June 2004 PMID 15172426

Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal.

James H O'Keefe, Loren Cordain, William H Harris, Richard M Moe, Robert Vogel

Mentions

157
Peak: 10 in May 2023
across 6 sources since Jan 2019

Extended reach

704,503
potential audience

Total likes

3,136

Video views

98,496

Mentions per month

Jan 2019 – Nov 2025

Where it's discussed

  • X / Twitter127 posts
  • Facebook12 posts
  • YouTube8 videos
  • News4 articles
  • Reddit3 posts
  • Blogs3 articles

AI synopsis

What people are saying

The discussions are highly engaged with scientific evidence, citing studies like the 2004 paper by O'Keefe and Cordain, along with references to hunter-gatherer populations and evolutionary biology, framing LDL levels of 50-70 mg/dL as optimal and natural. The tone ranges from supportive to slightly skeptical, emphasizing the importance of LDL management for cardiovascular health, and words like "proof," "evidence," and "optimal" convey the perceived significance of these findings.

AgreementStrong agreement

Most discussions strongly support the publication's conclusion that optimal LDL levels are between 50-70 mg/dL and that lower is better for health.

InterestHigh interest

Participants demonstrate high curiosity, discussing detailed research, historical perspectives, and implications for health and diet.

EngagementHigh engagement

Many refer to scientific studies, classical research, and evolutionary biology, indicating deep involvement and analysis.

ImpactHigh impact

The discussions could influence perspectives on diet, lipid management, and medical guidelines, reflecting significant potential influence.

Abstract in brief

  • Optimal low-density lipoprotein (LDL) levels are considered to be between 50 and 70 mg/dL, and lower levels within this range are associated with better health outcomes.
  • The normal LDL range observed in healthy humans, including neonates, primates, and wild mammals, is 50 to 70 mg/dL, and these groups typically do not develop atherosclerosis.
  • Research indicates that lowering LDL to around 70 mg/dL reduces the progression of atherosclerosis and the risk of heart disease without significant safety concerns, suggesting current guidelines that set higher LDL targets may result in undertreatment of high-risk individuals.

Top posts

Most liked on X and Bluesky
Danijel
@MiocanDanijel · X

Friendly reminder to our #Carnivore and #keto friends that LDL-c levels in our ancestors were very very low. If you want to be truly ancestoral get your LDL-c down. https://t.co/54DyAPIkcv

May 30, 2023 · 31 likes · 3 shares · 1,122 followers View post →
Simon Hill MSc, BSc
@theproof · X

https://t.co/Ls0Yo30zzJ https://t.co/c29XIShqSW

Mar 11, 2023 · 29 likes · 1 share · 34,117 followers View post →
Simon Hill MSc, BSc
@theproof · X

Loren Cordain (father of the Paleo diet) on Optimal LDL-C levels. https://t.co/Ls0Yo2IqlB

Nov 7, 2021 · 28 likes · 5 shares · 34,117 followers View post →
Simon Hill MSc, BSc
@theproof · X

Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal - ScienceDirect From the father of the Paleo Diet - Loren Cordain https://t.co/w5e8BA0Hb0

Sep 25, 2021 · 20 likes · 34,117 followers View post →
Simon Hill MSc, BSc
@theproof · X

@ScepticalDoctor @TyRBeal @TheVeganRD @MyNutritionSci @luke_spajic @waiterich @_HannahRitchie @JohnG_UK @drmatthewnagra @MattMadore576 @NutritionMadeS3 This is particularly surprising given they reference Loren Cordain's work but conveniently this piece of his out? https://t.co/Ls0Yo2IqlB

Feb 12, 2022 · 12 likes · 1 share · 34,117 followers View post →
Larronde Esteban
@EstebanDL · X

7. Y la próxima vez que te muestren este gráfico y te citen este paper del 2004 doi:10.1016/j.jacc.2004.03.046 Recordale que la aterosclerosis es mas compleja que bajar LDL y la realidad tiene otras aristas https://t.co/BDnR6Q5xQW

Jan 9, 2019 · 12 likes · 1 share · 23,721 followers View post →

All mentions

Enjoyer of Sinas
@Sinas_Enjoyer · X

@PurpledPill @grok @KritischePatri https://t.co/456FWSwvv5 Optimale LDL cholesterol voor het minimaliseren van hart- en vaatziekten. https://t.co/2wo779wb6X Deze meta analyse laat zien dat LDL cholesterol en de opbouw van atherosclerose letterlijk causaal aan elkaar verbonden zijn.

Nov 12, 2025 · 11 followers View post →
Ezequiel Forte
@ezeforte · X

@SaulNutri Si, el LDL fisiológico es de alrededor de 40 mg/dl, nacemos con eso, estás confundiéndote con LDL normal…con LDL >25 los receptores LDL ya están saturados, con 40 ya cumple todas las funciones fisiológicas https://t.co/cXGPdyZkwL

Oct 28, 2025 · 2 likes · 5,318 followers View post →
Brian Turner
@briankturner101 · X

RT @ScottAppliedSci: @SamaHoole Here’s a good, classic study if you’d like to follow up. Notice how ludicrously out of range our modern day…

Sep 22, 2025 · 1 share · 1,468 followers View post →
Andrew Scott
@ScottAppliedSci · X

@SamaHoole Here’s a good, classic study if you’d like to follow up. Notice how ludicrously out of range our modern day cholesterol levels are compared to conspecifics and closely related species. https://t.co/Xm88uN0VuU

Sep 22, 2025 · 7 likes · 1 share · 1,595 followers View post →
Breno Santos
@Brepoiughfhjkl · X

@TylerDurne62894 @fiscaldofim E com razão. Na verdade, o nível fisiológico do LDL na nossa espécie é entre 50 e 70 mg/dL. https://t.co/Emc1jq6wXW

Sep 20, 2025 · 1 followers View post →
Earthling
@_earthling74 · X

@Lpa_Doc @ApoDudz @Lpa_Doc can you comment on this paper? https://t.co/3v4sAhHBlm

Aug 25, 2025 · 428 followers View post →
Catalina Pogany
@pogany54 · X

RT @a_fisiolog57853: UN POCO DE PALEO, POR FAVOR. https://t.co/Vkua7lnkw5 https://t.co/ECC3fTO7CM

Aug 24, 2025 · 2 shares · 627 followers View post →
Daniel Moreno
@DanielG73818380 · X

RT @a_fisiolog57853: UN POCO DE PALEO, POR FAVOR. https://t.co/Vkua7lnkw5 https://t.co/ECC3fTO7CM

Aug 24, 2025 · 2 shares · 87 followers View post →
Walter Suárez Carmona
@a_fisiolog57853 · X

UN POCO DE PALEO, POR FAVOR. https://t.co/Vkua7lnkw5 https://t.co/ECC3fTO7CM

Aug 24, 2025 · 11 likes · 2 shares · 3,848 followers View post →
Leftist Trail Runner
@vegantrailrun · X

@MasalaFry69 @underwire6783 @lipherps @DavidAYON @RadioFreeTom So again… tightly regulated… what’s an acceptable level in the serum…. Here’s a paper showing Hunter gatherer populations and mammals and their baseline ldl and total cholesterol https://t.co/zBRYcSXay1

Jul 1, 2025 · 1,022 followers View post →
Miguifdez
@Miguelfdez0 · X

@BenBikmanPhD Indeed, I was mistaken. My comment came from studies like this one: https://t.co/X5C9nXF92Q But clearly, Bayturan shows that plaque can still progress even at those supposedly optimal levels in high-risk patients although "only" in 1 out of 5

May 22, 2025 · 154 followers View post →
Logical BTC
@MiguelGBTC · X

@BenBikmanPhD Indeed, I was mistaken. My comment came from studies like this one: https://t.co/X5C9nXF92Q But clearly, Bayturan shows that plaque can still progress even at those supposedly optimal levels in high-risk patients although "only" in 1 out of 5

May 22, 2025 · 141 followers View post →
Stephan Haller
@SteHaller · X

@FloZoe99 @DoctorTro I’m talking about studies done on indigenous people who still don’t eat modern food. Just look at the low cholesterol levels these people have. You don’t get that on a keto/carnivore diet. https://t.co/VAJPHN3arH https://t.co/A7QwjXrR6e

May 5, 2025 · 1,744 followers View post →
Stephan Haller
@SteHaller · X

@Pbogio @FloZoe99 @DoctorTro They have a high infant mortality but if they survive childhood they mostly live into their 70s some even into 80s. They mostly die from accidents, snake bites or infections. No CVDs. And very low blood lipids. (source: https://t.co/VAJPHN3arH) https://t.co/C1FKTgeYjx

May 4, 2025 · 1 like · 1,744 followers View post →
NoRepublicanIsRight
@BlkAlphaLiberal · X

@sf2000b @OSheaJW My guy this is not an opinion. After you have a heart attack, they treat your LDL to <70, even lower if you are CHD + diabetes. https://t.co/7feqxPRkTr

Mar 26, 2025 · 257 followers View post →
Unapologist
@vegan_rav · X

@grok @ThelastStyleb16 @MasalaFry69 @Special_Cactus Why is it that people with ldl of 50-70mg have the lowest rate of heart disease if there is only a weak association. https://t.co/gAzbGyG5UG

Mar 14, 2025 · 1,592 followers View post →
Longevity
@LongevityTao · X

Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal - ScienceDirect https://t.co/H6s2TUmdrQ

Jan 30, 2025 · 328 followers View post →
Alex Leaf
@AlexJLeaf · X

@chatpotpompier @CARepublicrat The data suggests otherwise. https://t.co/5h2K5YWQBv https://t.co/JfJssZcih3

Jan 26, 2025 · 2 likes · 3,938 followers View post →
Joseph Bodet
@4BetRFlow · X

@CaryKelly11 You might want to look at event rates at the differing levels of LDL. https://t.co/xTEUvklYkL https://t.co/Av8PVnewCI

Oct 20, 2024 · 1 like · 202 followers View post →
Dylan
@VeganBaecon · X

@NipseyHoussle LDL is most important but don’t let anyone tell you 200mg/dL is normal. In a society where heart disease is the leading cause of death, a normal cholesterol level leads to heart disease later in life. Optimal 200 is very bad and optimal is 50-70 https://t.co/ompI2o3xb0

Oct 4, 2024 · 1 like · 76 followers View post →
Dylan
@VeganBaecon · X

@ElieJarrougeMD Caught you fucking lying. Optimal levels are around 50-70mg/dL and can be achieved with diet and lifestyle changes. https://t.co/ompI2o2Zls

Jun 18, 2024 · 76 followers View post →
Biomass Bob
@SentientBlobBob · X

@STOPHEATHERTIME https://t.co/ME5nlEAUzP.

May 14, 2024 · 786 followers View post →
Tobias
@tobyloxy · X

@deportriggers @lavvspan @WORLDN0MAD @theproof I was hoping you might have the reference for that figure you showed. I’ve seen this paper with various mammal cholesterol levels but I’d never seen that figure you shared. https://t.co/86lcUfDtJA

May 2, 2024 · 15 followers View post →
Investisseur insoumis
@Invinsed · X

@PikeCapo @Vegan1478 Le cholestérol alimentaire est lié à des risques de cancer + élevé, sinon oui rien à voir sauf une petite portion de la population pour qui ca joue Et pour rappel le taux optimal de LDL-C : https://t.co/shNXtTDkQp

Apr 16, 2024 · 1,093 followers View post →
Christoffer Baustad Nilsen
@ChristofferBN · X

@Mister01896517 @travis_demaria @MohammedAlo Western populations, yes. Not hunter-gatherer populations. https://t.co/BERnAAGOcj https://t.co/21naQ3NAgY

Apr 6, 2024 · 586 followers View post →
Dr. Balloon ⚕️
@Est_Que_B · X

Cholesterol is not entirely responsible for atherosclerotic plaques but is part of the cascade that affects the arterial wall causing cardiovascular disease. Research data shows(https://t.co/xVNL58l3nC)atherosclerosis progression and coronary heart disease events are minimized

Feb 21, 2024 · 643 followers View post →
Earthling
@_earthling74 · X

@JesslovesMJK Thoughts Jessica? https://t.co/tgaQew5AsR

Jan 25, 2024 · 428 followers View post →
bird police
@slothfulbandit · X

@pnatarajanmd @Lpa_Doc https://t.co/qqnOKwxTw7

Jan 20, 2024 · 80 followers View post →
Foolproof Mastery
@FoolproofMaster · X

Sources: https://t.co/PleVg7mhxy https://t.co/pZOECsa7Qk https://t.co/5wEqewgHZe https://t.co/SPAy2oVFwr https://t.co/fW1GUzXpvt https://t.co/0K29D60YCE https://t.co/1M1pJTi1Jh

Nov 13, 2023 · 1,172 followers View post →
GladstoneBrookes
@GladstoneB81859 · X

@carniyogi @FoodFirst_Ty If you're going to take the position that a behaviour is healthy because it's ancestral, then presumably you have to accept that low cholesterol is healthy, since hunter-gatherer populations generally have cholesterol in the 50-70 mg/dl range. https://t.co/NUFsfHRoeC

Sep 29, 2023 · 1 like · 530 followers View post →
Danijel
@MiocanDanijel · X

@Augman_1957 @ValerieAnne1970 Ever heard of survivorship bias? Too complicated for you. And while you talk about them, you may check their LDL-c levels. What are yours? Ever wondered why only those with low LDL-c among them survived to old age? Survivorship/selection bias

Sep 24, 2023 · 1,122 followers View post →
Georgie & Donny
@jowaller12 · X

RT @MiocanDanijel: Wonder how the paleolithic perspective works with the most unpaleolithic levels of LDL-c? This people are slowly and ste…

Sep 22, 2023 · 1 share · 349 followers View post →
Danijel
@MiocanDanijel · X

Wonder how the paleolithic perspective works with the most unpaleolithic levels of LDL-c? This people are slowly and steadily killing themselves

Sep 22, 2023 · 9 likes · 1 share · 1,122 followers View post →
Unapologist
@vegan_rav · X

@gosforthgal @vivaluvegan @A_Research_Guru https://t.co/gAzbGyG5UG cholesterol/LDL being lower is optimal for heart disease risk

Sep 20, 2023 · 1 like · 1,592 followers View post →
Danijel
@MiocanDanijel · X

@ChaosReign1066 @ScepticalDoctor But this is the paper by Loren Cordain. Paleo founder. https://t.co/54DyAPIkcv

Jul 28, 2023 · 1,122 followers View post →
Danijel
@MiocanDanijel · X

And yet, carnivore zealots will claim that very high LDL-C is great thing to have. While the ancestors whose example they follow had LDL-C 3-4 times! lower than them. https://t.co/54DyAPIS23

Jul 11, 2023 · 5 likes · 1,122 followers View post →
bird police
@slothfulbandit · X

@connerdelights @grantadever Most people have cholesterol levels higher than what is natural and optimal, so decreasing intake would get them closer to it, even more so for saturated fat yes https://t.co/qqnOKwxTw7

Jun 21, 2023 · 80 followers View post →
Goodhealth_._
@CroxFit · X

@_advg_ @Ankur_J_Bordolo @chiragbarjatyaa @Drlipid I can give you the evidence, whole night about the claims, see if your personal bias and beliefs are interfering with facts, please avoid it. As a public servant, we have to look at the facts rather than anecdotal evidence and beliefs. https://t.co/dtqdAFW8XY

Jun 20, 2023 · 347 followers View post →
Goodhealth_._
@CroxFit · X

@_advg_ @Ankur_J_Bordolo @chiragbarjatyaa @Drlipid Yes, we do have recommendations Lower LDL-C is better!! https://t.co/dtqdAFW8XY https://t.co/pmDVDat9UN

Jun 20, 2023 · 347 followers View post →
Danijel
@MiocanDanijel · X

@wildgains Glad you brought it up. There is some interesting research on them. What do you think about it? https://t.co/54DyAPIkcv

Jun 16, 2023 · 1,122 followers View post →
Kevin Harris
@kevtharris · X

@shelly_187 @nutrition_facts https://t.co/YpQzSVBoFW I thought the idea was to be like our ancestors?

Jun 7, 2023 · 541 followers View post →
Francisco Câmara Ferreira
@FranciscoCmar10 · X

Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal https://t.co/6DTbYlQbzb

Jun 2, 2023 · 113 followers View post →
Christian James
@ChristianJsays · X

@LornaMa26788099 https://t.co/zojpsAmCbt

May 30, 2023 · 1 like · 3,262 followers View post →
Christian James
@ChristianJsays · X

@WeiZhangAtmos https://t.co/zojpsAmCbt

May 30, 2023 · 1 like · 3,262 followers View post →
Gabriel
@eugael_x · X

RT @PavlicaDanijel: Friendly reminder to our #Carnivore and #keto friends that LDL-c levels in our ancestors were very very low. If you wan…

May 30, 2023 · 3 shares · 108 followers View post →
JG FNP-BC
@soonergise · X

RT @PavlicaDanijel: Friendly reminder to our #Carnivore and #keto friends that LDL-c levels in our ancestors were very very low. If you wan…

May 30, 2023 · 3 shares · 248 followers View post →
Almighty Keto Diet
@KetoDiet365 · X

RT @PavlicaDanijel: Friendly reminder to our #Carnivore and #keto friends that LDL-c levels in our ancestors were very very low. If you wan…

May 30, 2023 · 3 shares · 806 followers View post →
Danijel
@MiocanDanijel · X

Friendly reminder to our #Carnivore and #keto friends that LDL-c levels in our ancestors were very very low. If you want to be truly ancestoral get your LDL-c down. https://t.co/54DyAPIkcv

May 30, 2023 · 31 likes · 3 shares · 1,122 followers View post →
Danijel
@MiocanDanijel · X

@Josh95859922 @BrianDangeno @KenDBerryMD @American_Heart @DoctorTro @SBakerMD @jordanbpeterson @megynkelly @EddieTrunk @hubermanlab @prageru @ericmmatheny @MartinKulldorff @kardiyobey Ever heard of antagonistic pleiotropy, survivorship bias? Maybe the only ones who survived had genetically low LDL. This study was conducted by paleo and low carb proponents btw. There is no doubt they eat meat. That meat is very different to ribeyes. https://t.co/54DyAPIkcv

May 24, 2023 · 1,122 followers View post →
Unapologist
@vegan_rav · X

@LornaMa26788099 That is really good. I think 2 converts to just over this but not by much https://t.co/gAzbGyG5UG

May 22, 2023 · 1 like · 1,592 followers View post →
Danijel
@MiocanDanijel · X

@termites12345 @robertlufkinmd For the reference. LDL levels in hunter gatherers. https://t.co/54DyAPIkcv

May 20, 2023 · 1,122 followers View post →
Danijel
@MiocanDanijel · X

@thelowcarb_rd @SentientBlobBob @DrNadolsky https://t.co/54DyAPIkcv I think both O’Keefee and Cordain are low carb proponents. Didn’t Loren “found” the Paleo diet?

May 4, 2023 · 1 like · 1,122 followers View post →
Earthling
@_earthling74 · X

@PeterFaberSP @mikeoniron @realDaveFeldman Peter- “Super low”, or “physiological”? https://t.co/tgaQew5AsR

Apr 27, 2023 · 1 like · 428 followers View post →
t jones
@thadjonesTN · X

@GoingParabolic ??? 200 LDL is... not good "The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis)." https://t.co/wy8ISo4YG7).

Apr 23, 2023 · 2 likes · 82 followers View post →
Furosemido
@internistax · X

@AeroValue @paselsab ref 1: https://t.co/m8ZgXGJNVA ref 2: Roberts WC. It's the cholesterol, stupid! Am J Cardiol. 2010 Nov 1;106(9):1364-6. doi: 10.1016/j.amjcard.2010.09.022.

Apr 2, 2023 · 45 followers View post →
Danijel
@MiocanDanijel · X

@CaryKelly11 Funny, bcs that piece of meat is almost purely protein. Might explain this https://t.co/54DyAPIkcv

Mar 25, 2023 · 1,122 followers View post →
Danijel
@MiocanDanijel · X

@TheNutrivore https://t.co/54DyAPIkcv I was informed by a carnivore that this is vegan propaganda. Yeah, Loren Cordain is a vegan propagandist.

Mar 25, 2023 · 5 likes · 1,122 followers View post →
Danijel
@MiocanDanijel · X

@PlantChompers @sciencebyjae That’s why we never see high LDL in real ancestoral dieters. https://t.co/54DyAPIkcv

Mar 18, 2023 · 1 like · 1,122 followers View post →
LIYAN
@LIYAN93109461 · X

RT @EddieRDMD: Journal of the American College of Cardiology: Low LDL-C levels decrease cardiovascular risk, mortality and improve longev…

Mar 13, 2023 · 1 share · 103 followers View post →
Dr. Eddie Ramirez
@EddieRDMD · X

Journal of the American College of Cardiology: Low LDL-C levels decrease cardiovascular risk, mortality and improve longevity. How to achieve that? ---> WFPBD https://t.co/Sux1yLwGha @drjkahn https://t.co/UZ2DKuXRsw

Mar 13, 2023 · 3 likes · 1 share · 4,724 followers View post →
Keto Grill & Bakery & Subjugation of the masses
@ketogrillbakery · X

Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal https://t.co/RGo4GkIdI0

Mar 12, 2023 · 1,437 followers View post →
Clive Hislop
@CliveHislop · X

RT @theproof: https://t.co/Ls0Yo30zzJ https://t.co/c29XIShqSW

Mar 12, 2023 · 1 share · 334 followers View post →
Simon Hill MSc, BSc
@theproof · X

https://t.co/Ls0Yo30zzJ https://t.co/c29XIShqSW

Mar 11, 2023 · 29 likes · 1 share · 34,117 followers View post →
Danijel
@MiocanDanijel · X

@StevenMBelknap @dewucare8 @sguyenet @SentientBlobBob @exfatloss @bigfatsurprise https://t.co/54DyAPIkcv Maybe bcs our ancestors didn’t eat fatty Frankenanimals and when they did they didn’t eat them every day plus they ate plenty of fiber?

Mar 10, 2023 · 1 like · 1,122 followers View post →
Harmless Frog
@FrogHarmless · X

@gAlecsyBrain I don't think meat-eating has much to do with it. Whether HGs eat a lot or little meat seems to have little impact on their lipids - they're low. https://t.co/NQZvjviL9h https://t.co/rnRr8ygM7f

Feb 15, 2023 · 1 like · 504 followers View post →
kungry
@kungry123 · X

@Scalesremoved @drcateshanahan @DiscoStew66 Between 50-70 ldl. https://t.co/NEpfnus47K

Nov 11, 2022 · 15 followers View post →
Pablo (RealFitness)
@pablo_rfitness · X

@Coloidesoxigeno @EscuelaFit Si te gusta Weston Andrew Valleau Price​, conocerás a Loren Cordain: https://t.co/BY2b2kavTa

Nov 10, 2022 · 319 followers View post →
Pablo (RealFitness)
@pablo_rfitness · X

@Yo_soy_JulyR Aquí algunas referencias para consultar: https://t.co/Dk8AsmW6fk https://t.co/gcZxOkAPtm https://t.co/zrcgbrfgt0 https://t.co/L4d4u4H1kT https://t.co/qTo82NAl0w https://t.co/BY2b2ksF7i https://t.co/xZTN7ZXUvw Su tweet es un despropósito y si es por parte de un médico más.

Nov 9, 2022 · 1 like · 319 followers View post →
kungry
@kungry123 · X

@MikeKon00166475 @casa_roberts_tx @ifixhearts Ldl of 50-70 is ideal. Eating meat, especially in the amount most corpse addicts do, will never allow that..https://t.co/NEpfnus47K

Nov 8, 2022 · 15 followers View post →
Fat Fighting
@FatFightingClub · X

@drcateshanahan Does the image in that presentation came from this article https://t.co/dDlj2Eom2E

Oct 15, 2022 · 1 like · 10,065 followers View post →
Simon Hill MSc, BSc
@theproof · X

@PaloSamo @DaleWil39870290 @RPuddick @drandyphung @ProfTimNoakes At a given level and in contexts where there is not famine and calorie deficits, yes. https://t.co/Ls0Yo2IqlB

Oct 12, 2022 · 1 like · 34,117 followers View post →
Holosign12
@holosign12 · X

@immer_mit_Rad @der_veganer https://t.co/6c7cxKEVBM

Sep 28, 2022 · 93 followers View post →
sam van der Velden
@VanderveldenSam · X

@kevinnbass Here's my hypothesis: ldl-c is highly variable if humans were evolved to have an average ldl-c of 25mg/dl we wouldn't have enough ldl-c 50% of the time, therefore we evolved to have a higher ldl-c, a normal ldl-c is between 50-70mg/dl https://t.co/t3SXaOAxKK

Aug 28, 2022 · 12 followers View post →
kungry
@kungry123 · X

@Chaddadbod @ElieJarrougeMD https://t.co/77vtykzuIN).

Aug 18, 2022 · 15 followers View post →
sam van der Velden
@VanderveldenSam · X

@PKennedyeMD @NutritionMadeS3 The normal ldl-c is actually between 50-70mg/dl. https://t.co/t3SXaOAxKK If the normal ldl-c was 25mg/dl it would be too low 50% of the time. 50-70mg/dl gives enough wiggle room so that it's never too low. Just my hypothesis

Aug 13, 2022 · 12 followers View post →
Sergio
@g3rsio · X

RT @FrogHarmless: @Drlipid Is that even achievable without rare mutations or drugs? Pretty sure primitives were fine with 50-70 mg/dl, wh…

Aug 7, 2022 · 2 shares · 107 followers View post →
brainboy
@brainbo39736743 · X

RT @FrogHarmless: @Drlipid Is that even achievable without rare mutations or drugs? Pretty sure primitives were fine with 50-70 mg/dl, wh…

Aug 7, 2022 · 2 shares · 196 followers View post →
Harmless Frog
@FrogHarmless · X

@Drlipid Is that even achievable without rare mutations or drugs? Pretty sure primitives were fine with 50-70 mg/dl, which *is* achievable with just lifestyle. https://t.co/NQZvjvidjJ https://t.co/eLk3ZeUJra

Aug 7, 2022 · 10 likes · 2 shares · 504 followers View post →
Pradeep Natarajan
@pnatarajanmd · X

@MaxJordan_N While statistically significant, diabetes association with statins is quite modest. Virtually no modern human has an optimal LDL-C & stands to benefit from additional LDL-C lowering https://t.co/qeaUb5Tn5Z https://t.co/esmzD5arqH

Jul 27, 2022 · 11 likes · 25,294 followers View post →
PC ⛓
@PC65049955 · X

RT @ZahcM: I've been looking into this paper. Very good material for my upcoming blog posts

Jul 15, 2022 · 6 shares · 1,477 followers View post →
Archimandrite
@lowcarblefty · X

RT @ZahcM: I've been looking into this paper. Very good material for my upcoming blog posts

Jul 15, 2022 · 6 shares · 674 followers View post →
Xinggang Wang
@xinggang_wang · X

RT @ZahcM: I've been looking into this paper. Very good material for my upcoming blog posts

Jul 15, 2022 · 6 shares · 664 followers View post →
MerCel Capital
@darylmox · X

RT @ZahcM: I've been looking into this paper. Very good material for my upcoming blog posts

Jul 15, 2022 · 6 shares · 1,083 followers View post →
Tony Scott
@DIY_Tardis · X

RT @ZahcM: I've been looking into this paper. Very good material for my upcoming blog posts

Jul 15, 2022 · 6 shares · 1,628 followers View post →
DiscoStew
@DiscoStew66 · X

RT @ZahcM: I've been looking into this paper. Very good material for my upcoming blog posts

Jul 15, 2022 · 6 shares · 10,670 followers View post →
ZahcM
@ZahcM · X

I've been looking into this paper. Very good material for my upcoming blog posts

Jul 15, 2022 · 12 likes · 6 shares · 1,908 followers View post →
Foolproof Mastery
@FoolproofMaster · X

Optimal low-density lipoprotein is 50 to 70 mg/dl (based on some hunter-gatherers) https://t.co/EFNNRPU99e

Jul 1, 2022 · 1,172 followers View post →
Harmless Frog
@FrogHarmless · X

@ifixhearts Kind of depends on definitions. I've seen speculation that true normal LDL for humans is considerably lower than what is considered "normal" (ie. not high) for contemporaries. https://t.co/NQZvjvidjJ https://t.co/TAem4IzhvN

Jun 13, 2022 · 504 followers View post →
Simon Hill MSc, BSc
@theproof · X

@Mespejel29 @Eli23541052 @kevinstock12 Even the father of the Paleo diet Loren Cordain accepts this https://t.co/Ls0Yo30zzJ

Jun 9, 2022 · 1 like · 34,117 followers View post →
kungry
@kungry123 · X

@Mespejel29 @theproof @kevinstock12 https://t.co/ElzxvmyACg.

Jun 9, 2022 · 15 followers View post →
kungry
@kungry123 · X

@Vallone9Anna @DavidDonaldElk1 @CaryKelly11 https://t.co/ElzxvmyACg.

Jun 3, 2022 · 15 followers View post →
lepandas
@lepandas · X

@sendit07109368 @Sundquist_ @esr71 @BernardoKastrup @CarnivoreMD if anything, this study proves my point, which I presented earlier. Let me present it again: https://t.co/nhtd0qgEVB

May 26, 2022 · 19 followers View post →
Princess Bitch
@TheDizzyBeauty · X

@zanesmith331 @SBakerMD Quite the contrary actually… https://t.co/SLi2VfPto0 https://t.co/b0nSaufOeR https://t.co/yDdh4uvA42 https://t.co/LEUJpxnMEq https://t.co/M31sDhBRqy

Apr 24, 2022 · 10,421 followers View post →
anton
@TariroAnton · X

@SanDiegoJoey @vegansince96 @ChampCaI I am taking about LDL. So even thinking that we measure some variables and in the healthy range, we can be wrong. This is so complex (about mechanisms). And no important usually. So, is better to base in studies where compare people i'm their whole https://t.co/BIz1hZB7vF

Apr 1, 2022 · 141 followers View post →
Carlos Colmenero
@colme99 · X

RT @Plant_proof: @ScepticalDoctor @TyRBeal @TheVeganRD @MyNutritionSci @luke_spajic @waiterich @_HannahRitchie @JohnG_UK @drmatthewnagra @M…

Feb 12, 2022 · 1 share · 77 followers View post →
Simon Hill MSc, BSc
@theproof · X

@ScepticalDoctor @TyRBeal @TheVeganRD @MyNutritionSci @luke_spajic @waiterich @_HannahRitchie @JohnG_UK @drmatthewnagra @MattMadore576 @NutritionMadeS3 This is particularly surprising given they reference Loren Cordain's work but conveniently this piece of his out? https://t.co/Ls0Yo2IqlB

Feb 12, 2022 · 12 likes · 1 share · 34,117 followers View post →
Sixten Robé
@RobeSixten · X

@5c59a6b6596c4e6 @Plant_proof https://t.co/jwOJ0BFFwu found it

Feb 5, 2022 · 76 followers View post →
Simon Hill MSc, BSc
@theproof · X

@twitevit You know more than the fathers of #lchf like Loren Cordain. https://t.co/Ls0Yo2IqlB

Jan 29, 2022 · 1 like · 34,117 followers View post →
Pogiwog
@pogiwog · X

@swede_irish @theArdenHart @DishonestApe @spicer_zack @Matt_Dillahunty @StudentDocBen Lower than Normal is better: https://t.co/3MERCA4Gje

Dec 23, 2021 · 58 followers View post →
Simon Hill MSc, BSc
@theproof · X

@simondankel @DiscoStew66 https://t.co/Ls0Yo2IqlB

Dec 9, 2021 · 34,117 followers View post →
LIYAN
@LIYAN93109461 · X

RT @Plant_proof: Loren Cordain (father of the Paleo diet) on Optimal LDL-C levels. https://t.co/Ls0Yo2IqlB

Nov 10, 2021 · 5 shares · 103 followers View post →
Ty Beal
@TyRBeal · X

RT @Plant_proof: Loren Cordain (father of the Paleo diet) on Optimal LDL-C levels. https://t.co/Ls0Yo2IqlB

Nov 9, 2021 · 5 shares · 12,344 followers View post →
Ty Beal
@TyBealPhD · X

RT @Plant_proof: Loren Cordain (father of the Paleo diet) on Optimal LDL-C levels. https://t.co/Ls0Yo2IqlB

Nov 9, 2021 · 5 shares · 12,576 followers View post →
A. River
@coalhoof · X

RT @Plant_proof: Loren Cordain (father of the Paleo diet) on Optimal LDL-C levels. https://t.co/Ls0Yo2IqlB

Nov 8, 2021 · 5 shares · 1,507 followers View post →
Beto
@betholand · X

RT @Plant_proof: Loren Cordain (father of the Paleo diet) on Optimal LDL-C levels. https://t.co/Ls0Yo2IqlB

Nov 8, 2021 · 5 shares · 70 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

RT @Plant_proof: Loren Cordain (father of the Paleo diet) on Optimal LDL-C levels. https://t.co/Ls0Yo2IqlB

Nov 7, 2021 · 5 shares · 32,288 followers View post →
Simon Hill MSc, BSc
@theproof · X

Loren Cordain (father of the Paleo diet) on Optimal LDL-C levels. https://t.co/Ls0Yo2IqlB

Nov 7, 2021 · 28 likes · 5 shares · 34,117 followers View post →
smurfsj
@smurfsj · X

Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal - ScienceDirect https://t.co/SvjmGRPkPw

Nov 1, 2021 · 137 followers View post →
Harmless Frog
@FrogHarmless · X

@nicknorwitz This, perhaps? It's a reasonable (but not ironclad) inference from hunter-gatherer data. https://t.co/fKY1rAgx2e https://t.co/c9gUn2tIBo

Oct 31, 2021 · 5 likes · 504 followers View post →
Simon Hill MSc, BSc
@theproof · X

@MarcBra04865806 @MennoHenselmans https://t.co/Ls0Yo2IqlB

Oct 27, 2021 · 34,117 followers View post →
OlivePUFA
@OlivePufa · X

@MarcBra04865806 @Plant_proof @MennoHenselmans https://t.co/tFdmNlSk01 https://t.co/t7mHii73kL

Oct 27, 2021 · 49 followers View post →
Simon Hill MSc, BSc
@theproof · X

@StefZonnenberg I am not aware of any evidence to suggest LDL at this level isn’t anything but optimal. If there has please share it. https://t.co/Ls0Yo301Kb

Oct 26, 2021 · 2 likes · 34,117 followers View post →
Simon Hill MSc, BSc
@theproof · X

Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal - ScienceDirect From the father of the Paleo Diet - Loren Cordain https://t.co/w5e8BA0Hb0

Sep 25, 2021 · 20 likes · 34,117 followers View post →
Simon Hill MSc, BSc
@theproof · X

Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal - ScienceDirect From the father of the Paleo Diet - Loren Cordain

Sep 25, 2021 · 4 likes · 34,117 followers View post →
elvenclarity
@elvenclarity · X

@yasubro we know erectile dysfunction is linked to cardiovascular health (https://t.co/9IPEnApjwr) and we know dietary cholesterol raises LDL-C (https://t.co/sm7wRSayqq) damaging cardiovascular health and increasing risk of ED developing. dietary veganism would result in the opposite.

Jul 30, 2021 · 3 likes · 163 followers View post →
Jevan
@Jevan · X

@SFZoe014 @VeganRecovering @HariSel45215838 If you can link me to where Cordain’s stance now is that cholesterol doesn’t matter or that we shouldn’t eat saturated fat in moderation I’d like to see it. He published a paper in 2004 arguing LDL < 70 was optimal https://t.co/GYGz97xQwn

Dec 13, 2020 · 302 followers View post →
Andrew Ryan
@OhhiyoGarmen · X

@sh_akers https://t.co/0SEkYDLZBk

Oct 18, 2020 · 27 followers View post →
Romain Gaillac
@GaillacR · X

@Fabiensapiens @JoliesRousses @thierrysouccar Et certaines études d'intervention sont critiquables : comparaison avec saucisse+fromage (lol) https://t.co/muYTNKKM8y Intervention sur sujets avec cholesterol ++ (effet plateau cf. supra) https://t.co/NiB2gXJosu (optimal levels: https://t.co/Rp40xhiapt) A suivre

Sep 2, 2020 · 313 followers View post →
sasha
@rattleclaws · X

@bubblehslol @nmplol you're missing a step there mate. High LDL cholesterol is STRONGLY correlated with heart disease: https://t.co/wUHEwoxjyy https://t.co/YOwEZxG2KG https://t.co/hL6aZKjz3u just because saturated fat diets don't always lead to high cholesterol, high cholesterol often leads to HD

Aug 25, 2020 · 4 likes · 77 followers View post →
Emil
@animusblue · X

@AviBittMD @BioLayne Or this: "Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl." https://t.co/0uaQoqQKaN

Jul 22, 2020 · 207 followers View post →
Emil
@animusblue · X

@celticcolin @BioLayne "Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl." https://t.co/0uaQoqQKaN

Jul 22, 2020 · 207 followers View post →
Natural Law Enforcer
@BChinatti · X

Statin pusher. Conflict of interests. Not really good

Mar 29, 2020 · 1 like · 1,216 followers View post →
Alex Leaf
@AlexJLeaf · X

@MilesHighLife @Drlipid O'Keefe, J. H., Cordain, L., Harris, W. H., Moe, R. M., & Vogel, R. (2004). Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. Journal of the American College of Cardiology, 43(11), 2142-2146. https://t.co/Uysa9rNWag

Sep 2, 2019 · 2 likes · 3,938 followers View post →
Healthy Nutrition Ⓥ
@Saverforlater · X

Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal - ScienceDirect #cardiology #heartdisease https://t.co/wXmZlGU3wh

Aug 10, 2019 · 2,102 followers View post →
Yves Dawtur
@Ydawtr · X

@POhukainen @FatEmperor @DaveKeto Optimal low-density lipoprotein is 50 to 70 mg/dl:Lower is better and physiologically normal James H O'KeefeJr MD*LorenCordain PhD†William HHarrisPhD*Richard MMoeMD, PhD*RobertVogelMD‡ Journal of the American College of Cardiology Volume 43, Issue 11, 2 June 2004, 2142-2146

Aug 4, 2019 · 764 followers View post →
Sergio Kaiser MD, PhD, FACC, FESC
@pabeda1 · X

@SABOURETCardio @khurramn1 @AtulPathak31 @pnatarajanmd @ErinMichos @rblument1 @skathire @dramitkhera @DrMarthaGulati @drpablocorral @HeartOTXHeartMD @RonBlankstein @DrMichaelShapir Among remaining hunter-gatherer subjects, LDL levels stand between 50-70 mg/dl according to the publication below: https://t.co/V75bwqDuZa But rare (and healthy) individuals w/LOF mutations in PCSK9 gene display LDL levels around 15 mg/dl see here

Aug 2, 2019 · 4 likes · 5,436 followers View post →
Larronde Esteban
@EstebanDL · X

7. Y la próxima vez que te muestren este gráfico y te citen este paper del 2004 doi:10.1016/j.jacc.2004.03.046 Recordale que la aterosclerosis es mas compleja que bajar LDL y la realidad tiene otras aristas https://t.co/BDnR6Q5xQW

Jan 9, 2019 · 12 likes · 1 share · 23,721 followers View post →