Aging Cell October 2008 PMID 18843793

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

Luigi Fontana, Edward P Weiss, Dennis T Villareal, Samuel Klein, John O Holloszy

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Mentions

Peak: 6 in Sep 2020

across 5 sources since Oct 2018

Extended reach

613,192

potential audience

Total likes

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Oct 2018 – Nov 2023

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AI synopsis

What people are saying

The discussions reflect a positive reception of the research, with comments like 'Reduced protein intake may become an important component of anti-cancer and anti-aging interventions,' highlighting potential applications. The tone varies from supportive to curious, emphasizing scientific interest and perceived significance, which aligns with higher interest and moderate engagement scores.

AgreementModerate agreement

Most discussions support the idea that protein restriction could be important for anti-aging and health benefits, showing general agreement.

InterestHigh interest

Posts demonstrate high interest, with many mentioning potential health and anti-aging breakthroughs.

EngagementModerate engagement

Participants engage by referencing the science, sharing opinions, and bringing up specific applications, indicating active involvement.

ImpactModerate impact

The conversations suggest that many see this research as potentially impactful for health strategies, especially in aging and disease prevention.

Abstract in brief

Long-term calorie restriction without malnutrition does not significantly change IGF1 levels or the IGF1-IGFBP3 ratio in humans, unlike in rodents where it decreases these markers and slows aging.
Moderate protein restriction (from 1.67 g/kg to 0.95 g/kg body weight daily) over three weeks lowers both total and free IGF1 levels in humans, indicating protein intake as a key factor in regulating circulating IGF1.
The findings suggest that reducing protein consumption might be an effective strategy for anti-aging and cancer prevention in humans, given its impact on IGF1 levels, which are linked to aging and disease processes.]

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All mentions

The Impact of Caloric Restriction on Longevity

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Physionic · Nov 13, 2023 131,765 views

Diet-Induced Acidosis and Its Potential Link to Cancer Development

Diet-induced acidosis caused by high animal protein and salt intake can influence cellular processes related to tumor growth. This review explores how acid-base imbalance may promote cancer initiation or progression…

lilykoi hawaii · Oct 20, 2018 20,006 views

B. Holiday (Diabetic lives matter).

@bholiday · X

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans https://t.co/9JNO210j1h

Nov 21, 2022 · 2,245 followers View post →

Colin Walsh

@happyspud1 · X

"Reduced protein intake may become an important component of anti-cancer and anti-aging interventions" - Fontana https://t.co/LxiWmMHKFb

Apr 2, 2022 · 2,406 followers View post →

Johns Hopkins Frailty Science #FrailtyFighter

@FrailtyScience · X

RT @agingdoc1: Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans (2008) https://t.co/…

Mar 22, 2022 · 1 share · 2,269 followers View post →

Agingdoc

@agingdoc1 · X

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans (2008) https://t.co/rsub2bG5HB @LuigiFontana22

Mar 22, 2022 · 5 likes · 1 share · 43,736 followers View post →

Simon Hill MSc, BSc

@theproof · X

@kevinnbass @ChrisMasterjohn Luigi Fontana is the guy to speak to here. Based in Sydney. https://t.co/hysJhhU3lM https://t.co/25AiCJsrpD

Dec 15, 2021 · 3 likes · 34,366 followers View post →

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Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

The Impact of Caloric Restriction on Longevity

Diet-Induced Acidosis and Its Potential Link to Cancer Development