Hum Genet March 2008 PMID 18172690

Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression.

Hans Eiberg, Jesper Troelsen, Mette Nielsen, Annemette Mikkelsen, Jonas Mengel-From, Klaus W Kjaer, Lars Hansen

Mentions

270
Peak: 12 in Feb 2020
across 6 sources since May 2019

Extended reach

1,453,524
potential audience

Total likes

14,552

Video views

733,703

Mentions per month

May 2019 – Oct 2025

Where it's discussed

  • X / Twitter105 posts
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  • Facebook33 posts
  • Blogs26 articles
  • YouTube7 videos
  • Reddit3 posts

AI synopsis

What people are saying

The discussions highlight a variety of thoughts, including an exploration of genetic ancestry with comments like, 'All people with blue eyes inherited the gene from a single person ~10k years ago.' Other users question the connection to inbreeding or royal ancestry, pointing out, 'They have one common ancestor.' This illustrates a mix of skepticism and curiosity regarding genetic implications, contributing to a varied sentiment where some use inquisitive and analytical language, while others adopt a more casual tone.

AgreementNeither agree nor disagree

Discussions reflect mixed feelings about the conclusions, with some users questioning the implications and validity of the findings.

InterestModerate interest

While there is some curiosity about the topic, it varies significantly, with certain posts showing more interest than others.

EngagementNeutral engagement

The depth of engagement appears moderate; some users make references to genetic implications while many others express casual commentary.

ImpactModerate impact

Many users express a belief that the findings could have noteworthy implications, though that belief is not universally held.

Abstract in brief

  • Blue eye color in humans is mainly linked to a mutation in a regulatory element of the HERC2 gene that inhibits the expression of the OCA2 gene, which is key to eye color variation.
  • Through studying a large Danish family, researchers identified specific SNPs (rs12913832 and rs1129038) that are associated with blue and brown eyes, with rs12913832 being crucial as it significantly reduces the activity of the OCA2 promoter.
  • A common haplotype was found in blue-eyed individuals across different regions, suggesting this mutation originated from a single ancestor, also hinting at a candidate gene (RABGGTA) potentially related to hair color.

Top posts

Most liked on X and Bluesky
Rock Mada
@RackMada · X

שנים באזור המדינות הסקנדינביות, זו עוד דוגמא למוטציה גנטית, שנגרמת מערבוב בגנים שלנו, שלא משפיעה לגמרי על השרידות שלנו, אבל מעניינת להבנה. למאמר המלא: https://t.co/W6Rjimh23z https://t.co/M5HW2CxZCW

Dec 23, 2019 · 49 likes · 36,517 followers View post →
Le Contemplateur
@LeContempIateur · X

Sources : https://t.co/HuI79ZgZAr & https://t.co/1LL07fL92x

Jun 8, 2025 · 13 likes · 1 share · 103,724 followers View post →
Viajantestoria2
@Viajantestoria2 · X

Olhos azuis em humanos: https://t.co/eNAtPngwzG Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans: https://t.co/Npxt5axrEk Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans: https://t.co/eDJtUEnYcq

Jan 18, 2025 · 2 likes · 6,633 followers View post →
Dr. Alexandra A. de Sousa
@AleAliSousa · X

@DrGBuckingham I think we should divide these responses up into Tinbergen's 4 questions https://t.co/jEGWTeidYm HT @AMCELL for this paper https://t.co/5DdzRuq5RY

Apr 26, 2022 · 2 likes · 488 followers View post →
Frankp
@CogitoErgoWtf · X

@RickWrightNow This is the reference, and, in that context, I don't know that anyone has refuted it. https://t.co/u29cLCSOWW

Aug 2, 2021 · 1 like · 1 share · 9,058 followers View post →
Cure Cancer Now
@CancerCureNow · X

MT/RT @Vilavaite When did they come into existence? https://t.co/sTJJ8F6jyF • blue eyes https://t.co/34QF4cjhyx https://t.co/ciUR4WYH36

Oct 20, 2019 · 1 like · 6,923 followers View post →

All mentions

The Genetic Basis of Blue Eye Color in Humans

This video explores the genetic factors behind blue eye color in humans, primarily focusing on a mutation in the HERC2 gene that inhibits OCA2 expression. Through research on a large Danish family, key SNPs associated…

Martina Mencucci · Apr 24, 2025 1,829 views
val
@tvsatellitee · X

@v4mpirebutch im pretty sure incest since u asked https://t.co/AuTCBV4Jd0

Oct 7, 2025 · 1 like · 1,626 followers View post →
Le Contemplateur
@LeContempIateur · X

Sources : https://t.co/HuI79ZgZAr & https://t.co/1LL07fL92x

Jun 8, 2025 · 13 likes · 1 share · 103,724 followers View post →
ScienceQriosity
@ScienceQriosity · X

@DanJRossOne @PaulWolfpackFan @JoshBradeen @a__philosopher https://t.co/eOA7e6lVIH

May 15, 2025 · 1 like · 1,077 followers View post →
Shaniece
@itsjustNiecy__ · X

@grhoopchat @TrendKulture @tariqnasheed No it does not. They have one common ancestor. And inbreeding has happened throughout human history especially in royal families. Do you even know what the true effects of inbreeding are? Because it definitely has nothing to do with eye color. https://t.co/Nnkhe5GqZQ https://t.co/VIyp4cJAcM

Feb 20, 2025 · 1 like · 1,531 followers View post →
Viajantestoria2
@Viajantestoria2 · X

Olhos azuis em humanos: https://t.co/eNAtPngwzG Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans: https://t.co/Npxt5axrEk Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans: https://t.co/eDJtUEnYcq

Jan 18, 2025 · 2 likes · 6,633 followers View post →
Leslie Douglas
@lesliedouglasx · X

@firecamber @BrahminReich @captivedreamer7 The article I plucked the first image from was written by an Indian, by the way. https://t.co/ccFA4KkzV8 https://t.co/vOR0BWySZZ

Jan 3, 2025 · 1 like · 2,069 followers View post →
José Pinto ✝️ Cristão Novo
@2dedostesta5 · X

Blue eye colour came first in Europe, with the transition to lighter skin ongoing through Mesolithic times. https://t.co/SCFPcALfXw https://t.co/OpVUtrecCt https://t.co/5b2q3Sae9N https://t.co/spGiqKE2CR https://t.co/0e3E2TIRNV

Jul 2, 2024 · 16 followers View post →
José Pinto ✝️ Cristão Novo
@2dedostesta5 · X

@BronskiJoseph https://t.co/spGiqKEAsp

Jul 2, 2024 · 16 followers View post →
Dr F Tétard Matr 1620 @nacrespirale.cpesr.fr
@NACREspirale · X

Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression https://t.co/BEgUnZKXa7

Jun 9, 2024 · 2,972 followers View post →
Chat de Nuit d'Ange Heureux
@ChatGrisBleu · X

Plus rare que chez les chats ...lol https://t.co/EYx3CP1x7C

Jun 8, 2024 · 391 followers View post →
・゚
@XxXbeladonaXxX · X

https://t.co/rv8xO5fHTQ https://t.co/M8XK7nBA4D

Feb 28, 2024 · 1 like · 326 followers View post →
Keith Robison
@OmicsOmicsBlog · X

@bioinformer Blue eye allele https://t.co/MrrY4NrI5s

Nov 30, 2023 · 10,005 followers View post →
Frank Rizzo
@FrankRi68868220 · X

@IbnNacer @Aya58640362 @jadeabove @Kyla_Lacey "Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression" https://t.co/kDZPWmHN4O

Nov 9, 2023 · 234 followers View post →
ᚺᛖᚱᛖᛏᛁᚲᚨᛚ ᚺᛖᚨᚦᛖᚾ
@Meirleachcrodh · X

This paper is the only thing backing the argument against me to my knowledge. Does this paper even consider archaic species? Is this definitive? https://t.co/xi2VYFUJTA

Nov 8, 2023 · 35 followers View post →
WinstonHammer
@WinstonHammer · X

@Meirleachcrodh @nrken19 All people with blue eyes inherited the gene from a single person ~10k years ago, it's the same location on the chromosome . The only other cause of blue eyes is ocular albinism... https://t.co/QqjB4c8Lkb

Nov 8, 2023 · 139 followers View post →
A Betrayed Maroon
@MBEmpower · X

@HardFacts555 @GEN80 @Acaydiya @TalbertSwan Comprehension really whoops your ass on a daily basis doesn't it.

Sep 26, 2023 · 1 like · 1,547 followers View post →
Dr.M.A.A.O.W.
@Marieaaow · X

@BobWhee30941193 @NatalkaKyiv Shows low level education.

Aug 13, 2023 · 14,484 followers View post →
kintasei
@htgnd · X

@nomad_976 https://t.co/OyOF88haFy

Jun 11, 2023 · 1,159 followers View post →
XDB
@XaverDB · X

@RichieCharger @TwitteFunnyMan @historyinmemes https://t.co/8TPrbliXIa With that mutation we might even be able to gage where that mutation started. What I’m saying is this isn’t just a one off discovery. This “theory” is based off of a multitude of other studies,research &observations

May 31, 2023 · 1,173 followers View post →
TaNaisha NOT MILD Lee Garrett
@TaNaishaJ · X

2/2 Source link: https://t.co/Xs5dxzcffr

Apr 13, 2023 · 2,604 followers View post →
von Gneisenau
@von_Gneisenau · X

@mtissian @AnnaVu123123 @OCanonist The gene for blue eyes appeared around 6000-10000 years ago, likely in the region around the Black Sea. https://t.co/q4nRxrRXrF

Feb 19, 2023 · 1,200 followers View post →
Cloaker
@pb_cloaker · X

@adam_bomb88 @NxtDeterio https://t.co/8Lk2K4L9OW

Feb 17, 2023 · 15 followers View post →
Vinceval
@stoicttg · X

@_maltahel_ @saneryurtsever @onderseren Ben de Kopenhag Universitesin de böyle bir araştırma yapıldığını okumuştum tekrar baktım şimdi. Bu orjinali ama ücretsiz yayımlanan link bulamadım. https://t.co/fMU87rQnNK Bu da Türkçe dilinde haber makalesi https://t.co/iAEWM1KFyu

Jul 7, 2022 · 44 followers View post →
CRCpaleos
@CRCpaleos · X

ARTÍCULO ORIGINAL (resumen) Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression https://t.co/ao10cZDSxe vía #HumanGenetics

May 3, 2022 · 3,139 followers View post →
Dr. Alexandra A. de Sousa
@AleAliSousa · X

@DrGBuckingham I think we should divide these responses up into Tinbergen's 4 questions https://t.co/jEGWTeidYm HT @AMCELL for this paper https://t.co/5DdzRuq5RY

Apr 26, 2022 · 2 likes · 488 followers View post →
blueblood414
@blueblood414 · X

Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression

Jan 7, 2022 · 1,408 followers View post →
Rick Wright USN Ret.
@RickWrightNow · X

RT @CogitoErgoWtf: @RickWrightNow This is the reference, and, in that context, I don't know that anyone has refuted it. https://t.co/u29cL…

Aug 2, 2021 · 1 share · 9,178 followers View post →
Frankp
@CogitoErgoWtf · X

@RickWrightNow This is the reference, and, in that context, I don't know that anyone has refuted it. https://t.co/u29cLCSOWW

Aug 2, 2021 · 1 like · 1 share · 9,058 followers View post →
Vertefeuille
@MMERSJJ · X

Européens seraient roux! Merci d'avoir lu.

Apr 22, 2021 · 504 followers View post →
James V. Kohl
@microRNApro · X

https://t.co/yC5kVrdOgh Two SNPs were perfectly associated with blue and brown eye colors (and hair color) during the past 6,000 years of food energy-dependent pheromone-regulated genetic processes that biophysically constrain viral latency in species from microbes to humans. /1

Dec 22, 2020 · 2,571 followers View post →
Stefanie Müller
@schwarzeacht · X

@Kratesch @Hazard171 Wir sind alle verwandt, wir sind eine Spezies. Aber die Aussage bezog sich wohl auf diese Publikation. https://t.co/T5wxw7xA9L

Sep 16, 2020 · 1 like · 406 followers View post →
فارس
@_Fariis · X

@7allo Reference: https://t.co/b5yeuQBZdR

Aug 19, 2020 · 5,072 followers View post →
Cure Cancer Now
@CancerCureNow · X

MT/RT @Vilavaite When did they come into existence? https://t.co/sTJJ8F6jyF • blue eyes https://t.co/34QF4cjhyx https://t.co/8zpDuhozQX

Mar 8, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

MT/RT @Vilavaite When did they come into existence? https://t.co/sTJJ8F6jyF • blue eyes https://t.co/34QF4cjhyx https://t.co/pnuB3z5V8H

Mar 6, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Feb 29, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Feb 26, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Feb 19, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Feb 18, 2020 · 6,923 followers View post →
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Feb 14, 2020 · 6,923 followers View post →
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Feb 12, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Feb 10, 2020 · 1 like · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Feb 9, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Feb 7, 2020 · 6,923 followers View post →
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Feb 5, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Feb 4, 2020 · 6,923 followers View post →
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Feb 2, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Jan 28, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Jan 18, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Jan 5, 2020 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Dec 27, 2019 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Dec 23, 2019 · 6,923 followers View post →
Rock Mada
@RackMada · X

שנים באזור המדינות הסקנדינביות, זו עוד דוגמא למוטציה גנטית, שנגרמת מערבוב בגנים שלנו, שלא משפיעה לגמרי על השרידות שלנו, אבל מעניינת להבנה. למאמר המלא: https://t.co/W6Rjimh23z https://t.co/M5HW2CxZCW

Dec 23, 2019 · 49 likes · 36,517 followers View post →
Cure Cancer Now
@CancerCureNow · X

MT/RT @Vilavaite When did they come into existence? https://t.co/sTJJ8FnUqd • blue eyes https://t.co/34QF4cASq5 https://t.co/iWmYBT1dSC

Dec 20, 2019 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Dec 16, 2019 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Dec 14, 2019 · 6,923 followers View post →
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Dec 12, 2019 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Dec 7, 2019 · 6,923 followers View post →
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@CancerCureNow · X

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Dec 3, 2019 · 6,923 followers View post →
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Nov 29, 2019 · 6,923 followers View post →
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Nov 24, 2019 · 6,923 followers View post →
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Nov 23, 2019 · 6,923 followers View post →
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Nov 20, 2019 · 6,923 followers View post →
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Nov 18, 2019 · 6,923 followers View post →
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@CancerCureNow · X

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Nov 15, 2019 · 6,923 followers View post →
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Nov 13, 2019 · 6,923 followers View post →
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Nov 11, 2019 · 6,923 followers View post →
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Nov 9, 2019 · 6,923 followers View post →
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@CancerCureNow · X

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Nov 7, 2019 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Nov 3, 2019 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Oct 31, 2019 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Oct 28, 2019 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Oct 21, 2019 · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Oct 20, 2019 · 1 like · 6,923 followers View post →
Cure Cancer Now
@CancerCureNow · X

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Oct 14, 2019 · 6,923 followers View post →
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Oct 5, 2019 · 6,923 followers View post →
Cure Cancer Now
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