Am J Physiol Endocrinol Metab February 2006 PMID 16188909

Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration.

Trent Stellingwerff, Lawrence L Spriet, Matthew J Watt, Nicholas E Kimber, Mark Hargreaves, John A Hawley, Louise M Burke

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Mentions

53
Peak: 13 in Aug 2019
across 4 sources since May 2019

Extended reach

1,786,327
potential audience

Total likes

32,616

Video views

1,319,862

Mentions per month

May 2019 – Jan 2025

Where it's discussed

  • X / Twitter40 posts
  • Facebook6 posts
  • YouTube5 videos
  • News2 articles

AI synopsis

What people are saying

Discussions frequently emphasize the physiological implications of the research, with posts mentioning decreased PDH activity and glycogenolysis after fat adaptation, reflecting a thorough engagement with the mechanisms involved. Words like 'fascinate,' 'must read,' and references to historical figures imply a high level of interest and recognition of the study's importance, which collectively suggest that the findings could influence future research and athletic practices.

AgreementStrong agreement

Most comments agree that fat adaptation affects muscle metabolism, specifically noting decreased PDH activity and glycogenolysis, with some discussing whether this compromise impacts exercise performance.

InterestHigh interest

Discussions reflect high interest, with users referencing specific studies, historical discussions, and inviting further reading, showing curiosity about physiological mechanisms.

EngagementHigh engagement

Many posts delve into detailed physiological interpretations, citing references and historical contexts, demonstrating deep engagement with the research.

ImpactModerate impact

While some recognize the significance of these metabolic shifts for athletic performance and training strategies, others suggest the findings might challenge existing paradigms or be relevant for practical athletic applications, indicating noticeable pote

Abstract in brief

  • The study investigates how five days on a high-fat diet followed by carbohydrate restoration affects fuel use during exercise, finding increased fat oxidation and decreased carbohydrate oxidation after fat adaptation.
  • Muscle enzyme activities related to carbohydrate metabolism, such as PDH, were lower in the fat-adapted state, leading to reduced glycogen breakdown during exercise.
  • These changes suggest that fat adaptation with carbohydrate restoration shifts muscle fuel utilization toward more fat burning and less carbohydrate use during aerobic activities.]

Top posts

Most liked on X and Bluesky
guzmannutrition
@guzmannutrition · X

#Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinated with the physiology & its practical implications. https://t.co/uZnRAbxqjI @TStellingwerff @LouiseMBurke @JohnAHawley @LSpriet #cycling #keto #sportsnutrition https://t.co/eRbW1sNm3T

Aug 13, 2019 · 80 likes · 15 shares · 6,205 followers View post →
Trent Stellingwerff, PhD / CSEP-CEP / FACSM / ChPC
@TStellingwerff · X

Tks @LouiseMBurke for sending & taking this photo ~20 yrs ago at @ACSMNews: discussing the fat adaptation/keto impact on decreasing CHO oxidation paper. I was a young nervous PhD student w/ @JohnAHawley @LouiseMBurke @LSpriet Hargreaves and Watt (& Jack!). https://t.co/lL8PC4NcaO https://t.co/zPfsUtmDwR

Nov 10, 2021 · 79 likes · 6 shares · 23,125 followers View post →
Charles Ashford
@cashford_ · X

Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had been restored. Are we taking away gears 5&6 with chronic low-carb diets? @TStellingwerff @LouiseMBurke #Coaches20 https://t.co/S2sV4BjfDS

Jan 10, 2020 · 34 likes · 10 shares · 2,620 followers View post →
Javier Gonzalez
@Gonzalez_JT · X

@ProfTimNoakes @LoreofRunning1 @DoctorTro @AKoutnik @RafaelPasschier @timpodlogar @mike_williams73 @DrBSteamjets @jp_walhin @campbellmenz @AaronHengist @theplews1 Its possible that ATP is defended so tightly that the capacity for high intensity exercise is limited in a scenario where the resythesis rate is suboptimal. It would be consisted with yours and others data https://t.co/X2YTPfjjql https://t.co/G6KaqBrX7z

Jan 29, 2025 · 5 likes · 10,174 followers View post →
@LoreofRunning
@LoreofRunning1 · X

Did @TStellingwerff discuss https://t.co/2sONGDGVoL in which hi-fat diet altered metabolism without altering exercise performance (p385). Thus correct title:"Decreased PDH activation and glycogenolysis during exercise following fat adaptation DOES NOT IMPAIR EXERCISE PERFORMANCE" https://t.co/cuN4Q3HHqD

Jan 26, 2023 · 3 likes · 7,858 followers View post →
Jamie Whitfield, PhD
@jwhitfie · X

@AthIllustrated @TStellingwerff @LouiseMBurke @ACSMNews @JohnAHawley @LSpriet Should be able to download it for free from @AJPEndoMetab Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration https://t.co/w0zefxeCrZ

Nov 10, 2021 · 3 likes · 1 share · 2,341 followers View post →

All mentions

Exploring the Science Behind the Ketogenic Diet

Keto was all the rage until it wasn't. Join Michael Aranda as he discusses the science behind the ketogenic diet, its origins as a treatment for epilepsy, and the current research surrounding its effects.

SciShow · May 1, 2019 866,393 views
Javier Gonzalez
@Gonzalez_JT · X

@ProfTimNoakes @LoreofRunning1 @DoctorTro @AKoutnik @RafaelPasschier @timpodlogar @mike_williams73 @DrBSteamjets @jp_walhin @campbellmenz @AaronHengist @theplews1 Its possible that ATP is defended so tightly that the capacity for high intensity exercise is limited in a scenario where the resythesis rate is suboptimal. It would be consisted with yours and others data https://t.co/X2YTPfjjql https://t.co/G6KaqBrX7z

Jan 29, 2025 · 5 likes · 10,174 followers View post →
@LoreofRunning
@LoreofRunning1 · X

Did @TStellingwerff discuss https://t.co/2sONGDGVoL in which hi-fat diet altered metabolism without altering exercise performance (p385). Thus correct title:"Decreased PDH activation and glycogenolysis during exercise following fat adaptation DOES NOT IMPAIR EXERCISE PERFORMANCE" https://t.co/cuN4Q3HHqD

Jan 26, 2023 · 3 likes · 7,858 followers View post →
David Gómez
@Davidgomct · X

La piruvato deshidrogenasa se ve comprometida después del aumento de grasas en la alimentación

Aug 18, 2022 · 5,150 followers View post →
Shaun Ward
@MyNutritionSci · X

@kevtharris @MPattersonRD @AlexJLeaf @JamesyMorton @close_nutrition https://t.co/HgCZpSrl5G

Feb 4, 2022 · 1 like · 2,384 followers View post →
Trent Stellingwerff, PhD / CSEP-CEP / FACSM / ChPC
@TStellingwerff · X

RT @jwhitfie: @AthIllustrated @TStellingwerff @LouiseMBurke @ACSMNews @JohnAHawley @LSpriet Should be able to download it for free from @AJ…

Nov 10, 2021 · 1 share · 23,125 followers View post →
Raul
@RaulM06 · X

RT @TStellingwerff: Tks @LouiseMBurke for sending & taking this photo ~20 yrs ago at @ACSMNews: discussing the fat adaptation/keto impact o…

Nov 10, 2021 · 6 shares · 855 followers View post →
Jamie Whitfield, PhD
@jwhitfie · X

@AthIllustrated @TStellingwerff @LouiseMBurke @ACSMNews @JohnAHawley @LSpriet Should be able to download it for free from @AJPEndoMetab Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration https://t.co/w0zefxeCrZ

Nov 10, 2021 · 3 likes · 1 share · 2,341 followers View post →
Louise Burke
@LouiseMBurke · X

RT @TStellingwerff: Tks @LouiseMBurke for sending & taking this photo ~20 yrs ago at @ACSMNews: discussing the fat adaptation/keto impact o…

Nov 10, 2021 · 6 shares · 16,055 followers View post →
Kenni Gentilino Martinelli
@KGMartinelli · X

RT @TStellingwerff: Tks @LouiseMBurke for sending & taking this photo ~20 yrs ago at @ACSMNews: discussing the fat adaptation/keto impact o…

Nov 10, 2021 · 6 shares · 12 followers View post →
Andres Felipe
@Anferupu · X

RT @TStellingwerff: Tks @LouiseMBurke for sending & taking this photo ~20 yrs ago at @ACSMNews: discussing the fat adaptation/keto impact o…

Nov 10, 2021 · 6 shares · 52 followers View post →
Cindy Kugler
@Exspec85 · X

RT @TStellingwerff: Tks @LouiseMBurke for sending & taking this photo ~20 yrs ago at @ACSMNews: discussing the fat adaptation/keto impact o…

Nov 10, 2021 · 6 shares · 230 followers View post →
American College of Sports Medicine
@ACSMNews · X

RT @TStellingwerff: Tks @LouiseMBurke for sending & taking this photo ~20 yrs ago at @ACSMNews: discussing the fat adaptation/keto impact o…

Nov 10, 2021 · 6 shares · 88,794 followers View post →
Trent Stellingwerff, PhD / CSEP-CEP / FACSM / ChPC
@TStellingwerff · X

Tks @LouiseMBurke for sending & taking this photo ~20 yrs ago at @ACSMNews: discussing the fat adaptation/keto impact on decreasing CHO oxidation paper. I was a young nervous PhD student w/ @JohnAHawley @LouiseMBurke @LSpriet Hargreaves and Watt (& Jack!). https://t.co/lL8PC4NcaO https://t.co/zPfsUtmDwR

Nov 10, 2021 · 79 likes · 6 shares · 23,125 followers View post →
guzmannutrition
@guzmannutrition · X

@B_Holmer @vincentninja68 2/2 Check references for more reading if you're keen. https://t.co/DebFySfGye https://t.co/bdwguKCUEx

May 3, 2021 · 1 like · 6,205 followers View post →
Jeppe Foged Vigh-Larsen
@jeppe_foged · X

@jlAreta @HermanPontzer @SamueleMarcora @sweatscience Maybe this work is relevant in this context https://t.co/7qChNn3Mz1 .. I need to read the actual old paper though...

Apr 23, 2021 · 401 followers View post →
Shaun Scott
@upyrbike · X

@ForTkdi @shashiiyengar @ProfTimNoakes @PeterBrukner @LouiseMBurke And this: 2006 Stellingwerff Hawley Burke Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration https://t.co/63tg2ANq0r

Dec 29, 2020 · 2 likes · 1,438 followers View post →
Michael Posthumus
@MikePosthumus · X

RT @cashford_: Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had be…

Jan 13, 2020 · 10 shares · 3,008 followers View post →
Greg Grosicki
@DrGregGrosicki · X

RT @cashford_: Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had be…

Jan 11, 2020 · 10 shares · 819 followers View post →
Alpine Cols
@AlpineCols · X

RT @cashford_: Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had be…

Jan 11, 2020 · 10 shares · 364 followers View post →
Andrew Creer
@AndrewCreer · X

RT @cashford_: Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had be…

Jan 11, 2020 · 10 shares · 209 followers View post →
Greg Grandgeorge
@T2MCoach · X

RT @cashford_: Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had be…

Jan 11, 2020 · 10 shares · 257 followers View post →
SmartNutrition
@SmartNutrition1 · X

RT @cashford_: Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had be…

Jan 10, 2020 · 10 shares · 2,659 followers View post →
Coach Jamie Norton
@jpnorton8 · X

RT @cashford_: Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had be…

Jan 10, 2020 · 10 shares · 157 followers View post →
Dr² Philip Skiba
@DrPhilipSkiba · X

RT @cashford_: Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had be…

Jan 10, 2020 · 10 shares · 7,731 followers View post →
Trent Stellingwerff, PhD / CSEP-CEP / FACSM / ChPC
@TStellingwerff · X

RT @cashford_: Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had be…

Jan 10, 2020 · 10 shares · 23,125 followers View post →
Steve Rafferty
@SteveRaffertySN · X

RT @cashford_: Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had be…

Jan 10, 2020 · 10 shares · 1,097 followers View post →
Charles Ashford
@cashford_ · X

Just five days of a low-carb, high fat diet caused a significant decrease in PDH activity, even after glycogen levels had been restored. Are we taking away gears 5&6 with chronic low-carb diets? @TStellingwerff @LouiseMBurke #Coaches20 https://t.co/S2sV4BjfDS

Jan 10, 2020 · 34 likes · 10 shares · 2,620 followers View post →
guzmannutrition
@guzmannutrition · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 21, 2019 · 15 shares · 6,205 followers View post →
Mario García Martínez-Gómez, BSc.
@Mariogomecete · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 14, 2019 · 15 shares · 155 followers View post →
Jeffery Nutrition
@JefferyNutr · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 14, 2019 · 15 shares · 287 followers View post →
Guillem Vizcaíno
@vizcaphysiology · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 14, 2019 · 15 shares · 192 followers View post →
laili
@laili_lai · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 13, 2019 · 15 shares · 67 followers View post →
Ed Gray
@EdwardAGray · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 13, 2019 · 15 shares · 104 followers View post →
Wendi A. Irlbeck MS, RDN, LD, CISSN
@Wendi_Irlbeck · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 13, 2019 · 15 shares · 53,917 followers View post →
Kieron Lewis
@lewiskd100 · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 13, 2019 · 15 shares · 1,160 followers View post →
DoctorTro
@DoctorTro · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 13, 2019 · 15 shares · 160,593 followers View post →
Abbie Smith-Ryan PhD
@asmithryan · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 13, 2019 · 15 shares · 6,128 followers View post →
Luca T
@QuiteLT · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 13, 2019 · 15 shares · 364 followers View post →
Rentia Denissen
@RentiaDenissen · X

RT @guzmannutrition: #Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinate…

Aug 13, 2019 · 15 shares · 147 followers View post →
guzmannutrition
@guzmannutrition · X

#Study on fat adaptation followed by high carbohydrate intake; a must read if you’re working with #athletes. Fascinated with the physiology & its practical implications. https://t.co/uZnRAbxqjI @TStellingwerff @LouiseMBurke @JohnAHawley @LSpriet #cycling #keto #sportsnutrition https://t.co/eRbW1sNm3T

Aug 13, 2019 · 80 likes · 15 shares · 6,205 followers View post →