PubHawk
January 2006 PMID 16418483

Extension of chronological life span in yeast by decreased TOR pathway signaling.

R Wilson Powers, Matt Kaeberlein, Seth D Caldwell, Brian K Kennedy, Stanley Fields

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Mentions

18
Peak: 3 in Feb 2023
across 4 sources since Jun 2020

Extended reach

57,036
potential audience

Total likes

175

Video views

5,172

Mentions per month

Jun 2020 – Aug 2024

Where it's discussed

  • News9 articles
  • Blogs4 articles
  • X / Twitter3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight scientific interest through mentions of biological mechanisms and methods, using phrases like 'classic genome-wide deletion screen' and 'extends lifespan,' which show engagement and recognition of the study's relevance in aging research. The tone is analytical and appreciative, emphasizing the scientific contributions of the article.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, showing moderate support and recognition of its importance.

InterestModerate interest

Participants display a moderate level of curiosity about the findings, referencing specific mechanisms like TOR signaling and its connection to aging.

EngagementModerate engagement

Posts include mentions of the methodology (genome-wide deletion screen) and biological implications, indicating thoughtful engagement.

ImpactModerate impact

The conversation reflects an understanding that the study's insights could influence aging research broadly, suggesting a moderate perceived impact.

Abstract in brief

  • The study used a high-throughput assay to analyze around 4,800 yeast gene deletion strains and found that mutations reducing TOR signaling extend the yeast's chronological life span (CLS), which models aging in postmitotic tissues of mammals.
  • Lowering TOR pathway activity, either through nutrient manipulation (removing amino acids like asparagine or glutamate) or pharmacological agents (such as rapamycin), improves cell survival during stationary phase by enhancing stress resistance and storage carbohydrate accumulation.
  • The research suggests that decreased TOR signaling activates a conserved stress response mechanism, involving factors like Msn2, that is crucial for life span extension across yeast and higher organisms, linking nutrient sensing to aging processes.]
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Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Extension of chronological life span in yeast by decreased TOR pathway signaling (2006) R Wilson Powers, @mkaeberlein, Seth Caldwell, @BKennedy_aging, Stanley Fields https://t.co/Cp1Yv1YEse The classic genome-wide deletion screen for ⬆️CLS mutations

Feb 7, 2023 · 19 likes · 2 shares · 43,803 followers View post →
Brian Kennedy
@BKennedy_aging · X

RT @agingdoc1: Extension of chronological life span in yeast by decreased TOR pathway signaling (2006) R Wilson Powers, @mkaeberlein, Seth…

Feb 22, 2023 · 2 shares · 7,182 followers View post →

All mentions

Artemy Shumskiy
@ArtemyShumskiy · X

RT @agingdoc1: Extension of chronological life span in yeast by decreased TOR pathway signaling (2006) R Wilson Powers, @mkaeberlein, Seth…

Feb 23, 2023 · 2 shares · 868 followers View post →
Brian Kennedy
@BKennedy_aging · X

RT @agingdoc1: Extension of chronological life span in yeast by decreased TOR pathway signaling (2006) R Wilson Powers, @mkaeberlein, Seth…

Feb 22, 2023 · 2 shares · 7,182 followers View post →
Agingdoc
@agingdoc1 · X

Extension of chronological life span in yeast by decreased TOR pathway signaling (2006) R Wilson Powers, @mkaeberlein, Seth Caldwell, @BKennedy_aging, Stanley Fields https://t.co/Cp1Yv1YEse The classic genome-wide deletion screen for ⬆️CLS mutations

Feb 7, 2023 · 19 likes · 2 shares · 43,803 followers View post →