March 2007 PMID 17223552

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells.

Prema B Rapuri, J C Gallagher, Zafar Nawaz

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Mentions

100

Peak: 23 in Sep 2021

across 4 sources since Dec 2019

Extended reach

345,375

potential audience

Total likes

181

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Mentions per month

Dec 2019 – Nov 2025

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AI synopsis

What people are saying

The overall tone reflects a solid recognition of the study's implications, as users discuss caffeine’s potential interference with vitamin D metabolism, citing research on VDR expression reduction and suggesting behavioral changes like sun exposure, implying a meaningful but moderate influence on health awareness and practices.

AgreementModerate agreement

Most discussions acknowledge the study's findings that caffeine reduces vitamin D receptor expression, with several commenters citing related research, indicating general agreement or acceptance of the results.

InterestHigh interest

The discussions demonstrate high interest, with users referencing scientific studies, health implications, and suggesting practical behavioral adjustments like sun exposure.

EngagementHigh engagement

The posts show deep engagement through mentions of specific molecular mechanisms, personal opinions, and calls for further research or action, such as avoiding caffeine and increasing sunlight exposure.

ImpactModerate impact

While the discussions highlight important health concerns, the impact appears moderate, focusing on raising awareness and modifying behaviors rather than citing major policy or clinical practice changes.

Abstract in brief

Caffeine reduces the expression of vitamin D receptor (VDR) protein in human bone-forming cells and decreases the activity of alkaline phosphatase, an enzyme important for bone health, when stimulated by active vitamin D (125OH2D3).
The study found that higher caffeine doses (0.2 to 10 mM) significantly lowered VDR levels and alkaline phosphatase activity, suggesting that caffeine may negatively impact bone metabolism by interfering with vitamin D's role in promoting bone formation.
These findings imply that caffeine consumption could contribute to osteoporosis risk by impairing the molecular pathways through which vitamin D supports bone health.]

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Дідо, я профєсор! · Nov 8, 2025 14 views

Impact of High Coffee Consumption on Vitamin D and Nutrients

High coffee consumption may impact vitamin D levels and nutrient absorption in the body. This video explores how excessive caffeine intake influences vitamins D, B, and C, and its indirect effects on holistic muscle…

InteGratiive Health · Nov 9, 2025 9 views

DisharahRahat

@DisharahRahat1 · X

RT @Haziqmahmur90an: @zaidkdahhaj here https://t.co/hyfDR6Lnfq https://t.co/rm9t4WWX5Q

Feb 12, 2025 · 2 shares · 191 followers View post →

Ildiko Velency

@IVelency · X

@DrJackKruse #Sunshine #Sun #Coffeine #Coffee More explanation is in the link: https://t.co/PYgHffGjX5 https://t.co/mFhzBzg4lV

Jun 29, 2024 · 764 followers View post →

Ildiko Velency

@IVelency · X

@DrJackKruse #Sunshine #Sun #Coffeine #Coffee https://t.co/PYgHffGjX5 https://t.co/BejcfiRAc1

Jun 29, 2024 · 764 followers View post →

No Know Universe, Lot-num.ber si.x.t.nine

@Franky53659510 · X

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Jun 21, 2024 · 2 shares · 1,056 followers View post →

haziq jual ayam tak cucuk

@Haziqmahmur90an · X

@zaidkdahhaj here https://t.co/hyfDR6Lnfq https://t.co/rm9t4WWX5Q

Jun 21, 2024 · 8 likes · 2 shares · 12,614 followers View post →

Ozzy

@ozzymandem · X

@RumpledFeather @BioLayne https://t.co/tcAlXMKjND

Apr 8, 2024 · 214 followers View post →

Brent

@BrentPa65278666 · X

Coffee is dehydrating in a 5G world Real energy is generated via the production of intercellular water Caffeine decreases vitamin D receptor protein expression. https://t.co/ZgRR7sHd5M https://t.co/APSZowPPqt

Jan 8, 2024 · 45 followers View post →

Savana Dehning

@nutritionsav · X

A study found that caffeine may decrease Vit D absorption contributing to issues associated with low Vit D like osteoporosis, depression, fatigue, immune system compromise, and more. #NUT3810S https://t.co/3JzhALT0US

Apr 16, 2023 · 2 followers View post →

☀️ RS₿

@RealSunBros · X

@zzeed @marinagamba1909 One of the vital benefits we get from sunning is vitamin D among others. However, caffeine does the opposite: https://t.co/ihLH24SVDV

Jul 13, 2022 · 9,400 followers View post →

fer

@ferfarfer · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Jul 5, 2022 · 19 shares · 9,959 followers View post →

козел кефир

@cacaoXtawco · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Mar 8, 2022 · 19 shares · 387 followers View post →

DisharahRahat

@DisharahRahat1 · X

RT @izwanshahmin: Bersarapanlah dengan kopi / teh tanpa gula. Kalau ikut core #KultusMatahari Kopi lebih elok dielakkan kerana ia mengangg…

Jan 9, 2022 · 16 shares · 191 followers View post →

Cheetah Underpants Hunter

@swelteer · X

Caffeine dose dependently ✅decreased the 1,25(OH)(2)D(3) induced VDR [vitamin D receptor] expression and at concentrations of 1 and 10mM, VDR expression was decreased by about 50-70%, respectively. https://t.co/pR7LY43MWw

Dec 28, 2021 · 108 followers View post →

DisharahRahat

@DisharahRahat1 · X

RT @izwanshahmin: Bersarapanlah dengan kopi / teh tanpa gula. Kalau ikut core #KultusMatahari Kopi lebih elok dielakkan kerana ia mengangg…

Oct 21, 2021 · 16 shares · 191 followers View post →

Marek Bogacki

@documentavi · X

RT @kfitzgeraldnd: Cell study. 2007 There’s more pubs if anyone else wants to dive into the M of A with us :-) https://t.co/48Zs3tyfa5

Oct 9, 2021 · 1 share · 1,424 followers View post →

Dr. Kara Fitzgerald

@kfitzgeraldnd · X

Cell study. 2007 There’s more pubs if anyone else wants to dive into the M of A with us :-) https://t.co/48Zs3tyfa5

Oct 9, 2021 · 1 like · 1 share · 5,682 followers View post →

⚡️ The Blue Light Diet ⚡️

@BlueLightDiet · X

@LattitudeSo There is already data on caffeine and vd receptors https://t.co/9dIeJwqKtM

Oct 8, 2021 · 3 likes · 32,643 followers View post →

Yeonra__

@Nasyura22 · X

RT @izwanshahmin: Bersarapanlah dengan kopi / teh tanpa gula. Kalau ikut core #KultusMatahari Kopi lebih elok dielakkan kerana ia mengangg…

Sep 24, 2021 · 16 shares · 19 followers View post →

ᴴⁱⁿᵃᵗᵃ

@nwzysrn · X

RT @izwanshahmin: Bersarapanlah dengan kopi / teh tanpa gula. Kalau ikut core #KultusMatahari Kopi lebih elok dielakkan kerana ia mengangg…

Sep 24, 2021 · 16 shares · 1,383 followers View post →

Ms Leo

@elyzleo · X

RT @izwanshahmin: Bersarapanlah dengan kopi / teh tanpa gula. Kalau ikut core #KultusMatahari Kopi lebih elok dielakkan kerana ia mengangg…

Sep 24, 2021 · 16 shares · 669 followers View post →

Durian

@mrsekhsan · X

RT @izwanshahmin: Bersarapanlah dengan kopi / teh tanpa gula. Kalau ikut core #KultusMatahari Kopi lebih elok dielakkan kerana ia mengangg…

Sep 23, 2021 · 16 shares · 76 followers View post →

Nvm.

@twtnvm · X

RT @izwanshahmin: Bersarapanlah dengan kopi / teh tanpa gula. Kalau ikut core #KultusMatahari Kopi lebih elok dielakkan kerana ia mengangg…

Sep 23, 2021 · 16 shares · 614 followers View post →

FulFil

@farhan_fulfil · X

RT @izwanshahmin: Bersarapanlah dengan kopi / teh tanpa gula. Kalau ikut core #KultusMatahari Kopi lebih elok dielakkan kerana ia mengangg…

Sep 23, 2021 · 16 shares · 32 followers View post →

SiKemboja Harumnya Kelewatan

@laksemykemboja · X

RT @izwanshahmin: Bersarapanlah dengan kopi / teh tanpa gula. Kalau ikut core #KultusMatahari Kopi lebih elok dielakkan kerana ia mengangg…

Sep 23, 2021 · 16 shares · 272 followers View post →

Zarith

@zarith4real · X

RT @izwanshahmin: Bersarapanlah dengan kopi / teh tanpa gula. Kalau ikut core #KultusMatahari Kopi lebih elok dielakkan kerana ia mengangg…

Sep 23, 2021 · 16 shares · 990 followers View post →

Suncle Izwan

@izwanshahmin · X

Sep 23, 2021 · 41 likes · 16 shares · 8,586 followers View post →

Grumman600

@grumman600 · X

@RWMaloneMD https://t.co/PrPBIx1mYA

Sep 23, 2021 · 1 like · 555 followers View post →

Shane

@Shane61680232 · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 1,951 followers View post →

Kubira

@oonayoy · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 950 followers View post →

Derma Essentials

@DermaEssentials · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 1,126 followers View post →

Neuropsicologo

@CHRISTIANGEL76 · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 295 followers View post →

shebasublime

@shebasublime · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 166 followers View post →

@profesorofthigs · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 815 followers View post →

Don Tidwell

@tidwell_don · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 2,782 followers View post →

Nvm.

@twtnvm · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 614 followers View post →

AlexEconOfficial

@econ_okx · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 26 followers View post →

datuk kamal

@karmenlunarxisc · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 39,761 followers View post →

козел кефир

@cacaoXtawco · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 387 followers View post →

Pauley G

@PVG0015 · X

RT @Grimhood: Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human os…

Sep 1, 2021 · 19 shares · 2,512 followers View post →

Mg2+ Papi, the BowTied Mg2+

@Grimhood · X

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells https://t.co/xAIFbIAAr8

Sep 1, 2021 · 110 likes · 19 shares · 133,408 followers View post →

Slapkoff ❤️‍

@LesathCap777 · X

https://t.co/WmNhnblzLT

May 2, 2021 · 604 followers View post →

أسيد | OSAID

@OSAID_FIT · X

@ck_eternity_ https://t.co/UZ00jVoxmF

May 1, 2021 · 25,425 followers View post →

Alyaa Zagzoog, PhD

@AlyaaZagzoog · X

RT @OSAID_FIT: @AlyaaZagzoog أهلا علياء ، قرأت قبل فترة دراسة عن تأثير الكافيين على مستقبلات فيتامين د " VDR " في النساء ، ياليت تطلعي عليه…

Apr 16, 2021 · 1 share · 11,425 followers View post →

أسيد | OSAID

@OSAID_FIT · X

@AlyaaZagzoog أهلا علياء ، قرأت قبل فترة دراسة عن تأثير الكافيين على مستقبلات فيتامين د " VDR " في النساء ، ياليت تطلعي عليها

Apr 16, 2021 · 2 likes · 1 share · 25,425 followers View post →

ENDALA klinika zdraví

@endalaclinic · X

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells - PubMed https://t.co/yfrodde4F5

Apr 1, 2021 · 254 followers View post →

Mitominder

@Mitominder · X

Feb 27, 2021 · 6 likes · 2,259 followers View post →

questioningconventionalscience

@isnotsettled · X

@FITrebelde @NataliaLindu @FMSFelizconpoco @davidregenera https://t.co/B8eFJ6rNr7

Sep 2, 2020 · 1 like · 83 followers View post →

Corazón de León

@gcorazondeleon · X

RT @Jappy_octopus: @mitokondriac https://t.co/cQD3oRcGcz

Jul 15, 2020 · 2 shares · 58 followers View post →

Lab+

@EV__LAB · X

RT @Jappy_octopus: @mitokondriac https://t.co/cQD3oRcGcz

Jul 14, 2020 · 2 shares · 284 followers View post →

Octópodo

@Jappy_octopus · X

@mitokondriac https://t.co/cQD3oRcGcz

Jul 14, 2020 · 7 likes · 2 shares · 1,752 followers View post →

Carolyn

@CFitzenreiter · X

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. - PubMed - NCBI https://t.co/dqeQxXhDrT

Dec 18, 2019 · 104 followers View post →

LivingRoom Chiro

@ChiropractorFin · X

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. - PubMed - NCBI https://t.co/i799REULVW

Dec 18, 2019 · 1,669 followers View post →

Dr. Kathy Williams

@kathyblabs · X

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. - PubMed - NCBI https://t.co/z2SccnNz3V

Dec 15, 2019 · 128 followers View post →

herrliberman

@cannaphiles · X

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. - PubMed - NCBI https://t.co/78arjFcGem

Dec 15, 2019 · 403 followers View post →

david kleehammer

@davidkleehammer · X

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. - PubMed - NCBI https://t.co/8XeBYjSueO

Dec 15, 2019 · 581 followers View post →

Manuel Ruep

@fuelonmusk69 · X

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. - PubMed - NCBI https://t.co/pZ8sv2Lmys

Dec 15, 2019 · 168 followers View post →

Cecil Zeringue

@ceesman · X

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. - PubMed - NCBI https://t.co/ijfECZ359z

Dec 14, 2019 · 153 followers View post →

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Coffee's Impact on Health: Benefits and Risks Explored

Impact of High Coffee Consumption on Vitamin D and Nutrients