J Am Coll Cardiol January 2006 PMID 16412867

Long-term caloric restriction ameliorates the decline in diastolic function in humans.

Timothy E Meyer, Sándor J Kovács, Ali A Ehsani, Samuel Klein, John O Holloszy, Luigi Fontana

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Mentions

20
Peak: 4 in Nov 2024
across 5 sources since Aug 2017

Extended reach

57,051
potential audience

Total likes

201

Video views

5,067

Mentions per month

Aug 2017 – Jun 2025

Where it's discussed

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AI synopsis

What people are saying

The discussions reflect a mostly supportive tone, with users referencing the article's core conclusion that long-term caloric restriction benefits diastolic heart function; for example, phrases like 'ameliorates decline' and 'beneficial effects' highlight recognition of its importance. Although some comments echo the basic findings, the tone remains informational rather than deeply investigative, demonstrating moderate engagement and perceived impact.

AgreementModerate agreement

Most discussions acknowledge the positive effects of caloric restriction on heart function, indicating general agreement with the publication's findings.

InterestModerate interest

Participants show moderate interest, mainly focusing on the connection between dieting and aging-related heart health improvements.

EngagementModerate engagement

Examples include someone referencing the study directly and others mentioning its potential implications, but without deep analysis.

ImpactModerate impact

The emphasis on health benefits, aging, and potential for lifestyle changes suggests these discussions recognize some significance of the findings.

Abstract in brief

  • Long-term caloric restriction in humans appears to slow down aging-related decline in diastolic heart function without affecting systolic function, possibly through reductions in blood pressure, inflammation, and myocardial fibrosis.
  • The study found that individuals practicing caloric restriction showed diastolic function similar to younger people and had lower levels of CRP, TNFalpha, and TGFbeta1 compared to a Western diet group, indicating less systemic inflammation and tissue stiffening.
  • These findings suggest that caloric restriction has specific benefits for heart health by improving diastolic function and reducing factors associated with cardiac aging, potentially through mechanisms involving decreased inflammation and fibrosis.]

Top posts

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Luigi Fontana, MD, PhD, FRACP
@LuigiFontanaMD · X

https://t.co/jD3slSX7TV https://t.co/GeRe410vUI

Jul 14, 2021 · 1 like · 3,169 followers View post →
Agingdoc
@agingdoc1 · X

Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans (2006) https://t.co/wOdJ7iArGL

Mar 22, 2022 · 1 share · 43,802 followers View post →
Luigi Fontana, MD, PhD, FRACP
@LuigiFontanaMD · X

Meyer, T. E. et al. Long-term caloric restriction ameliorates the decline in diastolic function in humans. J. Am. Coll. Cardiol. 47, 398–402 (2006). DOI: 10.1016/j.jacc.2005.08.069

Nov 29, 2024 · 3,161 followers View post →
John Greene
@Greene_Thoughts · X

RT @agingdoc1: Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans (2006) https://t.co/wOdJ7iArGL

Mar 22, 2022 · 1 share · 1,709 followers View post →

All mentions

Luigi Fontana, MD, PhD, FRACP
@LuigiFontanaMD · X

Meyer, T. E. et al. Long-term caloric restriction ameliorates the decline in diastolic function in humans. J. Am. Coll. Cardiol. 47, 398–402 (2006). DOI: 10.1016/j.jacc.2005.08.069

Nov 29, 2024 · 3,161 followers View post →
John Greene
@Greene_Thoughts · X

RT @agingdoc1: Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans (2006) https://t.co/wOdJ7iArGL

Mar 22, 2022 · 1 share · 1,709 followers View post →
Agingdoc
@agingdoc1 · X

Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans (2006) https://t.co/wOdJ7iArGL

Mar 22, 2022 · 1 share · 43,802 followers View post →
Luigi Fontana, MD, PhD, FRACP
@LuigiFontanaMD · X

https://t.co/jD3slSX7TV https://t.co/GeRe410vUI

Jul 14, 2021 · 1 like · 3,169 followers View post →
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