Arch Gen Psychiatry October 2007 PMID 17909125

The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes.

John S March, Susan Silva, Stephen Petrycki, John Curry, Karen Wells, John Fairbank, Barbara Burns, Marisa Domino, Steven McNulty, Benedetto Vitiello, Joanne Severe

Mentions

31
Peak: 2 in Sep 2023
across 4 sources since Aug 2022

Extended reach

2,073
potential audience

Total likes

1

Video views

1,670

Mentions per month

Aug 2022 – Feb 2025

Where it's discussed

  • News21 articles
  • X / Twitter4 posts
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reflects a mix of support and skepticism, with some posters citing specific statistics from the study (e.g., higher suicidal events in fluoxetine alone) and emphasizing the importance of evidence-based approaches, while others challenge the evidence or question the role of antidepressants in saving lives, indicating a nuanced debate with both informational and emotional undertones.

AgreementModerate agreement

Most discussions acknowledge the study's findings, especially regarding the increased safety of combination therapy and the importance of antidepressants, though some express skepticism or debate the broader implications.

InterestModerate interest

The discussion shows moderate interest, with remarks that highlight the significance of the research and its impact on understanding depression treatments.

EngagementHigh engagement

Several posts actively engage with the data, referencing specific findings like suicidal event rates and questioning the validity of opinions, indicating a high level of thoughtful engagement.

ImpactModerate impact

The conversation points to the study's potential influence on mental health treatment perspectives, especially by emphasizing safer medication options and the importance of evidence-based care.

Abstract in brief

  • The TADS study examined the long-term effectiveness and safety of fluoxetine, cognitive behavioral therapy (CBT), and their combination in treating adolescents with major depressive disorder over 36 weeks, showing that all treatments helped improve depression symptoms, with combination therapy being the most effective.
  • Response rates increased over time, reaching around 86% by week 36, and while suicidal ideation decreased during treatment, it was less reduced with fluoxetine alone compared to the other therapies, and suicidal events were more common in the fluoxetine group.
  • The study was a randomized controlled trial involving 327 adolescents, with assessments indicating that combination therapy yielded the best outcomes, and safety concerns such as suicidal events were monitored, highlighting the importance of careful treatment choice in this population.]

Top posts

Most liked on X and Bluesky
HighTech/LowLife
@SirJinno · X

@haterdiaries @rawr_meowlol @butleriano https://t.co/pHo0sXLejT Suicidal events were more common in patients receiving fluoxetine therapy (14.7%) than combination therapy (8.4%) or CBT (6.3%).

Feb 15, 2025 · 1 like · 245 followers View post →
Spiritbear
@_Spiritbear_ · X

@RingingUniverse @jibantik00 @wakeupsleeples @TPV_John Is your statement backed by facts or just your opinion? https://t.co/T3vXVoHy5L

Sep 6, 2024 · 53 followers View post →
Spiritbear
@_Spiritbear_ · X

@ChrisWhite_1972 @TPV_John Didn't have to do to much before antidepressants, depression cured itself in the form of suicide. You seriously need an explanation as to how antidepressants save lives? Here's probably the most important study on that issue. https://t.co/T3vXVoHy5L

Sep 5, 2024 · 53 followers View post →
gods sleepiest kitten
@esistmax · X

@_demetrius_3 @failninjaninja @SWENGTIM @proetrie https://t.co/N8I6OYa3nu this is for anxiety disorders, https://t.co/IxC6jiSZsi this is for depression. both studies show its highly effective, there are hundreds more. took me ~1 min of googling.

Aug 30, 2022 · 53 followers View post →

All mentions

HighTech/LowLife
@SirJinno · X

@haterdiaries @rawr_meowlol @butleriano https://t.co/pHo0sXLejT Suicidal events were more common in patients receiving fluoxetine therapy (14.7%) than combination therapy (8.4%) or CBT (6.3%).

Feb 15, 2025 · 1 like · 245 followers View post →
Spiritbear
@_Spiritbear_ · X

@RingingUniverse @jibantik00 @wakeupsleeples @TPV_John Is your statement backed by facts or just your opinion? https://t.co/T3vXVoHy5L

Sep 6, 2024 · 53 followers View post →
Spiritbear
@_Spiritbear_ · X

@ChrisWhite_1972 @TPV_John Didn't have to do to much before antidepressants, depression cured itself in the form of suicide. You seriously need an explanation as to how antidepressants save lives? Here's probably the most important study on that issue. https://t.co/T3vXVoHy5L

Sep 5, 2024 · 53 followers View post →
gods sleepiest kitten
@esistmax · X

@_demetrius_3 @failninjaninja @SWENGTIM @proetrie https://t.co/N8I6OYa3nu this is for anxiety disorders, https://t.co/IxC6jiSZsi this is for depression. both studies show its highly effective, there are hundreds more. took me ~1 min of googling.

Aug 30, 2022 · 53 followers View post →