PubHawk
April 2007 PMID 17011713

Low-carb diets, fasting and euphoria: Is there a link between ketosis and gamma-hydroxybutyrate (GHB)?

Andrew J Brown

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Mentions

46
Peak: 2 in Apr 2023
across 6 sources since Apr 2023

Extended reach

8,271
potential audience

Total likes

117

Video views

6,989

Mentions per month

Apr 2023 – Jul 2024

Where it's discussed

  • News32 articles
  • Blogs4 articles
  • X / Twitter3 posts
  • Facebook3 posts
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

Discussions reflect genuine curiosity, exemplified by comments like 'trying to find out how long the supercharged feeling lasts,' and reference scientific concepts such as BHB's role as a weak GABA agonist, which show efforts to understand the possible links between diet-induced ketosis and brain chemistry. The tone combines personal experiences and scientific speculation, highlighting both interest and engagement with the topic's broader implications.

AgreementModerate agreement

Most discussions acknowledge the potential connection between ketosis and GHB-like effects, with some references to the hypothesis involving BHB as a GABA agonist.

InterestHigh interest

Posts show high curiosity and enthusiasm, especially with personal anecdotes and questions about how long the euphoric feeling lasts.

EngagementModerate engagement

Participants engage with scientific ideas, mentioning related topics like GABA signaling and autism, indicating a willingness to connect different concepts.

ImpactModerate impact

While discussions hint at important neurological and behavioral implications, they are primarily exploratory and lack definitive conclusions, so the impact considered moderate.

Abstract in brief

  • The text explores the idea that feelings of euphoria experienced during fasting or low-carb diets may be linked to ketone bodies like beta-hydroxybutyrate (BHB) acting on the brain similarly to GHB, a drug of abuse, by possibly engaging GABAB receptors.
  • The author hypothesizes that BHB might induce mild euphoria as a weak partial agonist of GABAB receptors, similar to GHB, which could explain the well-being people report during ketosis.
  • Several research methods are proposed, such as receptor binding studies, animal perception tests, and human brain imaging, to investigate whether BHB and GHB share similar effects on brain chemistry and mood, especially given their structural similarities and their relevance regarding diet and drug abuse.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Wim van Duin
@WimVanDuin · X

@SBakerMD The BHB ketone body might play a role, which is a (weak) GABA agonist. Autism is linked to dysfunctional GABA signaling. https://t.co/8mZmXFzeWz https://t.co/Dj2sQkRv0t

Apr 7, 2023 · 5 likes · 1 share · 856 followers View post →
doug
@wiredoug · X

sitting in the garden with the mozzies at 1am and here we go down the rabbit hole to try and find out how long the supercharged feeling lasts? I would have quit milk ages ago if i had known it was going to be this much fun at 0 carbs https://t.co/ERQyihAGdB

Feb 6, 2024 · 5 likes · 332 followers View post →

All mentions

doug
@wiredoug · X

sitting in the garden with the mozzies at 1am and here we go down the rabbit hole to try and find out how long the supercharged feeling lasts? I would have quit milk ages ago if i had known it was going to be this much fun at 0 carbs https://t.co/ERQyihAGdB

Feb 6, 2024 · 5 likes · 332 followers View post →
Meysam
@Meysam25132328 · X

RT @WimVanDuin: @SBakerMD The BHB ketone body might play a role, which is a (weak) GABA agonist. Autism is linked to dysfunctional GABA sig…

Apr 8, 2023 · 1 share · 91 followers View post →
Wim van Duin
@WimVanDuin · X

@SBakerMD The BHB ketone body might play a role, which is a (weak) GABA agonist. Autism is linked to dysfunctional GABA signaling. https://t.co/8mZmXFzeWz https://t.co/Dj2sQkRv0t

Apr 7, 2023 · 5 likes · 1 share · 856 followers View post →