HIV Med July 2008 PMID 18705758

Male circumcision for the prevention of heterosexually acquired HIV infection: a meta-analysis of randomized trials involving 11,050 men.

E Mills, C Cooper, A Anema, G Guyatt

Mentions

7
Peak: 2 in Nov 2019
across 3 sources since Jun 2011

Extended reach

11,892
potential audience

Total likes

28

Video views

9,477

Mentions per month

Jun 2011 – Jul 2025

Where it's discussed

  • X / Twitter4 posts
  • YouTube2 videos
  • Reddit1 posts

AI synopsis

What people are saying

The overall sentiment reflects a high level of interest and engagement, with comments referencing specific trials, statistical debates, and systematic reviews, such as the mention of the Orange Farm study and questions about p-values. The tone varies from supportive to analytical, emphasizing the significance and complexities of the research's implications for public health strategies.

AgreementModerate agreement

Most discussions acknowledge the findings of the meta-analysis, referencing its significance in HIV prevention strategies, though some pose critical questions about statistical interpretations.

InterestHigh interest

The discussions demonstrate high interest by participants referencing specific studies, statistics, and related research, indicating engagement with the topic's implications.

EngagementModerate engagement

Participants delve into methodologic debates, such as p-value significance and systematic reviews, showing thoughtful analysis and deeper engagement beyond surface-level reactions.

ImpactModerate impact

The social discussions highlight potential policy influence and public health implications, recognizing the importance of male circumcision in HIV prevention as a notable impact.

Abstract in brief

  • This meta-analysis of three randomized controlled trials involving 11,050 men found that male circumcision significantly reduces the risk of heterosexually acquired HIV infection, with a relative risk of 0.44, meaning circumcised men are less than half as likely to acquire HIV compared to uncircumcised men.
  • The studies showed that approximately 1 in 72 men need to be circumcised to prevent one new HIV infection, highlighting its potential as an effective prevention strategy.
  • While male circumcision can significantly lower HIV risk, maintaining safe sexual practices is essential to ensure its protective benefits at the population level.

Top posts

Most liked on X and Bluesky
Gwinyai Masukume
@GwinyaiMasukume · X

@LLopezGonzalez @HSRCza #HVTN702 annual male rate of HIV infection, 1%, was lower than 1.8% of control population (18-24 years) in @agenceANRS 1265 trial Orange Farm, South Africa, ~15 years ago. https://t.co/0e4coCdw5e

Feb 4, 2020 · 778 followers View post →
Gwinyai Masukume
@GwinyaiMasukume · X

@PeterKilmarx @Witmapanga If the gold standard is a meta‐analysis of randomized trials, then: 1) https://t.co/0e4coCdw5e - 56% 2) https://t.co/H20iATaZQZ - 54% Do you agree with the American Statistical Association position on the p-value? https://t.co/notdlHASWI Also, https://t.co/ZwwSLh7BEh

Nov 16, 2019 · 778 followers View post →
Gwinyai Masukume
@GwinyaiMasukume · X

@docmmapris @Witmapanga @TheLancet Apologies if my earlier tweet was unclear https://t.co/0sifG6I3QF For female-to-male HIV transmission these are the kind of systematic reviews available 1) https://t.co/0e4coCdw5e 2) https://t.co/H20iATaZQZ For male-to-female HIV transmission, as of Nov 2019 there do not exist.

Nov 11, 2019 · 778 followers View post →
Amaide
@Amaidemid · X

@Holofernes334 @youness1_9 @ItsMoha07 @letocardducoin Male circumcision for the prevention of heterosexually acquired HIV infection: a meta-analysis of randomized trials involving 11,050 men

Jul 10, 2025 · 71 followers View post →

All mentions

Amaide
@Amaidemid · X

@Holofernes334 @youness1_9 @ItsMoha07 @letocardducoin Male circumcision for the prevention of heterosexually acquired HIV infection: a meta-analysis of randomized trials involving 11,050 men

Jul 10, 2025 · 71 followers View post →
Gwinyai Masukume
@GwinyaiMasukume · X

@LLopezGonzalez @HSRCza #HVTN702 annual male rate of HIV infection, 1%, was lower than 1.8% of control population (18-24 years) in @agenceANRS 1265 trial Orange Farm, South Africa, ~15 years ago. https://t.co/0e4coCdw5e

Feb 4, 2020 · 778 followers View post →
Gwinyai Masukume
@GwinyaiMasukume · X

@PeterKilmarx @Witmapanga If the gold standard is a meta‐analysis of randomized trials, then: 1) https://t.co/0e4coCdw5e - 56% 2) https://t.co/H20iATaZQZ - 54% Do you agree with the American Statistical Association position on the p-value? https://t.co/notdlHASWI Also, https://t.co/ZwwSLh7BEh

Nov 16, 2019 · 778 followers View post →
Gwinyai Masukume
@GwinyaiMasukume · X

@docmmapris @Witmapanga @TheLancet Apologies if my earlier tweet was unclear https://t.co/0sifG6I3QF For female-to-male HIV transmission these are the kind of systematic reviews available 1) https://t.co/0e4coCdw5e 2) https://t.co/H20iATaZQZ For male-to-female HIV transmission, as of Nov 2019 there do not exist.

Nov 11, 2019 · 778 followers View post →
American women practicing circumcision. In the USA, it is usually ...
Reddit

https://onlinelibrary.wiley.com/doi/10.1111/j.1468-1293.2008.00596.x. An article explaining this study: https://theconversation.com/messages ...

May 3, 2022 View →