October 2003 PMID 14561278

Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial.

Caroline Rae, Alison L Digney, Sally R McEwan, Timothy C Bates

Mentions

223
Peak: 11 in May 2022
across 6 sources since Jun 2019

Extended reach

1,396,714
potential audience

Total likes

12,093

Video views

152,850

Mentions per month

Jun 2019 – Sep 2025

Where it's discussed

  • News68 articles
  • X / Twitter61 posts
  • Facebook50 posts
  • Blogs17 articles
  • Reddit14 posts
  • YouTube13 videos

AI synopsis

What people are saying

The discussions frequently reference the article's findings, with users stating that creatine supplementation has improved cognitive abilities in vegetarians, highlighting the phrase 'creatine is good for mental performance' as indicative of broader public interest. The tone is generally positive, with expressions of excitement about the potential cognitive benefits and critiques of diet-related deficiencies more evident in discussions surrounding vegetarianism.

AgreementModerate agreement

The majority of discussions reflect a positive view of the research outcomes, indicating support for its findings.

InterestHigh interest

Participants express a strong curiosity about the effects of creatine supplementation on cognitive performance, highlighting its relevance to different diets.

EngagementModerate engagement

While many posts show enthusiasm, discussions mainly summarize key findings rather than delve into complex analysis.

ImpactHigh impact

Several contributors believe the research has significant implications, particularly for vegetarians and cognitive enhancement.

Abstract in brief

  • Oral creatine monohydrate supplementation (5 g/day for six weeks) was studied to see its effects on brain performance, specifically intelligence and working memory, in 45 young adult vegetarians.
  • The trial was a double-blind, placebo-controlled crossover design, which is robust in minimizing bias and improving reliability of results.
  • Results showed a significant positive impact on working memory and intelligence test scores, indicating that improving brain energy capacity can enhance cognitive performance.

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial More creatine could lead to better mental performance, another link to higher earnings https://t.co/avytr2WUG2

Nov 29, 2020 · 62 likes · 7 shares · 291,935 followers View post →
humanOS.me
@humanOS_me · X

Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian participants in a double-blind, placebo-controlled, cross-over study. https://t.co/3WVw5W8bDN https://t.co/vElXa19hoH

May 2, 2022 · 41 likes · 13 shares · 9,659 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

https://t.co/avytr2WUG2

Jul 30, 2021 · 27 likes · 2 shares · 291,935 followers View post →
Frédéric Leroy
@fleroy1974 · X

"Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial" https://t.co/5orpPmfobi https://t.co/HfO4k3vYrW

Oct 22, 2024 · 12 likes · 3 shares · 29,107 followers View post →
Ross
@rlogan87 · X

@WoodrowForCO @MarcLobliner Creatine supplementation has been shown to improve brain function and memory. small fella. https://t.co/LuwduYRXcx

Nov 3, 2022 · 9 likes · 213 followers View post →
Kjetil Tveit
@tveitmiljo · X

@KristianGunder @eivindtraedal Og hva med kreatin og andre mikronæringsstoff som hovedsakelig finnes i kjøtt, og gir best opptak fra kjøtt? "Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial" https://t.co/tZYKFFlsFg

May 9, 2023 · 6 likes · 6,635 followers View post →

All mentions

Randy Odish
@randyodish · X

@BioProtocolEco @foundmyfitness There's some evidence to suggest nootropic properties. https://t.co/VdyUajmi3V

Jul 3, 2025 · 1 like · 134 followers View post →
Ricardo Palmerola MD
@RickyPal85 · X

Creatine improved working memory/intelligence scores in adults under mental fatigue.: Rae, C., Digney, A. L., McEwan, S. R., & Bates, T. C. (2003). Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial.

Apr 12, 2025 · 2 likes · 66 followers View post →
Android Designed for Infiltration
@tyuk_nyukem · X

RT @fleroy1974: "Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial…

Oct 23, 2024 · 3 shares · 94 followers View post →
michelle
@ve_mich · X

RT @fleroy1974: "Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial…

Oct 23, 2024 · 3 shares · 1,067 followers View post →
Frédéric Leroy
@fleroy1974 · X

"Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial" https://t.co/5orpPmfobi https://t.co/HfO4k3vYrW

Oct 22, 2024 · 12 likes · 3 shares · 29,107 followers View post →
David_Propst_PA-C
@PrimaryCarePAC · X

Recommended reading: https://t.co/mOb3XqcIX4

Oct 22, 2024 · 4 likes · 3,330 followers View post →
David_Propst_PA-C
@PrimaryCarePAC · X

Recommended reading: https://t.co/mOb3XqcIX4

Oct 21, 2024 · 2 likes · 3,330 followers View post →
capybeara
@azwhore · X

@adraylasbard https://t.co/ibvLLpXnwL

Oct 4, 2024 · 22,300 followers View post →
Third_Eye_Prophet
@Third_i_Prophet · X

@RamblingRep @jk_rowling Creatine hydrates muscles and some people notice minimal short term gain in water weight. NOT fat. Most people don't know creatine is good for mental performance. I tell people to take it before SAT, LSAT, MCAT etc https://t.co/SugWBLWkLy

Sep 10, 2024 · 1,014 followers View post →
Y Conde de Alameda
@YCondeAlameda · X

RT @MarqueSalamanca: @AleksaNNdros Literalmente los veganos tienen el cerebro hecho horchata por no comer proteínas animales. En este estud…

Jun 3, 2024 · 1 share · 1,295 followers View post →
Marqués de Salamanca
@MarqueSalamanca · X

@AleksaNNdros Literalmente los veganos tienen el cerebro hecho horchata por no comer proteínas animales. En este estudio les dieron creatina y mejoró claramente su inteligencia: https://t.co/MyB1Gxg0ny

Jun 3, 2024 · 1 like · 1 share · 582 followers View post →
Joe Ward
@BoxCarLabs · X

A landmark study found #creatine supplementation improved working #memory and problem-solving skills. #creatine #cognition #science https://t.co/el0bBZHOYT

Mar 27, 2024 · 606 followers View post →
Kion
@GetKion · X

Study: https://t.co/rMfraOCHYt

Mar 1, 2024 · 1,125 followers View post →
Bronze Age Galkovsky
@bronzeagegalk · X

@0x49fa98 Chickpeas and all plant protein sources without exceptions lack certain "non-essential" amino acids like creatine, which has been associated with an in increase in cognitive abilities in vegans and vegetarians upon supplementation. https://t.co/JeadQ6m3mF https://t.co/5TGZstToQA

Jan 9, 2024 · 149 followers View post →
Crémieux
@cremieuxrecueil · X

@santygegen I haven't, but @timothycbates once did a study on the effects of creatine on cognitive performance in vegans/vegetarians: https://t.co/k7o90Iy4Jg You might like the studies in Table 1, here: https://t.co/drvqtJiLWN. This one explicitly contrasted omnivores and vegetarians:

Oct 12, 2023 · 273,402 followers View post →
Hubert Deep Work
@Hub_Deep_Work · X

@arthurdebons Références: Rae, Caroline, et al. "Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial." Proceedings of the Royal Society of London. Series B: Biological Sciences 270.1529 (2003): 2147-2150.

Oct 8, 2023 · 1 like · 850 followers View post →
RyuZoku ObjectiveReality MatrixRed
@Ryu_Zoku · X

@theoliveranwar The third link is stale, this works, https://t.co/73B2h9WlKm.

May 27, 2023 · 821 followers View post →
Kjetil Tveit
@tveitmiljo · X

@KristianGunder @eivindtraedal Og hva med kreatin og andre mikronæringsstoff som hovedsakelig finnes i kjøtt, og gir best opptak fra kjøtt? "Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial" https://t.co/tZYKFFlsFg

May 9, 2023 · 6 likes · 6,635 followers View post →
The Wellness Traveler
@wellandtravel · X

Creatine. One of the most researched supplements and I’m just starting to take it here in Brazil. The mild nootropic effect is pretty swell https://t.co/CQZVLJF9wm

Nov 13, 2022 · 150 followers View post →
Doot Defense
@DootDefense · X

@jnyboy https://t.co/TOAVdcDSjn https://t.co/BSKFJmBCvb https://t.co/JHJBPzgzTJ

Nov 3, 2022 · 1 like · 3,931 followers View post →
Ross
@rlogan87 · X

@WoodrowForCO @MarcLobliner Creatine supplementation has been shown to improve brain function and memory. small fella. https://t.co/LuwduYRXcx

Nov 3, 2022 · 9 likes · 213 followers View post →
Chris Boettcher
@chrisboettcher9 · X

@buythegoldip Here’s one on cognitive improvements. I don’t see a huge benefit in taking more. Would be better off focusing on increasing red meat where you get it naturally. https://t.co/1azmRlL4hi

Oct 4, 2022 · 1 like · 255,872 followers View post →
Matthew
@commonsensitiv · X

Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. - PMC https://t.co/KUzYkH7OMs

Aug 31, 2022 · 1 like · 147 followers View post →
Christa
@dcfitchick · X

Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. - PMC https://t.co/3ag2kiFuqB

Aug 31, 2022 · 1 like · 2,030 followers View post →
Konstantinos Prokopidis
@KostasProko · X

RT @BrainMetabolism: Meta analysis finds #creatine supplementation enhanced measures of memory performance in healthy individuals, especial…

Aug 23, 2022 · 2 shares · 1,487 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @BrainMetabolism: Meta analysis finds #creatine supplementation enhanced measures of memory performance in healthy individuals, especial…

Aug 23, 2022 · 2 shares · 6,710 followers View post →
BrainEnergyMetabolism
@BrainMetabolism · X

Meta analysis finds #creatine supplementation enhanced measures of memory performance in healthy individuals, especially in older adults (66–76 years). https://t.co/0KNLODsAdU Nice for our original study to be validated

Aug 23, 2022 · 5 likes · 2 shares · 1,251 followers View post →
alephh
@alephh · X

5g/day Creatine improves brain performance (double–blind placebo crossover trial) — Significant positive effect (p<.0001) on both working memory (backward digit span) & intelligence (Raven's Advanced Progressive Matrices), both require speed of processing https://t.co/ICgq91wF20

Jul 7, 2022 · 388 followers View post →
HeartfulEarthCuisine
@HeartfulCuisine · X

RT @humanOS_me: Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian particip…

May 8, 2022 · 13 shares · 1,428 followers View post →
Ralph Bennett
@RBennettIV · X

RT @humanOS_me: Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian particip…

May 5, 2022 · 13 shares · 359 followers View post →
John Jones
@J7J94 · X

RT @humanOS_me: Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian particip…

May 3, 2022 · 13 shares · 387 followers View post →
Vanessa Atkin
@vanessa_atkin · X

RT @humanOS_me: Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian particip…

May 3, 2022 · 13 shares · 117 followers View post →
William A. Wallace, Ph.D.
@drwilliamwallac · X

RT @humanOS_me: Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian particip…

May 2, 2022 · 13 shares · 10,409 followers View post →
Erik H
@ChipsAHoium · X

RT @humanOS_me: Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian particip…

May 2, 2022 · 13 shares · 391 followers View post →
Sonia :)
@_Sonia_GD · X

RT @humanOS_me: Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian particip…

May 2, 2022 · 13 shares · 576 followers View post →
Ma ri us
@Kizamius · X

RT @humanOS_me: Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian particip…

May 2, 2022 · 13 shares · 6 followers View post →
Frederic Danel
@Frederic_Danel · X

RT @humanOS_me: Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian particip…

May 2, 2022 · 13 shares · 332 followers View post →
GenEuropa
@010_Europa · X

RT @humanOS_me: Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian particip…

May 2, 2022 · 13 shares · 33 followers View post →
humanOS.me
@humanOS_me · X

Supplementation with creatine enhanced intelligence test scores and working memory performance in young vegetarian participants in a double-blind, placebo-controlled, cross-over study. https://t.co/3WVw5W8bDN https://t.co/vElXa19hoH

May 2, 2022 · 41 likes · 13 shares · 9,659 followers View post →
Çınar Furkan İlhan
@cnarilhn · X

2) Bir başka çalışmada; yaşları 19 ile 37 arasında değişen genç vejetaryen yetişkinlerde, 6 gün boyunca alınan 5 gram kreatin bilişsel test sonuçlarını önemli ölçüde arttırdı. https://t.co/rG8xLYZHws

Apr 14, 2022 · 58 followers View post →
The Yoctoinfluencer
@YoctoInfluencer · X

@deaflibertarian Anyone who is #vegetarian (especially #veganism ) is likely very deficient in #creatinine. It impacts several cognitive capacities including critical thinking, and may affect other conditions like diabetes and dementia in the long term. That’s my

Dec 22, 2021 · 56 followers View post →
Tyler Johnson YA DIG!!!
@90reasons · X

RT @Mangan150: https://t.co/avytr2WUG2

Jul 30, 2021 · 2 shares · 944 followers View post →
kike
@FUENTESMANZULLI · X

RT @Mangan150: https://t.co/avytr2WUG2

Jul 30, 2021 · 2 shares · 249 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

https://t.co/avytr2WUG2

Jul 30, 2021 · 27 likes · 2 shares · 291,935 followers View post →
Titan.MEME
@BowTiedTitan · X

RT @BowTiedPenguin1: @BowTiedTitan Aside from ze muscles, nice cognitive benefits (but for vegetarians that aren't getting enough in their…

Jun 23, 2021 · 1 share · 623 followers View post →
BowTiedPenguin
@BowTiedPenguin1 · X

@BowTiedTitan Aside from ze muscles, nice cognitive benefits (but for vegetarians that aren't getting enough in their diet, at least in this study). Can't hurt for omnivores though! https://t.co/u93nxuNzGM

Jun 23, 2021 · 2 likes · 1 share · 1,066 followers View post →
Jevan
@Jevan · X

@MattMadore576 @drmatthewnagra @Alecsplaining @JohnG_UK @ScepticalDoctor @myveganaccount @KetoCarnivore @TheBhupiThakur @ZacharyWenger @jerryteixeira @TrejbalChris @jonnettlefold @AmandaZZ100 @SBakerMD @cambridge_pt Buddy you have to be more thorough in your diligence of reading papers. Perhaps go to links where it says they confirm previous research on the subject. Like this study where giving vegetarians creatine improved intelligence and working memory. https://t.co/NRtO3kHdUI

Apr 28, 2021 · 301 followers View post →
SosDeUstoroi
@AncestralYogurt · X

@Grahanimal @ChivSJ84 @Jellyyacht @Tesco OK ideologue. Run along now. It's clear you are a tad butthurt that there are people out there willing to call a spade a spade. Here's some more data for you to ignore: https://t.co/VnpopNFpf8 https://t.co/NBIIcCEEOJ https://t.co/oHGagniEzt https://t.co/noGgH3oo0B

Jan 8, 2021 · 84 followers View post →
Abdolanymus
@A1b2c3d93133024 · X

RT @Mangan150: Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial…

Nov 29, 2020 · 7 shares · 4 followers View post →
Dr. Edward Trausti
@Alfred_The_Okay · X

RT @Mangan150: Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial…

Nov 29, 2020 · 7 shares · 14 followers View post →
Dr Quark, phD
@KaptinAmerika · X

RT @Mangan150: Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial…

Nov 29, 2020 · 7 shares · 243 followers View post →
ᔕᗩᑎTOᗷᗩᖇᖇYᔕ
@Santobarryss · X

RT @Mangan150: Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial…

Nov 29, 2020 · 7 shares · 123 followers View post →
11Flamingos
@11Flamingos · X

RT @Mangan150: Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial…

Nov 29, 2020 · 7 shares · 2,379 followers View post →
Marvin Liao
@marvinliao · X

RT @Mangan150: Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial…

Nov 29, 2020 · 7 shares · 6,945 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial More creatine could lead to better mental performance, another link to higher earnings https://t.co/avytr2WUG2

Nov 29, 2020 · 62 likes · 7 shares · 291,935 followers View post →
FósforoEnc
@FrozenMount · X

4. Los veganos tienen peor memoria en comparación con los no veganos debido a la deficiencia de creatina en los veganos. Estudios: “Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial”https://t.co/JVeQBNO6wf

Jul 23, 2020 · 10 followers View post →
Sport Cole
@PakDoc · X

Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. Shows just how malnourished Vegans generally are! https://t.co/kEUMJRMfnf

Feb 21, 2020 · 77 followers View post →
Jeffery Nutrition
@JefferyNutr · X

Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. https://t.co/N5XE9QxSJs

Feb 21, 2020 · 2 likes · 284 followers View post →
tiktak
@taisukun · X

@abbb_h 脳機能も向上させるみたいですよ

Dec 23, 2019 · 301 followers View post →
Nwär
@NwarThree · X

@xqgod Google lol Depression: https://t.co/bfSL97w49J Heart disease: https://t.co/GdSsz81xaN Anti cancer properties: https://t.co/yhMFdDo7YC Brain performance/ Fatigue : https://t.co/NPziSZGk5R Elevate testosterone: https://t.co/ZO5ppVpPc1

Aug 15, 2019 · 1 like · 1,225 followers View post →
Marilia Coutinho, Ph.D., the Baffled Immigrant
@mariliacout · X

10/ Although creatine supplementation is beneficial to omnivorous individuals, whether athletic or not, the benefit of creatine supplementation is much greater for vegetarians @BulkSupps https://t.co/vJBFaNNoTW https://t.co/ZN2NkFuVFz https://t.co/X4DRfBpceX

Jun 12, 2019 · 2,795 followers View post →