Br J Pharmacol March 2007 PMID 17245363

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.

A Thomas, G L Baillie, A M Phillips, R K Razdan, R A Ross, R G Pertwee

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Mentions

Peak: 2 in Feb 2021

across 4 sources since Feb 2020

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13,426

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Total likes

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2,405

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Feb 2020 – Feb 2021

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What people are saying

The group's discussions highlight the novelty of CBD acting as an inverse agonist at CB receptors and how this could explain its anti-inflammatory and therapeutic effects, with examples like 'potential medical benefits' and 'liver disease and regeneration.' The tone varies from scientific acknowledgment to curiosity and skepticism, demonstrating both an interest in understanding the mechanisms and recognition of its possible significance.

AgreementModerate agreement

Many posts acknowledge the scientific findings, with some recognizing CBD's potential medical benefits and its paradoxical role as an inverse agonist.

InterestHigh interest

Discussions show high interest in the biochemical mechanisms and possible health implications of CBD, indicating curiosity about its pharmacological effects.

EngagementModerate engagement

Posts include references to related health issues, such as liver disease and inflammation, reflecting active engagement with potential applications.

ImpactModerate impact

The mention of CBD’s anti-inflammatory and therapeutic potentials suggests that discussions see the research as moderately influential in medical and scientific contexts.

Abstract in brief

Cannabidiol, a non-psychoactive compound in cannabis, unexpectedly acts as a potent antagonist and inverse agonist of CB1 and CB2 cannabinoid receptors, despite its low affinity.
The study shows cannabidiol can effectively block and reverse the activity of other cannabinoid drugs in both mouse brain tissues and human CB2 transfected cells, highlighting its strong antagonistic properties.
This inverse agonist behavior at CB2 receptors might help explain cannabidiol's anti-inflammatory effects, expanding our understanding of its potential medical benefits.]

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All mentions

Medicinal Effects of CBD and Endocannabinoid Receptors

This video provides insights into cannabis and its medicinal effects, focusing on the CB1 and CB2 receptors. We explore how cannabinoids like CBD interact with these receptors, influencing various therapeutic outcomes.

Canal Mitocondria · Jun 21, 2020 2,340 views

Exploring CBD: Science, History, and Applications in Health

On this episode of H2O High On Health, we explore CBD, an important compound derived from Cannabis sativa. We discuss its scientific background, historical significance, and regulatory status, while highlighting its…

Science with Dr CK · Feb 25, 2020 65 views

OhMalG

@OhMalG · X

Feb 1, 2021 · 1 like · 489 followers View post →

OhMalG

@OhMalG · X

@AudibleFalafel @harleybaghdad CBD is an inverse agonist of CB1 and CB2 but I'm guessing you are not able to comprehend any of those words https://t.co/0jFi1M4b4H

Feb 1, 2021 · 6 likes · 489 followers View post →

UltimApe

@ultimape · X

@MMMalign @QueenOfTheWilis @MeFromBefore Worse than that. Check out CB1 and CB2 as it comes to liver disease and regeneration. Compare with: https://t.co/Au3FVCQBMA

Jan 29, 2021 · 1 like · 6,765 followers View post →

Is CBD a panacea?

@CBDme6 · X

CBD documented anti-inflammatory properties. https://t.co/WItpM7DnsJ

Oct 6, 2020 · 3,279 followers View post →