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Eur J Neurosci November 2004 PMID 15548201

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition.

Shoshanna Vaynman, Zhe Ying, Fernando Gomez-Pinilla

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Mentions

7
Peak: 4 in Sep 2021
across 2 sources since Mar 2021

Extended reach

28,912
potential audience

Total likes

127

Video views

2,285

Mentions per month

Mar 2021 – Jun 2024

Where it's discussed

  • X / Twitter5 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions commonly reference BDNF and its critical role in exercise-induced cognitive improvements, with statements like 'BDNF mediates learning and memory,' showing recognition of the research's relevance. The tone suggests curiosity and acknowledgment of the importance of the findings, but without strong disagreement or high emotional engagement.

AgreementModerate agreement

Most discussions agree with the research findings, emphasizing BDNF's role in exercise and cognition.

InterestModerate interest

The focus on specific molecular pathways like BDNF and synapsin I shows an interest in the biological mechanisms.

EngagementModerate engagement

Comments highlight understanding of experimental results and implications, indicating moderate engagement.

ImpactModerate impact

Participants recognize the significance of this research for neuroscience and potential applications, reflecting a moderate to high impact perception.

Abstract in brief

  • Exercise enhances cognitive performance and increases BDNF levels in the hippocampus, which is crucial for learning and memory.
  • Blocking BDNF during exercise prevents improvements in cognition and disrupts associated molecular pathways like CREB and synapsin I, highlighting BDNF’s mediating role.
  • Animals that performed better in the water maze had higher levels of BDNF, CREB, and synapsin I, suggesting their importance in the exercise-induced enhancement of hippocampal-dependent learning.
Read the full abstract

Top posts

Most liked on X and Bluesky
タツノコ
@mofmof_biz · X

運動は脳を変える。シナプスが活発化してより多くの記憶ができるようになる。運動することで脳由来神経栄養因子（BDNF）が放出されシナプスが活発化する。 https://t.co/htFtRJXt51

Sep 29, 2021 · 35 likes · 4 shares · 23,749 followers View post →
こみ太郎
@komiyamaGica · X

RT @mofmof_biz: 運動は脳を変える。シナプスが活発化してより多くの記憶ができるようになる。運動することで脳由来神経栄養因子（BDNF）が放出されシナプスが活発化する。 https://t.co/htFtRJXt51

Sep 29, 2021 · 4 shares · 1,517 followers View post →
✨︎︎
@YuYu98644462 · X

RT @mofmof_biz: 運動は脳を変える。シナプスが活発化してより多くの記憶ができるようになる。運動することで脳由来神経栄養因子（BDNF）が放出されシナプスが活発化する。 https://t.co/htFtRJXt51

Sep 30, 2021 · 4 shares · 992 followers View post →
Laura McTernan
@laura_mcternan · X

Paper overview: S. Vaynman et al,. 2004 Blocking BDNF action during exercise in rats reduces memory retention and learning acquisition to that of sedentary rats. Ie. The performance effect of exercise on cognition is lost. #Neurology #BDNF https://t.co/FXqe9URyQE

Jun 11, 2021 · 173 followers View post →

All mentions

The Impact of Exercise on Brain Health

In this video, we explore the significant changes in the brain resulting from regular exercise and the associated cognitive benefits backed by scientific research. Discover how physical activity enhances brain function…

Varun Joshi · Sep 12, 2021 39 views
✨︎︎
@YuYu98644462 · X

RT @mofmof_biz: 運動は脳を変える。シナプスが活発化してより多くの記憶ができるようになる。運動することで脳由来神経栄養因子（BDNF）が放出されシナプスが活発化する。 https://t.co/htFtRJXt51

Sep 30, 2021 · 4 shares · 992 followers View post →
こみ太郎
@komiyamaGica · X

RT @mofmof_biz: 運動は脳を変える。シナプスが活発化してより多くの記憶ができるようになる。運動することで脳由来神経栄養因子（BDNF）が放出されシナプスが活発化する。 https://t.co/htFtRJXt51

Sep 29, 2021 · 4 shares · 1,517 followers View post →
タツノコ
@mofmof_biz · X

運動は脳を変える。シナプスが活発化してより多くの記憶ができるようになる。運動することで脳由来神経栄養因子（BDNF）が放出されシナプスが活発化する。 https://t.co/htFtRJXt51

Sep 29, 2021 · 35 likes · 4 shares · 23,749 followers View post →
Laura McTernan
@laura_mcternan · X

Paper overview: S. Vaynman et al,. 2004 Blocking BDNF action during exercise in rats reduces memory retention and learning acquisition to that of sedentary rats. Ie. The performance effect of exercise on cognition is lost. #Neurology #BDNF https://t.co/FXqe9URyQE

Jun 11, 2021 · 173 followers View post →
Laura McTernan
@laura_mcternan · X

Via BDNF expression & associated pathways exercise improves learning ability & memory. Shown in S.Vaynman et al 2004 where the improved effects of exercise on learning were reversed by blocking hippocampal BDNF receptors #BrainResearch https://t.co/FXqe9URyQE

Mar 11, 2021 · 173 followers View post →