Am J Physiol Endocrinol Metab September 2007 PMID 17609255

Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle.

Anne Marie Winther Petersen, Faidon Magkos, Philip Atherton, Anna Selby, Kenneth Smith, Michael J Rennie, Bente Klarlund Pedersen, Bettina Mittendorfer

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Mentions

Peak: 21 in Mar 2021

across 6 sources since Jan 2019

Extended reach

138,863

potential audience

Total likes

240

Video views

4,908

Mentions per month

Jan 2019 – Mar 2025

Where it's discussed

X / Twitter44 posts
Facebook22 posts
News5 articles
YouTube4 videos
Reddit2 posts
Blogs2 articles

AI synopsis

What people are saying

Discussions frequently highlight the negative impact of smoking on muscle health, emphasizing terms like 'bad' and 'adverse effects.' Some posts delve into specifics, such as the increase in myostatin levels, to underscore biological mechanisms, while others underscore the practical implications in fitness routines. The tone generally combines curiosity with concern, reinforcing the perceived importance of the study’s findings.

AgreementStrong agreement

Most discussions concur that smoking negatively affects muscle growth, with multiple posts referencing the detrimental effects on muscle protein synthesis and gene expression, reinforcing the study's conclusions.

InterestHigh interest

Participants display high curiosity, discussing detailed mechanisms like myostatin increase and blood vessel dilation, indicating the topic's relevance to fitness and health.

EngagementModerate engagement

While many posts mention the findings, some offer brief reactions or reference sources, suggesting engagement but with limited deep analysis across the board.

ImpactHigh impact

The widespread emphasis on the adverse effects of smoking on muscles suggests the community perceives the research as having significant health and fitness implications.

Abstract in brief

Smoking negatively affects skeletal muscle by reducing protein synthesis and increasing the expression of genes like myostatin and MAFbx, which are associated with muscle breakdown.
Despite similar levels of inflammatory markers and amino acids in blood, smokers' muscles show decreased protein production and higher expression of gene markers linked to muscle wasting.
These findings suggest that smoking may contribute to muscle decline by impairing muscle repair mechanisms and promoting muscle degradation pathways.]

Read the full abstract

All mentions

Effects of Smoking on Muscle Growth and Breakdown Mechanisms

Smoking negatively impacts skeletal muscle by reducing protein synthesis and increasing genes linked to muscle breakdown, which may hinder muscle growth and repair.

David Vlaic · Nov 11, 2020 3,360 views

Smoking Impairs Muscle Growth by Reducing Protein Synthesis

This study demonstrates that smoking negatively impacts skeletal muscle by decreasing protein synthesis and increasing muscle breakdown markers like myostatin and MAFbx, leading to impaired muscle repair and potential…

Scientifik Health · Jul 22, 2024 761 views

Smoking Impairs Muscle Growth and Promotes Muscle Wasting

The study examines the effects of smoking on muscle protein synthesis and key factors related to muscle development and maintenance. It highlights how smoking negatively impacts muscle growth and repair mechanisms.

Profe Miguel - Salud Integral · Jan 10, 2024 695 views

Potential Benefits and Risks of Microdosing Nicotine

Nicotine is a natural alkaloid found in tobacco, used in cigarettes and e-liquids, with perceived positive effects on mental alertness. This video explores whether non-smoked nicotine offers health benefits through…

personaaltreener Marek Tihhonov · Mar 29, 2025 93 views

Gorge Jimbino

@GJimbino · X

@JimJubilee @foolay_oshea They weren’t smoking marijuana in this study if that what you were thinking. It’s nicotine cigarettes https://t.co/G5sUAOEwjR

Feb 27, 2024 · 70 followers View post →

낑깡

@cherrycurrant · X

@Goodking_Apple 누가낑글부른거갘기도하고 https://t.co/avJ1V6bKku https://t.co/kTRe4bTQ4W

Aug 15, 2023 · 1 like · 87 followers View post →

snazz

@MONKEYPHONK · X

@lilboweepe bad! DOI:10.1152/ajpendo.00301.2007

Jun 2, 2023 · 173 followers View post →

Azrael/K | meow

@bigdickazrael · X

@urlucent Yep, can lead to increase in myostatin levels https://t.co/YrmeCkfHf4

Dec 16, 2022 · 1,168 followers View post →

Ben Ogorek

@BenOgorek · X

Now smoking seems definitely bad for muscle gains, but I'm interested in the claim above that nicotine "dilates blood vessels in skelatal muscle" https://t.co/RwO6pTuEPR

Dec 11, 2022 · 811 followers View post →

Azrael/K | meow

@bigdickazrael · X

@whte_rabbit Thats just you. Smoking has been proven to have adverse effects on muscle mass Sources: https://t.co/YrmeCkgf4C https://t.co/pqKAyjAYKP https://t.co/qxNiJUMW1r

Dec 10, 2022 · 1,168 followers View post →

Konstantinos Prokopidis

@KostasProko · X

More on smoking and skeletal muscle: https://t.co/6jrErXtyuO https://t.co/WZTLYs1wFO https://t.co/8joa4oEYI5 https://t.co/EHBGjPxDYT

Sep 20, 2022 · 1,490 followers View post →

Bryce Hanna

@photobiogenesis · X

@pawgshill I believe this is the study I found when I was researching, small sample size, but about 33% more myostatin in the smoking group https://t.co/pQ8yKab9fI.

Apr 6, 2021 · 34,128 followers View post →

Guille Varela

@nutriguille · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Apr 3, 2021 · 22 shares · 205 followers View post →

AddictRc20 aldhu carbon

@Addict_Foil · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 9, 2021 · 22 shares · 558 followers View post →

J.M.PEACE

@JMHUSTLE · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 6, 2021 · 22 shares · 643 followers View post →

claimshero.eth

@claimshero__eth · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 5, 2021 · 22 shares · 128 followers View post →

Tenamaxtli Cardona

@tenamaxtli_lopz · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 5, 2021 · 22 shares · 252 followers View post →

Andrés Logroño

@AndrsLogrono · X

Mar 5, 2021 · 2 likes · 1,325 followers View post →

Dr. Michael Sagner, MD

@DrMichaelSagner · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 5, 2021 · 22 shares · 5,359 followers View post →

Yoly Collado

@yolyhealthtrain · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 5, 2021 · 22 shares · 526 followers View post →

فيصل بن فهد العوسي Faisal F. Alousi

@FaisalOusi · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 5, 2021 · 22 shares · 654 followers View post →

Inaki bestetraining

@InakiSedano · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 5, 2021 · 22 shares · 201 followers View post →

Xenon

@CO2caine · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 552 followers View post →

OJSN

@iamojsn · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 14,942 followers View post →

operezf

@operezf · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 2,101 followers View post →

PoL ,

@POL6M · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 2,378 followers View post →

David Scott

@DavidScottPhD · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 2,947 followers View post →

Simone do Carmo

@Sport_Bokkie · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 907 followers View post →

Vince

@Vince_Mrgn · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 124 followers View post →

Konstantinos Prokopidis

@KostasProko · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 1,490 followers View post →

Mark Maslow

@MarkMaslow · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 3,027 followers View post →

Mikebarbell

@mikemo93 · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 3,705 followers View post →

Supah Koopa

@Supah_Koopa · X

RT @JornTrommelen: Long-term smokers have lower muscle protein synthesis rates compared to non-smokers. Full breakdown: https://t.co/T8lLw…

Mar 4, 2021 · 22 shares · 297 followers View post →

Jorn Trommelen, PhD

@JornTrommelen · X

Mar 4, 2021 · 67 likes · 22 shares · 7,621 followers View post →

Chuck

@ripchuckwashere · X

Dec 29, 2020 · 6 likes · 559 followers View post →

のちお@ボディメイク

@nochiokinniku · X

喫煙は筋肉のタンパク質合成過程を障害し、筋肉の維持障害に関連する遺伝子の発現を増加させると結論している喫煙はサルコペニアのリスクを増加させる可能性が高い https://t.co/VjAMyE1yp1

Oct 15, 2020 · 1 like · 36 followers View post →

Matsuda Hajime

@mazda_h · X

RT @iamojsn: https://t.co/o9HCKmD5Gy

Oct 15, 2020 · 1 share · 1,483 followers View post →

OJSN

@iamojsn · X

https://t.co/o9HCKmD5Gy

Oct 15, 2020 · 6 likes · 1 share · 14,942 followers View post →

Hayato

@Hayato567890 · X

RT @APSPublications: Our most mentioned article last week: Smoking impairs muscle protein synthesis and increases the expression of myost…

Jan 15, 2019 · 3 shares · 252 followers View post →

Martin Frank

@FranklyPhysiol · X

RT @APSPublications: Our most mentioned article last week: Smoking impairs muscle protein synthesis and increases the expression of myost…

Jan 14, 2019 · 3 shares · 2,434 followers View post →

Canarybirder

@Canarybirder · X

RT @APSPublications: Our most mentioned article last week: Smoking impairs muscle protein synthesis and increases the expression of myost…

Jan 14, 2019 · 3 shares · 27 followers View post →

David Scott

@DavidScottPhD · X

RT @Jozo_Grgic: Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. https://t.co/qI6WS…

Jan 14, 2019 · 3 shares · 2,947 followers View post →

APS Publications

@APSPublications · X

Our most mentioned article last week: Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle https://t.co/urCl6uMO16 https://t.co/WyfYBBay5T

Jan 14, 2019 · 2 likes · 3 shares · 7,373 followers View post →

EskeleThor

@EskeleThor · X

RT @Jozo_Grgic: Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. https://t.co/qI6WS…

Jan 14, 2019 · 3 shares · 405 followers View post →

Darren Candow, PhD, CSEP-CEP, FISSN

@darrencandow · X

RT @Jozo_Grgic: Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. https://t.co/qI6WS…

Jan 14, 2019 · 3 shares · 6,728 followers View post →

PictureFit

@Picture_Fit · X

Interesting study on smoking's effect on your muscle gains. Not that more reasons are needed to discourage smoking already, but maybe straw on camel's back for some. https://t.co/Ndt4lo9k4u

Jan 8, 2019 · 5 likes · 4,431 followers View post →

Emanon

@RadioMy · X

Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle [2007, N=16] via /r/AdvancedFitness https://t.co/g5lNRTOU8C

Jan 8, 2019 · 1,166 followers View post →

Emanon

@RadioMy · X

Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle [2007, N=16] via /r/AdvancedFitness https://t.co/g5lNRTOU8C https://t.co/lD38G5Tupd

Jan 8, 2019 · 1,166 followers View post →

Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Effects of Smoking on Muscle Growth and Breakdown Mechanisms

Smoking Impairs Muscle Growth by Reducing Protein Synthesis

Smoking Impairs Muscle Growth and Promotes Muscle Wasting

Potential Benefits and Risks of Microdosing Nicotine