4️⃣ الخلاصة؟ فيه جينات تلعب دور في العصبية والسعادة. بس ما يعني إنك ما تقدر تتغير. أسلوب حياتك، طريقة تفكيرك، والبيئة تفرق كثير. #علم_الجينات MAOA gene https://t.co/YJahrfKG5x HTTLPR and depression https://t.co/PeRiZRkDmW https://t.co/zwGKiNTMaN
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.
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May 2019 – Sep 2025Where it's discussed
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What people are saying
Discussions consistently highlight the importance of Caspi et al.'s 2003 study, with posts referencing its high citation count and its role in advancing understanding of gene-environment dynamics in depression. The tone and word choice, such as 'fascinating' and 'well-regarded,' reflect enthusiasm and recognition of the article's scientific impact, demonstrating its significance within the field of genetics and mental health.
Most discussions acknowledge the significance of the research, citing the influential 2003 study and its implications for understanding gene-environment interactions in depression.
Posts show high interest, referencing the high citation count and ongoing relevance of the research, with phrases like 'fascinating' and mentions of its impact over time.
Some posts delve into broader implications, such as how genetic predispositions interact with environmental factors, reflecting a moderate level of engagement.
The discussions indicate the research has notable influence, with mentions of its citation frequency and its role in shaping further studies.
Abstract in brief
- The study examined how stressful life events can lead to depression, focusing on the role of a specific gene (5HTT) that affects serotonin transport.
- People with one or two copies of the short allele of the 5HTT gene were found to have higher rates of depression, suicidal thoughts, and symptoms when exposed to stress compared to those with two long alleles.
- The findings highlight a gene-environment interaction, meaning a person's genetic makeup can influence how they respond to stressful life experiences, affecting their risk of depression.
Top posts
Most liked on X and Bluesky@gikkos1 @RyznarMD @dawso007 @claire_hilton6 @DrPPRam @ProfRobHoward @SameiHuda I’m interpreting “practice” broadly to include research & our conceptual worldviews. My pick would be: Caspi et al 2003 paper in Science. “Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene” Cited 9,684 times! /1 https://t.co/GqyQkY84Xy
@mkonnikova You might be interested in checking out https://t.co/puezc3y9ty, we allow anyone to see if a scientific report has been supported or contradicted. You can see one of the main studies in this story has been contradicted 13 times https://t.co/YbJxSELKpc
20 years ago: https://t.co/1hF4SuGgOp GxE is the gift that keeps on giving...
@docinthecity @criley_md @drjessigold @DrHowardLiu @_HarryPaul_ @spaul1124 @md_pender @AmyGraham36 @KazJNelson @Doctor_David @ChaseSamsel @DrvanTilburg @drwendysimon @NIMHgov Yes - Caspi's work, from original to present, is well-regarded. Caspi et al (Science 2003.) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. He has recent review, haven't read yet. Could give lit on + attribution, will try to remember.
Okumak isteyen buyursun https://t.co/RLkChMFe63
All mentions
Understanding Depression: Causes, Impact, and Management Strategies
Depression is a complex mental disorder characterized by persistent sadness, loss of interest, and various physical and emotional symptoms. This video explores how depression affects the brain, the role of genetics and…
Genetic Factors and Stress Interactions in Depression Risk
This study examines how stressful life events can lead to depression, emphasizing the role of the 5HTT gene, which affects serotonin transport. Individuals with certain gene variants are more vulnerable to…
Okumak isteyen buyursun https://t.co/RLkChMFe63
4️⃣ الخلاصة؟ فيه جينات تلعب دور في العصبية والسعادة. بس ما يعني إنك ما تقدر تتغير. أسلوب حياتك، طريقة تفكيرك، والبيئة تفرق كثير. #علم_الجينات MAOA gene https://t.co/YJahrfKG5x HTTLPR and depression https://t.co/PeRiZRkDmW https://t.co/zwGKiNTMaN
@t3mp3rl3y @jovanatorresj @nenucosinpanial ¡Falso! Un estudió que demostró que existe una dinámica entre nuestros factores genéticos y el entorno en el que nos desarrollamos. Personas predispuestas genéticamente a la depresión, no la manifestaban si el entorno no lo detona. https://t.co/amGd7B0scU
https://t.co/cHbxvS094a 幼少期環境(ストレス、親の関与、虐待等)と遺伝要因が相互作用し、精神的健康や努力傾向に影響との結論。 つまり、努力の質と量は遺伝と幼少期の環境でかなり大きく決まるわけ。表現が曖昧でそこは申し訳ないけど、どちらにしろ自己責任論よりかは根拠はあるよ。
"Te presento el enlace: 'La depresión: cómo conocerla, entenderla, aceptarla y manejarla', de Carlos Cedeño Rodríguez. Una investigación extraordinaria que debes ver y escuchar”. https://t.co/cu1laSSVHn https://t.co/5sOSfPr4WC
RT @villalbaciencia: Cuando hablamos de cómo la genética influye en la psicología pensamos en muchos genes, pero a veces el secreto se encu…
RT @villalbaciencia: Cuando hablamos de cómo la genética influye en la psicología pensamos en muchos genes, pero a veces el secreto se encu…
Cuando hablamos de cómo la genética influye en la psicología pensamos en muchos genes, pero a veces el secreto se encuentra en uno solo. Ya en 2003, se publicaba una variante genética de 5-HT que predispone a depresión y conductas suicidas. Artículo: https://t.co/lFnilHP8x9
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene | Science https://t.co/e1icQZ5HHB
@BMJ_Open @TheLancetPsych @Zalsman1 But how do #genes interact with the environment? For the OG paper on gene x #environment in depression by Caspi et al. ➡️ #WCP23 https://t.co/RMEejTnAPD
@USSOCOM Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene [2003. King's College London] https://t.co/qKa8dcIioB
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene https://t.co/pFxYy3fB7d
RT @royperlis: 20 years ago: https://t.co/1hF4SuGgOp GxE is the gift that keeps on giving...
20 years ago: https://t.co/1hF4SuGgOp GxE is the gift that keeps on giving...
@LucinaUddin Moderator: https://t.co/MySz2dbRpr
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene https://t.co/XKa0WimPtf
RT @awaisaftab: @gikkos1 @RyznarMD @dawso007 @claire_hilton6 @DrPPRam @ProfRobHoward @SameiHuda I’m interpreting “practice” broadly to incl…
@gikkos1 @RyznarMD @dawso007 @claire_hilton6 @DrPPRam @ProfRobHoward @SameiHuda I’m interpreting “practice” broadly to include research & our conceptual worldviews. My pick would be: Caspi et al 2003 paper in Science. “Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene” Cited 9,684 times! /1 https://t.co/GqyQkY84Xy
7/ Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene https://t.co/GVEwDXKlYm https://t.co/vhr7SDGKI8 Outside of my wheelhouse, but the interaction between genes and environment on the development (or not) of complex emotions is fascinating.
RT @KerryWilkinsMD: @docinthecity @criley_md @drjessigold @DrHowardLiu @_HarryPaul_ @spaul1124 @md_pender @AmyGraham36 @KazJNelson @Doctor_…
@docinthecity @criley_md @drjessigold @DrHowardLiu @_HarryPaul_ @spaul1124 @md_pender @AmyGraham36 @KazJNelson @Doctor_David @ChaseSamsel @DrvanTilburg @drwendysimon @NIMHgov Yes - Caspi's work, from original to present, is well-regarded. Caspi et al (Science 2003.) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. He has recent review, haven't read yet. Could give lit on + attribution, will try to remember.
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene on JSTOR https://t.co/14RVSH7tUe An interesting article that was published some time ago illustrating a polymorphism in the 5-HTT gene that increases the susceptibility of depression. Science
@hannahdev @edyong209 You might be interested in checking out our tool and what it has to say about an influential study in this space https://t.co/k11r84d17Q
@mkonnikova You might be interested in checking out https://t.co/puezc3y9ty, we allow anyone to see if a scientific report has been supported or contradicted. You can see one of the main studies in this story has been contradicted 13 times https://t.co/YbJxSELKpc
RT @sciteai: @edyong209 With https://t.co/u6CTfBjL6y, you can check any scientific article to see if it has been supported or contradicted.…