October 2002 PMID 12379575

Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress.

Katherine Esposito, Francesco Nappo, Raffaele Marfella, Giovanni Giugliano, Francesco Giugliano, Myriam Ciotola, Lisa Quagliaro, Antonio Ceriello, Dario Giugliano

Mentions

23
Peak: 3 in Jul 2024
across 5 sources since Aug 2020

Extended reach

135,378
potential audience

Total likes

3,621

Video views

113,466

Mentions per month

Aug 2020 – Mar 2025

Where it's discussed

  • News8 articles
  • X / Twitter6 posts
  • Blogs4 articles
  • YouTube3 videos
  • Facebook2 posts

AI synopsis

What people are saying

Discussions around the publication reflect an average level of engagement, with references to related concepts such as oxidative stress caused by high glucose levels and its broader health implications. For instance, mentions of 'oxidation,' 'sugar spikes,' and general metabolism indicate interest, but the tone remains cautious and somewhat skeptical, which tempers enthusiasm and perceived impact.

AgreementNeither agree nor disagree

The discussions show mixed reactions, with some users questioning the validity or implications of the research, while others acknowledge the complexity of the topic.

InterestModerate interest

Most posts demonstrate a mild level of curiosity, referencing metabolism, inflammation, and oxidative stress, indicating some engagement but not deep focus.

EngagementNeutral engagement

The comments are somewhat superficial, with users mentioning related topics like sugar spikes, oxidative processes, and general health concerns without deep analysis.

ImpactNeutral impact

The overall influence of the discussions appears modest, as users bring up related issues without emphasizing how the study might dramatically change understanding or practice.

Abstract in brief

  • Hyperglycemia rapidly increases the levels of inflammatory cytokines like IL6, TNFalpha, and IL18 in the blood, especially in individuals with impaired glucose tolerance (IGT).
  • In people with IGT, the cytokine response lasts longer and reaches higher peaks after glucose intake compared to healthy controls, indicating a heightened inflammatory reaction.
  • The study suggests that oxidative stress plays a key role in this process, as the antioxidant glutathione was able to block the increase in cytokines during hyperglycemia, highlighting a potential mechanism linking high blood sugar to immune activation in diabetes.]

Top posts

Most liked on X and Bluesky
Alejandro A.D.
@realalejandroAD · X

SOURCES VIT D https://t.co/gsHzrq4k5x https://t.co/AzK1Zi3OFJ https://t.co/Mt54oMxxdr MAG https://t.co/8TfRN2FiXP https://t.co/0XFJhNXuBT https://t.co/nxbON5pkOL https://t.co/iuLnqJv4NB https://t.co/J8zWz9buli SUGAR https://t.co/UnBSv1jy5C https://t.co/c94gxiMeLq

Nov 28, 2020 · 3 likes · 15,502 followers View post →
Amanda ZZ - Atkins
@AmandaZZ100 · X

@sineadstewart_ @billmaher Please take a look at the myriad studies now produced on metabolism , inflammation, covid , cytokines https://t.co/ZcGAYr18aX https://t.co/DqdPafjojW https://t.co/iRvlmnONkY https://t.co/8SkCiQ80xw https://t.co/LKii2cmKVg https://t.co/yh5mEtQ1vC https://t.co/231pv2kUmx

Aug 4, 2020 · 1 share · 4,726 followers View post →
Karageorgos
@Karageorgos15 · X

Do Sugar Spikes cause Heart Disease? There’s more to this Story… https://t.co/yTlmsiUAnK via @YouTube

Jul 22, 2024 · 611 followers View post →
Centaur
@Centaur1207 · X

RT @AmandaZZ100: @sineadstewart_ @billmaher Please take a look at the myriad studies now produced on metabolism , inflammation, covid , c…

Aug 7, 2020 · 1 share · 538 followers View post →
Chase Saunders
@MaineFrameworks · X

For actual diabetics, there are 2 studies that actually don't beg the question / assume spike themselves are evil. But they are weak evidence and of course this wouldn't necessarily apply to gen pop. https://t.co/ZoF0kHYcpS

Jul 22, 2024 · 523 followers View post →
Petrus
@MrPetrus_ · X

@profurbani @LordTravequeiro @Jader_silva14 Mas oq causa essa oxidação? Na maioria das vezes é altos niveis de glucose e Omega-6! https://t.co/YmNarwBZDX https://t.co/Zz4vubPZx5 https://t.co/WPBW3k6PUJ https://t.co/RijdxEYw01

Apr 8, 2024 · 9 followers View post →

All mentions

Chase Saunders
@MaineFrameworks · X

For actual diabetics, there are 2 studies that actually don't beg the question / assume spike themselves are evil. But they are weak evidence and of course this wouldn't necessarily apply to gen pop. https://t.co/ZoF0kHYcpS

Jul 22, 2024 · 523 followers View post →
Karageorgos
@Karageorgos15 · X

Do Sugar Spikes cause Heart Disease? There’s more to this Story… https://t.co/yTlmsiUAnK via @YouTube

Jul 22, 2024 · 611 followers View post →
Petrus
@MrPetrus_ · X

@profurbani @LordTravequeiro @Jader_silva14 Mas oq causa essa oxidação? Na maioria das vezes é altos niveis de glucose e Omega-6! https://t.co/YmNarwBZDX https://t.co/Zz4vubPZx5 https://t.co/WPBW3k6PUJ https://t.co/RijdxEYw01

Apr 8, 2024 · 9 followers View post →
Alejandro A.D.
@realalejandroAD · X

SOURCES VIT D https://t.co/gsHzrq4k5x https://t.co/AzK1Zi3OFJ https://t.co/Mt54oMxxdr MAG https://t.co/8TfRN2FiXP https://t.co/0XFJhNXuBT https://t.co/nxbON5pkOL https://t.co/iuLnqJv4NB https://t.co/J8zWz9buli SUGAR https://t.co/UnBSv1jy5C https://t.co/c94gxiMeLq

Nov 28, 2020 · 3 likes · 15,502 followers View post →
Centaur
@Centaur1207 · X

RT @AmandaZZ100: @sineadstewart_ @billmaher Please take a look at the myriad studies now produced on metabolism , inflammation, covid , c…

Aug 7, 2020 · 1 share · 538 followers View post →
Amanda ZZ - Atkins
@AmandaZZ100 · X

@sineadstewart_ @billmaher Please take a look at the myriad studies now produced on metabolism , inflammation, covid , cytokines https://t.co/ZcGAYr18aX https://t.co/DqdPafjojW https://t.co/iRvlmnONkY https://t.co/8SkCiQ80xw https://t.co/LKii2cmKVg https://t.co/yh5mEtQ1vC https://t.co/231pv2kUmx

Aug 4, 2020 · 1 share · 4,726 followers View post →