PubHawk
July 2004 PMID 15133062

Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice.

Nobuyuki Sudo, Yoichi Chida, Yuji Aiba, Junko Sonoda, Naomi Oyama, Xiao-Nian Yu, Chiharu Kubo, Yasuhiro Koga

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Mentions

89
Peak: 4 in May 2021
across 6 sources since Jan 2019

Extended reach

266,823
potential audience

Total likes

33

Video views

513

Mentions per month

Jan 2019 – Nov 2025

Where it's discussed

  • News46 articles
  • X / Twitter19 posts
  • Blogs17 articles
  • Facebook4 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The posts collectively show strong support and fascination with the study, often citing its pioneering role in establishing gut-brain connections, with language like 'started it all' and mentioning critical factors like early microbial colonization, which suggests both high interest and recognition of its impact on future neuroscience and microbiome research.

AgreementStrong agreement

Most posts agree with the significance of the research, highlighting its foundational role in understanding how microbiota influence stress responses.

InterestHigh interest

Discussions show high engagement with the topic, referencing key findings and related concepts like gut-brain interactions.

EngagementModerate engagement

Posts engage actively with the subject, including references to methods (e.g., germ-free mice) and potential implications, indicating deep interest.

ImpactHigh impact

Many posts recognize the study's potential to influence future research in microbiome and neurobiology, emphasizing its groundbreaking nature.

Abstract in brief

  • The study found that mice without any microbiota (germ-free mice) showed a much higher stress hormone response (ACTH and corticosterone) and reduced brain neurotrophic factors compared to normal mice, indicating that microbiota influence brain development and stress regulation.
  • Reintroducing beneficial bacteria like Bifidobacterium infantis early in development can reverse these stress response abnormalities, highlighting the importance of early microbial exposure for proper HPA system development.
  • The timing of microbial exposure is crucial, as early colonization corrects the HPA response, but later reconstitution does not, suggesting that microbial interactions during a critical early period are essential for normal stress system development.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Nick Norwitz MD PhD
@nicknorwitz · X

Fact of day 142: Giving germ-free baby mice “bifidobacterium infantis” helps to sooth their overactive stress response https://t.co/ZCDZuRa8EN #microbiome #anxietydisorder .@DrUmaNaidoo https://t.co/YmI9PltyXO

Jul 12, 2020 · 6 likes · 1 share · 113,986 followers View post →
MDS
@movedisorder · X

Early understanding of the gut-brain axis began with studies of developing mice. Read one of the first studies into this pivotal field here: https://t.co/xQXirM0KqQ #MDSNeuroCompass #Neuroscience https://t.co/9tNpaBbEMG

May 17, 2021 · 5 likes · 4 shares · 17,121 followers View post →
Dr. Sheba A-J
@ShebaAJ · X

the paper that started it all #MMM2019 https://t.co/mALH9E6MSW @jfosterlab

Jan 17, 2019 · 4 likes · 1 share · 2,988 followers View post →
Agingdoc
@agingdoc1 · X

Stress and gut microbiota: Does postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response? https://t.co/3YsJMscGnV

Dec 9, 2022 · 2 likes · 43,816 followers View post →
心療内科夜想曲
@cKvWsvTnZAoU8Yr · X

「腸内細菌の脳機能への関与」を示し、それまでの常識を覆した先駆的研究 ・無菌マウスは通常マウスと比較すると、拘束ストレス負荷によるACTHの上昇が有意に亢進 ・ビフィズス菌を移植されたマウスでは、高ストレス反応は正常化 J Physiol 2004 九大心療内科の須藤教授 https://t.co/3TmAgmCDum

Mar 23, 2021 · 2 likes · 2 shares · 399 followers View post →
Agingdoc
@agingdoc1 · X

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice https://t.co/iJaDbKeLTz

Dec 9, 2022 · 1 like · 43,816 followers View post →

All mentions

El área de Broca
@elareadebroca.bsky.social · Bluesky

Sudo, N.; Chida, Y.; Aiba, Y (2004). «Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice». J Physiol 558 (1): 263-275.

Nov 29, 2025 · 1 like · 1 share View post →
Friedrich
@Friedri23257098 · X

Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response ... https://t.co/5Zrz1Gj6tK

Sep 12, 2024 · 542 followers View post →
Agingdoc
@agingdoc1 · X

Stress and gut microbiota: Does postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response? https://t.co/3YsJMscGnV

Dec 9, 2022 · 2 likes · 43,816 followers View post →
Agingdoc
@agingdoc1 · X

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice https://t.co/iJaDbKeLTz

Dec 9, 2022 · 1 like · 43,816 followers View post →
movedoc
@movedoc · X

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice https://t.co/x5fiWTvGbO

Jan 8, 2022 · 486 followers View post →
mrnn
@mrnn53697955 · X

出生後の微生物コロニー形成はマウスのストレス応答に関わる視床下部-下垂体-副腎系をプログラムする ストレス耐性獲得における腸内細菌叢の働きには臨界期が存在するのである。 https://t.co/JqRnlWh1yh

Aug 4, 2021 · 13 followers View post →
Prof.Dr.M.A.Aleem
@drmaaleem · X

RT @movedisorder: Early understanding of the gut-brain axis began with studies of developing mice. Read one of the first studies into this…

May 17, 2021 · 4 shares · 1,216 followers View post →
Helen Martirosova,PhD, MSc
@HMartirosova · X

RT @movedisorder: Early understanding of the gut-brain axis began with studies of developing mice. Read one of the first studies into this…

May 17, 2021 · 4 shares · 86 followers View post →
Manon Auffret
@Manon_Auffret · X

RT @movedisorder: Early understanding of the gut-brain axis began with studies of developing mice. Read one of the first studies into this…

May 17, 2021 · 4 shares · 745 followers View post →
MDS
@movedisorder · X

Early understanding of the gut-brain axis began with studies of developing mice. Read one of the first studies into this pivotal field here: https://t.co/xQXirM0KqQ #MDSNeuroCompass #Neuroscience https://t.co/9tNpaBbEMG

May 17, 2021 · 5 likes · 4 shares · 17,121 followers View post →
さとし
@sa1tsh · X

RT @cKvWsvTnZAoU8Yr: 「腸内細菌の脳機能への関与」を示し、それまでの常識を覆した先駆的研究 ・無菌マウスは通常マウスと比較すると、拘束ストレス負荷によるACTHの上昇が有意に亢進 ・ビフィズス菌を移植されたマウスでは、高ストレス反応は正常化 J Phy…

Mar 24, 2021 · 2 shares · 291 followers View post →
冬の星座
@Orion_STAR_99 · X

RT @cKvWsvTnZAoU8Yr: 「腸内細菌の脳機能への関与」を示し、それまでの常識を覆した先駆的研究 ・無菌マウスは通常マウスと比較すると、拘束ストレス負荷によるACTHの上昇が有意に亢進 ・ビフィズス菌を移植されたマウスでは、高ストレス反応は正常化 J Phy…

Mar 23, 2021 · 2 shares · 245 followers View post →
心療内科夜想曲
@cKvWsvTnZAoU8Yr · X

「腸内細菌の脳機能への関与」を示し、それまでの常識を覆した先駆的研究 ・無菌マウスは通常マウスと比較すると、拘束ストレス負荷によるACTHの上昇が有意に亢進 ・ビフィズス菌を移植されたマウスでは、高ストレス反応は正常化 J Physiol 2004 九大心療内科の須藤教授 https://t.co/3TmAgmCDum

Mar 23, 2021 · 2 likes · 2 shares · 399 followers View post →
Dr. Uma Naidoo
@DrUmaNaidoo · X

RT @nicknorwitz: Fact of day 142: Giving germ-free baby mice “bifidobacterium infantis” helps to sooth their overactive stress response htt…

Jul 13, 2020 · 1 share · 12,895 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

Fact of day 142: Giving germ-free baby mice “bifidobacterium infantis” helps to sooth their overactive stress response https://t.co/ZCDZuRa8EN #microbiome #anxietydisorder .@DrUmaNaidoo https://t.co/YmI9PltyXO

Jul 12, 2020 · 6 likes · 1 share · 113,986 followers View post →
JUAN ARIEL JARA GUER
@Tigerariel40 · X

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice https://t.co/qv0Rcin9Pp

Dec 20, 2019 · 158 followers View post →
しそごはん用研究者（薬学部講師）
@ONODA_in_Onodac · X

ストレス応答系への影響はこっちの論文だった。 前のやつは不安様行動だわ。 https://t.co/klunwbQKIh

May 23, 2019 · 1 share · 3,549 followers View post →
Lucassen lab University of Amsterdam
@LucassenPJ · X

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice - Sudo - 2004 - The Journal of Physiology - Wiley Online Library https://t.co/VGI39GNRCj

Jan 17, 2019 · 1,471 followers View post →
John F. Cryan
@jfcryan · X

RT @ShebaAJ: the paper that started it all #MMM2019 https://t.co/mALH9E6MSW @jfosterlab

Jan 17, 2019 · 1 share · 22,432 followers View post →
Dr. Sheba A-J
@ShebaAJ · X

the paper that started it all #MMM2019 https://t.co/mALH9E6MSW @jfosterlab

Jan 17, 2019 · 4 likes · 1 share · 2,988 followers View post →