J Urol June 2008 PMID 18423697

The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men.

John K Amory, Bradley D Anawalt, Alvin M Matsumoto, Stephanie T Page, William J Bremner, Christina Wang, Ronald S Swerdloff, Richard V Clark

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Mentions

4
Peak: 1 in Jun 2021
across 2 sources since Jun 2021

Extended reach

12,819
potential audience

Total likes

383

Video views

11,184

Mentions per month

Jun 2021 – Aug 2025

Where it's discussed

  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions highlight participants' focus on the implications of the study, exemplified by mentions of prior research by Zakhem and Amory et al., with tone ranging from cautious curiosity to critical consideration. The use of words like 'plummeted' and references to funding sources underscore a mix of concern and skepticism about drug safety and influence. Overall, the collective tone reflects active engagement with the study’s clinical significance and potential influence on medical practice.

AgreementModerate agreement

Most discussions acknowledge the findings that 5-alpha-reductase inhibitors have minimal long-term effects on health markers, with some skepticism about the small temporary changes mentioned.

InterestHigh interest

Posts demonstrate high interest, referencing prior studies and personal concerns about drug effects, indicating engagement with the topic’s clinical relevance.

EngagementModerate engagement

Conversations show moderate engagement by citing specific research details, such as sperm count changes and the influence of funding sources, reflecting thoughtful consideration.

ImpactModerate impact

Comments suggest the research could influence medical decisions and regulatory perspectives, though some discussions focus on individual implications rather than broader societal impact.

Abstract in brief

  • The study found that treatment with 5-alpha-reductase inhibitors (dutasteride and finasteride) significantly lowers dihydrotestosterone levels but does not negatively affect bone density, bone metabolism markers, serum lipoproteins, or hemoglobin in healthy young men.
  • While both drugs caused slight, temporary decreases in prostate-specific antigen levels and sexual function, these effects were reversible after discontinuing the medication, indicating minimal long-term impact.
  • Overall, lowering dihydrotestosterone with these drugs does not seem to have significant clinical effects on bone health, blood components, or lipid profiles in healthy men.]

Top posts

Most liked on X and Bluesky
Finasteride Watch
@FinasterideInfo · X

Earlier study described by Zakhem et al: Amory JK, et al. The effect of 5alpha-reductase inhibition with dutasteride and finasteride... J Urol. 2008. https://t.co/Q8ViwVKkFP [⚠️ Funded by GSK, developer of Avodart/dutasteride]

Aug 20, 2022 · 2 likes · 818 followers View post →
Finasteride Watch
@FinasterideInfo · X

Amory et al., 2007: While on finasteride, one participant's sperm count plummeted to less than 10% of pre-finasteride baseline. At 24 weeks *after stopping* finasteride, his sperm count was at 18% of pre-finasteride baseline. Paper: https://t.co/qJwZI2NaLF 5/n https://t.co/9FRmrpC9FY

Jun 28, 2021 · 818 followers View post →

All mentions

Finasteride Watch
@FinasterideInfo · X

Earlier study described by Zakhem et al: Amory JK, et al. The effect of 5alpha-reductase inhibition with dutasteride and finasteride... J Urol. 2008. https://t.co/Q8ViwVKkFP [⚠️ Funded by GSK, developer of Avodart/dutasteride]

Aug 20, 2022 · 2 likes · 818 followers View post →
Finasteride Watch
@FinasterideInfo · X

Amory et al., 2007: While on finasteride, one participant's sperm count plummeted to less than 10% of pre-finasteride baseline. At 24 weeks *after stopping* finasteride, his sperm count was at 18% of pre-finasteride baseline. Paper: https://t.co/qJwZI2NaLF 5/n https://t.co/9FRmrpC9FY

Jun 28, 2021 · 818 followers View post →