Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene.

Abstract in brief

• The study investigates how yo-yo dieting and the fat substitute olestra influence the distribution of the toxic chemical hexachlorobenzene (14C-hexachlorobenzene) in different organs, particularly focusing on changes related to weight cycling in mice.
• Weight loss mobilizes stored lipophilic toxins from fat tissues, leading to increased concentrations in organs like the brain, liver, and adipose tissue, and these changes can be reversed or fluctuated with subsequent weight gain and loss.
• The addition of dietary olestra significantly enhances the excretion of the toxin and reduces its accumulation in the brain, suggesting olestra’s potential to mitigate the toxic effects associated with weight cycling and fat-leakage of environmental pollutants.]