Hepatology December 2005 PMID 16317692

Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.

Anne M Larson, Julie Polson, Robert J Fontana, Timothy J Davern, Ezmina Lalani, Linda S Hynan, Joan S Reisch, Frank V Schiødt, George Ostapowicz, A Obaid Shakil, William M Lee

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Mentions

25
Peak: 2 in Dec 2021
across 5 sources since Jun 2014

Extended reach

29,281
potential audience

Total likes

16

Video views

47

Mentions per month

Jun 2014 – Nov 2025

Where it's discussed

  • X / Twitter10 posts
  • Instagram7 posts
  • Facebook3 posts
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

Discussions reflect a shared recognition of the article's importance, with comments citing specific statistics like 65% survival rates and over 51% increasing cases, and some users urging others to look up additional information. The tone indicates balanced support and an interest in the broader implications of the findings.

AgreementModerate agreement

Most discussions acknowledge that acetaminophen overdose is a major cause of acute liver failure, aligning with the article's findings.

InterestModerate interest

Participants show moderate curiosity, evidenced by requests for external sources and citation of studies supporting the publication's conclusions.

EngagementModerate engagement

Comments include references to statistics, research, and calls for further investigation, indicating some depth.

ImpactModerate impact

The conversations highlight the significance of the research, emphasizing its implications for public health and medical practices.

Abstract in brief

  • The study analyzed 662 patients with acute liver failure across 22 US centers over six years, finding that 42% of cases were due to acetaminophen overdose, with the incidence increasing from 28% in 1998 to 51% in 2003.
  • Most acetaminophen-induced liver failures stem from either unintentional overdoses, often involving multiple medications or substance use, or intentional suicide attempts, with similar outcomes in survival rates for both groups.
  • The research highlights that acetaminophen hepatotoxicity surpasses other causes of acute liver failure in the US, emphasizing the need for better education and safer medication practices to prevent high-risk consumption.]

Top posts

Most liked on X and Bluesky
ようかん
@Yokan_Sw · X

アセトアミノフェン誘発性急性肝不全:米国の多施設共同前向き研究の結果 低栄養や肝障害によるグルタチオン枯渇によりアセトアミノフェン活性型代謝物が肝細胞壊死を引き起こす。 https://t.co/ydMsOqA5z7

Jun 18, 2023 · 6 likes · 6,142 followers View post →
tune
@keisuke4713 · X

訴訟山積み https://t.co/C0OYqCCjIz 2005年 重度アセトアミノフェン肝毒性→急性肝不全:既知 https://t.co/Cp0Hk0QL5D https://t.co/kJ0UqeJewx 過剰摂取が何百もの自殺未遂、死亡、肝移植の原因 2006年統計 https://t.co/ozDq2LPRXp 年推定56千緊急治療室訪問 26千入院  年平均過剰摂取死者458人

Dec 22, 2021 · 6 likes · 3 shares · 3,745 followers View post →
Marcin Snoch
@MSnoch · X

@Patrick22House Wąski indeks terapeutyczny to mają TLPD , czy warfaryna. Według badań mediana dawki dla zatruć paracetamolem to 24 g , czyli odpowiednik 48 tabl

May 25, 2022 · 3 likes · 252 followers View post →
MSV So Much For Sobriety
@anti_nihilist · X

@sadalsvvd "Overall, 178 subjects (65%) survived, 74 (27%) died without transplantation, and 23 subjects (8%) underwent liver transplantation; 71% were alive at 3 weeks... acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the US." https://t.co/dHT5GOFMbJ

Oct 6, 2021 · 1 like · 279 followers View post →
Javi Ciborro
@papayaykware · X

https://t.co/WSVcy7we4d

Mar 16, 2023 · 8,014 followers View post →
at sushi
@JOf1MMMIos9r0y0 · X

RT @keisuke4713: 訴訟山積み https://t.co/C0OYqCCjIz 2005年 重度アセトアミノフェン肝毒性→急性肝不全:既知 https://t.co/Cp0Hk0QL5D https://t.co/kJ0UqeJewx 過剰摂取が何百もの自殺未遂…

Mar 13, 2023 · 3 shares · 4,097 followers View post →

All mentions

SmallHead at Second
@straightupnail · X

@SamuraiDoggo @DobermanStrong @BY1959 https://t.co/Bmd0iARGob You can also type into google “what’s the leading cause of liver failure in the US”

Sep 22, 2025 · 90 followers View post →
ようかん
@Yokan_Sw · X

アセトアミノフェン誘発性急性肝不全:米国の多施設共同前向き研究の結果 低栄養や肝障害によるグルタチオン枯渇によりアセトアミノフェン活性型代謝物が肝細胞壊死を引き起こす。 https://t.co/ydMsOqA5z7

Jun 18, 2023 · 6 likes · 6,142 followers View post →
Javi Ciborro
@papayaykware · X

https://t.co/WSVcy7we4d

Mar 16, 2023 · 8,014 followers View post →
at sushi
@JOf1MMMIos9r0y0 · X

RT @keisuke4713: 訴訟山積み https://t.co/C0OYqCCjIz 2005年 重度アセトアミノフェン肝毒性→急性肝不全:既知 https://t.co/Cp0Hk0QL5D https://t.co/kJ0UqeJewx 過剰摂取が何百もの自殺未遂…

Mar 13, 2023 · 3 shares · 4,097 followers View post →
at sushi
@JOf1MMMIos9r0y0 · X

RT @keisuke4713: 訴訟山積み https://t.co/C0OYqCCjIz 2005年 重度アセトアミノフェン肝毒性→急性肝不全:既知 https://t.co/Cp0Hk0QL5D https://t.co/kJ0UqeJewx 過剰摂取が何百もの自殺未遂…

Dec 22, 2022 · 3 shares · 4,097 followers View post →
Marcin Snoch
@MSnoch · X

@Patrick22House Wąski indeks terapeutyczny to mają TLPD , czy warfaryna. Według badań mediana dawki dla zatruć paracetamolem to 24 g , czyli odpowiednik 48 tabl

May 25, 2022 · 3 likes · 252 followers View post →
あ
@339atamayama · X

RT @keisuke4713: 訴訟山積み https://t.co/C0OYqCCjIz 2005年 重度アセトアミノフェン肝毒性→急性肝不全:既知 https://t.co/Cp0Hk0QL5D https://t.co/kJ0UqeJewx 過剰摂取が何百もの自殺未遂…

Dec 22, 2021 · 3 shares · 361 followers View post →
tune
@keisuke4713 · X

訴訟山積み https://t.co/C0OYqCCjIz 2005年 重度アセトアミノフェン肝毒性→急性肝不全:既知 https://t.co/Cp0Hk0QL5D https://t.co/kJ0UqeJewx 過剰摂取が何百もの自殺未遂、死亡、肝移植の原因 2006年統計 https://t.co/ozDq2LPRXp 年推定56千緊急治療室訪問 26千入院  年平均過剰摂取死者458人

Dec 22, 2021 · 6 likes · 3 shares · 3,745 followers View post →
MSV So Much For Sobriety
@anti_nihilist · X

@sadalsvvd "Overall, 178 subjects (65%) survived, 74 (27%) died without transplantation, and 23 subjects (8%) underwent liver transplantation; 71% were alive at 3 weeks... acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the US." https://t.co/dHT5GOFMbJ

Oct 6, 2021 · 1 like · 279 followers View post →
Cosmo
@cosmojg · X

@SobAlert @LEAD_Coalition @HeidiHmoretti @LoriShemek @BadAzzWarrior @FasdhubScotland Try searching the web for "leading cause of acute liver failure" and see for yourself. Alternatively, here are some studies which support my claim: https://t.co/KiQrb359qX https://t.co/8ZaRzjum4C https://t.co/4c7u8CcCzr

Jul 19, 2021 · 2,004 followers View post →
Acetaminophen | The Most Common Drug Ingredient in America
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http://onlinelibrary.wiley.com/doi/10.1002/hep.20948/pdf. 3. “Acetaminophen Use Patterns” Presentation. https://www.pharmacoepi.org/meetings/28ICPE ...

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Oct 19, 2025 View →
Dolore cronico, stop continui, recuperi infiniti. È la storia di chi si ...
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Oct 12, 2025 View →
Let's Talk About Over-the-Counter (OTC) Medications Many people ...
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DOI: 10.1002/hep.20948 ✓Per un piano Nutrizionale e d'Allenamento personalizzato: Scrivimi in Direct!✓. more. View all 10 comments. 10 ...

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DOI: 10.1002/hep.20948 ✓Per un piano Nutrizionale e d'Allenamento personalizzato: Scrivimi in Direct!✓. more. View all 14 comments.

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... help to bring real-estate prices back down from the stratosphere. ... 1364–72, doi:10.1002/hep.20948. **Note: This specific study reported ...

Feb 28, 2021 View →
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If there's anything you need, please mention in case I or someone I know can help. ... 1364–72, doi:10.1002/hep.20948. **Note: This specific study ...

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U.S. Health Coalition Releases New Resource on Acetaminophen ...
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"Promoting the safe and responsible use of acetaminophen to healthcare professionals and consumers will help to reinforce its appropriate ...

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Increasing role of acetaminophen in acute liver failure in the United ...
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Obaid Shakil, William M. Lee, and the Acute Liver Failure Study Group, Hepatology; December 2005 (DOI: 10.1002/hep.20948). Journal.

Nov 29, 2005 View →