Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.

Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sought to understand how mammalian cells detect cytoplasmic nucleic acids, which indicate pathogen infection 1/n https://t.co/U920tTIS8i https://t.co/COCjqm8WeP

JC

Jurassic Carl

@carl_jurassic · X

@RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA gene therapy shots when you’re literally the dood who won a Nobel Prize for that sh1t. https://t.co/wRRVRO84ox+ https://t.co/Nzh5dztOuz https://t.co/vT7EMXLbTg https://t.co/tqdTkc76ng

Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substituir la Uridina por Pseudouridina. Publicaron sus resultados en la revista Immunity en 2005. Y durante años no les hicieron mucho caso. https://t.co/kfLKRMtWqG

Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sought to understand how mammalian cells detect cytoplasmic nucleic acids, which indicate pathogen infection 1/n

The paper that made #COVID vaccine possible: "RNA containing m6A or s2U modifications did not induce detectable levels of IL-8" Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/m7jm3jG25O

HE

hamhead.eth

@HamHead5813 · X

@simply_crushed @DrNeilStone There are other mechanisms of action at play involving the pseudouridine modification, which ablates TLRs responsible for tumor rejection. The Nobel prize must be protected, that's why we're seeing diversions, blaming SV40. https://t.co/7ti2afHhNL

CM

Commander Shinku of the 77th Mutton.

@shinko_hadoken · X

@BillDeWall9500 @Alex_on_A14 @cbeckj @sduncanhealth @Boris4T @BreezerGalway @J91U17 @KinseyKat1 @archie57426 @JimeeLiberty @mercutioad @crabb_vicki @redheadlass1402 @dirk_fasshauer @barryjohnreid21 @Scary7Dr @NeverV82625 @JKelleyK @Kristos416 @AnnLove4All @richykirsh @zee_parody @jilel76 @Mike6150817700 @market_memetics @Veeteejay1 @Charlie81789387 @Pouldeau61 @Yaboot710 @swords_mr @GhostOfChaplin @EyeOfTheMagi @ckellywpg @HossmanOfficial @epigeneticallyj @AbbyMaeKat @lavalmxhr @RobbiePNoCap @mcfunny @VaxPaparazzi @tcjepson @karleastlondon @BurgerLab12 @Cloud7Connected @KilldareDoc3088 @TruthHurts02160 @Mike61508177700 @nobodyknows1017

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DoFactsMatter

@DoFactsMatter · X

@grok @MdBreathe @ChildrensHD @joerogan @jimmy_dore @TuckerCarlson @P_McCulloughMD @KimIversenShow @RenzTom @drdrew @DrSuzanneH7 @DocAhmadMalik @drcole12 @delbigtree @solari_the @RobertKennedyJr @kurtmetzger @miserablelib @DrDMartinWorld @IamBrookJackson @MendenhallFirm @grok after looking at this study would you say that it is accurate to state that "vaccine mRNA degrades within days?" https://t.co/AAwHsO7q34

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Goran

@Goran_Koncar · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

TC

Tom Czerniawski

@BlackTomThePyr8 · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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Lisa

@lisamichelle125 · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

AN

Aussie Nomad

@damonmcclure3 · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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Denis

@Denis73024375 · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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Bonifide

@Envisionist11 · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

K

KopfUp

@KopfUp · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

A

alwaysaskY888

@Y888AB5 · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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SursumCorda

@SursumCorda5555 · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

CB

Charles Bell

@Charles46398951 · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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AkAmber ✌

@akamber · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

JB

John Beaudoin, Sr., The Real CdC, The Last Boomer

@JohnBeaudoinSr · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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DDHReynolds

@DDHReynolds · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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Sunnie

@sunniewithrain · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

TW

Tricia Walker

@TriciaW4lker · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

MB

Marek Bogacki

@documentavi · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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Jeron

@J_Cerveza_Spain · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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Jikkyleaks

@Jikkyleaks · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

TI

Tommy Emmett III

@MeasslainteIRL · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

TS

Tony Scott

@DIY_Tardis · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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Phleming ☕️☕️☕️

@Phleming1 · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

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ChuckC

@ChuckC_0423 · X

RT @carl_jurassic: @RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA g…

JC

Jurassic Carl

@carl_jurassic · X

@RetsefL It takes some serious balls to deny the suppressed immune response (among other effects) to m1Ψ modified mRNA gene therapy shots when you’re literally the dood who won a Nobel Prize for that sh1t. https://t.co/wRRVRO84ox+ https://t.co/Nzh5dztOuz https://t.co/vT7EMXLbTg https://t.co/tqdTkc76ng

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Nate Weymouth

@NateWeymouth · X

@lonnibesancon @barriere_dr Pseudouridine modifications are immunosuppressive. Here’s Kariko paper cited. Seneff paper was a review or opinion. Please also read Pardi & Weissman 2018 before pandemic warned of potential problems Learn biology Lonni. Image guy! CV enclosed. https://t.co/d7D8WLJzbf https://t.co/c9v0NKrzjk

@matthewherper And for those that want links: https://t.co/Db6OKwIH3h and https://t.co/CVbbFQUugH

@No94559907 @ironwill_gg @GregoryPamart @Chamchamat Par exemple, travaux sur des vaccins à ARNm est : Kariko ,Buckstein, Ni & Weissman. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.” Immunity. 23/08/2005 Ça fait 20 ans !

mRNA ワクチンの基礎研究の論文でも矛盾点を指摘する。論文フォーマットの弱点を指摘するモデルが内部にありそう。 Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA - ScienceDirect https://t.co/6uQSXZIgvp

RT @2oHXOWb6kK9pjEf: じゃあRNAワクチンのメカニズムも知らずに反ワク叩きしてる人たちは何なのよ https://t.co/03ohv1WRQb

じゃあRNAワクチンのメカニズムも知らずに反ワク叩きしてる人たちは何なのよ https://t.co/03ohv1WRQb

@Undercover51273 @JanciToxDoc @ShankaraChetty @FluoridePoison @damonmcclure3 @KevinMcCairnPhD @Kevin_McKernan @CharlesRixey @resiapretorius @JohnBeaudoinSr @SuziHoutz @OlooneyJohn @welcometheeagle @aravindmc Marino, Weismann 2005 et al. https://t.co/XwluC2EfZ4

理系で「自身の研究結果は引用しない」（エビデンスとして不適？）説に遭遇ｗ 例えばノーベル賞受賞者でも自分の先行研究論文は普通に引用してるぞ？ｗ 論文読んだことないの？学者騙り？ → Suppression of RNA Recognition by Toll-like Receptors: The Impact of N... https://t.co/ueIWDWNZBT

カリコ博士の論文より 「ヌクレオチド修飾は、RNAが樹状細胞を活性化する可能性を抑制すると結論付けた。」 mRNAにヌクレオチド修飾を施すことで【免疫の働きを抑えて】ヒトの細胞内に入れることが可能になった。https://t.co/oLCMm2k2Q0

@ciola74 @Massi_Fantini84 https://t.co/R7iFSOi9t1 2005

@quay_dr https://t.co/FdmbZpogQx

@BillyRuffian14 @arthur_mp @DD_Geopolitics The same can be said about vaccines. Anti-covid-19 vaccine advocates have been criticized. However, it is self-evident from Dr. Carrico's paper https://t.co/zwZEjQYngL that the technology has immeasurable risks, as it suppresses the activity of the human immune system and

@elonmusk You are super smart. Why haven't you, to date, not seen how dangerous the mRNA shots are? Its as easy as reading the 2023 Nobel Prize in Medicine's seminal study showing that their modified mRNA turned off part of the innate immune system https://t.co/CVbbFQUugH

@DanWhipple_ @MakisMD Also recommend the Nobel Prize winners own study that references what they discovered. I believe this is the correct link: https://t.co/CVbbFQTWr9

@AlexBerenson https://t.co/9Kqc6LBTJX

RT @LJoJn146: @Amothersanthem @Fynnderella1 @jeffblack757 @JohnBeaudoinSr @naomirwolf @JesslovesMJK @HouseLyndseyRN @AaronSiriSG @DrDMartin…

RT @LJoJn146: @Amothersanthem @Fynnderella1 @jeffblack757 @JohnBeaudoinSr @naomirwolf @JesslovesMJK @HouseLyndseyRN @AaronSiriSG @DrDMartin…

@Amothersanthem @Fynnderella1 @jeffblack757 @JohnBeaudoinSr @naomirwolf @JesslovesMJK @HouseLyndseyRN @AaronSiriSG @DrDMartinWorld @jemmm85517813 @ShannonJoyRadio @DrKellyVictory @TrialsiteN At the same time I might point out that I personally believe EVERYONE, both pro and con to this technology, should be required to read Drs Weissman and Kariko's seminal study that began this mess: https://t.co/CVbbFQTWr9 b/c it "ablates" the immune system THEY said.

RT @zenbrainest: @hubermanlab 2. Fund more basic research: the real breakthroughs in actually discovering new treatments/cures all-too-fre…

RT @zenbrainest: @hubermanlab 2. Fund more basic research: the real breakthroughs in actually discovering new treatments/cures all-too-fre…

@hubermanlab 2. Fund more basic research: the real breakthroughs in actually discovering new treatments/cures all-too-frequently arises because of unexpected discoveries: --PROTACS: basic chemical biology https://t.co/TIEOUJyTvy --mRNA vaccines https://t.co/6HKBotlOWv

@kdogni @DrSuzanneH7 2/ I personally belive everyone should also read paper by Drs Drew Weissman & Katalin Kariko on their discovery how to literally "ablate" (look up the meaning of) immune system in order to get mRNA past the immune system's "Toll-Like Receptors" https://t.co/CVbbFQTWr9

@Robischeauxd @wealthnavi_days @ton2x68k @yuya0310 「動物実験に成功していない」というのは何を指すんでしょう。 2005年にはmRNAを構成するヌクレオシド塩基のうち、ウリジンをシュードウリジンに置換した修飾mRNAを用いると炎症反応が抑えられることが発見されています。 Suppression of RNA recognition by Toll-like receptors: the impact of

@Kevin_McKernan Convenience link: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA. 2015 in Immunity, 1764 citations. Open access. https://t.co/0KW4LtdftL ..

2005のカリコさんの論文。m-RNAのウリジンをN1-メチルシュードウリジンに就職することでtoll様受容体の反応を回避してm-RNAを接種できるという物。この技術は本当にすごいと思った。 https://t.co/Nk9RLr9bUg

For anyone new to the fight against the highly dangerous and ineffective Covid19 jabs, I personally recommend reading the original Weissman/Kariko paper. It CLEARLY shows that modification of nucleosides causes ablation of NORMAL immune responses. https://t.co/CVbbFQTWr9

RT @HamHead5813: @Hypothesis @blob1972453 Specifically, TLR 3, 7 & 8. And, evidence.

@DopplerEffect93 @questionmore5 @Debunk_the_Funk @BretWeinstein https://t.co/kIqODhHEJi Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

@ueto333ueto mRNAワクチンの実用化は、修飾ヌクレオシド m5C,　m6A, m5U, s2U又はシュードウリジンを組み込むとToll様受容体の活性が消失し、mRNAが細胞内に入るのを防ぐ自然免疫系の働きを抑えることで可能になったので、別の修飾ヌクレオシド使用の可能性はあるとは思いますが。 https://t.co/9olGKvY0fI

論文第23巻第2号P165-175 2005年8月 Toll様受容体によるRNA認識の抑制：ヌクレオシド修飾の影響とRNAの進化的起源 https://t.co/lSzmGCpFke

RT @minsei_twi: @Hitmonchan_29 こういう状況を予見する論文もあったんですけどね… メディアや、ネットでの悪質な言論統制や、工作アカウントを使って、真実をかき消していましたよね… ワクチンの修飾RNAは、Toll 様受容体（TLR）を刺激せずに、…

RT @minsei_twi: @Hitmonchan_29 こういう状況を予見する論文もあったんですけどね… メディアや、ネットでの悪質な言論統制や、工作アカウントを使って、真実をかき消していましたよね… ワクチンの修飾RNAは、Toll 様受容体（TLR）を刺激せずに、…

@Hitmonchan_29 こういう状況を予見する論文もあったんですけどね… メディアや、ネットでの悪質な言論統制や、工作アカウントを使って、真実をかき消していましたよね… ワクチンの修飾RNAは、Toll 様受容体（TLR）を刺激せずに、樹状細胞の活性化を回避する為に、免疫記憶をしない https://t.co/fTS2CkUadO

@Hypothesis @blob1972453 Specifically, TLR 3, 7 & 8. And, evidence.

@JustJay80 @steviebdotblue @DailyJLee And here. A bit more in depth, with this snippet explaining why "turbo cancer" became a thing after mass "vaccinations". "Ψ modifications block stimulation of TLR7 and TLR8." TLRs are important for tumor rejection. https://t.co/7ti2afHhNL

RT @tovoltando: @odyssey3543 @morimori0722ryo @k_hirahata 左の画像内の、2005年の論文はこちら。mRNAワクチンでのウリジン修飾と免疫抑制の関係が理解できる。 https://t.co/oLCMm2k2Q0

@odyssey3543 @morimori0722ryo @k_hirahata 左の画像内の、2005年の論文はこちら。mRNAワクチンでのウリジン修飾と免疫抑制の関係が理解できる。 https://t.co/oLCMm2k2Q0

@minoru_s2023 そのため、免疫系上流で異物の感知と免疫系での働きを促す警鐘役であるToll様受容体のRNA認識をヌクレオシド修飾（ワクチンmRNAのシュードウリジン）によって抑制できることを発見したのが、mRNAワクチンの実用化を可能にしたと言われるカリコ博士の2005年の論文。https://t.co/oLCMm2k2Q0

独自に抑制することを実証しました」 https://t.co/oLCMm2k2Q0

Die Gründe? Sind nicht völlig klar.

@alfwarrior Según los propios Kariko y W, los nucleótidos modificados implican que las DCs produzcan menos citoquinas al detectar ARN. El ARNmod también se caracteriza por activar menos TLRs que el no modificado. Donde está la ventaja de todo esto? Yo no la veo. https://t.co/9Kqc6LBTJX

@maxihasi1 @AndreasSkoda @PlanetPommes @DrDavidBerger https://t.co/KIJjfC3gFO https://t.co/tHz1fcaBz6 https://t.co/wR0atk7eZZ https://t.co/uFiiWeVjpv https://t.co/KoP3ze6P89 https://t.co/yIJzCUR2GJ

@sjs856 It's too bad you can't refute it. Say, are there studies showing the TLRs remain active after their activity is abolished with a pseudoU modification? https://t.co/7ti2afHhNL

@vsalvatordali @sjs856 Go, read. https://t.co/7ti2afHhNL

RT @HamHead5813: Is SV40 being blamed for the N1-MethylpseudoU modifications effects on TLRs? Are the 2023 Nobel Prize winners being prote…

Is SV40 being blamed for the N1-MethylpseudoU modifications effects on TLRs? Are the 2023 Nobel Prize winners being protected in doing so? Makes me wonder @Kevin_McKernan.

@CurvyAiArt @Hypothesis @Kevin_McKernan Here ya go! https://t.co/7ti2afGJYd

@mcassieP @SpiritualAnark Telling me I’m wrong when you have no clue what you’re talking about is insanity. https://t.co/USkK04gBO9

@HamHead5813 @KStateTurk He was speaking of endosomal TLRs which TLR2 is not. This paper shows no damage to TLRs from pseudouridine. https://t.co/USkK04gBO9

RT @sjs856: The white supremacists are in the thread fightin for they LIFE!!

The white supremacists are in the thread fightin for they LIFE!!

@sjs856 "Finally, we show that RNA-mediated immune stimulation is suppressed proportionally with the number of modified nucleosides present in RNA and that even a few modifications are sufficient to exert a suppressive effect." https://t.co/7ti2afGJYd Let me guess, "white ignorance"?

@sjs856 Evidence suggest otherwise. "White ignorance"? You think white people are ignorant? "but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity." https://t.co/7ti2afGJYd

@ToBornin @psychoticdream1 This is the same type of mRNA that is within you. Why do you think that modification was done? https://t.co/rG8Eqx8ul9

細胞内に入れようとしても炎症が起きて実用化できなかったmRNA遺伝子導入剤を製品化できるようにした技術が、2005年のカタリン・カリコ博士の下記の論文。免疫機能を抑えることが明記されている。 https://t.co/zwZEjQYngL

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA - ScienceDirect https://t.co/c9PClJ7dmX

@Hypothesis And then. . . https://t.co/7ti2afGJYd "pseudouridine ablates activity."

@stephanieseneff @Bonbonhamilton Yup. What are your opinions? I believe TLRs 3, 7 & 8 activity is being ablated but some people here on @X say they remain active after being treated with pseudouridine modified mRNA. https://t.co/7ti2afGJYd

Read the paper that Moderna and Pfizer’s vaccines were based on. There is no experimental protocol to test for TLR7/8 inhibition by first treating the cells with modRNA and then a selective agonist. https://t.co/mBa2ujZzeS

RT @NadiaT214201: @MartinZ_uncut @StevePascolo DCs ne phagocytent pas dans le cas des thérapies contre le covid à cause du méthylpseudourid…

RT @NadiaT214201: @MartinZ_uncut @StevePascolo DCs ne phagocytent pas dans le cas des thérapies contre le covid à cause du méthylpseudourid…

@MartinZ_uncut @StevePascolo DCs ne phagocytent pas dans le cas des thérapies contre le covid à cause du méthylpseudouridine qui supprime leur activat°, source: Prix Nobel⬇️. On ne peut pas comparer l'ARN naturel avec cet ARN chimiquement altéré. https://t.co/M93MX7kQob https://t.co/Esi34uxCU3 https://t.co/EGV5qoOLCa

@Theover01372863 @DHShades No, those modified mRNA "sequences" being injected are not naturally occuring phenomena. https://t.co/7ti2afGJYd "We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity."

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary o… https://t.co/lHoCvYecNO https://t.co/JkhuCoZXRE

@sjs856 @KalmiaLatifolia @johnmaddox @FactsAreGood @Brewbits22 I already did. Here it is again. "but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity." https://t.co/7ti2afGJYd

@sjs856 @KalmiaLatifolia @johnmaddox @FactsAreGood @Brewbits22 https://t.co/7ti2afGJYd Here ya go!

@KalmiaLatifolia @sjs856 @johnmaddox @FactsAreGood @Brewbits22 Sure I do. https://t.co/7ti2afGJYd "We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity." No mention of specificity.

@KalmiaLatifolia @johnmaddox @sjs856 @FactsAreGood @Brewbits22 Here's a scientific publication. Tell me, what does ablate mean? "We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity." https://t.co/7ti2afGJYd

@KalmiaLatifolia @johnmaddox @sjs856 @FactsAreGood @Brewbits22 What about TLRs 3 & 8?

@KalmiaLatifolia @johnmaddox @sjs856 @FactsAreGood @Brewbits22 Again, not specifically. "Dendritic cells (DCs) exposed to such modified RNA express significantly less cytokines and activation markers than those treated with unmodified RNA." https://t.co/7ti2afGJYd

インタビュー中でトポル先生が生物医学界史上最も重要な発見と評価した「ウリジンをシュードウリジンで置換すると炎症反応が抑えられる」論文を2005年に発表した際、カリコ先生はロックフェラー大学と日本で発表したが、反応は薄かったと。 https://t.co/lvEEgyVAx3 /

@Hypothesis @KennyGr61411855 https://t.co/7ti2afGJYd "We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity." https://t.co/pkCw2LOfZ5

@sjs856 You should be more precise and say, "pseudouridine modified mRNA". Simply saying it's just mRNA is actually misinformation. https://t.co/pkCw2LOfZ5 https://t.co/7ti2afGJYd

@zap_lock "We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity." https://t.co/7ti2afGJYd

@zap_lock The pseudouridine modification ablates toll-like receptors 3, 7 & 8. You're blatantly lying. That's called, misinformation, and it's dangerous. @CommunityNotes https://t.co/pkCw2LOfZ5 https://t.co/7ti2afGJYd

@TuckerCarlson @joerogan @RWMaloneMD @FLSurgeonGen @JoeRogan and @RWMaloneMD and @FLSurgeonGen During my research in Immunochemistry, I stumbled upon a paper titled 'Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification & the Evolutionary Origin of RNA' by Drs Kariko. This paper sparked my

@DrSiYoung @LummHandy Well, according to this paper, they are being ablated by the pseudouridine modification. https://t.co/7ti2afGJYd What are TLR 3, 7 & 8 responsible for? Anything to do with cancers, like, AT ALL? In all your life, have you heard the term "turbo cancer"? I've not prior 2021.

@DrSiYoung @LummHandy Here's some more info. https://t.co/7ti2afGJYd

@LummHandy Too bad we don't hear much from them. So much for that uni then, eh Andy? Here, I have faith that you can read. Dig in! https://t.co/7ti2afGJYd

@useheadnheart @IzZatRight @kickybarr @Debunk_the_Funk @thevivafrei

@FredLamboray @strud78 @CNRS Une autre étude de Katalin Kariko et Drew Weissman: Suppression de la reconnaissance de l'ARN par les récepteurs Toll-like : impact de la modification des nucléosides et origine évolutive de l'ARN https://t.co/HmPnD2C2Ic

@DornEatsIt @IanCopeland5 @Earthdriver @rohangilkes It's the word used in this paper. What other word would you like to use? https://t.co/7ti2afGJYd

@DornEatsIt @IanCopeland5 @Earthdriver @rohangilkes Again. "We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or

@DornEatsIt @IanCopeland5 @Earthdriver @rohangilkes "We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity." https://t.co/7ti2afGJYd

@IanCopeland5 @Earthdriver @rohangilkes No need. Toss this one up in your nest and discuss the importance of toll like receptors. "We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity." https://t.co/7ti2afGJYd

@Hypothesis Yeah I would hope so, but my dr. friend recommended I go read Kuby. I did, learn't all about the TLRs. Then there is this, you wouldn't inject pseudouridine unless you had cancer already, or I wouldn't not for a ILI https://t.co/TlqVFCfWh0

@cactusnan12 @hartgroup_org They hadn't tested the mRNA element on humans. Use of Pseudouridine to turn off your killer T cells? The thing that prevents cancer? Take Lemsip to get over the Flu or Covid, it's better than cancer! https://t.co/TlqVFCfors

@zap_lock "We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity." https://t.co/7ti2afGJYd Toll-Like Receptors (TLR) are pretty important. Pseudouridine "ablates activity".

@Tahmin10 @tipsiztibbiyeli @drkaracenk Dönüm noktası 2 2005 yılında bu direncin önüne pseudouridine ile geçilebileceğini keşfettiler. Bu teknoloji bugünkü mRNA aşılarında kullanılıyor. https://t.co/D4zBe1H9V9

@2BJDJ I'm left handed but right brained, is this why I don't get how it's okay to inject this stuff into unsuspecting humans? https://t.co/TlqVFCfors

@CumberpatchM Facts matter - https://t.co/TlqVFCfors

@Debunk_the_Funk @BretWeinstein @michaelshermer They go everywhere, that's correct. https://t.co/qFvFwGfoBx And the pseudouridine modifications ablate TLR activity, so there's that. https://t.co/7ti2afGJYd

RT @LargeGoldBrick: @SharpieDj @DocAhmadMalik I came across this yesterday whilst finding my daughter credible evidence that the vaccine wa…

@SharpieDj @DocAhmadMalik I came across this yesterday whilst finding my daughter credible evidence that the vaccine was toxic by design. 2005 it was known pseudouridine reduces the immune system's ability to keep cancer at bay - https://t.co/TlqVFCfors

@yerbooti65358 @SGriffin_Lab Don't worry about those 2005 publications though, they're "outdated".

@bluepatriot1975 Who knows. Here's some reading materials. Enjoy! "We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity." https://t.co/7ti2afGJYd

RT @keisuke4713: Ψ修飾RNAはTLR7/8を活性化せず、 m6A・s2U有するRNAはTLR3を活性化しないと判明 Toll様受容体によるRNA認識⬇️ Nucleoside修飾影響とRNA進化的起源https://t.co/6mbgQrEFsn

Ψ修飾RNAはTLR7/8を活性化せず、 m6A・s2U有するRNAはTLR3を活性化しないと判明 Toll様受容体によるRNA認識⬇️ Nucleoside修飾影響とRNA進化的起源https://t.co/6mbgQrEFsn

RT @keisuke4713: このtransfectiされた修飾mRNAと相互作用するTLR感受性⬇️→TLR3、TLR7、TLR8活性除去、cytokine⬇️ :仮説 Karikoら2005論文 Toll様受容体によるRNA認識⬇️ nucleoside修飾の影響とRN…

RT @keisuke4713: このtransfectiされた修飾mRNAと相互作用するTLR感受性⬇️→TLR3、TLR7、TLR8活性除去、cytokine⬇️ :仮説 Karikoら2005論文 Toll様受容体によるRNA認識⬇️ nucleoside修飾の影響とRN…

T

ttt

@tu18581858 · X

RT @keisuke4713: このtransfectiされた修飾mRNAと相互作用するTLR感受性⬇️→TLR3、TLR7、TLR8活性除去、cytokine⬇️ :仮説 Karikoら2005論文 Toll様受容体によるRNA認識⬇️ nucleoside修飾の影響とRN…

このtransfectiされた修飾mRNAと相互作用するTLR感受性⬇️→TLR3、TLR7、TLR8活性除去、cytokine⬇️ :仮説 Karikoら2005論文 Toll様受容体によるRNA認識⬇️ nucleoside修飾の影響とRNAの進化的起源 https://t.co/6mbgQrEFsn ＊ステルス

@DopplerEffect93 @Hampson14Jane @AllenDMartin @KarlSinclair10 @Debunk_the_Funk https://t.co/1ARYVJPR6N

RM

R Marcucio

@mcfunny · X

@oldsmokindragon @NikolovScience but here https://t.co/yaQYjSSKzt

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA: Immunity https://t.co/PLhpCFI7vE

The 2023 Nobel Prize in Physiology or Medicine was jointly awarded to Drs. Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications. Read the primary literature from thier seminole findings published in 2005: https://t.co/2fIo4IMaUz https://t.co/4rhRcbA5G4

I discussed the seminal paper that was the defining step towards potential applications of mRNA as drugs/vaccines. https://t.co/IlEhPJyEC7 They got intrigued by the observation that there were big differences in how cells reacted to RNA from different sources 2/.. https://t.co/koIBMs9OUK

@georgeWaw Komitet Noblowski powoływał się chyba na 3 prace Karikó, K., Buckstein, M., Ni, H. i Weissman, D. Suppression of RNA Recognition by Toll-like Receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165-175 (2005). Karikó, K., Muramatsu,

@BarryESharp @DrSusanOliver1 https://t.co/TlqVFCfors

"El RNA, la molécula que contiene la información para producir las proteínas, induce fuerte respuesta inmune indeseada. En el 2005, Karikó y Weissman publicaron un artículo en el que incorporando nucleósidos modificados en el RNA, eliminaron la respuesta + https://t.co/SbajwO3oow

Kaiko-2005 Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA: Immunity https://t.co/bXtt9eO82j

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @zhanxw: I skimmed Kariko's 2005 Immunity paper. 1) I like the figures (e.g., the way they group x-axis labels); 2) No raw data provided…

I skimmed Kariko's 2005 Immunity paper. 1) I like the figures (e.g., the way they group x-axis labels); 2) No raw data provided; 3) "data not shown" appeared 8 times. (link:https://t.co/I4GlT22Tw6) https://t.co/d4Ddiz9vHU

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

受賞の決め手となったkey publicationsが面白い https://t.co/AQFMzlApE1 https://t.co/P4NahnC58e https://t.co/qDGAHk1uqZ

2005 publication by the Nobel Laurates hereunder https://t.co/6ueP7j4eVm

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @virusfantom:

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

@probaproba18 @DezsyKlara @ToroczkaiLaszlo Katalin Karikó; Michael Buckstein; Houping Ni; Drew Weissman (August 2005). "Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA". Immunity. 23 (2): 165–75.

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

5/

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @zaynMalikKizak: Czy eksperymentowała z modyfikowanymi sekwencjami mRNA typu HIV na ludziach, w tym być może na sobie i została usunięta…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @itzmedevi: இந்த கண்டுபிடிப்பே COVID19 mRNA தடுப்பூசியிலும் பயன்படுத்தப்பட்டு effective ஆக பல மக்களை காப்பாற்றியுள்ளது. 2005ல் காட்டலி…

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

Kariko先生の研究これでしょうか。2005年。フリーアクセスで全文読めます。……えー、私は若干専門外なので正しく理解できてるか自信ありません。 https://t.co/wi9ayxGi2I

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

RT @Mounotella: La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné a…

La Science est profondément malade : quand des récompense sont décernées à la fraude, c'est que la Science a été condamné aux oubliettes. Cet article de #Kariko est collector : il aurait du être rétracté et ces vaccins n'auraient pas du voir le jour. https://t.co/wh5bw4ICCz https://t.co/5lqtXzONoj

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

“The article” https://t.co/HDLUtEEjrt

இந்த கண்டுபிடிப்பே COVID19 mRNA தடுப்பூசியிலும் பயன்படுத்தப்பட்டு effective ஆக பல மக்களை காப்பாற்றியுள்ளது. 2005ல் காட்டலின் மற்றும் வெய்ஸ்மேனின் ஆய்வறிக்கை

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @Lo_Zanzi: @jkagan1 From the paper in the (niche

@NormalBirthBRAZ @mellziland O paper chave nessa história é de 2005!!!! https://t.co/2Zuqaq4LuR

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

https://t.co/ZRXKfchVRA

RT @EARL_med_tw:

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @EARL_med_tw:

RT @pvilloslada1: The article describing how to modify RNA nucleosides, leading to RNA therapies, today won the Nobel prize. Congrats! http…

RT @EARL_med_tw:

RT @criordor: El paper clave para el avance de vacunas de ARNm https://t.co/CLnBCTMwu4

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

RT @Lo_Zanzi: @jkagan1 From the paper in the (niche

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA: Immunity https://t.co/dPJtusmvlM

RT @EARL_med_tw:

@jschoggins Not quite publication Immune https://t.co/f2IryEs3Mg

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sought to understand how mammalian cells detect cytoplasmic nucleic acids, which indicate pathogen infection 1/n

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

@kkariko @WeissmanLab Their 2005 paper about RNA modifications was a major leap in understanding how RNA is sensed by the immune system and enabled the development of mRNA vaccines: https://t.co/CkaUopeCsA

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @criordor: El paper clave para el avance de vacunas de ARNm https://t.co/CLnBCTMwu4

RT @criordor: El paper clave para el avance de vacunas de ARNm https://t.co/CLnBCTMwu4

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/Rby3AXtfFK #NobelPrize2023

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

RT @peiferlabunc: Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sough…

@IlSanta64 @giusbrindisi "A questi due fortunelli invece viene dato il Nobel in quattro e quattrotto"

Another remarkable example of basic science leading to critical clinical breakthroughs. These scientists initially sought to understand how mammalian cells detect cytoplasmic nucleic acids, which indicate pathogen infection 1/n https://t.co/U920tTIS8i https://t.co/COCjqm8WeP

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/esaoF5p86E

Soppressione del riconoscimento dell'RNA da parte dei recettori toll-like: l'impatto della modificazione nucleosidica e l'origine evolutiva dell'RNA https://t.co/9kcSS4kuO7

The 2005 paper in "Immunity" mentioned, & linked to, in the "Nature" article above: “Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA” via "Nature Briefing" 2/2 https://t.co/QDfeQD7FoZ

@jkagan1 From the paper in the (niche

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA: Immunity https://t.co/tKWJy6Rnib

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

Many here believe & propagate the false narrative that pseudouridine modification of mRNA enhances immune responses, here is a tweet to straighten your facts

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @Innov_Medicine: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origi…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA #NobelPrize @kkariko https://t.co/jPAsZYBXWn https://t.co/SJgmAXMPOD

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

Key research publication: Karikó, K., Buckstein, M., Ni, H. and Weissman, D. Suppression of RNA Recognition by Toll-like Receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165–175 (2005). #NobelPrize #Science #medicine

Fue entonces que Karikó y Weissman reportaron en 2005 que si se modificaba un poquito ese ARN podía ser mucho mejor tolerado por las células y disminuir su inmunogenicidad, facilitando su uso https://t.co/gxjruvYQ3u https://t.co/hjlfIncTaL

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

mRNAベースのワクチンは、これまで遭遇したことのない特定の感染症を攻撃する高レベルの抗体を含む、強固な免疫反応を引き起こした。他のワクチンとは異なり、生ウイルスや弱毒ウイルスを注射する必要はない。 Suppression of RNA Recognition by Toll-like Receptors: https://t.co/Lm36cNKBIa

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA: Immunity https://t.co/T2XziRV1VJ

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @nori83474632: 今年のノーベル賞のもとになった論文です。 Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and th…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @HironoriFunabi1: 人工的に作ったmRNAに化学修飾を施しておくと、mRNAを細胞内に導入しても自然免疫システムを発動しないことが分かった。この発見は2005年に発表されたが、当初それほど注目されていなかった。14/ https://t.co/dXWFG1…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

From Dr Kariko (2005): Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/EoqB0GP3Iu

今年のノーベル賞のもとになった論文です。 Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/N4WzkMsOEI

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

@NOS Geweldig nieuws. Lees hun oorspronkelijke doorbraakartikel op @sciencedirect van @ElsevierConnect https://t.co/gnk5Hs5RzD

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

Jelikož imunita reaguje na cizorodé nukleové kyseliny nepříliš vlídně (ono se není čemu divit — jak se do vás dostane cizí nukleová kyselina??), bylo fajn zjistit, jak imunitní systém trochu obejít. A následně znalosti ze základního výzkumu využít. https://t.co/oCVnNrOaVR

RT @LluisMontoliu: Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substit…

RT @Masaki_ponpoko: みんなも一緒に関連論文読もう〜〜！！！ 1. https://t.co/897gGMK3NB 2. https://t.co/k4U6uWksG2 3. https://t.co/4vHwdirlCB プレスリリース https://…

Kariko y Weissman descubrieron en 2005 que para estabilizar el ARN e impedir la respuesta inflamatoria había que substituir la Uridina por Pseudouridina. Publicaron sus resultados en la revista Immunity en 2005. Y durante años no les hicieron mucho caso. https://t.co/kfLKRMtWqG

RT @Masaki_ponpoko: みんなも一緒に関連論文読もう〜〜！！！ 1. https://t.co/897gGMK3NB 2. https://t.co/k4U6uWksG2 3. https://t.co/4vHwdirlCB プレスリリース https://…

みんなも一緒に関連論文読もう〜〜！！！ 1. https://t.co/897gGMK3NB 2. https://t.co/k4U6uWksG2 3. https://t.co/4vHwdirlCB プレスリリース https://t.co/Z56L4uOy3y

Katalin Karikó 先生（ハンガリー）、Drew Weissman先生（アメリカ）のご受賞対象研究の主な業績論文は2005年~2010年の頃、パンデミックで大きな話題になるより10年前のご研究です。 Immunity 23, 165–175 (2005). https://t.co/IN0zRd3g0P Mol Ther 16, 1833–1840 (2008). https://t.co/1fe906jzhA

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary o… https://t.co/zbmBLDbYvO

@Debunk_the_Funk https://t.co/UW6BPcYksT

@Gregh1977H @MakisMD TLR immune surveillance suppression (K&W themselves) https://t.co/q1wKD7wfZ6 S2/p53 https://t.co/ezADc1wUEE Antigens https://t.co/qJ8dz1GpAK Sh!tloads of spike- 30 day mRNA https://t.co/Kydgbk0QHR Wasted several years of my life at the place that is responsible for them,

RT @robinmonotti: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

RT @CartlandDavid: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

RT @CartlandDavid: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

RT @CartlandDavid: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

RT @CartlandDavid: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

RT @CartlandDavid: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA: Immunity https://t.co/dDGnoesW9b

RT @robinmonotti: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

RT @robinmonotti: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

RT @robinmonotti: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

RT @robinmonotti: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

RT @robinmonotti: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin…

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA "DNA and RNA stimulate the mammalian innate immune system through activation of Toll-like receptors (TLRs). DNA containing methylated CpG motifs, https://t.co/sk6yEtO3Xs

@YvanDutil @JohnBeaudoinSr Toll-like receptors had to be suppressed to get the mRNA into your cells but unintended consequences... https://t.co/1IxWxzD3QD

@matandrory https://t.co/TVPGd0Gi6d https://t.co/QRL47tNEgl https://t.co/Bs8jMMJ44U

RT @dr_cottrell: BOOM. Malone is small fry. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification a…

RT @dr_cottrell: BOOM. Malone is small fry. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification a…

RT @dr_cottrell: BOOM. Malone is small fry. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification a…

RT @dr_cottrell: BOOM. Malone is small fry. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification a…

RT @dr_cottrell: BOOM. Malone is small fry. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification a…

BOOM. Malone is small fry. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/0OgeBZl1rD

@Woodynist Kariko, Kauffman et Bera évoquent tous les trois l'impact de l'ARNm synthétique vs naturel, je ne sais pas si ça peut t'aider https://t.co/Ql2dHVOgWf https://t.co/nM7ZEbcjTv https://t.co/1i1xVicR4B

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/edt6QbTzq5

「この医師は言う」独自理論は何ら裏付けがない空想でしかない。 「米ペンシルベニア大学やオランダのラドバウド大学の論文」とやらも、試験管内の研究にすぎず、ここから結論を引き出すことは不可能。 https://t.co/vAAjIrWmp4

@ClarqueAllen @prog_r0k @davidmbrentwood @BadFCCTakes @KelemenCari REFERENCES 1 – Karikó et al. (2005) Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA. Immunity. 2 – Medzhitov R. (2001) Toll-like receptors and innate immunity. Nature Reviews Immunology. HAhahahahahh

2005年のImmunity に出た最初のmRNAの論文が出て、15年くらいで社会的に需要の大きい実用化を果たしたと言う点では、iPSとかと同じ流れだけど… https://t.co/AQFMzlApE1

【自分用備忘録】Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA - Immunity 1567回引用　Kariko K et al. 2005. https://t.co/d2zjXeKV8t

Sources: https://t.co/nefCDpfCrS https://t.co/zjUrGclOze Their 2005 paper in Immunity is https://t.co/q4DHWt7zVg

RT @FUMISPKt: 多量のｍRNAがエンドソームでPRRに認識されたら大変なことが起こるので一部改変した。これぐらいからdoi: 10.1016/j.immuni.2005.06.008.すこし勉強すれば？

RT @FUMISPKt: 多量のｍRNAがエンドソームでPRRに認識されたら大変なことが起こるので一部改変した。これぐらいからdoi: 10.1016/j.immuni.2005.06.008.すこし勉強すれば？

@GeraldGrosz honni soit qui mal y pense: Immunity, Vol. 23, 165–175, August, 2005, https://t.co/7zFyIMWT8u Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA Katalin Karikó https://t.co/eiHNChGAQA

@HartmutButepage @OBarschel @Sternen__Himmel Bildung hilft gegen Ängste https://t.co/YCdvnMCpdX

多量のｍRNAがエンドソームでPRRに認識されたら大変なことが起こるので一部改変した。これぐらいからdoi: 10.1016/j.immuni.2005.06.008.すこし勉強すれば？ https://t.co/ubj5HabNgY

RT @daisukehiratsu1: 2005年Kariko論文は、RNAウリジンのシュールド化で自然免疫感知機能TLR3、TLR7を非活性化する事を発見。しかし、それは免疫全般を抑制 Karikó K, et al. Suppression of RNA recognit…

2005年Kariko論文は、RNAウリジンのシュールド化で自然免疫感知機能TLR3、TLR7を非活性化する事を発見。しかし、それは免疫全般を抑制 Karikó K, et al. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA Immunity

Ausführliche Zusammenfassung zur mRNA-Technologie; interessant dabei die besondere Rolle von mRNA und Lipiden bei der Abgrenzung erster lebender Systeme von ihrer Umwelt vor ca. 3,5 Milliarden Jahren (LUCA: last universal common ancestor). https://t.co/0DE3IU9Ir5

mRNA – Chancen & Risiken. Umfassend analysiert | Gert Scobel https://t.co/HQIgScsCza via @YouTube

mRNA – Chancen & Risiken. Umfassend analysiert | Gert Scobel https://t.co/hPUm9m4alG

Der Bundestag debattierte über die #Impfpflicht, die Inzidenzen steigen weiter. Welche Chancen und Risiken bietet die mRNA-Technologie? Gert #Scobel ist nicht nur Philosoph, sondern auch Wissenschaftsjournalist und schaut mal genauer hin. https://t.co/8lYNrWhuvk

⁦@FallTove⁩ Kommande Nobelpristagare? Kom ihåg från vem ni hörde det först ;)) Banbrytande grundforskning!

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary o… https://t.co/7pvUB2te7o

@ColachoRamirez2 @mantecaltacho @FVT2012 @NestorF77103829 @GFebles @d__calero @oscarsito1956 @SciutoDr @Antonio68729224 @DrDanielSalinas Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/PCJ1WIZPfD

RT @zaynMalikKizak: #Kariko: „Wnioskujemy, że modyfikacje nukleozydów tłumią potencjał mRNA do aktywacji DC. Wrodzony układ odpornościowy…

RT @zaynMalikKizak: Czy eksperymentowała z modyfikowanymi sekwencjami mRNA typu HIV na ludziach, w tym być może na sobie i została usunięta…

#Kariko: „Wnioskujemy, że modyfikacje nukleozydów tłumią potencjał mRNA do aktywacji DC. Wrodzony układ odpornościowy może zatem wykryć mRNA pozbawione modyfikacji nukleozydowej jako środek selektywnej odpowiedzi na bakterie lub tkankę martwiczą.” #zaJob https://t.co/MxP2jSDc1E

RT @zaynMalikKizak: Czy eksperymentowała z modyfikowanymi sekwencjami mRNA typu HIV na ludziach, w tym być może na sobie i została usunięta…

Czy eksperymentowała z modyfikowanymi sekwencjami mRNA typu HIV na ludziach, w tym być może na sobie i została usunięta za to w konsekwencji z kadry naukowej i zawodowej Uniwersytetu Pensylwanii? https://t.co/MxP2jSDc1E

発表論文：Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA URL:https://t.co/esT6CXeTK8

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary o… https://t.co/K5u7kZdVrY

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/FEQeRfVAD0

RT @virusfantom:

RT @virusfantom:

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA DNA and RNA stimulate the mammalian innate immune system through activation of TLRs.DNA containing methylated CpG motifs is not https://t.co/ApRO5qInPu

It wasn't until Katalin Karikó and Drew Weissman's nucleoside modification could mRNA therapies be non-immunogenic: "Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA". Immunity. 2005 #WomenInSTEM

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary o… https://t.co/il949bT5fm

“革新的”研究成果がコロナワクチン開発に 女性科学者の思い 【NHK】 https://t.co/Q9Vc0v1SBC https://t.co/COKqx2JZOd https://t.co/23v5onaixy

RT @cellcaller3: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin o…

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary o… https://t.co/WZwVTfyCwJ

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modificat… https://t.co/F8ZOFa2YXa via @digiphile

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Une partie de l’histoire des vaccins à ARN messager est racontée en détails dans ce portrait de @kkariko, qui signale notamment un article fondateur publié en 2005 https://t.co/YMrHPhAt8n https://t.co/dlQ06HKfAp

https://t.co/WlbjmlVgez

RT @daforerog: Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of…

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/S9wgkJ2Mwg

RT @2u3v4w: @ojs6_tift @6CLW77Y102 mRNAワクチンはTLRによる認識を抑制するように作られているんですね。 自然免疫を回避する技術、すごいというか怖いというか。 抑制回避をうまく使えば良薬、悪用すれば劇薬？ Suppression of…

The seminal work of Katalin Karikò, see: Karikó K., Buckstein M., Ni H., Weissman D. Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity. 2005;23:165–175. doi: 10.1016/j.immuni.2005.06.008

Suppression of RNA Recognition by Toll-like Receptors: The Impact of N... https://t.co/vQTFr1JjtM

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA - ScienceDirect https://t.co/KJalUWpC5K

3. Pero en 2005, Katalin Karikó y Drew Weissman mostraron que al reemplazar las uridinas por pseudouridinas (Ψ) podían disminuir la activación del sistema inmune innato y aumentar la traducción y estabilidad del mRNA. https://t.co/tHhycm8VYc

Suppression of RNA Recognition by Toll-like Receptors: The Impact of N... https://t.co/AHwinqcvZl

RT @apmweber: The paper that made #COVID vaccine possible: "RNA containing m6A or s2U modifications did not induce detectable levels of IL-…

Nice piece on history behind mRNA vaccines. Food for thought on funding models - elevating research answering current questions at the expense of work needed to tackle the most important questions of the future. The key 'unappreciated' paper was https://t.co/aBM6r7tBI0 https://t.co/ICGY8pMdhe

U vs Ψ https://t.co/RBrK8TE08p https://t.co/MOFmPAd0m4 https://t.co/yNStHRwkUj https://t.co/eoFe6UzCgE

RT @apmweber: The paper that made #COVID vaccine possible: "RNA containing m6A or s2U modifications did not induce detectable levels of IL-…

RT @apmweber: The paper that made #COVID vaccine possible: "RNA containing m6A or s2U modifications did not induce detectable levels of IL-…

@eliasblanco @latercera Estimado contertulio! En resumen, las pseudouridinas disminuyen la activación del sistema inmune innato y de PKR. Aumentan la traducción del mRNA (y también podrían aumentar la estabilidad). Este es el paper clave de Katalin Karikó https://t.co/tHhycm8VYc

The paper that made #COVID vaccine possible: "RNA containing m6A or s2U modifications did not induce detectable levels of IL-8" Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/m7jm3jG25O

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA https://t.co/S9wgkJ2Mwg @kkariko

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA - is this the basis for mRNA vaccines ? https://t.co/xb3vjGWWTW

Kalikoさんが発見した化学修飾ってのはトール様受容体のことなんだ。 // Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA - PubMed https://t.co/g48hmRiI7f

@ojs6_tift @6CLW77Y102 mRNAワクチンはTLRによる認識を抑制するように作られているんですね。 自然免疫を回避する技術、すごいというか怖いというか。 抑制回避をうまく使えば良薬、悪用すれば劇薬？ Suppression of RNA Recognition by Toll-like Receptors: doi 10.1016/j.immuni.2005.06.008 https://t.co/v0sK9lZhaB

RT @florindanpopesq: #MustRead pioneering article: Karikó K, Buckstein M, Ni H, Weissman D. Suppression of RNA recognition by Toll-like rec…

RT @florindanpopesq: #MustRead pioneering article: Karikó K, Buckstein M, Ni H, Weissman D. Suppression of RNA recognition by Toll-like rec…

"Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA" by kariko@mail.med.upenn.edu. Some scientists now believe that this and other work by Katalin Karikó deserves a Nobel Prize. https://t.co/E2CFZ1cZ20

@PeterHotez https://t.co/4p34hS2M1t Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA PMID: 16111635 2005 !

@crackedscience Access the paywalled article from your library: https://t.co/RZTGs9wKmK Promote scholarly access to content by simply adding https://t.co/SXSePSX5De in front of any DOI