October 2007 PMID 17652429

Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways.

Louise Deldicque, Daniel Theisen, Luc Bertrand, Peter Hespel, Louis Hue, Marc Francaux

Download social card

Mentions

Peak: 4 in Mar 2024

across 5 sources since Sep 2021

Extended reach

849,140

potential audience

Total likes

11,981

Video views

818,879

Mentions per month

Sep 2021 – Mar 2025

Where it's discussed

News8 articles
X / Twitter7 posts
Facebook5 posts
YouTube4 videos
Blogs2 articles

AI synopsis

What people are saying

The comments mainly reference popular muscle-building videos and supplements, such as 'Most Powerful LEGAL Supplements,' with no direct critique or detailed discussion of the scientific findings. The tone is casual and focused on fitness rather than engaging deeply with the research, reflecting limited impact and interest.

AgreementNeither agree nor disagree

The discussions do not explicitly support or oppose the publication, showing neutrality.

InterestNeutral interest

The posts show a general curiosity but lack detailed analysis or enthusiasm for the study.

EngagementNeutral engagement

Participants mainly share casual comments and questions centered around muscle-building topics, indicating superficial engagement.

ImpactNeutral impact

The discussions do not seem to influence opinions or suggest significant alterations in understanding or practice.

Abstract in brief

Creatine promotes the differentiation of C2C12 myogenic cells by activating key signaling pathways, specifically p38 and Akt/PKB, leading to increased protein synthesis and formation of mature muscle proteins.
The study shows that blocking the mTOR/p70s6k pathway or p38 kinase prevents creatine's effects, indicating these pathways are crucial for its action; creatine was ineffective when these pathways were inhibited.
Creatine increases the phosphorylation of several proteins involved in muscle differentiation and enhances nuclear levels of transcription factors like MEF2 and MyoD, further supporting its role in promoting muscle cell maturation.]

Read the full abstract

All mentions

Top 7 Legal Supplements for Muscle Building and Fat Loss

This video highlights seven legal performance-enhancing supplements essential for muscle gain and fat loss. It discusses their effectiveness and importance for fitness optimization, supported by scientific research.

Thomas DeLauer · Mar 10, 2024 817,454 views

Creatine Supplementation for Enhanced Muscle Growth and Performance

This video explains what creatine is, its benefits for muscle growth and strength, proper dosage, and potential side effects, providing an essential guide for those using creatine to optimize their bodybuilding and…

Health Insiders · Nov 8, 2024 914 views

Creatine Supplementation for Muscle Growth and Performance Insights

Creatine stores energy and enhances muscle growth and strength. This video explains what creatine is, how to use it effectively, its benefits, dosage, and potential side effects, providing an essential guide for…

Health Insiders · Sep 26, 2021 342 views

Effects of Sleep Deprivation, Overtraining Signs & Creatine Benefits

Insufficient sleep undermines dietary efforts to reduce adiposity. Creatine promotes muscle differentiation by activating p38 and Akt/PKB pathways, enhancing protein synthesis and muscle protein formation.

Wolf Supplements · Mar 26, 2023 170 views

Bat Eats Moth

@BatEatsMoth · X

7 Most Powerful LEGAL Supplements for Building Muscle & Losing Fat https://t.co/5vpMJGPOeR via @YouTube

Mar 17, 2025 · 12,547 followers View post →

dominicg

@dominic91002523 · X

7 Most Powerful LEGAL Supplements for Building Muscle & Losing Fat https://t.co/EQwh1eeDYD via @YouTube

Jul 26, 2024 · 699 followers View post →

Elihu

@RealLilTrump · X

https://t.co/YjeQTGeHY3

May 29, 2024 · 1 like · 2,178 followers View post →

HOT ROCK TV

@HOTROCKTV · X

7 Most Powerful LEGAL Supplements for Building Muscle & Losing Fat https://t.co/P1ZC0JW35p via @YouTube

Apr 30, 2024 · 11,002 followers View post →

OhPervyOne

@Oh_Pervy_One · X

Can I get your opinion, @ZackStrength ? (IDK if you watch @ThomasDeLauer) "7 Most Powerful LEGAL Supplements for Building Muscle & Losing Fat" https://t.co/uOQ6YWGNIc

Mar 16, 2024 · 669 followers View post →

blubber_bones

@blubber_bones · X

7 Most Powerful LEGAL Supplements for Building Muscle & Losing Fat https://t.co/U99SU0P3vK

Mar 10, 2024 · 1,093 followers View post →

Kevin

@KevinPSweeney · X

https://t.co/MgjebioUX7

Mar 10, 2024 · 2,075 followers View post →