November 2008 PMID 18703413

Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.

Alexandra Shapiro, Wei Mu, Carlos Roncal, Kit-Yan Cheng, Richard J Johnson, Philip J Scarpace

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Mentions

17
Peak: 4 in Dec 2023
across 6 sources since Jan 2014

Extended reach

183,952
potential audience

Total likes

66

Video views

1,494

Mentions per month

Jan 2014 – Sep 2025

Where it's discussed

  • News6 articles
  • X / Twitter4 posts
  • Facebook3 posts
  • YouTube2 videos
  • Instagram1 posts
  • Blogs1 articles

AI synopsis

What people are saying

Several discussions highlight the significance of the study's findings, such as comments about how

AgreementModerate agreement

Most discussions support the article’s findings on fructose and weight gain, with some recognizing the limitations of rat studies but noting the relevance to human health.

InterestHigh interest

The discussions show high interest, as many comments reference the metabolic mechanisms and implications for diet, indicating engagement with the topic.

EngagementModerate engagement

Posts include comments on experimental details and broader health impacts, reflecting moderate engagement without deep technical debate.

ImpactModerate impact

The conversations suggest the research could influence perspectives on diet and health, making it somewhat impactful but not yet transformative.

Abstract in brief

  • Chronic fructose intake causes leptin resistance in rats, which means their bodies don't respond properly to leptin, a hormone that helps regulate appetite and body weight.
  • When these fructose-fed rats are later switched to a high-fat diet, they gain significantly more weight compared to rats that didn't develop leptin resistance, suggesting that fructose makes it harder for the body to control weight during high-fat consumption.
  • The study shows that fructose-induced leptin resistance happens before increases in body fat or other metabolic issues, and it leads to faster and greater weight gain when exposed to high-fat foods.

Top posts

Most liked on X and Bluesky
Cynthia Thurlow, NP
@_CynthiaThurlow · X

Dec 13, 2023 · 2 likes · 56,126 followers View post →
Travis Smith, D.O. FAAEM
@RosenelliEM · X

Fructose-induced leptin resistance exacerbates weight gain. https://t.co/TQprAEuiCt

Dec 30, 2023 · 2 likes · 5,088 followers View post →
اخصائية تغذية علاجية / ديمه
@dem_2 · X

يلعب نمط حياتك ونظامك الغذائي دورًا رئيسيًا في تنظيم مستويات اللبتين ووزن جسمك. تناول الأطعمة المصنعة والسريعة والمشروبات المحلاة بالسكر والكثير من الفركتوز يمكن أن يؤدي إلى مقاومة اللبتين وبالتالي السمنة . https://t.co/ThrYe6qqpB

Jul 25, 2022 · 1 like · 65,009 followers View post →
Cynthia Thurlow, NP
@_CynthiaThurlow · X

Of course, this being a rat study gives some limitations but it's pretty obvious that the energy overload of a high fat/high carb diet is not ideal for human health.

Dec 12, 2023 · 1 like · 56,126 followers View post →

All mentions

Travis Smith, D.O. FAAEM
@RosenelliEM · X

Fructose-induced leptin resistance exacerbates weight gain. https://t.co/TQprAEuiCt

Dec 30, 2023 · 2 likes · 5,088 followers View post →
Cynthia Thurlow, NP
@_CynthiaThurlow · X

Dec 13, 2023 · 2 likes · 56,126 followers View post →
Cynthia Thurlow, NP
@_CynthiaThurlow · X

Of course, this being a rat study gives some limitations but it's pretty obvious that the energy overload of a high fat/high carb diet is not ideal for human health.

Dec 12, 2023 · 1 like · 56,126 followers View post →
اخصائية تغذية علاجية / ديمه
@dem_2 · X

يلعب نمط حياتك ونظامك الغذائي دورًا رئيسيًا في تنظيم مستويات اللبتين ووزن جسمك. تناول الأطعمة المصنعة والسريعة والمشروبات المحلاة بالسكر والكثير من الفركتوز يمكن أن يؤدي إلى مقاومة اللبتين وبالتالي السمنة . https://t.co/ThrYe6qqpB

Jul 25, 2022 · 1 like · 65,009 followers View post →
Homocysteine and Leptin as independent drivers of inflammation ...
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... 10.1152/ajpregu.00195.2008 (16) Mark J. Dekker, Qiaozhu Su, Chris Baker, Angela C. Rutledge, and Khosrow Adeli Fructose: a highly lipogenic nutrient ...

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R1370–75, https://doi.org/10.1152/ajpregu.00195.2008. 28. Karen L. Teff, “Dietary Fructose Reduces Circulating Insulin and. Leptin, Attenuates Postprandial ...

Dec 28, 2025 View →
Fruit sugar is perfect for humans
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org/doi/full/10.1152/ajpregu. 00195.2008 Just some science for you. journal-of-hepatology.eu. Fructose- and sucrose- but not glucose-sweetened ...

Sep 29, 2025 View →
The Hormone Diet: Foods to Restore Hormone Balance
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... 10.1152/ajpregu.00195.2008. Cushing's Syndrome: National Institute of Diabetes and Digestive and Kidney Diseases. (2018.) “Cushing's Syndrome ...

Nov 6, 2023 View →
Whole Foods Plant-Based Diet: Is It Right For You?
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... 10.1152/ajpregu.00195.2008. Cushing's Syndrome: National Institute of Diabetes and Digestive and Kidney Diseases. (2018.) “Cushing's Syndrome ...

Nov 6, 2023 View →
If you believe your health care plan/insurance company is not ...
Instagram

... 10.1152/ajpregu.00195.2008 *** Fruit also contains fructose but because fruit contains fiber, water, vitamins, minerals, and antioxidants ...

Jun 29, 2022 View →
Am Wochenende hat der 28-jährige Stuttgarter Bäcker Jonathan ...
Facebook

DOI: 10.1152/ajpregu. 00195.2008. researchgate.net. (PDF) A Review of Phytate, Iron, Zinc, and Calcium. 4 yrs. Alex Lampe. Lucie Li ich habe ...

Jan 17, 2022 View →
Julian - Facebook
Facebook

... 10.1152/ajpregu.00195.2008 | Facebook. Log in. Facebook. No photo ... doi: 10.1152/ajpregu.00195.2008. Aracely Zuniga and 6 others ·

May 31, 2017 View →
The Not-So-Sweet Truth About Sugar: 10 Ways It's Ruining Your ...
Blogs

... 10.1152/ajpregu.00195.2008 or http://ajpregu.physiology.org/content/295/5/R1370. 6. Reilly, Rachel. (February 19, 2013). Long-term Research ...

Jan 17, 2014 View →
Fructose Sets Table For Weight Gain Without Warning | ScienceDaily
News

AJP Regulatory Integrative and Comparative Physiology, October, 2008; DOI: 10.1152/ajpregu.00195.2008. Cite This Page: MLA; APA; Chicago.

Oct 19, 2008 View →
Sättigung: Fructose macht nicht nur Zwerge dick
News

... 10.1152/ajpregu.00195.2008). In einem weiteren Experiment, in dem die Mäuse eine hochkalorische, fettreiche Diät erhielten, nahmen sie stark ...

Oct 16, 2008 View →