The collective discussions demonstrate strong support and interest in the classic 2001 Rivers study, with references to its role in transforming sepsis care, as seen in phrases like 'defining therapy goals' and 'changing treatment.' The tone conveys admiration for its historical significance and ongoing relevance, evidenced by questions about specific fluids used and calls for visual summaries, reflecting deep engagement and recognition of its high impact on critical care practices.
AgreementStrong agreement
Most discussions recognize the importance and effectiveness of the Rivers protocol, highlighting its role in reducing sepsis mortality.
InterestHigh interest
Participants show high interest, referencing specific studies, historical context, and guidelines related to early goal-directed therapy.
EngagementHigh engagement
Many posts involve detailed references, questions, and mentions of subsequent research and guidelines, indicating deep engagement.
ImpactHigh impact
The widespread acknowledgment of the study’s influence on sepsis treatment and guideline development suggests a high perceived impact.
Abstract in brief
Early goal-directed therapy (EGDT) for severe sepsis and septic shock involves carefully adjusting heart function and blood flow to improve oxygen delivery, and this study tested its effectiveness before patients entered intensive care.
The study found that patients who received early EGDT had a lower in-hospital mortality rate (30.5%) compared to those who received standard therapy (46.5%), along with better blood oxygen levels and metabolic markers during treatment.
These results suggest that implementing early goal-directed therapy in the emergency department can significantly improve outcomes in severe sepsis and septic shock patients, reducing death rates and stabilizing vital parameters before intensive care.
Die vor 20 Jahren publizierte "Rivers"Studie hat die #Sepsis Therapie grundlegend verändert. Sie definierte Therapieziele, die innerhalb von 6h erreicht werden sollten. Sie zeigte eine Mortalitätssenkung von 46,5 auf 30,5% (1/4)
https://t.co/w2k04z8fNc
Momentos que mantienen humilde (de por vida y aún más allá de ella) al Dr. Rivers
https://t.co/pMCQC5o0vs https://t.co/rjk0uHuW1v
Jan 28, 2023 · 33 likes · 4 shares · 94,094 followersView post →
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Vitor Borin P. de Souza
@vitorborin_ · X
@eeagorajose Até onde eu sei, esse 30mL/kg veio do estudo do Rivers de 2001 que criou um protocolo de fazer isso pra sepse (https://t.co/ryaFHMSV9d)
Foi um valor que os pesquisadores simplesmente determinaram arbitrariamente. E aparentemente a gente decidiu adotar isso arbitrariamente pra
New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock." #Infographic #FOAMed
Full infographic: https://t.co/U90jH1As4z
Full paper: https://t.co/MSSFWFAtm0 https://t.co/RjHycJ3yCL
Feb 22, 2019 · 21 likes · 13 shares · 12,146 followersView post →
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Chris Carroll MD
@ChrisCarrollMD · X
Dr Rivers’ trial, a single center randomized trail of early goal directed therapy showed that focusing early goals improved outcomes in #sepsis https://t.co/kus5tz9AjG
Feb 12, 2019 · 15 likes · 4 shares · 20,132 followersView post →
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Joel M. Topf, MD FACP
@kidney_boy · X
Anybody know what crystalloid was used in the Rivers EGDT trial? https://t.co/h2xU8JuFPq @Boka_MD
May 16, 2020 · 14 likes · 2 shares · 63,764 followersView post →
This educational video reviews the current state of septic shock management, emphasizing recent clinical trials comparing early goal-directed therapy with standard care and its impact on patient survival and organ…
This episode discusses critical care advancements, focusing on early goal-directed therapy, fluid responsiveness, oxygen delivery, and integrating data points for patient management. Highlights include recent trials and…
@ChristosArgyrop @doc_BLocke @PatientStormDoc @RWJE_BA Well I disagree I don’t know how sepsis is vaporware. Rivers protocol has saved a lot of lives too https://t.co/5ktehZt4TT
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock | New England Journal of Medicine #kikiislore #poorsorewhores https://t.co/1gmcpumpOK
@DrHezael12 @OrlandoRPN I distinguish various presentations and phases of shock before reaching irreversible stages.A constant goal is hemodynamic optimization. If severe sepsis or septic shock: Early Goal Direct Therapy
See also:https://t.co/AgRoJ4cRpx
@eeagorajose Até onde eu sei, esse 30mL/kg veio do estudo do Rivers de 2001 que criou um protocolo de fazer isso pra sepse (https://t.co/ryaFHMSV9d)
Foi um valor que os pesquisadores simplesmente determinaram arbitrariamente. E aparentemente a gente decidiu adotar isso arbitrariamente pra
Mar 20, 2024 · 3 likes · 6,832 followersView post →
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OxAIMPHEM
@OxAIMPHEM · X
In this intro to critical appraisal Dr Shah will be taking us through two classics of emergency and critical care literature:
1) Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock (https://t.co/vdvQml7vOY)
Aug 31, 2023 · 12 likes · 2 shares · 21,523 followersView post →
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Adrian Soto-Mota
@AdrianSotoMota · X
For context, in a 2001, a paper by Rivers et al showed a large mortality reduction when implementing EGDT.
https://t.co/kZbZLh03Po
This protocol was quickly adopted by the then emerging Surviving Sepsis Guidelines and it was the Standard of Care until not too long ago.
Jul 21, 2023 · 1 like · 9,224 followersView post →
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rita gayed
@GayedRita · X
RT @SCCMSE: However, this study focused on all components of sepsis care without an emphasis on fluid therapy specifically. #SCCMSEChat
htt…
"Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand."
#WorldSepsisDay
https://t.co/zgqiBNhzU9
"Early goal-directed therapy provides significant benefits with respect to outcome in patients with severe sepsis and septic shock."
Let's improve patient outcomes
#WSD22 #sepsisday #Valuelife
https://t.co/zgqiBNhzU9
Die vor 20 Jahren publizierte "Rivers"Studie hat die #Sepsis Therapie grundlegend verändert. Sie definierte Therapieziele, die innerhalb von 6h erreicht werden sollten. Sie zeigte eine Mortalitätssenkung von 46,5 auf 30,5% (1/4)
https://t.co/w2k04z8fNc
Rivers publishes EGDT in the NEJM in November of 2001. In December of 2001 the Surviving Sepsis Campaign is born. Am I correct too a causal relationship there? Break through in approach inspires development of new guidelines
https://t.co/h2xU8JuFPq
https://t.co/Hv2gEFE5fX
May 11, 2020 · 3 likes · 1 share · 63,764 followersView post →
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I’am Shey
@shey_lalalala · X
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock | NEJM https://t.co/VKlBuWRkzq
@RyanGamlin The original study was small but the evidence base has grown since then. This target was also used in the Rivers trial. https://t.co/6ZqxD4UAXs https://t.co/FHO9NQhNCt
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Mar 13, 2019 · 13 shares · 9,098 followersView post →
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Syed Shahrul Naz
@drshahrul80 · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 23, 2019 · 13 shares · 6,929 followersView post →
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Alvin Chin
@AylC1989 · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 23, 2019 · 13 shares · 361 followersView post →
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Werner Scheinpflug
@WernerMedEd · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 23, 2019 · 13 shares · 70 followersView post →
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DrNeilMD
@realDrNeilMD · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 23, 2019 · 13 shares · 202 followersView post →
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MDPusheen
@shortwhitekoat · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 23, 2019 · 13 shares · 94 followersView post →
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Pierre Arbulú
@mtd98 · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 22, 2019 · 13 shares · 707 followersView post →
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Michael Neeki
@MichaelNeeki · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 22, 2019 · 13 shares · 130 followersView post →
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Kate Sokolowska-Redfern
@Katita1981 · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 22, 2019 · 13 shares · 980 followersView post →
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Teresa Chan | 陳敏怡
@TChanMD · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 22, 2019 · 13 shares · 14,609 followersView post →
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Asit Misra ☀️
@misraasit · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 22, 2019 · 13 shares · 716 followersView post →
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ES
@runningfester · X
RT @WeAreCanadiEM: New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe…
Feb 22, 2019 · 13 shares · 212 followersView post →
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CanadiEM
@WeAreCanadiEM · X
New #MVPInfographic highlighting a 2001 paper from @NEJM titled "Early-Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock." #Infographic #FOAMed
Full infographic: https://t.co/U90jH1As4z
Full paper: https://t.co/MSSFWFAtm0 https://t.co/RjHycJ3yCL
Feb 22, 2019 · 21 likes · 13 shares · 12,146 followersView post →
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H.E. Hinson, MD MCR FAAN FNCS
@HollyEHinson · X
RT @ChrisCarrollMD: Dr Rivers’ trial, a single center randomized trail of early goal directed therapy showed that focusing early goals impr…
Feb 18, 2019 · 4 shares · 1,861 followersView post →
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Syed Shahrul Naz
@drshahrul80 · X
RT @ChrisCarrollMD: Dr Rivers’ trial, a single center randomized trail of early goal directed therapy showed that focusing early goals impr…
Feb 17, 2019 · 4 shares · 6,929 followersView post →
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〽️atthew Duprey
@PharmDuprey · X
RT @ChrisCarrollMD: Dr Rivers’ trial, a single center randomized trail of early goal directed therapy showed that focusing early goals impr…
Feb 17, 2019 · 4 shares · 1,082 followersView post →
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Chris Carroll MD
@ChrisCarrollMD · X
Dr Rivers’ trial, a single center randomized trail of early goal directed therapy showed that focusing early goals improved outcomes in #sepsis https://t.co/kus5tz9AjG
Feb 12, 2019 · 15 likes · 4 shares · 20,132 followersView post →
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Matt Thomas
@mjcthomas74 · X
https://t.co/7xHlyi9Dxh EGDT original paper? #SICOWE19
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