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J Pharmacol Exp Ther July 2003 PMID 12660312

Human pharmacology of ayahuasca: subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics.

Jordi Riba, Marta Valle, Gloria Urbano, Mercedes Yritia, Adelaida Morte, Manel J Barbanoj

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Mentions

37
Peak: 2 in Nov 2019
across 5 sources since Feb 2015

Extended reach

53,271
potential audience

Total likes

2,966

Video views

52,535

Mentions per month

Feb 2015 – Nov 2025

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AI synopsis

What people are saying

Discussions reflect a strong interest in understanding ayahuasca's effects, with posts often mentioning the timing of DMT peaks and its mood-enhancing properties, while some explore its potential medical uses; this tone of curiosity and consideration for broader implications underscores the overall impact and engagement.

AgreementModerate agreement

Most discussions acknowledge the validity of the research, highlighting the relevance of the findings on subjective and cardiovascular effects.

InterestHigh interest

Participants display high curiosity, often referencing specific elements like DMT peaks and monoamine metabolites, showing engagement with the study details.

EngagementModerate engagement

Many responses delve into implications, such as the therapeutic potential and physiological mechanisms, indicating a moderate depth of engagement.

ImpactModerate impact

There is a shared recognition that the study could influence future research and clinical applications, though some consider it preliminary.

Abstract in brief

  • Ayahuasca, a traditional South American brew, contains DMT and harmala alkaloids, which together produce strong psychedelic effects and influence cardiovascular variables in users.
  • The study found that ayahuasca leads to perceptual changes, improved mood, and increased diastolic blood pressure, with DMT levels peaking about 1.5 hours after ingestion, aligning with its strongest effects.
  • Despite harmine acting as an MAO inhibitor, urine analysis showed increased monoamine metabolites, suggesting harmine's primary effects occur in the gut and liver, preventing DMT breakdown and enabling it to reach the brain.
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Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine ... https://t.co/xmqPVoaBHz #Ayahuasca

Jun 8, 2020 · 408 followers View post →

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Criticality Blog
@CriticalityBlog · X

Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine ... https://t.co/xmqPVoaBHz #Ayahuasca

Jun 8, 2020 · 408 followers View post →
Medicinal Plant Monograph | PDF | Biology | Plants
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doi: 10.1124/jpet.103.049882 209-218. Rivier, L., & Lindgren, J.-E. (1972). "Ayahuasca," the South American Hallucinogenic Drink: An Ethnobotanical and Chemical

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