April 1963 PMID 13990765

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.

P J RANDLE, P B GARLAND, C N HALES, E A NEWSHOLME

Mentions

13
Peak: 1 in Oct 2020
across 2 sources since Oct 2020

Extended reach

137,841
potential audience

Total likes

2,866

Video views

80,681

Mentions per month

Oct 2020 – Feb 2025

Where it's discussed

  • X / Twitter11 posts
  • YouTube2 videos

AI synopsis

What people are saying

Participants show strong interest through sharing educational videos and discussing the cycle's role in insulin resistance, often using technical language or referencing the original paper. The tone indicates both respect and curiosity, with some debates about the cycle's implications for dietary choices and diabetes management, reflecting a nuanced engagement with the research's relevance.

AgreementModerate agreement

Most discussions recognize the importance of the Randle cycle in understanding diabetes and metabolic disturbances, showing general support for the publication's findings.

InterestHigh interest

The discussions demonstrate high interest, with many participants sharing videos, requesting comments, and emphasizing the cycle's significance.

EngagementHigh engagement

Users are actively engaging, referencing the original study, explaining mechanisms, and debating implications, indicating deep involvement.

ImpactModerate impact

While some recognize the article's foundational role, the overall perception suggests moderate impact, as some discussions are more about understanding than immediate application.

Abstract in brief

  • The glucose-fatty acid cycle describes how the metabolism of glucose and fatty acids are interconnected, affecting insulin resistance and overall energy use in the body.
  • In diabetes mellitus, an imbalance in this cycle contributes to metabolic disturbances by promoting fat accumulation and impairing insulin's ability to regulate blood sugar.
  • Understanding this cycle helps explain how excess fatty acids can worsen insulin sensitivity, leading to the complications associated with diabetes.]

Top posts

Most liked on X and Bluesky
Master Metabolism
@lowmegatron · X

@jaybeebrtweets @AlpacaAurelius Article: The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus PJ RANDLE. P B GARLAND. C N HALES. E A NEWSHOLME Youtube videos: Randle Cycle: If you don't know, now you know The Randle Cycle Part 2: If you didn't know,

Dec 1, 2024 · 2 likes · 34,112 followers View post →
Nick Krontiris
@nick_krontiris · X

refs: https://t.co/INdwVltn4O https://t.co/yygU4eZHgq

Oct 11, 2020 · 2 likes · 19,484 followers View post →
Ketogenic European
@Ketogenic_EU · X

@bfhhealth have you seen this https://t.co/u7BfKAWAfs any thoughts?

Jan 5, 2023 · 2 likes · 1,034 followers View post →
HRH King Edward Yellow
@HRH_Ted · X

@robertlufkinmd You'll then need to discuss this with my friend the Professor: I'll put you on to him... Here's the link to the paper Randle PJ, et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1 : 785–789, 1963.

May 3, 2023 · 1,006 followers View post →
jaggedtoad8386
@jaggedtoad8386 · X

@brian_sanders1 https://t.co/pUSIRhxR0A

Oct 24, 2024 · 491 followers View post →
EnergeticLama
@EnergeticLama · X

@CarnivoreAugust You replied to multiple people, not just me. This is a famous paper showing how elevated beta oxidation is synonymous with the diabetic state https://t.co/OrxGU1TLqv. Elevated FFAs cause slower metabolism and vice versa.

Dec 10, 2023 · 392 followers View post →

All mentions

Master Metabolism
@lowmegatron · X

@jaybeebrtweets @AlpacaAurelius Article: The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus PJ RANDLE. P B GARLAND. C N HALES. E A NEWSHOLME Youtube videos: Randle Cycle: If you don't know, now you know The Randle Cycle Part 2: If you didn't know,

Dec 1, 2024 · 2 likes · 34,112 followers View post →
jaggedtoad8386
@jaggedtoad8386 · X

@brian_sanders1 https://t.co/pUSIRhxR0A

Oct 24, 2024 · 491 followers View post →
Michael Haufe
@mlhaufe · X

@unclebobmartin @chris_neff_pgh A more detailed and accurate description (technical) https://t.co/CFUBdM96cr

Aug 9, 2024 · 174 followers View post →
Henry
@henry77761681 · X

@TarbuckSam @DavidVio2 @ScepticalDoctor I shall work in more depth through the Randle cycle. He did some crucial pioneering work apparently. Have a look at this video where the Randle cycle is explained with the knowledge that we have today. I would like to know your comments on this guy. https://t.co/hDklDWfxsl

Apr 3, 2024 · 241 followers View post →
EnergeticLama
@EnergeticLama · X

@CarnivoreAugust You replied to multiple people, not just me. This is a famous paper showing how elevated beta oxidation is synonymous with the diabetic state https://t.co/OrxGU1TLqv. Elevated FFAs cause slower metabolism and vice versa.

Dec 10, 2023 · 392 followers View post →
Codrean
@thiamineenjoyer · X

@Themannnagain Errado. Jejum obriga o corpo a fazer lipolise. Lipólise aumenta os acidos graxos livres (AGL) que causam resistência insulínica, possivelmente pelo ciclo de Randle. https://t.co/vtHsX6ulIY

Nov 29, 2023 · 123 followers View post →
Oracle of Ass Pain ©️
@RauchStopp_AT · X

@CharlesStassi It's called the Randle Cycle: https://t.co/dG5IhloMCl

Oct 22, 2023 · 9 followers View post →
HRH King Edward Yellow
@HRH_Ted · X

@robertlufkinmd You'll then need to discuss this with my friend the Professor: I'll put you on to him... Here's the link to the paper Randle PJ, et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1 : 785–789, 1963.

May 3, 2023 · 1,006 followers View post →
Ketogenic European
@Ketogenic_EU · X

@bfhhealth have you seen this https://t.co/u7BfKAWAfs any thoughts?

Jan 5, 2023 · 2 likes · 1,034 followers View post →
GroidFarmer
@GroidFarmer · X

@SeedOilDsrspctr @theberserk64 @jonasirw @2POINT1QUAD And while you focus on non-issues, you’re inflaming yourself with carbs by chronically activating the Randle cycle. Randle et al. 1963. “The Glucose Fatty-Acid Cycle: Its Role in Insulin Sensitivity and the Metabolic Disturbances of Diabetes Mellitus.” https://t.co/SOldwUHyNR

Nov 25, 2022 · 95 followers View post →
Nick Krontiris
@nick_krontiris · X

refs: https://t.co/INdwVltn4O https://t.co/yygU4eZHgq

Oct 11, 2020 · 2 likes · 19,484 followers View post →