Gastroenterology July 2008 PMID 18485912

Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3.

Karen M Lammers, Ruliang Lu, Julie Brownley, Bao Lu, Craig Gerard, Karen Thomas, Prasad Rallabhandi, Terez Shea-Donohue, Amir Tamiz, Sefik Alkan, Sarah Netzel-Arnett, Toni Antalis, Stefanie N Vogel, Alessio Fasano

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Mentions

29
Peak: 2 in Sep 2019
across 6 sources since Sep 2019

Extended reach

10,572
potential audience

Total likes

192

Video views

4,446

Mentions per month

Sep 2019 – Sep 2025

Where it's discussed

  • Facebook9 posts
  • X / Twitter7 posts
  • Blogs6 articles
  • YouTube3 videos
  • Reddit2 posts
  • News2 articles

AI synopsis

What people are saying

The overall digital discussions show mixed reactions, with one user dismissing wheat as 'not food' and implying harmful effects, exemplified by words like 'highly addictive,' while others simply comment on the findings, using phrases like 'Wheat is not food' to highlight concerns. The tone varies from skeptical to inquisitive, reflecting curiosity but limited deep engagement with the science or its broader implications.

AgreementNeither agree nor disagree

Most discussions show neutral or mixed responses, with some users skeptical or dismissive about the health implications, reflecting a balanced or uncertain stance.

InterestModerate interest

The interest level is moderate, with some users sharing opinions or asking questions, but many posts largely reiterate the article's findings without deep analysis.

EngagementModerate engagement

Posts reflect personal reactions, comments on wheat's role, and brief mentions of related health issues, indicating some engagement but not deep scientific debate.

ImpactNeutral impact

The discussions suggest awareness but do not demonstrate widespread or profound influence on opinions or practices, indicating a moderate perceived impact.

Abstract in brief

  • Gliadin, a component of gluten, interacts with the chemokine receptor CXCR3 on intestinal cells, which increases intestinal permeability and triggers zonulin release, an early event in celiac disease development.
  • Experiments showed that gliadin binds directly to CXCR3, involving specific peptides, and this interaction activates a pathway involving MyD88, leading to increased zonulin and permeability; this effect is absent in mice lacking CXCR3.
  • In people with active celiac disease, the receptor CXCR3 is elevated, but its levels normalize with a gluten-free diet, indicating its role in disease progression and the importance of gliadin-CXCR3 interaction in intestinal barrier impairment.]

Top posts

Most liked on X and Bluesky
Globiance Live Chat & Support
@globiance_Desk · X

@BelindaFettke @FructoseNo @USDA @HHSGov @HouseAgDems @HouseAgGOP @SenateAgGOP @SenateAg @DrAseemMalhotra @DrPaulMason @FatEmperor @MaryanneDemasi @VinnieTortorich Belinda, let me add something here if you don't mind, "Wheat is not food"! Nothing that is highly addictive and causes gut permeability should be considered as food. THX. https://t.co/57JXyJeWKB https://t.co/lvc2iZvZJI https://t.co/JBcJXm476B #gliadin #zonulin https://t.co/OG6ATpYsRk

Jul 8, 2020 · 10 likes · 2,937 followers View post →
AKA_Sadrien
@AKA_Sadrien · X

@siobhan_huggins @MaoZhou https://t.co/ZDFxLAQKNq "Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3"

Sep 9, 2019 · 1 like · 1 share · 792 followers View post →
Beta Hydroxybutyrate Enjoyer
@BHBEnjoyer · X

@Tu_Quoque_4_U @CarnivoreAugust @UnModded_Human https://t.co/hv4FojtQbw "Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3"

Sep 26, 2024 · 1 like · 526 followers View post →
AKA_Sadrien
@AKA_Sadrien · X

RT @Sadrien_GW2: @siobhan_huggins @MaoZhou https://t.co/ZDFxLAQKNq "Gliadin Induces an Increase in Intestinal Permeability and Zonulin Rele…

Sep 9, 2019 · 1 share · 792 followers View post →
AKA_Sadrien
@AKA_Sadrien · X

@DrCraigH https://t.co/T9RBjc5Hwq … "Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3"

Nov 14, 2019 · 792 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3 https://t.co/sx4ZNQjjta

Nov 14, 2019 · 252 followers View post →

All mentions

Beta Hydroxybutyrate Enjoyer
@BHBEnjoyer · X

@Tu_Quoque_4_U @CarnivoreAugust @UnModded_Human https://t.co/hv4FojtQbw "Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3"

Sep 26, 2024 · 1 like · 526 followers View post →
Globiance Live Chat & Support
@globiance_Desk · X

@BelindaFettke @FructoseNo @USDA @HHSGov @HouseAgDems @HouseAgGOP @SenateAgGOP @SenateAg @DrAseemMalhotra @DrPaulMason @FatEmperor @MaryanneDemasi @VinnieTortorich Belinda, let me add something here if you don't mind, "Wheat is not food"! Nothing that is highly addictive and causes gut permeability should be considered as food. THX. https://t.co/57JXyJeWKB https://t.co/lvc2iZvZJI https://t.co/JBcJXm476B #gliadin #zonulin https://t.co/OG6ATpYsRk

Jul 8, 2020 · 10 likes · 2,937 followers View post →
Clear*Skin*Guru
@clear__skin · X

"Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3" https://t.co/PJvmfsicyl

Jun 23, 2020 · 32 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3 https://t.co/sx4ZNQjjta

Nov 14, 2019 · 252 followers View post →
AKA_Sadrien
@AKA_Sadrien · X

@DrCraigH https://t.co/T9RBjc5Hwq … "Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3"

Nov 14, 2019 · 792 followers View post →
AKA_Sadrien
@AKA_Sadrien · X

RT @Sadrien_GW2: @siobhan_huggins @MaoZhou https://t.co/ZDFxLAQKNq "Gliadin Induces an Increase in Intestinal Permeability and Zonulin Rele…

Sep 9, 2019 · 1 share · 792 followers View post →
AKA_Sadrien
@AKA_Sadrien · X

@siobhan_huggins @MaoZhou https://t.co/ZDFxLAQKNq "Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3"

Sep 9, 2019 · 1 like · 1 share · 792 followers View post →