Arterioscler Thromb Vasc Biol June 2005 PMID 15774905

Flow-mediated dilatation is impaired by a high-saturated fat diet but not by a high-carbohydrate diet.

Jennifer B Keogh, Jessica A Grieger, Manny Noakes, Peter M Clifton

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Mentions

29
Peak: 4 in Jul 2019
across 4 sources since Jul 2019

Extended reach

2,506,225
potential audience

Total likes

65,677

Video views

2,372,850

Mentions per month

Jul 2019 – Jun 2025

Where it's discussed

  • X / Twitter20 posts
  • YouTube4 videos
  • Reddit3 posts
  • Facebook2 posts

AI synopsis

What people are saying

Discussions show a nuanced exploration of the article, with users referencing specific findings such as butter's detrimental effect on endothelial function and debating the health impacts of seed oils. The tone varies from supportive to skeptical, with examples like 'butter looks bad even compared to something unhealthy' and critiques of study designs, illustrating both interest and engagement in understanding its significance.

AgreementModerate agreement

Most discussions acknowledge the study's findings that saturated fats impair endothelial health while other fats do not, showing overall support or curiosity about the results.

InterestModerate interest

The discussions reflect moderate interest, with participants examining different types of fats, health implications, and interpretations of related data.

EngagementModerate engagement

Posts demonstrate active engagement through referencing other studies, sharing opinions, and debating methodologies, indicating thoughtful participation.

ImpactModerate impact

The social discussions could influence perspectives on dietary fats, as multiple users analyze and question common beliefs about butter and seed oils, suggesting some potential influence on public understanding.

Abstract in brief

  • Flowmediated dilation (FMD), a measure of endothelial health, is negatively affected by a high saturated fat (SFA) diet but not by high carbohydrate (CARB) or unsaturated fat (MUFA and PUFA) diets.
  • A lowfat high-glycemic load CARB diet does not impair FMD even though it raises triglycerides and lowers HDL cholesterol, unlike the SFA diet.
  • The SFA diet also increased inflammatory markers like Pselectin, indicating potential rise in inflammation, while other fats did not show this effect.

Top posts

Most liked on X and Bluesky
Tom Babington
@Tom_Babington1 · X

Tucker's back with some omega 6 hate The study he links used reused fat from a deep fryer in addition to a high SFA meal. Guess what? deep fried food ain't great, no shit Meanwhile.. https://t.co/W7XSlMlHEH. https://t.co/GeNEUGg2yF https://t.co/HcI62PL0oS @The_Nutrivore https://t.co/ThBO7U6pI6

Jun 26, 2020 · 7 likes · 2 shares · 1,206 followers View post →
Patrick Flynn
@PatFlynnCOS · X

So far as I know, there is no comprehensive study demonstrating their harm; in fact, there seems to be evidence to the contrary wrt heart disease & inflammation. https://t.co/qdKpAk4zt2 https://t.co/UccNmUJHUW

Nov 18, 2024 · 3 likes · 4,178 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@JimmySm58405905 @ChristianTams @MiocanDanijel https://t.co/8p1N7zqwzA 68000 people. 39 year follow up. Seed oils aren’t harmful, the opposite actually.

Jan 19, 2024 · 2 likes · 2,132 followers View post →
Rich Severin PT, DPT, PhD, CCS
@ptreviewer · X

However elevated/excessive low density lipoprotein in the blood (bad cholesterol) directly and independently impairs vascular function and creates increased oxidative stress. https://t.co/mvF38Je7JW https://t.co/wnQrMQiPIX

Mar 28, 2021 · 1 like · 5,882 followers View post →
Patrick Flynn
@PatFlynnCOS · X

In fact, they may actually be beneficial in certain circumstances. For example, swapping saturated fat with polyunsaturated fatty acids (PUFAs) in a 1-to-1 ratio seems to result in either a neutral or positive effect. https://t.co/qdKpAk4zt2

Nov 18, 2024 · 1 like · 4,178 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@SamaHoole iTs JuSt UnSciEnTiFic. Here, I’ll do what you’re clearly too dumb to do. https://t.co/EVVSn8sBw0 https://t.co/8p1N7zqwzA https://t.co/fWYqTdrj6x https://t.co/fhZmtvsQtw https://t.co/UctjoCPqJ7 https://t.co/YFmyb7CqaX

Nov 7, 2023 · 1 like · 1 share · 2,132 followers View post →

All mentions

Ash
@Jeff17503539993 · X

Flow-Mediated Dilatation Is Impaired by a High–Saturated Fat Diet but Not by a High-Carbohydrate Diet https://t.co/FSlYakhBNY

Jun 12, 2025 View post →
YoKyrox
@yokyrox · X

@MasalaFry69 @MarcLobliner https://t.co/XdjsOx6wmN Oopsies… seems like there’s a lot of data here. A tbsp of butter is healthy, but I would not eat a whole stick of butter a day. I’m not suggesting you don’t eat saturated fats.

Dec 25, 2024 · 474 followers View post →
Patrick Flynn
@PatFlynnCOS · X

In fact, they may actually be beneficial in certain circumstances. For example, swapping saturated fat with polyunsaturated fatty acids (PUFAs) in a 1-to-1 ratio seems to result in either a neutral or positive effect. https://t.co/qdKpAk4zt2

Nov 18, 2024 · 1 like · 4,178 followers View post →
Patrick Flynn
@PatFlynnCOS · X

So far as I know, there is no comprehensive study demonstrating their harm; in fact, there seems to be evidence to the contrary wrt heart disease & inflammation. https://t.co/qdKpAk4zt2 https://t.co/UccNmUJHUW

Nov 18, 2024 · 3 likes · 4,178 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@JimmySm58405905 @ChristianTams @MiocanDanijel https://t.co/8p1N7zqwzA 68000 people. 39 year follow up. Seed oils aren’t harmful, the opposite actually.

Jan 19, 2024 · 2 likes · 2,132 followers View post →
PlusUltra44
@PUltra44 · X

@feld0001 @KraZMagazin https://t.co/kJFFT2XzC1

Jan 12, 2024 · 154 followers View post →
PlusUltra44
@PUltra44 · X

@pnzrkpfw_iv @SolBrah @LuggiSchimmel https://t.co/kJFFT2XzC1

Dec 30, 2023 · 154 followers View post →
Benji
@Ben_Kenob1 · X

@SamaHoole There is probably a pathway that shows seed oils cause inflammation. But, overall when inflammation is actually measured it’s either the same or lower when people replaced saturated fat with polyunsaturated fat. https://t.co/j2sFZ3PQlO https://t.co/uoS7p56XFc

Dec 29, 2023 · 148 followers View post →
Donald Kanupp
@NutritionSciGuy · X

RT @FoodFirst_Ty: @SamaHoole iTs JuSt UnSciEnTiFic. Here, I’ll do what you’re clearly too dumb to do. https://t.co/EVVSn8sBw0 https://t.…

Nov 7, 2023 · 1 share · 51 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@SamaHoole iTs JuSt UnSciEnTiFic. Here, I’ll do what you’re clearly too dumb to do. https://t.co/EVVSn8sBw0 https://t.co/8p1N7zqwzA https://t.co/fWYqTdrj6x https://t.co/fhZmtvsQtw https://t.co/UctjoCPqJ7 https://t.co/YFmyb7CqaX

Nov 7, 2023 · 1 like · 1 share · 2,132 followers View post →
Dr Kevin Lee
@kevinlomentamd · X

https://t.co/vU5VudoqbX

Sep 17, 2023 · 49 followers View post →
Jayden Anker
@JaydenAnker1 · X

@TuckerGoodrich Saturated fat still impairs blood flow…. https://t.co/1L2pcQQriq . MUFA and PUFA do not. (Assuming not from toxics vegetable oils).

May 30, 2023 · 35 followers View post →
Rich Severin PT, DPT, PhD, CCS
@ptreviewer · X

However elevated/excessive low density lipoprotein in the blood (bad cholesterol) directly and independently impairs vascular function and creates increased oxidative stress. https://t.co/mvF38Je7JW https://t.co/wnQrMQiPIX

Mar 28, 2021 · 1 like · 5,882 followers View post →
Zaahid
@Nutell5sandwich · X

RT @Tom_Babington1: Tucker's back with some omega 6 hate The study he links used reused fat from a deep fryer in addition to a high SFA me…

Jun 27, 2020 · 2 shares · 47 followers View post →
Tom Babington
@Tom_Babington1 · X

Tucker's back with some omega 6 hate The study he links used reused fat from a deep fryer in addition to a high SFA meal. Guess what? deep fried food ain't great, no shit Meanwhile.. https://t.co/W7XSlMlHEH. https://t.co/GeNEUGg2yF https://t.co/HcI62PL0oS @The_Nutrivore https://t.co/ThBO7U6pI6

Jun 26, 2020 · 7 likes · 2 shares · 1,206 followers View post →
DCD-MK
@DCDMK · X

@ForTkdi @FatEmperor And here is another, high glycemic meal, DOES NOT impair endothelial function, but saturated fat does. https://t.co/Kk2o6GI8Vi It cannot get any worse than this for low carbers, i sometimes feel sorry for you guys.

Mar 20, 2020 · 61 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@zoeharcombe @janvyjidak fair criticism yet animal-based junk still managed to look even worse... I agree the experimental design is complicated tho a cleaner design: https://t.co/8xvB0MDUMz SFA (butter) halved FMD compared to refined carbs

Jul 22, 2019 · 28,121 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@KurtLass1 @DiscoStew66 the other study is more striking. butter was detrimental even compared to a control containing refined carbohydrates. the point is not "eat refined carbs" (no one advises this), it's "butter looks bad even compared to something unhealthy" https://t.co/8xvB0MDUMz

Jul 22, 2019 · 28,121 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@LAnachBERLIN @drjkahn someone else pointed that out so I linked the below I disagree the comparison needs to be zero carb/fat (almost no one eats zero carb or zero fat, and probably no one should), but I linked it anyway saturated fat zero carb halved epithelial function https://t.co/8xvB0MDUMz

Jul 21, 2019 · 28,121 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@DiscoStew66 True. I agree that creates confounds and isn't the best test. Plus it doesn't differentiate btw fats which is critical this 1 is more pertinent: saturated fat (butter) halves FMD (i.e. epithelial function) compared to other fat sources issues? https://t.co/8xvB0MDUMz https://t.co/SdT60Yvcks

Jul 21, 2019 · 28,121 followers View post →