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Annu Rev Neurosci September 2005 PMID 16022602

An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.

Gary Aston-Jones, Jonathan D Cohen

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Mentions

18
Peak: 1 in Sep 2020
across 4 sources since Sep 2020

Extended reach

16,311
potential audience

Total likes

800

Video views

13,886

Mentions per month

Sep 2020 – Nov 2025

Where it's discussed

  • News9 articles
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  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions show a balanced interest in the relationship between LC activity and performance, with mentions of the inverted-U relationship and evidence from studies like Ashton-Jones & Cohen, highlighting their significance in cognitive control theories. The tone varies from supportive to inquisitive, emphasizing curiosity about how arousal levels influence behavior and performance.

AgreementModerate agreement

Many posts reference the LC-NE system's role and show support for its significance, indicating a generally positive agreement with the publication.

InterestModerate interest

Discussions reflect moderate curiosity, with some posts mentioning foundational concepts like the inverted-U relationship and related evidence, suggesting a willingness to explore the topic further.

EngagementModerate engagement

Posts include references to theoretical models and empirical evidence, indicating a moderate level of detailed engagement and critical thinking.

ImpactNeutral impact

While some posts consider the implications of the theory, others remain more descriptive, pointing to a recognition of its importance but not a consensus on immediate impact.

Abstract in brief

  • The locus coeruleus-norepinephrine (LC-NE) system is more complex than just regulating arousal; it plays a specific role in controlling behavior by switching between two activity modes: phasic (focused on task-related decisions to improve performance) and tonic (disengagement and exploration when task utility decreases).
  • Phasic activity driven by decision outcomes helps to facilitate behavior and optimize performance, while tonic activity signals a decline in utility, prompting the individual to explore new options.
  • The LC receives input from brain regions like the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC), which monitor task utility, and in turn, produce LC activity patterns that help optimize behavior over different time scales.]
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Top posts

Most liked on X and Bluesky
Sam Wass
@ProfSamWass · X

First, we look at the evidence for the @GaryAstonJones framework - which describes how both hyper- and hypo-arousal is associated with immediate reductions in both cognitive and affective control https://t.co/WYA7WhNesY 3/7

Sep 1, 2020 · 2,316 followers View post →
Ale
@A23R05 · X

Inverted-U relationship between LC activity and performance on tasks that require focused attention Source: Ashton-Jones & Cohen 2005, https://t.co/hwd49V1wxH 1/n https://t.co/jTuBm6YMu3

Sep 12, 2022 · 110 followers View post →

All mentions

Ale
@A23R05 · X

Inverted-U relationship between LC activity and performance on tasks that require focused attention Source: Ashton-Jones & Cohen 2005, https://t.co/hwd49V1wxH 1/n https://t.co/jTuBm6YMu3

Sep 12, 2022 · 110 followers View post →
Sam Wass
@ProfSamWass · X

First, we look at the evidence for the @GaryAstonJones framework - which describes how both hyper- and hypo-arousal is associated with immediate reductions in both cognitive and affective control https://t.co/WYA7WhNesY 3/7

Sep 1, 2020 · 2,316 followers View post →