Arch Pharm Res October 2008 PMID 18958421

Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells.

Hyo-Hyun Park, Soyoung Lee, Hee-Young Son, Seung-Bin Park, Mi-Sun Kim, Eun-Ju Choi, Thoudam S K Singh, Jeoung-Hee Ha, Maan-Gee Lee, Jung-Eun Kim, Myung Chul Hyun, Taeg Kyu Kwon, Yeo Hyang Kim, Sang-Hyun Kim

Mentions

9
Peak: 1 in Jan 2023
across 4 sources since Jan 2023

Extended reach

190,759
potential audience

Total likes

6,284

Video views

189,534

Mentions per month

Jan 2023 – Feb 2024

Where it's discussed

  • News3 articles
  • Blogs3 articles
  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

The group discusses the effects of compounds like Pycnogenol on mast cells, suggesting a cautious optimism about natural compounds influencing inflammatory responses. Words like 'zeigen einen positiven Effekt' (show a positive effect) indicate a favorable view, but the limited scope of comments reflects moderate engagement and impact.

AgreementModerate agreement

The discussion shows some agreement, especially with references to positive effects and potential benefits, though not explicitly endorsing all findings.

InterestModerate interest

Participants express a basic level of curiosity, indicated by mentioning specific compounds like Pycnogenol and its effects on mast cells.

EngagementNeutral engagement

Engagement appears moderate; there's some mention of testing and effects but limited in-depth analysis or discussion about mechanisms.

ImpactNeutral impact

The overall impact seems neutral, as the discussion hints at potential benefits but doesn't highlight significant shifts in understanding or application.

Abstract in brief

  • Mast cells are involved in allergic reactions and inflammation by releasing histamine and proinflammatory cytokines; flavonoids are natural compounds that have antiinflammatory properties.
  • Five flavonoids (fisetin, kaempferol, myricetin, quercetin, and rutin) reduced histamine release and intracellular calcium levels in a specific mast cell line (RBL-2H3).
  • Fisetin, quercetin, and rutin decreased the expression and production of key proinflammatory cytokines in human mast cells, suggesting that flavonoids may help treat allergic inflammatory diseases by reducing mast cell activation.

Top posts

Most liked on X and Bluesky
Dr. Nina Kreddig | MCAS-Beratung
@mastzellenhilfe · X

@StageCat3 @mcas_hope @MelsMastCells Probiert habe ich das noch nicht, aber https://t.co/ZryjxCCiT7 und https://t.co/3S6RuumgZb zeigen einen positiven Effekt von Pycnogenol auf die Mastzellen

Jan 29, 2023 · 2 likes · 1,226 followers View post →

All mentions

Dr. Nina Kreddig | MCAS-Beratung
@mastzellenhilfe · X

@StageCat3 @mcas_hope @MelsMastCells Probiert habe ich das noch nicht, aber https://t.co/ZryjxCCiT7 und https://t.co/3S6RuumgZb zeigen einen positiven Effekt von Pycnogenol auf die Mastzellen

Jan 29, 2023 · 2 likes · 1,226 followers View post →