This collection of discussions demonstrates a high level of interest and engagement with the STAR*D report, including references to its historical context, re-analyses, and critiques, through language that shows thoughtful reflection and recognition of its influence in the field of psychiatry and depression treatment.
AgreementModerate agreement
Most discussions recognize the significance of the STAR*D report, with some even referencing critiques of its methodology, indicating general support and acknowledgment of its importance.
InterestHigh interest
The discussions involve mentions of detailed aspects of the research and its implications, suggesting high engagement and curiosity about depression treatments and research history.
EngagementModerate engagement
Posts cite specific studies, re-analyses, and critiques, indicating active participation and deeper reflection on the research findings.
ImpactModerate impact
The mention of how treatments work for many but not all, and references to ongoing debates, show that the report influences current conversations around depression treatment strategies.
Abstract in brief
This report reviews the outcomes of adults with major depressive disorder who underwent up to four sequential treatment steps in a trial, showing that remission rates decrease with each additional treatment step.
Patients who achieved remission during treatment were more likely to stay relapse-free during the subsequent year, while those needing more treatment steps had higher relapse risks.
The findings highlight the need for research to develop personalized treatment plans and more effective therapies to improve long-term outcomes for depression.
A few more thoughts on STAR*D. This is mostly a critic of the main paper of STAR*D: Rush et al. (2006). Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR* D report. American Journal of Psychiatry
Oct 23, 2024 · 10 likes · 2,670 followersView post →
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Nicolas Badre
@BadreNicolas · X
• 1977 Psychiatry: Pretest. Nelson, J.
• Original STAR*D (Rush et al. 2006): https://t.co/rUWEFaf5ir…
• Re-analysis (Pigott et al. 2023): https://t.co/g6X1VP29mR… https://t.co/rqhHBLg0N8
Jun 4, 2025 · 9 likes · 1 share · 2,670 followersView post →
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Nicolas Badre
@BadreNicolas · X
List of pharma companies mentioned in the disclosure of STAR*D (picture below).
• Original STAR*D (Rush et al. 2006): https://t.co/rUWEFaf5ir
• Re-analysis (Pigott et al. 2023): https://t.co/g6X1VP29mR
• Recent textbook mention of STAR*D Tasman (2024, p1844)
• 2006 STAR*D https://t.co/iktyMGHyUl
For 30% of patients with #depression symptoms persist even after multiple treatment attempts. (2/5) #medication #psychotherapy #psychiatry
https://t.co/PTHhzFncR2
https://t.co/opFcD0LQxR
Feb 18, 2023 · 4 likes · 9,137 followersView post →
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Roy Perlis
@royperlis · X
Folks studying AD response predictors or novel tx can acknowledge that AD don't work for everyone *without* perpetuating misinfo about effectiveness. Up to 2/3 remit with up to 4 rx trials, iff they stay in treatment that long. Most others improve. https://t.co/34q9uIsF5p
Mar 9, 2022 · 4 likes · 1,475 followersView post →
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Neureka
@neurekaApp · X
We know that treatments help, BUT patients often try several of them to find one that fits.
Mar 30, 2022 · 2 likes · 1,278 followersView post →
This episode discusses international alerts regarding ADHD medications, scrutiny of Dr. Fraga's ADHD segments, and the STARD study reanalysis on antidepressant efficacy and patient improvement in real-world settings.
Did you know that up to 30 of people with depression don't respond to traditional antidepressants? Ketamine therapy offers rapid relief by boosting neuroplasticity, with significant improvements often within hours or…
List of pharma companies mentioned in the disclosure of STAR*D (picture below).
• Original STAR*D (Rush et al. 2006): https://t.co/rUWEFaf5ir
• Re-analysis (Pigott et al. 2023): https://t.co/g6X1VP29mR
• Recent textbook mention of STAR*D Tasman (2024, p1844)
• 2006 STAR*D https://t.co/iktyMGHyUl
A few more thoughts on STAR*D. This is mostly a critic of the main paper of STAR*D: Rush et al. (2006). Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR* D report. American Journal of Psychiatry
Oct 23, 2024 · 10 likes · 2,670 followersView post →
@HamishMcAW These are some fast-paced talks, lots to take in! Here's an interesting paper @HamishMcAW mentioned:
https://t.co/uznffQGNTg
Jul 24, 2023 · 1 like · 1 share · 98,478 followersView post →
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Nicole Laurent, LMHC
@KetoCounselor · X
For 30% of patients with #depression symptoms persist even after multiple treatment attempts. (2/5) #medication #psychotherapy #psychiatry
https://t.co/PTHhzFncR2
https://t.co/opFcD0LQxR
Feb 18, 2023 · 4 likes · 9,137 followersView post →
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tociss
@tociss · X
Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report https://t.co/1nlR3nyvT3
Aug 1, 2022 · 1 like · 13,061 followersView post →
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Neureka
@neurekaApp · X
We know that treatments help, BUT patients often try several of them to find one that fits.
Mar 30, 2022 · 2 likes · 1,278 followersView post →
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Roy Perlis
@royperlis · X
Folks studying AD response predictors or novel tx can acknowledge that AD don't work for everyone *without* perpetuating misinfo about effectiveness. Up to 2/3 remit with up to 4 rx trials, iff they stay in treatment that long. Most others improve. https://t.co/34q9uIsF5p
Mar 9, 2022 · 4 likes · 1,475 followersView post →
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Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X
@psychgeist52 One thing to acknowledge human "complexity" & another to crush it with pitiless repetition of biological sledgehammers in the name of "curing". cf Rush, et al. (2006). Acute & longer-term outcomes in depressed outpatients...: A STAR*D report. https://t.co/KN13vSENBd
org/10.1176/ajp.2006.163.11.1905 Cuijpers, P., et al. (2013). Psychotherapy for depression in adults: A meta-analysis of comparative outcome studies ...
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