February 2002 PMID 11832527

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan

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Mentions

509

Peak: 24 in Feb 2022

across 7 sources since Nov 2015

Extended reach

2,706,881

potential audience

Total likes

15,636

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1,075,619

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Nov 2015 – Oct 2025

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AI synopsis

What people are saying

Overall, the discussions express strong agreement with the study’s conclusion that lifestyle interventions significantly reduce the risk of developing type 2 diabetes, as seen in posts citing a 58% reduction versus 31% with metformin. The tone ranges from informational, citing specific research results, to motivational, encouraging exercise and dietary changes, demonstrating high interest and engagement. The focus on evidence and potential influence on healthcare practices underscores the recognized high impact of the study.

AgreementStrong agreement

Most discussions show strong support for the study’s findings that lifestyle changes are more effective than medication in preventing type 2 diabetes.

InterestHigh interest

The posts demonstrate high interest, referencing specific studies, data percentages, and debating interventions like diet and physical activity.

EngagementHigh engagement

Posts include detailed commentary, sharing evidence, comparing interventions, and encouraging active participation, indicating deep engagement.

ImpactHigh impact

Participants recognize the significance of the findings for health practices and policy, emphasizing lifestyle intervention as a more effective strategy to prevent diabetes.

Abstract in brief

The study involved over 3,200 adults with high blood sugar levels but not yet diabetic, who were assigned to either a placebo, metformin, or a lifestyle change program focusing on weight loss and physical activity.
Over an average follow-up of 2.8 years, the lifestyle program reduced diabetes incidence by 58%, and metformin by 31%, with lifestyle changes proving more effective.
To prevent one case of diabetes in three years, 69 people would need to follow the lifestyle program, whereas 139 would need to take metformin, indicating lifestyle modifications are a more effective prevention strategy.]

Read the full abstract

All mentions

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jiujiujiu martin

@M78849SunShow · X

RT @Vivianzh2025: @HotmailfromSH 没错，正是生活方式和饮食习惯在“推波助澜”。糖尿病前期（糖前）就是身体最后的“黄金警铃”！如果不干预，每年约5%-10%的患者会直奔2型糖尿病（https://t.co/2PD6TPZl4Y）。DPP研究证明：只…

Oct 29, 2025 · 2 shares · 1 followers View post →

尘满面

@s666666_jiujiuj · X

Oct 29, 2025 · 2 shares · 205 followers View post →

Vivian

@Vivianzh2025 · X

@HotmailfromSH 没错，正是生活方式和饮食习惯在“推波助澜”。糖尿病前期（糖前）就是身体最后的“黄金警铃”！如果不干预，每年约5%-10%的患者会直奔2型糖尿病（https://t.co/2PD6TPZl4Y）。DPP研究证明：只需减重5%-7%，每周150分钟中等强度运动，就能有效逆转风险——这是最低“起效门槛”！（https://t.co/zieCdp1IVp）（

Oct 29, 2025 · 4 likes · 2 shares · 20 followers View post →

Solin L.R.

@SolinLujanRuz · X

@BarbonDisociado @endocrinorosero https://t.co/EU0OpkTqIy entre otros estudios te envío dos referencias. Hay varios estudios que nos aproximan y sustentan este tipo de intervención. Los hallazgos y validez de datos orientan nuestra práctica profesional. Estamos a la espera de más estudios, pero sin duda estamos https://t.co/UluHNKLKEs

Oct 19, 2025 · 1 like · 213 followers View post →

Sriganesh Srihari | Biomedical Data Science

@srigsri23 · X

source https://t.co/9AYAXS0pN5

Aug 23, 2025 · 2,106 followers View post →

Jon Brudvig

@jonbrudvig.bsky.social · Bluesky

Key Sources:

Aug 13, 2025 · 1 like · 1 share View post →

saner konyali

@saner13104 · X

Tiştê ku ferz dikin nîne. Lêkolîna orîjînal: https://t.co/ci1Y514nro Guhertinên şêwaza jiyanê rêjeya bûyerê %58 kêm dike û karanîna metformin jî %31 kêm dike. diet m @merck @OrganonLatam #Gardasil HPV

Jul 7, 2025 View post →

dr. alman

@tim_tashi · X

@vmuecke_k https://t.co/lDMtLvA8XK Die Ergebnisse zeigten, dass: •Lebensstilinterventionen die Inzidenz von Typ-2-Diabetes um 58 % reduzierten. •Metformin die Inzidenz um 31 % senkte.

Jun 3, 2025 · 208 followers View post →

Rishan Juan Ignacio Tadeo

@ChocogatoRacing · X

Conozco gente que muy disciplinada está en control sin farmacoterapia. La Metformina también ayuda. Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin.a N Engl J Med 2002;346:393-403 https://t.co/BoUz9CYkrn

Apr 20, 2025 · 6 likes · 4,124 followers View post →

Kenichi SUZUKI

@suz25944 · X

【26/100】 2型糖尿病発症の高リスク群で，ライフスタイル改善やメトホルミンは発症を抑制（N Engl J Med 2002）https://t.co/CfzNaMZqyi Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

Mar 6, 2025 · 1 like · 5 followers View post →

ANIL

@anilmusicus · X

min 10 min walk after each calorie intake is the way https://t.co/EntPvgmj3H

Feb 16, 2025 · 140 followers View post →

JACJ M.D.

@JACJ183 · X

RT @DrGiovanniD: @docramiro Quizás solo para contextualizar, un programa intensivo enfocado en perder peso mediante dieta sana y actividad…

Dec 18, 2024 · 1 share · 1,127 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

@docramiro Quizás solo para contextualizar, un programa intensivo enfocado en perder peso mediante dieta sana y actividad física (el clásico ECA US-DPP), fue superior a metformina (58% vs 31% reducción en incidencia DM2). La metformina sin duda excelente opción. S2 https://t.co/WYJ4V6urTK

Dec 18, 2024 · 13 likes · 1 share · 16,004 followers View post →

@nelsonkalema

@JourneyingStoic · X

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin | New England Journal of Medicine https://t.co/1GtP4hxHIY

Nov 4, 2024 · 314 followers View post →

Tr0mium

@tr0mium · X

@bigfatsurprise In early to middle stages of course it would. 50% of patients recover fully their insulin-resistance by loosing about 10kg/20pounds of weight - best way is to eat unprocessed/organic food. https://t.co/ILw5A1O88r https://t.co/Ci2rDUNpG7

Aug 29, 2024 · 441 followers View post →

abmozu

@abmozu · X

@A5ura1 @Ibrahim_PharmD تقليل احتمالية الإصابة بالسكري النوع الثاني: 31% doi: 10.1056/NEJMoa012512 تنزيل الوزن: 3.2% وأقل. doi: 10.1016/j.phrs.2021.105782 تغيير نمط الحياة (رياضة ١٥٠ .قيقة بالأسبوع وكميات الطعام): تقليل احتمالية الإصابة بالسكري النوع الثاني:58%. تنزيل الوزن: أقل شي 7%

Aug 21, 2024 · 2 likes · 8,097 followers View post →

Jake Mey, PhD, RD

@CakeNutrition · X

RT @NutritionNerd: Today at #Nutriton2024: Implementing the Diabetes Prevention Program (DPP) in Diverse Settings Quick history lesson. In…

Jul 1, 2024 · 1 share · 8,661 followers View post →

Tanya Halliday, PhD, RD

@NutritionNerd · X

Today at #Nutriton2024: Implementing the Diabetes Prevention Program (DPP) in Diverse Settings Quick history lesson. Initial DPP program manuscript comparing this lifestyle intervention vs. metformin vs. placebo was published in ‘02 https://t.co/VwE8QYViLU #YINIxNutrition2024 https://t.co/aUMCGx6Naq

Jul 1, 2024 · 5 likes · 1 share · 9,233 followers View post →

Swapnil Hiremath @hswapnil.medsky.social

@hswapnil · X

@_monteirolucas_ @NEJM Good point! From the original @DPPResearchGrp analysis https://t.co/4NM8RguNZt figure below I love metformin but it doesn’t reduce kidney failure There should be enough follow up from original DPP to show now if there was kidney failure difference? We should ask for that data https://t.co/DKdlMvZXae

May 24, 2024 · 1 like · 21,702 followers View post →

Dr Alo, DO, FACC

@MohammedAlo · X

@MarketPicker https://t.co/QCCIymciwX

Jan 28, 2024 · 12,656 followers View post →

UCSF Department of Medicine

@UCSFDOM · X

3/ TODAY study https://t.co/7z5jOIjdj3 showed kids w/ ⬆️ rates of microvascular complication. Can prevent DM w/ wt loss: landmark DPP study: https://t.co/ulghQyqd1d "Legacy" effect: even w/ wt regain, DM cx ⬇️! Lower A1C better, but at what cost? 1st step: Lifestyle counseling. https://t.co/13Tke3Hjlr

Sep 28, 2023 · 1,307 followers View post →

An echo in the chamber

@BeLikeWahter · X

RT @foundmyfitness: Exercise vs. metformin study: https://t.co/S6ygnN4Dlk You can get the full episode with @gibalam and read the show not…

Sep 23, 2023 · 11 shares · 440 followers View post →

BB3 Daily ROAR

@BB3DailyRoar · X

RT @foundmyfitness: Exercise vs. metformin study: https://t.co/S6ygnN4Dlk You can get the full episode with @gibalam and read the show not…

Sep 22, 2023 · 11 shares · 75 followers View post →

Rx Readmore Livemore

@SopitaSirirata1 · X

RT @foundmyfitness: Exercise vs. metformin study: https://t.co/S6ygnN4Dlk You can get the full episode with @gibalam and read the show not…

Sep 22, 2023 · 11 shares · 167 followers View post →

Chan Yeow

@ChanYeow1 · X

RT @foundmyfitness: Exercise vs. metformin study: https://t.co/S6ygnN4Dlk You can get the full episode with @gibalam and read the show not…

Sep 22, 2023 · 11 shares · 971 followers View post →

Winterviooltje

@winterviooltje · X

RT @foundmyfitness: Exercise vs. metformin study: https://t.co/S6ygnN4Dlk You can get the full episode with @gibalam and read the show not…

Sep 22, 2023 · 11 shares · 313 followers View post →

PietHeintheDane

@DanePiet · X

RT @foundmyfitness: Exercise vs. metformin study: https://t.co/S6ygnN4Dlk You can get the full episode with @gibalam and read the show not…

Sep 22, 2023 · 11 shares · 45 followers View post →

Alex

@atttshine5_0 · X

RT @foundmyfitness: Exercise vs. metformin study: https://t.co/S6ygnN4Dlk You can get the full episode with @gibalam and read the show not…

Sep 22, 2023 · 11 shares · 22 followers View post →

Snookman

@Mybjjnotes · X

RT @foundmyfitness: Exercise vs. metformin study: https://t.co/S6ygnN4Dlk You can get the full episode with @gibalam and read the show not…

Sep 22, 2023 · 11 shares · 463 followers View post →

Dr. Rhonda Patrick

@foundmyfitness · X

Exercise vs. metformin study: https://t.co/S6ygnN4Dlk You can get the full episode with @gibalam and read the show notes here: https://t.co/kKLuMglaoi

Sep 22, 2023 · 62 likes · 11 shares · 610,757 followers View post →

Raphael Sirtoli

@raphaels7 · X

RT @raphaels7: https://t.co/JzbFBmqWKw i'm detecting a trend... https://t.co/sISLzuQjsr

Jul 17, 2023 · 1 share · 8,597 followers View post →

Raphael Sirtoli

@raphaels7 · X

https://t.co/JzbFBmqWKw i'm detecting a trend... https://t.co/sISLzuQjsr https://t.co/aexQMFzEIJ

Jul 14, 2023 · 4 likes · 1 share · 8,597 followers View post →

David Toniolo

@davidtoniolo · X

@ZakJackPT https://t.co/HYVxksDW4r Links to articles contained within YouTube description!

May 20, 2023 · 1 like · 846 followers View post →

Jhon

@Jhonjagudelo · X

@endocrinorosero https://t.co/T6xMYhQcLm

May 13, 2023 · 1 like · 1,861 followers View post →

Alyne Reyra

@MitzemoaNoyollo · X

RT @DrGiovanniD: @Din_Jarin67 Con gusto, el primer artículo es el ECA que comento. También te comparto evidencias de su evaluación en MX. P…

Apr 23, 2023 · 2 shares · 610 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

Apr 21, 2023 · 14 likes · 2 shares · 16,004 followers View post →

GetATechSalesJob

@GetATechSalesJ · X

@chris_sheehan2 Walking is walking man, good stuff buuuut Here is some motivation to sprinkle some 10-15min ones throughout the day https://t.co/PS4wcf6hLR

Mar 10, 2023 · 3,555 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

@victorAC25 Claro con mucho gusto, saludos. https://t.co/oUbNOa0mdc https://t.co/ATGwgqoQq5

Mar 6, 2023 · 7 likes · 16,004 followers View post →

HERBHEAD

@Herbheadd · X

Diabetes Prevention Program Research Group stated - > "CONCLUSIONS: Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin" https://t.co/I9VZeEbzQ3

Feb 1, 2023 · 208 followers View post →

Philippe Stephenson, MD

@TotalCytopath · X

@IdiotTracker @AngryCardio @calleymeans @jpmorgan Interestingly not negative (or certainly catastrophic). But then you have some successes, e.g. https://t.co/YRDF8ON1rR

Jan 9, 2023 · 2,294 followers View post →

Anny A. Romero Secin

@Aromerosecin · X

RT @primastcar:

Nov 14, 2022 · 8 shares · 848 followers View post →

Sergio Hevia

@SerHevNav · X

RT @primastcar:

Nov 14, 2022 · 8 shares · 723 followers View post →

Jose Miguel Alvarez

@michcabodoc · X

RT @primastcar:

Nov 14, 2022 · 8 shares · 119 followers View post →

Sabrina

@sabrihoy · X

RT @primastcar:

Nov 14, 2022 · 8 shares · 3,258 followers View post →

Medtorek

@Medtorek · X

RT @primastcar:

Nov 14, 2022 · 8 shares · 13,864 followers View post →

Francisca Martínez

@famartinez2001 · X

RT @primastcar:

Nov 14, 2022 · 8 shares · 9,952 followers View post →

José A Alvarez Tamargo

@JAlvrzTmrgo · X

RT @primastcar:

Nov 14, 2022 · 8 shares · 318 followers View post →

Primastcar

@primastcar · X

Nov 14, 2022 · 8 likes · 8 shares · 2,339 followers View post →

Kiloss App

@kilossapp · X

En az %7 kilo vermek tip 2 diyabete yakalanma ihtimalini %58 oranında azaltabilir. Referans: Knowler WC, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393-403. https://t.co/687ztsIbhq

Sep 1, 2022 · 2 followers View post →

Sputnik my love ...

@SputnikMyLove_ · X

RT @IberianCitizen: ⛲️⛲️⛲️⛲️⛲️⛲️⛲️ (1) https://t.co/nGI0AJxBPM (2) https://t.co/ndZWwnIr0N (3) https://t.co/rA0h0UYSjc (4) https://t.co/Xof…

Aug 13, 2022 · 9 shares · 343 followers View post →

Adel Abu Hamdeh

@AdelAHamdeh · X

@AgnesWold @OstlundOllie @Skroink @wuest23 Den riskreduktion på 58% som omnämns i dokumentet från Regionen kommer nog från någon av dessa artiklar: 1.https://t.co/JHiyKOodta 2.https://t.co/rlLeWJaGCE https://t.co/CMDnt6i0G0

Jul 3, 2022 · 1 like · 2,359 followers View post →

AMMOM

@ammommx · X

RT @IberianCitizen: ⛲️⛲️⛲️⛲️⛲️⛲️⛲️ (1) https://t.co/nGI0AJxBPM (2) https://t.co/ndZWwnIr0N (3) https://t.co/rA0h0UYSjc (4) https://t.co/Xof…

Jun 16, 2022 · 9 shares · 1,998 followers View post →

Fjletona

@fjletona · X

RT @IberianCitizen: ⛲️⛲️⛲️⛲️⛲️⛲️⛲️ (1) https://t.co/nGI0AJxBPM (2) https://t.co/ndZWwnIr0N (3) https://t.co/rA0h0UYSjc (4) https://t.co/Xof…

Jun 15, 2022 · 9 shares · 460 followers View post →

Villahermosa se vistió de fiesta con la primavera

@Gust_1971 · X

RT @IberianCitizen: ⛲️⛲️⛲️⛲️⛲️⛲️⛲️ (1) https://t.co/nGI0AJxBPM (2) https://t.co/ndZWwnIr0N (3) https://t.co/rA0h0UYSjc (4) https://t.co/Xof…

Jun 15, 2022 · 9 shares · 489 followers View post →

Aethor

@winters22987 · X

RT @IberianCitizen: ⛲️⛲️⛲️⛲️⛲️⛲️⛲️ (1) https://t.co/nGI0AJxBPM (2) https://t.co/ndZWwnIr0N (3) https://t.co/rA0h0UYSjc (4) https://t.co/Xof…

Jun 14, 2022 · 9 shares · 7 followers View post →

Liliana LOZANO

@Liliana56219368 · X

RT @IberianCitizen: ⛲️⛲️⛲️⛲️⛲️⛲️⛲️ (1) https://t.co/nGI0AJxBPM (2) https://t.co/ndZWwnIr0N (3) https://t.co/rA0h0UYSjc (4) https://t.co/Xof…

Jun 14, 2022 · 9 shares · 306 followers View post →

IberianCitizen

@IberianCitizen · X

Jun 14, 2022 · 33 likes · 9 shares · 12,928 followers View post →

Longevity Bloomington

@LongevityBtown · X

You don't have to lose a ton of weight to make a positive impact on your health An average weight loss of 6.7% reduced the incidence of diabetes by 58% in the group participating in the American Diabetes Prevention Program https://t.co/OBiucIIS57

Jun 2, 2022 · 47 followers View post →

Dorothy Lawrence

@dorothylaws_ · X

RT @DrKristieLeong: @NicoleStoutPT Here's a link:https://t.co/J0xEVuNbBF

May 20, 2022 · 1 share · 812 followers View post →

Ari’s Gold

@TheLINKPill · X

@FourthIR Walk after you eat. Stan gets all his high level athletes to walk after meals including @JonnyBones https://t.co/Y7pE1IXrjJ

May 15, 2022 · 917 followers View post →

Stephan J. Guyenet

@sguyenet · X

@GidMK I think it's potentially clinically meaningful. If we assume they plateau at 5 kg of weight loss below starting, that's in the ballpark of DPP (depending on time point). https://t.co/j1zuXsmIPE https://t.co/x1zyiku9Y0

May 11, 2022 · 1 like · 48,840 followers View post →

Stephan J. Guyenet

@sguyenet · X

@theproof @MichaelAlbertMD Yes, it does, and to a substantial extent. DPP trial demonstrated this. https://t.co/j1zuXsmIPE https://t.co/dbhV3e9Fhw https://t.co/BY04ivcvyP

Apr 17, 2022 · 8 likes · 48,840 followers View post →

Koushik R. Reddy, MD, FACC, FACLM, DipABLM,LMI

@KoushikReddyMD · X

@SABOURETCardio @drscottyk USA: https://t.co/VpGwB0Yssj Finland: https://t.co/fcpAy7j39N China: https://t.co/pinTTagvmk

Apr 11, 2022 · 2 likes · 4,942 followers View post →

Cindy Kugler

@Exspec85 · X

RT @jasongootman: "The lifestyle intervention was significantly more effective than metformin." #wellness #selfcare #weightloss #wellnessco…

Mar 31, 2022 · 1 share · 230 followers View post →

Jason Gootman

@jasongootman · X

"The lifestyle intervention was significantly more effective than metformin." #wellness #selfcare #weightloss #wellnesscoaching https://t.co/uWXqsWe2wD

Mar 31, 2022 · 1 like · 1 share · 81 followers View post →

Rishan Juan Ignacio Tadeo

@ChocogatoRacing · X

Cambios en el estilo de vida resultan en una menor progresión a diabetes. https://t.co/oCIhV10aU7 https://t.co/eLajo42Kql

Feb 24, 2022 · 3 likes · 4,124 followers View post →

Dani Trainer

@Dani_trainer_ · X

Tratamientos en personas con prediabetes.

Feb 24, 2022 · 2 likes · 18,445 followers View post →

La Triada Clasica MI

@ClasicaMi · X

DPP study 2/7

Feb 23, 2022 · 41 followers View post →

La Triada Clasica MI

@ClasicaMi · X

DPP study 1/7

Feb 23, 2022 · 8 likes · 41 followers View post →

Dietitians Gulf

@DietitiansGulf · X

RT @365nutrition: أيهما أفضل للوقاية من النوع الثاني لمرض السكري، أخذ الدواء (جلوكوفاج) أو تغيير نمط الحياة؟ في هذه الدراسة: https://t.co…

Feb 19, 2022 · 4 shares · 19,973 followers View post →

Abdisalam Hajji Yusuf Moalim

@Abdisalam_Hajji · X

RT @DrAbdiMahamud: To #BeatNCDs & #COVID19 intensive program of lifestyle modification. The incidence of diabetes was reduced by 58% with l…

Feb 17, 2022 · 2 shares · 2,087 followers View post →

Evan Allen

@EAllen0417 · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 17, 2022 · 12 shares · 2,804 followers View post →

Sama

@Sma01392669 · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 17, 2022 · 12 shares · 56 followers View post →

teetoq8

@teetoq8 · X

Feb 16, 2022 · 4 shares · 31 followers View post →

hamed

@hamed98582706 · X

Feb 16, 2022 · 4 shares · 3 followers View post →

عبدالله المسباح

@365nutrition · X

أيهما أفضل للوقاية من النوع الثاني لمرض السكري، أخذ الدواء (جلوكوفاج) أو تغيير نمط الحياة؟ في هذه الدراسة: https://t.co/lyVnFuzDdL تغيير نمط الحياة (نزول ٧٪ من وزن الجسم وممارسة الرياضة لمدة ١٥٠ دقيقة أسبوعيا) أدى للوقاية بنسبة —> ٥٨٪ بينما لمن أخذ الدواء كانت أقل —> ٣١٪ 1️⃣

Feb 16, 2022 · 7 likes · 4 shares · 31,087 followers View post →

Ralph Bennett

@RBennettIV · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 15, 2022 · 12 shares · 372 followers View post →

Dr Sunil Menon

@drmenonsunil9 · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 15, 2022 · 12 shares · 1,290 followers View post →

Kiefier Hunter

@TheChiefKief24 · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 15, 2022 · 12 shares · 1,049 followers View post →

Suggestic | Telehealth & AI-Powered Engagement

@suggestic · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 15, 2022 · 12 shares · 10,349 followers View post →

Jordigasleo1512

@Jordigasleo1512 · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 15, 2022 · 12 shares · 31 followers View post →

Dr. Woodall

@DrWoodallND · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 15, 2022 · 12 shares · 677 followers View post →

alexis castaneda

@alex_castaneda_ · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 15, 2022 · 12 shares · 879 followers View post →

Dr Sam Pappas

@DrSamPappas · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 15, 2022 · 12 shares · 2,089 followers View post →

Pedro Carrera Bastos

@pmcbastos · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 15, 2022 · 12 shares · 1,465 followers View post →

Carlos Colmenero

@colme99 · X

RT @humanOS_me: People with prediabetes were randomly assigned to either metformin, placebo, or a lifestyle modification program (n=3234).…

Feb 15, 2022 · 12 shares · 77 followers View post →

humanOS.me

@humanOS_me · X

Feb 15, 2022 · 46 likes · 12 shares · 9,673 followers View post →

Showboat7

@Showboat7 · X

RT @DrAbdiMahamud: To #BeatNCDs & #COVID19 intensive program of lifestyle modification. The incidence of diabetes was reduced by 58% with l…

Feb 15, 2022 · 2 shares · 1,501 followers View post →

Dr Abdi R Mahamud

@DrAbdiMahamud · X

To #BeatNCDs & #COVID19 intensive program of lifestyle modification. The incidence of diabetes was reduced by 58% with lifestyle intervention & by 31%with metformin, as compared with placebo. These effects were similar in ♂️ & ♀️ and in all racial groups. https://t.co/KH4PBwEeB8

Feb 11, 2022 · 5 likes · 2 shares · 2,873 followers View post →

Julia B.

@JuliaB_fitness · X

@retiredzorro @CharlesMBrenner @kyall_walker @peterxing (Metformin is basically a mitochondrial poison and mTORC1 signaling/responses seemingly decline with age/time in humans). And it was shown two decades ago that lifestyle intervention is better than metformin). https://t.co/IHh9h7iygF

Dec 24, 2021 · 2,272 followers View post →

Mauricio Gonzalez MD.

@DrMauricioGon · X

Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393-403. doi:10.1056/NEJMoa012512

Dec 17, 2021 · 12 likes · 148,888 followers View post →

#HelpYouGetGAINS

@helpYOUgetGAINS · X

Twice as Effective as Metformin! https://t.co/jQIcrBHKhO via @YouTube https://t.co/a13p4aZecE

Nov 23, 2021 · 16,831 followers View post →

Stephan J. Guyenet

@sguyenet · X

@ArsenaultBenoit Thanks for this. I would argue that targeting body weight is a powerful way of targeting adipose tissue function. Certainly has shown its utility in preventing T2DM. https://t.co/sZxaRdxV8e

Sep 30, 2021 · 5 likes · 48,840 followers View post →

Swapnil Hiremath @hswapnil.medsky.social

@hswapnil · X

@Cankidneydoc @LittleBigGloms Sorry meant rosiglitazone But there’s also this https://t.co/Ca2A5Ip4N0 and https://t.co/n1x7zeTlfj

Sep 29, 2021 · 1 like · 21,702 followers View post →

BowTiedZero

@BowTiedZero · X

https://t.co/JjacLbrsMR

Sep 6, 2021 · 281 followers View post →

Stephan J. Guyenet

@sguyenet · X

@apr5356 @KickStarter60 https://t.co/sZxaRdxV8e

Jul 14, 2021 · 48,840 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

Nombra un artículo que consideres que ha hecho la diferencia en tu campo. Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin DiRECT Trial Look AHEAD Trial

Jun 28, 2021 · 11 likes · 1 share · 16,004 followers View post →

Stephan J. Guyenet

@sguyenet · X

@traderjodie @DanielJDrucker There are studies of this, e.g. DPP. That said, I agree that getting good results with diet/lifestyle approaches is a major challenge. DPP involved a substantial effort to support compliance to the intervention. https://t.co/sZxaRdxV8e

Jun 10, 2021 · 3 likes · 48,840 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

@ntapia Con dietas hipo calóricas altas en carbohidratos (aprox 50-55%) con la inclusión de estos alimentos (plátano y muchos otros) alimentos se reduce la incidencia de diabetes, se pierde peso, se reduce la resistencia a la insulina. https://t.co/oUbNO9IKOC

Jun 3, 2021 · 8 likes · 16,004 followers View post →

Viri diana

@viridiana_dlt · X

RT @DrGiovanniD: En breve compartiremos los materiales adaptados a modalidad ONLINE del Programa de Prevención de Diabetes en español. Lo…

Apr 10, 2021 · 7 shares · 101 followers View post →

ひろし@栄養でアスリートになる！

@1_sarubaka · X

境界型糖尿病患者に ①生活習慣指導介入群（低エネルギー、低脂肪食と運動療法）、 ②メトホルミン内服群、 ③プラセボ群に分けたとき、4年間の介入により、 ③群に比べて ①群は31%、②群は58% 糖尿病の発症を抑制できた。メトホルミン敗北

Apr 3, 2021 · 1 like · 350 followers View post →

Carlos Bauche Madero

@carbauche · X

RT @DrGiovanniD: En breve compartiremos los materiales adaptados a modalidad ONLINE del Programa de Prevención de Diabetes en español. Lo…

Mar 28, 2021 · 7 shares · 3,063 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

RT @DrGiovanniD: En breve compartiremos los materiales adaptados a modalidad ONLINE del Programa de Prevención de Diabetes en español. Lo…

Mar 28, 2021 · 7 shares · 16,004 followers View post →

Alan GH

@AlanGH26 · X

RT @DrGiovanniD: En breve compartiremos los materiales adaptados a modalidad ONLINE del Programa de Prevención de Diabetes en español. Lo…

Mar 28, 2021 · 7 shares · 127 followers View post →

Enrique Alonso Mauricio Sandoval

@enriqueblt · X

RT @DrGiovanniD: En breve compartiremos los materiales adaptados a modalidad ONLINE del Programa de Prevención de Diabetes en español. Lo…

Mar 27, 2021 · 7 shares · 82 followers View post →

Guille Varela

@nutriguille · X

RT @DrGiovanniD: En breve compartiremos los materiales adaptados a modalidad ONLINE del Programa de Prevención de Diabetes en español. Lo…

Mar 27, 2021 · 7 shares · 205 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

Mar 27, 2021 · 38 likes · 7 shares · 16,004 followers View post →

Viri diana

@viridiana_dlt · X

RT @DrGiovanniD: La prueba.

Mar 20, 2021 · 2 shares · 101 followers View post →

Enrique Alonso Mauricio Sandoval

@enriqueblt · X

RT @DrGiovanniD: La prueba.

Mar 20, 2021 · 2 shares · 82 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

La prueba.

Mar 20, 2021 · 3 likes · 2 shares · 16,004 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

RT @DrGiovanniD: En

Mar 12, 2021 · 3 shares · 16,004 followers View post →

Viri diana

@viridiana_dlt · X

RT @DrGiovanniD: En

Mar 12, 2021 · 3 shares · 101 followers View post →

luis alberto malaga

@malaga1711 · X

RT @DrGiovanniD: En

Mar 12, 2021 · 3 shares · 1,601 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

Mar 11, 2021 · 5 likes · 3 shares · 16,004 followers View post →

Deirdre Tobias, ScD

@deirdre_tobias · X

@NutricionLP @doctorinigo Thanks! Main DPP results: 10.1056/NEJMoa012512 1-yr diet: 10.1016/j.annepidem.2004.02.004

Feb 18, 2021 · 1 like · 9,607 followers View post →

Ethan J. Weiss

@ethanjweiss · X

@tboynew Not even same time zone. Maybe not even same planet. From DPP https://t.co/86kQEOMCG6 https://t.co/9O7n3NwHRD

Feb 10, 2021 · 4 likes · 30,102 followers View post →

Mathew Titus the Great

@mathewtitus · X

Ten Minute Walk Twice as Effective as Metformin https://t.co/6mpjc3oDnU https://t.co/XLIl5WU7Cs

Feb 9, 2021 · 544 followers View post →

Dr Imhotep

@IMHOTEP111 · X

Twice as Effective as Metformin! https://t.co/MPfJxP5wLZ via @YouTube

Feb 6, 2021 · 1,228 followers View post →

taka@薬剤師　論文紹介

@taka_phaper · X

https://t.co/avCAmqAwth こちらが元文献運動負荷と体重コントロールがいかに重要わかります。

Feb 3, 2021 · 26 followers View post →

Dr Imhotep

@IMHOTEP111 · X

Twice as Effective as Metformin! ?????https://t.co/MPfJxONVnp via @YouTube

Feb 1, 2021 · 1,228 followers View post →

Deirdre Tobias, ScD

@deirdre_tobias · X

@mizmoose @GidMK Also, apologies for not including the references in the original post: Main DPP trial results: Knowler et al (NEJM 2002) https://t.co/U9tVPOY995 1 yr diet data: Mayer-Davis et al (Annals of Epi 2004) https://t.co/FjRYZGog04

Jan 14, 2021 · 1 like · 9,607 followers View post →

Jeanette

@GoneInAWhisper · X

Twice as Effective as Metformin! https://t.co/RFlCRKHjN1 via @YouTube

Jan 4, 2021 · 431 followers View post →

Auténticamente Yo

@healthand_skin · X

RT @DrGiovanniD:

Nov 26, 2020 · 2 shares · 168 followers View post →

Percys T. M.

@percys7mix · X

https://t.co/lPFUINcYiC

Nov 26, 2020 · 295 followers View post →

Vegan Sağlık

@VeganSaglikPro · X

Tip 2 Diyabetin önlenmesinde; hayat tarzı değişikliklerinin, ilaçlardan ve plasebodan daha etkili olduğu bulunmuştur. https://t.co/egjbDZoSOM

Nov 26, 2020 · 9 likes · 5,440 followers View post →

Dan Mormont

@FriP_drA · X

RT @DrGiovanniD:

Nov 26, 2020 · 2 shares · 201 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

Nov 26, 2020 · 13 likes · 2 shares · 16,004 followers View post →

José Llumiquinga Mar

@etsajose · X

RT @DrGiovanniD: https://t.co/oUbNOa0mdc https://t.co/QcpICLIoAX Aquí una guía basada en evidencia revisada por pares para hacerlo. https:…

Nov 22, 2020 · 1 share · 191 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

https://t.co/oUbNOa0mdc https://t.co/QcpICLIoAX Aquí una guía basada en evidencia revisada por pares para hacerlo. https://t.co/ulfjF6coIu

Nov 21, 2020 · 5 likes · 1 share · 16,004 followers View post →

R Giovanni Diaz-Zavala

@DrGiovanniD · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 16, 2020 · 17 shares · 16,004 followers View post →

Vanessa Murrieta

@VanessaM_98 · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 15, 2020 · 17 shares · 84 followers View post →

Ramcés Falfán-Valencia

@RFalfanV · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 15, 2020 · 17 shares · 1,190 followers View post →

yessicamap

@yessicamap · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 15, 2020 · 17 shares · 555 followers View post →

Brenda Gonzalez

@bgonzaleez28 · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 15, 2020 · 17 shares · 12 followers View post →

Carlos.

@Marq2012C · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 15, 2020 · 17 shares · 86 followers View post →

Auténticamente Yo

@healthand_skin · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 14, 2020 · 17 shares · 168 followers View post →

Café negro y sin azúcar ☕

@FannyMuS · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 14, 2020 · 17 shares · 357 followers View post →

Ana Isabel Rodriguez

@nutanaisrod · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 14, 2020 · 17 shares · 254 followers View post →

Travis

@Enriqec11 · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 14, 2020 · 17 shares · 860 followers View post →

luis alberto malaga

@malaga1711 · X

RT @DrGiovanniD: 5 Referencias de DIABETES que no puedes perderte: https://t.co/oUbNO9IKOC https://t.co/PtgY4f6VbD https://t.co/ATGwgqGr…

Nov 14, 2020 · 17 shares · 1,601 followers View post →

Jesus Rene Sanchez

@VirtualRene · X

RT @bioconsultgroup: Reduction in the incidence of type 2 diabetes with lifestyle intervention #diabetes https://t.co/QVNVeDbiaZ

Aug 8, 2020 · 5 shares · 1,166 followers View post →

Vladimir

@Vladimi28202414 · X

RT @bioconsultgroup: Reduction in the incidence of type 2 diabetes with lifestyle intervention #diabetes https://t.co/QVNVeDbiaZ

Aug 8, 2020 · 5 shares View post →

Errum Ayman

@AymanErrum · X

RT @bioconsultgroup: Reduction in the incidence of type 2 diabetes with lifestyle intervention #diabetes https://t.co/QVNVeDbiaZ

Aug 8, 2020 · 5 shares · 8 followers View post →

salwa medhat

@salwamedhat4 · X

RT @bioconsultgroup: Reduction in the incidence of type 2 diabetes with lifestyle intervention #diabetes https://t.co/QVNVeDbiaZ

Aug 8, 2020 · 5 shares · 12 followers View post →

Jenifer Carolina Chirinos Peña

@Jenifer08168405 · X

RT @bioconsultgroup: Reduction in the incidence of type 2 diabetes with lifestyle intervention #diabetes https://t.co/QVNVeDbiaZ

Aug 7, 2020 · 5 shares · 1 followers View post →

Bio Consult

@bioconsultgroup · X

Reduction in the incidence of type 2 diabetes with lifestyle intervention #diabetes https://t.co/QVNVeDbiaZ

Aug 7, 2020 · 22 likes · 5 shares · 14 followers View post →

都（みやこ）@栄養士

@boy_nutrition · X

★知っておきたい糖尿研究：DPP ライフスタイル介入とメトホルミン投与はいずれも，2型糖尿病発症の高リスク例において発症を有意に抑制又、ライフスタイル介入はメトホルミン投与に比べ有効性が高かった大切な研究。文献中の図を簡素化して集団指導で使ってます https://t.co/SdykzFqTHx

Apr 18, 2020 · 2 likes · 2,287 followers View post →

د. صالح الفايدي

@Elfaidy_s · X

تخسيس الوزن لذوى الوزن الزايد والسمنة بمعدل 7% يمكن أن يمنع ظهور السكري النوع الثاني Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention... https://t.co/svQYuhSUEu

Dec 11, 2019 · 228 followers View post →

XaviSo

@overpeter_ · X

@StanEfferding I just watched this interesting video https://t.co/TMAp00GE1H and I wanted to ask for the reference. Could you share the link to the paper? Thank you!

Aug 9, 2019 · 540 followers View post →

@MFraylick · X

Twice as Effective as Metformin! https://t.co/S9AF1VHIg1 via @YouTube

Aug 5, 2019 · 674 followers View post →

AT@脳外科専修医

@medic34392444 · X

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin N Engl J Med 2002; 346: 393-403 （生活習慣への介入とメトホルミン処方は2型糖尿病高リスク者の発症抑制にいずれも有効だが、生活習慣介入の方がより効果が高い）

Jun 26, 2019 · 161 followers View post →

はね＠産業医

@hane_ohp · X

RT @fightingSANGYOI: Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin N Engl J Med 2002; 346: 393-403…

Jun 25, 2019 · 1 share · 8,267 followers View post →

旧・ガチ産業医

@fightingSANGYOI · X

Jun 25, 2019 · 1 like · 1 share · 6,140 followers View post →

myendoconsult

@myendoconsult · X

DPP : Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The Diabetes Prevention Program https://t.co/7dY49zt0EB

Apr 9, 2019 · 19 followers View post →

Dr Anastasia Mihailidou FAHA FCSANZ FESC

@AnastasiaSMihai · X

@Uqayyum123 Our general practitioners have started people in prediabetes & obese women & also for PCOS Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin @NEJM https://t.co/TKJjtvG0IK

Apr 7, 2019 · 1 like · 19,276 followers View post →

Madalyn

@MadsPharmLife · X

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. - PubMed - NCBI https://t.co/bUNJDEhnNH

Feb 4, 2019 · 19 followers View post →

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

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