Physiol Rev April 2004 PMID 15044685

Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading.

Michael Kjaer

Download social card

Mentions

23
Peak: 2 in Apr 2019
across 4 sources since Nov 2018

Extended reach

83,134
potential audience

Total likes

970

Video views

36,545

Mentions per month

Nov 2018 – Dec 2024

Where it's discussed

  • News10 articles
  • X / Twitter6 posts
  • YouTube5 videos
  • Blogs2 articles

AI synopsis

What people are saying

Discussions overall demonstrate strong engagement through references to visual evidence and personal research experiences, with remarks like 'lovely visual evidence' and statements about injury implications, highlighting genuine interest. The tone combines technical appreciation and curiosity, emphasizing the article’s relevance to ongoing research and medical considerations.

AgreementModerate agreement

Most discussions agree with the significance of the ECM's role in musculoskeletal adaptation, referencing reviews and visual evidence supporting the article's findings.

InterestHigh interest

Participants show high interest, mentioning their own past research, appreciating visual evidence, and discussing implications for injury prevention and treatment.

EngagementModerate engagement

Comments include sharing personal opinions, referencing related studies, and raising questions about injury mechanisms—indicating meaningful exchanges.

ImpactModerate impact

While some users reflect on research implications for clinical practice and injury management, the overall perceived impact remains moderate rather than transformative.

Abstract in brief

  • The extracellular matrix (ECM), especially connective tissue like collagen, plays a crucial role in maintaining tissue structure and transmitting force in tendons, ligaments, bones, and muscles, with its turnover being stimulated by mechanical loading such as physical activity.
  • Exercise increases collagen synthesis, enzyme activity for collagen degradation, and growth factor release, leading to enhanced tissue metabolism and collagen turnover, which can improve the mechanical strength and load resistance of tendons and muscles.
  • Aging and inactivity decrease collagen turnover and alter tissue stiffness through processes like glycation and crosslinking, while chronic mechanical loading promotes collagen synthesis and crosslinking, ultimately modifying the tissue’s mechanical and viscoelastic properties.]

Top posts

Most liked on X and Bluesky
Martino V. Franchi
@MVFranchi · X

@gregory_sawicki Hey Gregory, In theory, muscle should adapt faster, but I haven't looked yet at the latest research on this. I loved this review back when I was doing my PhD https://t.co/Gx1X1EgTg9 However, this is a great (and recent) review on human tendons

Jan 22, 2022 · 16 likes · 5,996 followers View post →
Andreas Serner
@aserner · X

@BradyDGreen @lorenzo_masci @DrTaniaPizzari @Seth0Neill @footballmed @LaTrobeSEM Yes Thanks! I still worry that calling intram. tendon/apon. disruption only a connective tissue disrupt. is implying no connective tissue involvement in other inj. This may influence our focus in both prev. & treatment #ECM #MTJ - https://t.co/T7RE5Qvweh - https://t.co/MwqKSRHR36 https://t.co/fYUutgR5gQ

Apr 30, 2019 · 3 likes · 1 share · 7,080 followers View post →
Karl Kadler
@KarlKadler · X

@Poppi62 @DaveFernig @HammedBadmos @CTAdodge 3/3 Very nice review of tendon from Michael Kjaer .... https://t.co/CHAbS01uwm. And lovely visual evidence of matrix abundance from decell tissues e.g. kidney PMID: 23584091 (Song et al.) and heart PMID: 28456953 (Hodgson et al.)

May 20, 2022 · 1 like · 1 share · 1,036 followers View post →
Achilles Tendons
@Seth0Neill · X

RT @aserner: @BradyDGreen @lorenzo_masci @DrTaniaPizzari @Seth0Neill @footballmed @LaTrobeSEM Yes Thanks! I still worry that calling intram…

Apr 30, 2019 · 1 share · 30,105 followers View post →
MarkQuarter
@MarkQuarter · X

RT @KarlKadler: @Poppi62 @DaveFernig @HammedBadmos @CTAdodge 3/3 Very nice review of tendon from Michael Kjaer .... https://t.co/CHAbS01uwm…

Dec 28, 2024 · 1 share · 1,598 followers View post →
Jack
@Jack75173493 · X

Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading https://t.co/v6MfetPQUD

Oct 3, 2024 · 767 followers View post →

All mentions

MarkQuarter
@MarkQuarter · X

RT @KarlKadler: @Poppi62 @DaveFernig @HammedBadmos @CTAdodge 3/3 Very nice review of tendon from Michael Kjaer .... https://t.co/CHAbS01uwm…

Dec 28, 2024 · 1 share · 1,598 followers View post →
Jack
@Jack75173493 · X

Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading https://t.co/v6MfetPQUD

Oct 3, 2024 · 767 followers View post →
Karl Kadler
@KarlKadler · X

@Poppi62 @DaveFernig @HammedBadmos @CTAdodge 3/3 Very nice review of tendon from Michael Kjaer .... https://t.co/CHAbS01uwm. And lovely visual evidence of matrix abundance from decell tissues e.g. kidney PMID: 23584091 (Song et al.) and heart PMID: 28456953 (Hodgson et al.)

May 20, 2022 · 1 like · 1 share · 1,036 followers View post →
Martino V. Franchi
@MVFranchi · X

@gregory_sawicki Hey Gregory, In theory, muscle should adapt faster, but I haven't looked yet at the latest research on this. I loved this review back when I was doing my PhD https://t.co/Gx1X1EgTg9 However, this is a great (and recent) review on human tendons

Jan 22, 2022 · 16 likes · 5,996 followers View post →
Achilles Tendons
@Seth0Neill · X

RT @aserner: @BradyDGreen @lorenzo_masci @DrTaniaPizzari @Seth0Neill @footballmed @LaTrobeSEM Yes Thanks! I still worry that calling intram…

Apr 30, 2019 · 1 share · 30,105 followers View post →
Andreas Serner
@aserner · X

@BradyDGreen @lorenzo_masci @DrTaniaPizzari @Seth0Neill @footballmed @LaTrobeSEM Yes Thanks! I still worry that calling intram. tendon/apon. disruption only a connective tissue disrupt. is implying no connective tissue involvement in other inj. This may influence our focus in both prev. & treatment #ECM #MTJ - https://t.co/T7RE5Qvweh - https://t.co/MwqKSRHR36 https://t.co/fYUutgR5gQ

Apr 30, 2019 · 3 likes · 1 share · 7,080 followers View post →