@haterdiaries @rawr_meowlol @butleriano https://t.co/pHo0sXLejT Suicidal events were more common in patients receiving fluoxetine therapy (14.7%) than combination therapy (8.4%) or CBT (6.3%).
The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes.
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Aug 2022 – Feb 2025Where it's discussed
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News21 articles
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X / Twitter4 posts
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Blogs4 articles
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YouTube2 videos
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What people are saying
The overall tone reflects a mix of support and skepticism, with some posters citing specific statistics from the study (e.g., higher suicidal events in fluoxetine alone) and emphasizing the importance of evidence-based approaches, while others challenge the evidence or question the role of antidepressants in saving lives, indicating a nuanced debate with both informational and emotional undertones.
Most discussions acknowledge the study's findings, especially regarding the increased safety of combination therapy and the importance of antidepressants, though some express skepticism or debate the broader implications.
The discussion shows moderate interest, with remarks that highlight the significance of the research and its impact on understanding depression treatments.
Several posts actively engage with the data, referencing specific findings like suicidal event rates and questioning the validity of opinions, indicating a high level of thoughtful engagement.
The conversation points to the study's potential influence on mental health treatment perspectives, especially by emphasizing safer medication options and the importance of evidence-based care.
Abstract in brief
- The TADS study examined the long-term effectiveness and safety of fluoxetine, cognitive behavioral therapy (CBT), and their combination in treating adolescents with major depressive disorder over 36 weeks, showing that all treatments helped improve depression symptoms, with combination therapy being the most effective.
- Response rates increased over time, reaching around 86% by week 36, and while suicidal ideation decreased during treatment, it was less reduced with fluoxetine alone compared to the other therapies, and suicidal events were more common in the fluoxetine group.
- The study was a randomized controlled trial involving 327 adolescents, with assessments indicating that combination therapy yielded the best outcomes, and safety concerns such as suicidal events were monitored, highlighting the importance of careful treatment choice in this population.]
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Most liked on X and Bluesky@RingingUniverse @jibantik00 @wakeupsleeples @TPV_John Is your statement backed by facts or just your opinion? https://t.co/T3vXVoHy5L
@ChrisWhite_1972 @TPV_John Didn't have to do to much before antidepressants, depression cured itself in the form of suicide. You seriously need an explanation as to how antidepressants save lives? Here's probably the most important study on that issue. https://t.co/T3vXVoHy5L
@_demetrius_3 @failninjaninja @SWENGTIM @proetrie https://t.co/N8I6OYa3nu this is for anxiety disorders, https://t.co/IxC6jiSZsi this is for depression. both studies show its highly effective, there are hundreds more. took me ~1 min of googling.
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Evaluating the Long-Term Efficacy and Safety of Antidepressants for Adolescents
It makes me wonder as a child psychiatrist if antidepressants are even effective for teenagers. The TADS study examined long-term outcomes of fluoxetine, CBT, and their combination, showing all treatments helped improve…
Evaluating the Long-Term Effectiveness of Antidepressant Treatments for Adolescents
The TADS study examined the long-term effectiveness and safety of fluoxetine, cognitive behavioral therapy (CBT), and their combination in treating adolescents with major depressive disorder over 36 weeks, showing that…
@haterdiaries @rawr_meowlol @butleriano https://t.co/pHo0sXLejT Suicidal events were more common in patients receiving fluoxetine therapy (14.7%) than combination therapy (8.4%) or CBT (6.3%).
@RingingUniverse @jibantik00 @wakeupsleeples @TPV_John Is your statement backed by facts or just your opinion? https://t.co/T3vXVoHy5L
@ChrisWhite_1972 @TPV_John Didn't have to do to much before antidepressants, depression cured itself in the form of suicide. You seriously need an explanation as to how antidepressants save lives? Here's probably the most important study on that issue. https://t.co/T3vXVoHy5L
@_demetrius_3 @failninjaninja @SWENGTIM @proetrie https://t.co/N8I6OYa3nu this is for anxiety disorders, https://t.co/IxC6jiSZsi this is for depression. both studies show its highly effective, there are hundreds more. took me ~1 min of googling.
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