were similar between the valsartan and placebo groups, patients taking valsartan experienced a 13.2% reduction in combined adverse events (like hospitalization or severe symptoms), mainly due to fewer hospitalizations for heart failure.
  • Valsartan also improved heart failure symptoms, heart function, and quality of life, but its effectiveness varied depending on other medications patients were taking; it helped some groups but was less effective or potentially harmful when used alongside certain drugs like ACE inhibitors and beta-blockers.]

Top posts

Most liked on X and Bluesky
Muthu Vaduganathan
@mvaduganathan · X

Enalapril was the best studied RASi & was tested at doses *higher* than those proven to ↓ mortality in #CONSENSUS & #SOLVD Valsartan was never proven to ↓ mortality & would have been considered a straw man comparator...perhaps by the very same people

Sep 27, 2024 · 43 likes · 7 shares · 9,315 followers View post →
たけちゃん
@nitrotake · X

バルサルタンvsプラセボのデザインだけど、ベースラインを見たら92%の人がACE-Iを使っているやん。 Val-HeFT Cohn JN,et al.N Engl J Med. 2001 Dec 6;345(23):1667-75.PMID:11759645 https://t.co/Gbd90TjGeP

Jun 19, 2021 · 5 likes · 2 shares · 1,441 followers View post →
SABOURETCardiologist
@SABOURETCardio · X

@GiuseppeGalati_ @hvanspall @MarcoMetra @MicheleSenni @DrRajivsankar @rahatheart1 @AndreasGevaert @DrMarthaGulati @ShelleyZieroth @mirvatalasnag @DrNasrien @AspriAlexia @KTamirisaMD @MKIttlesonMD @HanCardiomd @pumpinghearts @IC_LaFe @ehj_ed @Vilavaite https://t.co/NHOrsvycqI #CardioTwitter

Jul 13, 2020 · 3 likes · 31,507 followers View post →
David Dobarro
@DrDavidDobarro · X

@roi_cal @doctorchecho @mgalandejuana En absoluto. Valsartan no redujo mortalidad por todas las causas: https://t.co/jrQFL7ZEkk La comparación de SV con IECA es pertinente. ARA2 solo son alternativa a IECA en caso de tos en IC-FEr; por no demostrar reducción de mortalidad por todas las causas. Los IECA si. Y SV más.

Aug 24, 2023 · 1 like · 568 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Oct 19, 2021 · 1 like · 140 followers View post →
Dr. Martha Gulati ♥️
@DrMarthaGulati · X

RT @mvaduganathan: Enalapril was the best studied RASi & was tested at doses *higher* than those proven to ↓ mortality in #CONSENSUS & #SOL…

Sep 27, 2024 · 7 shares · 65,332 followers View post →

All mentions

orion77
@orion7710 · X

RT @mvaduganathan: Enalapril was the best studied RASi & was tested at doses *higher* than those proven to ↓ mortality in #CONSENSUS & #SOL…

Sep 29, 2024 · 7 shares · 1,400 followers View post →
Dr. A. Murshid الدكتور/ عبدالإله عبدالرحمن مرشد
@murshid_eyad2 · X

RT @mvaduganathan: Enalapril was the best studied RASi & was tested at doses *higher* than those proven to ↓ mortality in #CONSENSUS & #SOL…

Sep 28, 2024 · 7 shares · 5,078 followers View post →
Andrew J Sauer MD
@AndrewJSauer · X

RT @mvaduganathan: Enalapril was the best studied RASi & was tested at doses *higher* than those proven to ↓ mortality in #CONSENSUS & #SOL…

Sep 28, 2024 · 7 shares · 19,632 followers View post →
Giacomo
@GiacoVirgili · X

RT @mvaduganathan: Enalapril was the best studied RASi & was tested at doses *higher* than those proven to ↓ mortality in #CONSENSUS & #SOL…

Sep 27, 2024 · 7 shares · 408 followers View post →
Dr. Martha Gulati ♥️
@DrMarthaGulati · X

RT @mvaduganathan: Enalapril was the best studied RASi & was tested at doses *higher* than those proven to ↓ mortality in #CONSENSUS & #SOL…

Sep 27, 2024 · 7 shares · 65,332 followers View post →
Niccolo Bonini
@BoniniNiccolo · X

RT @mvaduganathan: Enalapril was the best studied RASi & was tested at doses *higher* than those proven to ↓ mortality in #CONSENSUS & #SOL…

Sep 27, 2024 · 7 shares · 113 followers View post →
soda_troubles,https://med-mastodon.com/@haysam
@set_fortess · X

RT @mvaduganathan: Enalapril was the best studied RASi & was tested at doses *higher* than those proven to ↓ mortality in #CONSENSUS & #SOL…

Sep 27, 2024 · 7 shares · 2,599 followers View post →
Muthu Vaduganathan
@mvaduganathan · X

Enalapril was the best studied RASi & was tested at doses *higher* than those proven to ↓ mortality in #CONSENSUS & #SOLVD Valsartan was never proven to ↓ mortality & would have been considered a straw man comparator...perhaps by the very same people

Sep 27, 2024 · 43 likes · 7 shares · 9,315 followers View post →
David Dobarro
@DrDavidDobarro · X

@roi_cal @doctorchecho @mgalandejuana En absoluto. Valsartan no redujo mortalidad por todas las causas: https://t.co/jrQFL7ZEkk La comparación de SV con IECA es pertinente. ARA2 solo son alternativa a IECA en caso de tos en IC-FEr; por no demostrar reducción de mortalidad por todas las causas. Los IECA si. Y SV más.

Aug 24, 2023 · 1 like · 568 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Sep 2, 2022 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWPdaq

Aug 27, 2022 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Jul 12, 2022 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Jun 28, 2022 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Jun 14, 2022 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

May 11, 2022 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Apr 10, 2022 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Apr 2, 2022 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Oct 19, 2021 · 1 like · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Oct 14, 2021 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Jul 30, 2021 · 140 followers View post →
alxyz
@alxyz12 · X

RT @nitrotake: バルサルタンvsプラセボのデザインだけど、ベースラインを見たら92%の人がACE-Iを使っているやん。 Val-HeFT Cohn JN,et al.N Engl J Med. 2001 Dec 6;345(23):1667-75.PMID:11…

Jun 20, 2021 · 2 shares · 471 followers View post →
あずーる@Azule
@Anazuresky2 · X

RT @nitrotake: バルサルタンvsプラセボのデザインだけど、ベースラインを見たら92%の人がACE-Iを使っているやん。 Val-HeFT Cohn JN,et al.N Engl J Med. 2001 Dec 6;345(23):1667-75.PMID:11…

Jun 19, 2021 · 2 shares · 5,551 followers View post →
たけちゃん
@nitrotake · X

バルサルタンvsプラセボのデザインだけど、ベースラインを見たら92%の人がACE-Iを使っているやん。 Val-HeFT Cohn JN,et al.N Engl J Med. 2001 Dec 6;345(23):1667-75.PMID:11759645 https://t.co/Gbd90TjGeP

Jun 19, 2021 · 5 likes · 2 shares · 1,441 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Jun 2, 2021 · 140 followers View post →
Yasser UMKCRCT
@ymhs92 · X

Among patients with heart failure, valsartan was associated with lower rates of combined endpoint mainly related to decreased hospitalizations for HF compared with placebo with similar mortality #UMKCRCT https://t.co/Vo7vBvxjeB

Apr 11, 2021 · 9 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Feb 20, 2021 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Dec 19, 2020 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Dec 2, 2020 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Nov 21, 2020 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Sep 24, 2020 · 140 followers View post →
OneLineSummary Bot
@OLS_Bot · X

Val-HeFT - 2001 - Valsartan vs placebo in LVF - ↓hospital admissions, ∅mortality - https://t.co/MmIlNWOFkS

Aug 23, 2020 · 140 followers View post →
SABOURETCardiologist
@SABOURETCardio · X

@GiuseppeGalati_ @hvanspall @MarcoMetra @MicheleSenni @DrRajivsankar @rahatheart1 @AndreasGevaert @DrMarthaGulati @ShelleyZieroth @mirvatalasnag @DrNasrien @AspriAlexia @KTamirisaMD @MKIttlesonMD @HanCardiomd @pumpinghearts @IC_LaFe @ehj_ed @Vilavaite https://t.co/NHOrsvycqI #CardioTwitter

Jul 13, 2020 · 3 likes · 31,507 followers View post →