Earlier study described by Zakhem et al: Amory JK, et al. The effect of 5alpha-reductase inhibition with dutasteride and finasteride... J Urol. 2008. https://t.co/Q8ViwVKkFP [⚠️ Funded by GSK, developer of Avodart/dutasteride]
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men.
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Jun 2021 – Aug 2025Where it's discussed
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X / Twitter2 posts
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YouTube2 videos
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What people are saying
Discussions highlight participants' focus on the implications of the study, exemplified by mentions of prior research by Zakhem and Amory et al., with tone ranging from cautious curiosity to critical consideration. The use of words like 'plummeted' and references to funding sources underscore a mix of concern and skepticism about drug safety and influence. Overall, the collective tone reflects active engagement with the study’s clinical significance and potential influence on medical practice.
Most discussions acknowledge the findings that 5-alpha-reductase inhibitors have minimal long-term effects on health markers, with some skepticism about the small temporary changes mentioned.
Posts demonstrate high interest, referencing prior studies and personal concerns about drug effects, indicating engagement with the topic’s clinical relevance.
Conversations show moderate engagement by citing specific research details, such as sperm count changes and the influence of funding sources, reflecting thoughtful consideration.
Comments suggest the research could influence medical decisions and regulatory perspectives, though some discussions focus on individual implications rather than broader societal impact.
Abstract in brief
- The study found that treatment with 5-alpha-reductase inhibitors (dutasteride and finasteride) significantly lowers dihydrotestosterone levels but does not negatively affect bone density, bone metabolism markers, serum lipoproteins, or hemoglobin in healthy young men.
- While both drugs caused slight, temporary decreases in prostate-specific antigen levels and sexual function, these effects were reversible after discontinuing the medication, indicating minimal long-term impact.
- Overall, lowering dihydrotestosterone with these drugs does not seem to have significant clinical effects on bone health, blood components, or lipid profiles in healthy men.]
Top posts
Most liked on X and BlueskyAmory et al., 2007: While on finasteride, one participant's sperm count plummeted to less than 10% of pre-finasteride baseline. At 24 weeks *after stopping* finasteride, his sperm count was at 18% of pre-finasteride baseline. Paper: https://t.co/qJwZI2NaLF 5/n https://t.co/9FRmrpC9FY
All mentions
Impact of Finasteride on Bone, Muscle, and Prostate Health in Men
This study examines whether finasteride affects muscle strength, bone density, and prostate size when combined with testosterone in older men. Results indicate it does not hinder muscle or bone benefits but prevents…
Assessing Sexual Side Effects of Hair Loss Treatments with 5ARIs
Treatment with 5-reductase inhibitors like finasteride and dutasteride significantly increases the risk of sexual side effects, including decreased desire and erectile dysfunction. Consider these risks when evaluating…
Earlier study described by Zakhem et al: Amory JK, et al. The effect of 5alpha-reductase inhibition with dutasteride and finasteride... J Urol. 2008. https://t.co/Q8ViwVKkFP [⚠️ Funded by GSK, developer of Avodart/dutasteride]
Amory et al., 2007: While on finasteride, one participant's sperm count plummeted to less than 10% of pre-finasteride baseline. At 24 weeks *after stopping* finasteride, his sperm count was at 18% of pre-finasteride baseline. Paper: https://t.co/qJwZI2NaLF 5/n https://t.co/9FRmrpC9FY
FW