Proc Natl Acad Sci U S A December 2007 PMID 18024590

Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation.

P Shaw, K Eckstrand, W Sharp, J Blumenthal, J P Lerch, D Greenstein, L Clasen, A Evans, J Giedd, J L Rapoport

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87
Peak: 11 in May 2025
across 5 sources since Mar 2019

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AI synopsis

What people are saying

The social discussions revolve around detailed references to MRI-based research showing delayed cortical maturation in children with ADHD, with participants using technical language and sharing insights into how these findings could alter understanding and intervention. Their tone reflects both curiosity and recognition of the research's importance, contributing to a highly engaged and impactful overall perception.

AgreementStrong agreement

Most discussions affirm the study’s conclusion that ADHD involves delays in cortical development, demonstrating strong consensus among participants.

InterestHigh interest

The discussions showcase a high level of curiosity and engagement with the research, citing detailed findings and implications.

EngagementHigh engagement

Participants actively reference specific studies, MRI techniques, and neuroanatomical details, indicating deep interest and thoughtful analysis.

ImpactHigh impact

The conversations highlight the significance of the research, with some contemplating how these findings might influence future diagnosis and treatment approaches.

Abstract in brief

  • The study investigates whether ADHD is caused by a delay in brain development or a different developmental path by analyzing cortical maturation in children with the disorder.
  • Using MRI scans and advanced techniques, researchers found that children with ADHD experience a significant delay in reaching peak cortical thickness across most of the brain, especially in regions linked to attention and motor control.
  • The findings suggest that rather than a completely different development pattern, ADHD involves a delayed maturation process that could impact cognitive and behavioral functions, particularly in prefrontal brain areas.

Top posts

Most liked on X and Bluesky
Nicholas Fabiano, MD
@NTFabiano · X

These findings are from a study in @PNASNews which estimated cortical thickness at >40,000 cerebral points from 824 magnetic resonance scans acquired prospectively on 223 children with ADHD and 223 typically developing controls. https://t.co/K5PW97CMKC 2/9 https://t.co/ukWswZ1fsn

Feb 26, 2025 · 106 likes · 6 shares · 124,987 followers View post →
てんねんDr.「子どもの発達障害がよくわかる本」発売中
@adhdsavetheplan · X

https://t.co/e3qZAdfKqQ

Nov 30, 2024 · 105 likes · 11 shares · 74,486 followers View post →
てんねんDr.「子どもの発達障害がよくわかる本」発売中
@adhdsavetheplan · X

@noaiko_nolife はい(アブストだけですが) https://t.co/e3qZAdfKqQ

Nov 30, 2024 · 61 likes · 4 shares · 74,486 followers View post →
Sumi
@vuSbl8As0klvJhP · X

ソースはこちら https://t.co/RpuOiVT1K7

Jul 13, 2024 · 44 likes · 5 shares · 771 followers View post →
足立匡基 (ADACHI Masaki)
@adachi_psy · X

ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans, J. Giedd, & J.L. Rapoport, Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation, Proc. Natl.

May 19, 2025 · 43 likes · 11 shares · 5,107 followers View post →
勉強会のマイ|心理学で起業|子どもの自死と向き合う
@maimai4611 · X

参考にした資料: Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J. P., Greenstein, D., ... & Rapoport, J. L. (2007).Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Sciences, 104(49),

Jun 9, 2025 · 5 likes · 3,875 followers View post →

All mentions

萍
@1AvJQgGTqN39792 · X

https://t.co/Bs0KmndcQb

Nov 16, 2025 · 1 like · 6 followers View post →
勉強会のマイ|心理学で起業|子どもの自死と向き合う
@maimai4611 · X

参考にした資料: Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J. P., Greenstein, D., ... & Rapoport, J. L. (2007).Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Sciences, 104(49),

Jun 9, 2025 · 5 likes · 3,875 followers View post →
羽賀綾
@YQtY9Ogj3PLmLZN · X

RT @adachi_psy: ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans,…

May 21, 2025 · 11 shares · 280 followers View post →
発達障害のニュースと資料⭐️
@2030mirai · X

RT @adachi_psy: ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans,…

May 21, 2025 · 11 shares · 30,973 followers View post →
発達障害の豆知識(と工夫)
@miraijoho · X

RT @adachi_psy: ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans,…

May 21, 2025 · 11 shares · 29,823 followers View post →
みらいのリスト⭐️障害・福祉・備え⭐️「やさしい社会の基礎知識」
@mirailist · X

RT @adachi_psy: ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans,…

May 21, 2025 · 11 shares · 30,868 followers View post →
“Xaoc“横山沙紀(梟雄ルーツ大館鳥潟家)
@_turquoiseshop · X

RT @adachi_psy: ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans,…

May 21, 2025 · 11 shares · 346 followers View post →
高槻のヒト
@Starving_nomad · X

RT @adachi_psy: ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans,…

May 21, 2025 · 11 shares · 1,319 followers View post →
霞草
@AfiaVw · X

RT @adachi_psy: ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans,…

May 21, 2025 · 11 shares · 1,338 followers View post →
穏やかな日々
@R103ci1f2h16415 · X

RT @adachi_psy: ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans,…

May 20, 2025 · 11 shares · 661 followers View post →
こんどう みなこ【禁煙ばー縁~ENISHI~店主】
@kinenbarenishi · X

RT @adachi_psy: ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans,…

May 20, 2025 · 11 shares · 1,951 followers View post →
виробник коробок
@H_K_Y2022 · X

RT @adachi_psy: ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans,…

May 19, 2025 · 11 shares · 354 followers View post →
足立匡基 (ADACHI Masaki)
@adachi_psy · X

ADHDの脳の発達に関する引用情報をつけておきます。 P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J.P. Lerch, D. Greenstein, L. Clasen, A. Evans, J. Giedd, & J.L. Rapoport, Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation, Proc. Natl.

May 19, 2025 · 43 likes · 11 shares · 5,107 followers View post →
What’s next?
@two_30 · X

RT @NTFabiano: These findings are from a study in @PNASNews which estimated cortical thickness at >40,000 cerebral points from 824 magnetic…

Feb 27, 2025 · 6 shares · 719 followers View post →
Marcia S Newman
@marciasgreen · X

RT @NTFabiano: These findings are from a study in @PNASNews which estimated cortical thickness at >40,000 cerebral points from 824 magnetic…

Feb 27, 2025 · 6 shares · 4,949 followers View post →
Siwalee K.
@lee_kos · X

RT @NTFabiano: These findings are from a study in @PNASNews which estimated cortical thickness at >40,000 cerebral points from 824 magnetic…

Feb 27, 2025 · 6 shares · 5 followers View post →
Sophia Dahl
@sophiadahl1 · X

RT @NTFabiano: These findings are from a study in @PNASNews which estimated cortical thickness at >40,000 cerebral points from 824 magnetic…

Feb 27, 2025 · 6 shares · 84,197 followers View post →
あるく
@ayumu_tomaru · X

RT @NTFabiano: These findings are from a study in @PNASNews which estimated cortical thickness at >40,000 cerebral points from 824 magnetic…

Feb 26, 2025 · 6 shares · 298 followers View post →
∂≈∞ --- ∫∫∫∆∏∑∫∫∫ π⃜÷⃜×⃜•⃜|⃜¶⃜∆⃜$⃜%⃜|⃜+⃜
@liontarakos · X

RT @NTFabiano: These findings are from a study in @PNASNews which estimated cortical thickness at >40,000 cerebral points from 824 magnetic…

Feb 26, 2025 · 6 shares · 4,230 followers View post →
Nicholas Fabiano, MD
@NTFabiano · X

These findings are from a study in @PNASNews which estimated cortical thickness at >40,000 cerebral points from 824 magnetic resonance scans acquired prospectively on 223 children with ADHD and 223 typically developing controls. https://t.co/K5PW97CMKC 2/9 https://t.co/ukWswZ1fsn

Feb 26, 2025 · 106 likes · 6 shares · 124,987 followers View post →
Mari Oho
@mari_oho · X

RT @adhdsavetheplan: @noaiko_nolife はい(アブストだけですが) https://t.co/e3qZAdfKqQ

Feb 4, 2025 · 4 shares · 16 followers View post →
13番目のキリエ
@kyrie_13th · X

RT @adhdsavetheplan: https://t.co/e3qZAdfKqQ

Dec 9, 2024 · 11 shares · 109 followers View post →
UD教育社
@UD_Educations · X

https://t.co/IYbmF7QfNK ▲グラフの論文の原文です(元ツイの方があげてくださっていました

Dec 8, 2024 · 5 likes · 557 followers View post →
Takeshi Yamakado
@takeshiyamakado · X

【注意欠陥・多動性障害は皮質成熟の遅れを特徴とする】皮質点の50%が厚さのピークに達する年齢の中央値は0.5歳で、通常発達している対照群の平均年齢7.5歳よりも有意に遅いものでした。遅れは、注意や運動計画などの認知プロセスの制御に重要な前頭前野領域で最も顕著。 https://t.co/MDKBOBdGrG

Dec 2, 2024 · 625 followers View post →
hyvayt
@hyvayt · X

RT @adhdsavetheplan: @noaiko_nolife はい(アブストだけですが) https://t.co/e3qZAdfKqQ

Dec 1, 2024 · 4 shares · 21 followers View post →
nanasi
@nanasi43 · X

RT @adhdsavetheplan: https://t.co/e3qZAdfKqQ

Dec 1, 2024 · 11 shares · 495 followers View post →
yuto@ITLIFE
@creep22245 · X

https://t.co/0qfiOZcDWN

Dec 1, 2024 · 419 followers View post →
Kasshii_Political
@Kasshii_Politic · X

RT @adhdsavetheplan: https://t.co/e3qZAdfKqQ

Dec 1, 2024 · 11 shares · 146 followers View post →
oc11kai
@oc11kai · X

RT @adhdsavetheplan: https://t.co/e3qZAdfKqQ

Dec 1, 2024 · 11 shares · 355 followers View post →
かしこ。
@EboshiNo · X

RT @adhdsavetheplan: https://t.co/e3qZAdfKqQ

Nov 30, 2024 · 11 shares · 508 followers View post →
さくら
@sakuranokaori19 · X

RT @adhdsavetheplan: https://t.co/e3qZAdfKqQ

Nov 30, 2024 · 11 shares · 463 followers View post →
Shogo Ishimaru
@i_shogo03 · X

RT @adhdsavetheplan: https://t.co/e3qZAdfKqQ

Nov 30, 2024 · 11 shares · 346 followers View post →
なつ
@junomasu · X

RT @adhdsavetheplan: https://t.co/e3qZAdfKqQ

Nov 30, 2024 · 11 shares · 136 followers View post →
キョンシー
@MummydeKansutoK · X

RT @adhdsavetheplan: https://t.co/e3qZAdfKqQ

Nov 30, 2024 · 11 shares · 605 followers View post →
モん。
@1LdV17J3Nm1Y3wj · X

RT @adhdsavetheplan: @noaiko_nolife はい(アブストだけですが) https://t.co/e3qZAdfKqQ

Nov 30, 2024 · 4 shares · 222 followers View post →
てんねんDr.「子どもの発達障害がよくわかる本」発売中
@adhdsavetheplan · X

https://t.co/e3qZAdfKqQ

Nov 30, 2024 · 105 likes · 11 shares · 74,486 followers View post →
てんねんDr.「子どもの発達障害がよくわかる本」発売中
@adhdsavetheplan · X

@noaiko_nolife はい(アブストだけですが) https://t.co/e3qZAdfKqQ

Nov 30, 2024 · 61 likes · 4 shares · 74,486 followers View post →
Fathima Gani R
@fgrsmiles · X

Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation | PNAS https://t.co/SqohliliVV

Aug 11, 2024 · 100 followers View post →
くろこ。
@zoeetrose · X

RT @vuSbl8As0klvJhP: ソースはこちら https://t.co/RpuOiVT1K7

Jul 18, 2024 · 5 shares · 741 followers View post →
hey!rim!
@rim_clo · X

RT @vuSbl8As0klvJhP: ソースはこちら https://t.co/RpuOiVT1K7

Jul 14, 2024 · 5 shares · 74 followers View post →
K助
@K_tekito_2 · X

RT @vuSbl8As0klvJhP: ソースはこちら https://t.co/RpuOiVT1K7

Jul 14, 2024 · 5 shares · 789 followers View post →
降燕雪兎
@kdrtbmykt · X

RT @vuSbl8As0klvJhP: ソースはこちら https://t.co/RpuOiVT1K7

Jul 13, 2024 · 5 shares · 854 followers View post →
ゆーりひめ
@he8UN3yoo7rneX9 · X

RT @vuSbl8As0klvJhP: ソースはこちら https://t.co/RpuOiVT1K7

Jul 13, 2024 · 5 shares · 528 followers View post →
Sumi
@vuSbl8As0klvJhP · X

ソースはこちら https://t.co/RpuOiVT1K7

Jul 13, 2024 · 44 likes · 5 shares · 771 followers View post →
ooe
@ooe52208169 · X

「性自認が異性(性自認が体とズレている)」ことは証明できなくても、「大脳の発達具合が同年代の定型発達者とズレている」ことなら、医学的に証明できそうなきがする。 https://t.co/qDGGOfFk4s

Feb 9, 2024 · 4 likes · 560 followers View post →
はちたま どんぐり
@8tama_donguri · X

ADHDの前頭葉の発達は、定型発達より遅延するが同じカーブで発達するので後から追いつく、という論文 あと伸びするって信じることの影響大きいです From the Cover: Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation - PMC https://t.co/xnAgFMLP3H

Nov 28, 2023 · 2 likes · 406 followers View post →
P
@blaccpikasso · X

Actually read an article apparently adhd correlates to an earlier development of motor skills so while I won’t be making sound decisions til 35 I was able to move better as a kid … what a GREAT trade off

Nov 21, 2023 · 827 followers View post →
Matthew
@Roland00Address · X

@BenKuchera work together as a team. b) we also did in 2007 a longitudial ADHD study, studying neuroantomy of ADHD kids compared to controls, most of the frontal lobe is 1 to 2 years delayed in ADHD, but there is one area which develops faster in adhd children. https://t.co/9c1fmekIFp https://t.co/ySOEbzyStJ

May 23, 2023 · 845 followers View post →
Matthew
@Roland00Address · X

@brendonowicz @gordonneuro 15 year old research below, research we should rethink with new light from, for it implicates SCAN, and other networks that connect to SCAN. (pediatric ADHD, but this logic applies to everything with executive function, and the mind-body integration) https://t.co/0XSMmj2wef https://t.co/qdyCmBlP3b

May 15, 2023 · 1 like · 845 followers View post →
I Dissent
@DissentFu · X

@nassirghaemi 10.1073/pnas.0707741104 This study used MRI scans to compare brain development in children with ADHD to typically developing children. The study found that children with ADHD had a delay in cortical maturation in several brain regions, which could contribute to the cognitive and

Mar 4, 2023 · 2 likes · 4,578 followers View post →
I Dissent
@DissentFu · X

@nassirghaemi Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J. P., Greenstein, D., ... & Rapoport, J. L. (2007). Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Sciences, 104(49), 19649-19654. doi:

Mar 4, 2023 · 4 likes · 4,578 followers View post →
I Dissent
@DissentFu · X

@MarkLRuffalo 10.1073/pnas.0707741104

Mar 4, 2023 · 4,578 followers View post →
I Dissent
@DissentFu · X

@MarkLRuffalo Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J. P., Greenstein, D., ... & Rapoport, J. L. (2007). Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Sciences, 104(49), 19649-19654. doi:

Mar 4, 2023 · 4,578 followers View post →
しろクマー
@sirokumah · X

RT @dc1394: @kanakasansakura @mirai4510 横から失礼します。こちらが原著論文のようです。 https://t.co/TZvIdYXrNr

Oct 17, 2022 · 1 share · 1,257 followers View post →
dc1394
@dc1394 · X

@kanakasansakura @mirai4510 横から失礼します。こちらが原著論文のようです。 https://t.co/TZvIdYXrNr

Oct 16, 2022 · 3 likes · 1 share · 4,964 followers View post →
Psic24h© Consultório particular
@Psic24h · X

Shaw P, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. PNAS. 2007; 104: 19649-654.

May 23, 2021 · 23 followers View post →
[{MAVERICK}]
@Moileon2019 · X

Shaw P, Eckstrand K, Sharp W, Blumenthal J, Lerch JP, Greenstein D, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci U S A. 2007; 104: 19649-54. https://t.co/5SIFppspxK https://t.co/Y3L15RUJwK

Mar 31, 2019 · 94 followers View post →