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Discussions consistently highlight the stability of gluconeogenesis, with many posters quoting or summarizing the paper's findings, such as its resistance to perturbation even during fasting or high-protein intake. The tone ranges from agreement to curiosity, reflecting deep engagement and recognition of the research's significance.
Most discussions support the idea that gluconeogenesis remains relatively stable across various conditions, with several posts emphasizing this consistency.
The community shows high interest, with many engaging deeply by referencing specific studies and physiological mechanisms.
Posts analyze, debate, and reference multiple sources, indicating active and detailed engagement with the research.
The discussions influence understanding of metabolic processes and could inform dietary or medical approaches, suggesting moderate to high impact.
@AKoutnik @ProfTimNoakes @vermeulen_emiel @PhilipPrins11 I would completely agree. Also that most changes in hepatic glucose production are from changes in glycogenolysis rather than gluconeogenesis https://t.co/7krzK7TeaB
Pretty compelling review that the rate of GNG is generally hard to perturb. Even diabetic physiology and starvation hardly budge it. I'd guess extremely high protein intake also wouldn't do much. CC @KetoCarnivore https://t.co/jUhYGRPTqS https://t.co/iY6EWPq9Tg
@anti_wokeist According to this paper, following a fast of 40 hours lactate contributes 92% to GNG. Don't know how similar the situation would be for a ketogenic diet. https://t.co/lNc8nrc2sX
@BillOccham @MacroFour @raphaels7 @KevinH_PhD @HermanPontzer Yes. It should be noted that GNG will be happening at a similar rate even outside of fasted conditions. It's probably why extra glucose is available longer than might be expected from a naive analysis. https://t.co/jUhYGRPTqS
@EvolvingMSA @SBakerMD Worth reading. Will answer a lot of questions you seem to be speculating on. https://t.co/2lw9OROztP
@PurestVitality @thelowcarb_rd https://t.co/2lw9OROztP
This video explores how the body manages fuel during prolonged starvation, emphasizing the roles of insulin, free fatty acids, and ketone bodies like betahydroxybutyric acid. It highlights advances in measurement…
This video explores fuel metabolism during starvation, emphasizing the roles of insulin, free fatty acids, and betahydroxybutyric acid. It highlights recent advances in measurement techniques like indirect calorimetry…
@OneSeaElephant @SBakerMD But gluconeogenesis is a 24/7 thing https://t.co/imDgewyL0f
RT @Gonzalez_JT: @AKoutnik @ProfTimNoakes @vermeulen_emiel @PhilipPrins11 I would completely agree. Also that most changes in hepatic gluco…
RT @Gonzalez_JT: @AKoutnik @ProfTimNoakes @vermeulen_emiel @PhilipPrins11 I would completely agree. Also that most changes in hepatic gluco…
@AKoutnik @ProfTimNoakes @vermeulen_emiel @PhilipPrins11 I would completely agree. Also that most changes in hepatic glucose production are from changes in glycogenolysis rather than gluconeogenesis https://t.co/7krzK7TeaB
@joycloete @SBakerMD @KetoCarnivore "Current data support the hypothesis that the rate of glucose appearance changes but the rate of gluconeogenesis remains remarkably stable in widely varying metabolic conditions in people without diabetes" https://t.co/imDgewydaH
@rf121rf @BreezyEvergreen @CarnivoreAugust @richcollins Well you're wrong then as GNG happens even in the high carb context. https://t.co/lNc8nrc2sX
@anti_wokeist According to this paper, following a fast of 40 hours lactate contributes 92% to GNG. Don't know how similar the situation would be for a ketogenic diet. https://t.co/lNc8nrc2sX
@PurestVitality @thelowcarb_rd https://t.co/2lw9OROztP
@EvolvingMSA @SBakerMD Worth reading. Will answer a lot of questions you seem to be speculating on. https://t.co/2lw9OROztP
@upyrbike @LowCarbEP @MHS_tweeting It may not be exactly fixed but multiple studies I have read come out at a pretty similar value. https://t.co/h8yT0EMQj4
@BillOccham @MacroFour @raphaels7 @KevinH_PhD @HermanPontzer Yes. It should be noted that GNG will be happening at a similar rate even outside of fasted conditions. It's probably why extra glucose is available longer than might be expected from a naive analysis. https://t.co/jUhYGRPTqS
@MigraineBook @richcollins @nicknorwitz @HermanPontzer No. GNG is hard to perturb markedly, probably because the organism relies on a near-constant rate of glucose production to avoid deadly shortages. https://t.co/jUhYGRPTqS
Gluconeogenesis rate is hard to perturb significantly. https://t.co/jUhYGRPTqS
Pretty compelling review that the rate of GNG is generally hard to perturb. Even diabetic physiology and starvation hardly budge it. I'd guess extremely high protein intake also wouldn't do much. CC @KetoCarnivore https://t.co/jUhYGRPTqS https://t.co/iY6EWPq9Tg
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