Am J Physiol Cell Physiol August 2007 PMID 17428837

Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress.

Yuri Y Sautin, Takahiko Nakagawa, Sergey Zharikov, Richard J Johnson

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Posts express strong agreement by emphasizing uric acid's unexpected benefits in stroke treatment and its superiority over drugs like Actemra, with language conveying excitement about new research. The tone varies from clinical comparisons to speculative comments on disease implications, reflecting high curiosity and a recognition of potential medical breakthroughs.

AgreementModerate agreement

Most discussions support the findings by highlighting uric acid's harmful effects in adipocytes and its potential as a treatment advantage over other drugs, reflecting general agreement with the publication.

InterestHigh interest

Posts demonstrate high interest, with mentions of uric acid outperforming other treatments and its role in serious diseases, showing active engagement with the topic.

EngagementModerate engagement

Some posts delve into specific studies, comparing different treatments and the complex roles of uric acid, indicating moderate to deep engagement.

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Discussions suggest the findings could influence medical perspectives on uric acid's role in health and disease, indicating a moderate impact on current understanding.

Abstract in brief

Uric acid, while known as an antioxidant that may protect against aging, can cause harmful effects in fat cells (adipocytes) by increasing oxidative and nitrosative stress through NADPH oxidase activity.
During adipocyte differentiation, uric acid promotes the production of reactive oxygen species (ROS), activates specific kinases (p38 and ERK1/2), reduces nitric oxide availability, and increases protein nitrosylation and lipid oxidation, contributing to cellular damage.
These findings suggest that high uric acid levels (hyperuricemia) may promote oxidative stress in fat tissue, which is linked to insulin resistance, cardiovascular diseases, and metabolic syndrome, potentially playing a causal role in these conditions.]

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Uric Acid's Impact on Fat Cells and Oxidative Stress Mechanisms

Uric acid, an antioxidant, can cause harm in adipocytes by increasing oxidative and nitrosative stress via NADPH oxidase activity. Elevated uric acid levels may lead to insulin resistance, cardiovascular issues, and…

Quang Huy · Aug 18, 2024 11 views

Understanding Uric Acid's Role in Gout and Metabolic Health

Quang Huy · Jun 17, 2024 8 views

Ronald M. Chavin

@rmchavin · X

Nov 29, 2024 · 211 followers View post →

Ronald M. Chavin

@rmchavin · X

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Ronald M. Chavin

@rmchavin · X

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Ronald M. Chavin

@rmchavin · X

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Ronald M. Chavin

@rmchavin · X

Although gout patients will only eat foods (like yogurt) that won't end up raising blood uric acid levels, low blood uric acid levels are a very bad omen for some diseases, including COVID-19 and Parkinson's: https://t.co/eP8Boa72Vl https://t.co/MlXfdnRY8Z https://t.co/3iyda3M2xX

Feb 24, 2023 · 211 followers View post →

金森重樹@ダイエットonlineサロン

@ShigekiKanamori · X

RT @kojija: 【尿酸は脂肪細胞のROSとNADPHオキシダーセ活性増加→酸化ストレス⇧】 https://t.co/byViHmNNJC

Dec 3, 2021 · 1 share · 124,352 followers View post →

KOJI@プライマルコーチ

@kojija · X

【尿酸は脂肪細胞のROSとNADPHオキシダーセ活性増加→酸化ストレス⇧】 https://t.co/byViHmNNJC

Dec 3, 2021 · 8 likes · 1 share · 2,315 followers View post →

Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress.

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Uric Acid's Impact on Fat Cells and Oxidative Stress Mechanisms

Understanding Uric Acid's Role in Gout and Metabolic Health