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Overall, discussions reflect a balanced recognition of the research's importance, with phrases like 'novel mechanisms' and 'potential for therapeutics' illustrating the perceived significance. Posts mentioning 'advanced models' or 'immune responses' show interest without deep technical engagement, highlighting a general appreciation rather than detailed critique.
Most discussions recognize the relevance of local vitamin D activation in immune defense, showing general agreement with the publication.
There is moderate curiosity about implications for diseases like long COVID, with mentions of immune cell activity and disease mechanisms, but some posts are more informational than enthusiastic.
While some posters discuss specific mechanisms and models, many simply share summaries or mention upcoming research without deep analysis or personal insight.
Several discussions point to the potential significance in disease understanding and therapy development, indicating a moderate perceived impact, especially in disease contexts like autoimmune and infectious diseases.
Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill infected cells. Restoring NK cell function in the lab may point to new treatments. https://t.co/ryJs9jwiuN
Researchers developed new M1 biomarkers shared by human and mouse primary macrophages with the potential for broad applications in both basic research and clinical practice. Learn more in The JI: https://t.co/OqgiV7L5Ao. https://t.co/SduLbQFYbk
A lot of peripheral tolerance relies on a cell type called the regulatory T cell. In essence, rather than attacking when activated, regulatory T cells suppress immune responses to curb tissue damage. These were discovered by Nobel winner Shimon Sakaguchi in 1995: academic.oup.com/jimmunol/art...
1/1 Ziemlich wichtiger Forschungsartikel von @polybiorf.bsky.social und @virusesimmunity.bsky.social - Immunphänotypisierung im Liquor cerebrospinalis zeigt unterschiedliche Immuntypen der myalgischen Enzephalomyelitis/des chronischen Fatigue Syndroms: academic.oup.com/jimmunol/art...
A pattern of hyperactive monocytes & exhausted NK cells in MIS-C, suggesting that misregulated antibody-effector cell interactions contribute to disease comment in @AmerAcadPeds https://t.co/Fccb4e5p1e paper by @Jenna_K_Dick @HamiltonHartLab @J_Immunol https://t.co/JUubBJsth5 https://t.co/BIFHBUT0AU
Data indicated that PD-1+TIM-3+ T cells play a central role in T-cell exhaustion during Bovine Leukemia Virus-induced tumorigenesis. Read more to find valuable insights for future therapeutic strategies against BLV infection: https://t.co/6MlJ8HPWGz. https://t.co/0P435fIUI6
Vitamin D plays a crucial role in immune health, mood, and bone strength. Despite Indonesia's tropical climate, deficiency rates are high, affecting various health aspects. This video explores the causes, consequences…
This video discusses the importance of consuming vitamin D3 with K2, highlighting the most effective K2 types. Proper intake can be life-saving, especially for those taking supplements regularly.
RT @J_Immunol: Researchers developed new M1 biomarkers shared by human and mouse primary macrophages with the potential for broad applicati…
RT @J_Immunol: Researchers developed new M1 biomarkers shared by human and mouse primary macrophages with the potential for broad applicati…
RT @J_Immunol: Researchers developed new M1 biomarkers shared by human and mouse primary macrophages with the potential for broad applicati…
RT @J_Immunol: Researchers developed new M1 biomarkers shared by human and mouse primary macrophages with the potential for broad applicati…
RT @J_Immunol: Researchers developed new M1 biomarkers shared by human and mouse primary macrophages with the potential for broad applicati…
RT @J_Immunol: Researchers developed new M1 biomarkers shared by human and mouse primary macrophages with the potential for broad applicati…
Researchers developed new M1 biomarkers shared by human and mouse primary macrophages with the potential for broad applications in both basic research and clinical practice. Learn more in The JI: https://t.co/OqgiV7L5Ao. https://t.co/SduLbQFYbk
When you learn that the main way we clear out people's guts also causes Clostridioides difficile infection risk, and that impairs mucosal immunity in the gut and that has knock on impacts on disease resistance... Oh man. https://t.co/MUCGz2RD4c https://t.co/dz7NYHTXu1
RT @J_Immunol: Researchers established a novel Sjögren syndrome–related interstitial lung disease mouse model replicating human disease pat…
RT @LabWaggoner: Restriction of IgA secretion in gut plasma cells is driven by a tissue-specific glycolytic program @J_Immunol @SUNY @joelw…
Researchers established a novel Sjögren syndrome–related interstitial lung disease mouse model replicating human disease pathology, offering a valuable tool for investigating pathogenesis and advancing therapeutics. Find this #TopRead article in The JI: https://t.co/SLFY72S6KB. https://t.co/UJHoVryhO9
RT @SuckPoppit: https://t.co/UmStIDhmAa
RT @LabWaggoner: Restriction of IgA secretion in gut plasma cells is driven by a tissue-specific glycolytic program @J_Immunol @SUNY @joelw…
Restriction of IgA secretion in gut plasma cells is driven by a tissue-specific glycolytic program @J_Immunol @SUNY @joelwilmore https://t.co/tKeajncYhf https://t.co/6qI6o2kTE8
Restriction of IgA secretion in gut plasma cells is driven by a tissue-specific glycolytic program @jimmunol.bsky.social @sunyofficial.bsky.social academic.oup.com/jimmunol/adv...
An experimental mRNA platform to create isolated, monospecific Th1 responses @J_Immunol @EisenlohrLab @ChildrensPhila @MikeHoganPhD https://t.co/rpfwSyfZt2 https://t.co/ZUDC1DR9n7
An experimental mRNA platform to create isolated, monospecific Th1 responses @jimmunol.bsky.social @childrensphila.bsky.social @mikehoganphd.bsky.social academic.oup.com/jimmunol/adv...
Previous studies demonstrated that Nfkbid affects T1D in NOD-based mouse models. This article reevaluates the role of Bcl3 in T1D and stresses the need for caution when congenically introducing mutations derived from other mouse background strains: https://t.co/tM5ZkR7EU8 https://t.co/TjNAQp52CT
RT @Euskalkolektibo: En la Uni de Pensilvania analizaron sangre de pacientes Long Covid y descubrieron que las células T específicas que se…
RT @J_Immunol: The latest issue of The JI is now online! Read cutting edge research, brief reviews, and more.
RT @J_Immunol: This November #TopRead from @luoweicool and @ShlomchikLab demonstrated that PTEN deficiency selectively expanded germinal ce…
RT @J_Immunol: This November #TopRead from @luoweicool and @ShlomchikLab demonstrated that PTEN deficiency selectively expanded germinal ce…
This November #TopRead from @luoweicool and @ShlomchikLab demonstrated that PTEN deficiency selectively expanded germinal center B cells in Peyer’s patches but had no impact on those induced by immunization, revealing an unknown role for PTEN. Read more: https://t.co/Yy6OzLobNO. https://t.co/dac1fgWczK
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
Submit your abstracts for IMMUNOLOGY2026™ now and ensure that your original abstract is published in The Journal of Immunology as a supplement: https://t.co/PSupZO5mVe Explore last year's IMMUNOLOGY2025™ abstracts now: https://t.co/mYPuhAXI1d https://t.co/JwB0NJtQoS
This November #TopRead from @luoweicool and @ShlomchikLab demonstrated that PTEN deficiency selectively expanded germinal center B cells in Peyer’s patches but had no impact on those induced by immunization, revealing an unknown role for PTEN. Read more: https://t.co/Yy6OzLobNO. https://t.co/cvGPosV0VJ
RT @J_Immunol: In this #TopRead article, Dr. Christine Bowman and her team at @arcusbio provide a mechanistic rationale for CD39 inhibition…
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
Dietary iron deficiency impairs effector function of memory T cells following influenza infection https://t.co/nLAH1Kyh50
RT @J_Immunol: In this #TopRead article, Dr. Christine Bowman and her team at @arcusbio provide a mechanistic rationale for CD39 inhibition…
Data indicated that PD-1+TIM-3+ T cells play a central role in T-cell exhaustion during Bovine Leukemia Virus-induced tumorigenesis. Read more to find valuable insights for future therapeutic strategies against BLV infection: https://t.co/6MlJ8HPWGz. https://t.co/0P435fIUI6
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
RT @FlorinDanPopesc:
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
NK Cell and Monocyte Dysfunction in Multisystem Inflammatory Syndrome in Children | The Journal of Immunology | Oxford Academic. (MIS-C) is a severe complication of SARSCoV-2 infection characterized by multiorgan involvement and inflammation. https://t.co/60amf5hRm8
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
RT @LabWaggoner: A pattern of hyperactive monocytes & exhausted NK cells in MIS-C, suggesting that misregulated antibody-effector cell inte…
In this #TopRead article, Dr. Christine Bowman and her team at @arcusbio provide a mechanistic rationale for CD39 inhibition to promote antitumor immunity via the enhancement of eATP-driven myeloid cell activation of T cells. Learn more in The JI: https://t.co/VsS6XGVy19. https://t.co/JfYd45J6p6
RT @LabWaggoner: A pattern of hyperactive monocytes & exhausted NK cells in MIS-C, suggesting that misregulated antibody-effector cell inte…
MIS-C, NK cells are hypofunctional with low cytotoxicity and cytokines, hindering viral clearance. CD16/SARS-CoV-2 engagers restore NK function in vitro, revealing Ab- and NK cell–mediated viral clearance restoration. https://t.co/O2aYb81qpA https://t.co/SHilBHhylH
RT @J_Immunol: The latest issue of The JI is now online! Read cutting edge research, brief reviews, and more.
RT @LabWaggoner: A pattern of hyperactive monocytes & exhausted NK cells in MIS-C, suggesting that misregulated antibody-effector cell inte…
RT @LabWaggoner: A pattern of hyperactive monocytes & exhausted NK cells in MIS-C, suggesting that misregulated antibody-effector cell inte…
RT @atranscendedman: Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill…
Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill infected cells. Restoring NK cell function in the lab may point to new treatments. academic.oup.com/jimmunol/art...
Researchers studied children with MIS-C and found that while monocytes were overactive, NK cells were too weak to kill infected cells. Restoring NK cell function in the lab may point to new treatments. https://t.co/ryJs9jwiuN
A pattern of hyperactive monocytes & exhausted NK cells in MIS-C, suggesting that misregulated antibody-effector cell interactions contribute to disease comment in @AmerAcadPeds https://t.co/Fccb4e5p1e paper by @Jenna_K_Dick @HamiltonHartLab @J_Immunol https://t.co/JUubBJsth5 https://t.co/BIFHBUT0AU
The latest issue of The JI is now online! Read cutting edge research, brief reviews, and more.
RT @OleksandrKashu2: Beyond genetics: Lyme disease’s unexpected role in connective tissue health - findings from a murine model for borreli…
Beyond genetics: Lyme disease’s unexpected role in connective tissue health - findings from a murine model for borrelia burgdorferi infection and the human clinical study MAESTRO https://t.co/4VMH2pSROd
Beyond genetics: Lyme disease’s unexpected role in connective tissue health - findings from a murine model for borrelia burgdorferi infection and the human clinical study MAESTRO academic.oup.com/jimmunol/art...
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @FlorinDanPopesc:
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
Corrected link academic.oup.com/jimmunol/art...
RT @Euskalkolektibo: En la Uni de Pensilvania analizaron sangre de pacientes Long Covid y descubrieron que las células T específicas que se…
@Marc_Veld Link results in 'Token was not provided. Please go back to the article page and click the PDF link again.' Available from the Journal of Immunology: https://t.co/ViYu7dwL61;
Uncovering combination therapies for Immune-Mediated Inflammatory Diseases through systems biology analysis on longitudinal patient data 3497 https://t.co/fVIEnJPW8e
RT @Euskalkolektibo: En la Uni de Pensilvania analizaron sangre de pacientes Long Covid y descubrieron que las células T específicas que se…
RT @Euskalkolektibo: En la Uni de Pensilvania analizaron sangre de pacientes Long Covid y descubrieron que las células T específicas que se…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @Euskalkolektibo: En la Uni de Pensilvania analizaron sangre de pacientes Long Covid y descubrieron que las células T específicas que se…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
En la Uni de Pensilvania analizaron sangre de pacientes Long Covid y descubrieron que las células T específicas que se dirigen al SARS-CoV-2, eran altamente activas en el 40 %, lo que sugiere que la actividad inmune persistente impulsa los síntomas. https://t.co/371Ww7WmEx
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
RT @atranscendedman: University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells ta…
University of Pennsylvania scientists analyzed blood from long COVID patients and found that virus-specific T cells targeting SARS-CoV-2, EBV, or VZV were highly active in at least 40% of them, suggesting persistent immune activation drives symptoms. academic.oup.com/jimmunol/art...
Beyond genetics: Lyme disease’s unexpected role in connective tissue health - findings from a murine model for borrelia burgdorferi infection and the human clinical study MAESTRO 3972 url: academic.oup.com/jimmunol/art...
Single cell epigenomic profiling identifies a distinct classical monocyte subset driving inflammation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME) 4815 url: academic.oup.com/jimmunol/art...
IL-15 complex enhances therapeutic efficacy of anti-PD-L1 in a T cell–dependent and NK cell–independent manner in a murine model of pancreatic ductal adenocarcinoma @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
α2-Adrenergic modulation of neuroimmune interactions differs between the spleen and mesenteric lymph nodes @rosslabuc.bsky.social @uofcincy.bsky.social @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
AI and flow cytometry @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
We are pleased to share our new publication linking TRAV1-2 negative MAIT cells, CD4 coexpression, and tuberculosis. A conserved innate-like T cell subset with more TCR diversity than previously appreciated. academic.oup.com/jimmunol/adv... #Immunology #maitcells #TCRdiversity
Role of companion dogs in cancer immunotherapy development academic.oup.com/jimmunol/art...
Preserving intracellular glutamate supports CD8 T cell anti tumour function. Research from the Rathmell lab point to Glutamine synthetase a potential target for cancer immunotherapy academic.oup.com/jimmunol/art...
Neuroinflammatory canine disorders: unveiling disease mechanisms from a One Health perspective url: academic.oup.com/jimmunol/art...
CD155 density on target cells drives divergent NK cell responses owing to DNAM-1 loss @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
FcɛR1γ-based activating CAR enhanced NK cell function against HLA-E+ cells @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment url: academic.oup.com/jimmunol/art...
Fibroblast activation protein promotes NK cell invasion and tumor infiltration @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Dietary iron deficiency impairs effector function of memory T cells following influenza infection @jimmunol.bsky.social @columbiauniversity.bsky.social academic.oup.com/jimmunol/adv...
Noncanonical role for TIRAP in IRF5-dependent signaling downstream of human TLR7+TLR8, where selective disruption of TIRAP recruitment by a SLAMF1-derived peptide effectively attenuates IFNβ production @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
The stress-responsive kinase eEF2K suppresses Cyclin D1 expression, which stabilizes PD-L1 levels and promotes immune evasion in melanoma. eEF2K inhibition decreases PD-L1 expression and enhances CD8+ T-cell infiltration and cytotoxicity in vivo. #immunosky academic.oup.com/jimmunol/art...
This would shave 15mins from 30% of House episodes 'These findings highlight biological features that effectively distinguish sarcoidosis from TB and healthy populations and can be considered for the development of an optimized diagnostic method for sarcoidosis.' academic.oup.com/jimmunol/adv...
'We found that while follicular B2 (Fo B), marginal zone, and B1 cells are highly phagocytic of BCR-engaging targets through their BCR, only peritoneal cavity B1 cells could internalize noncognate Ag-coated beads or phagocytose and kill bacteria' #Immunology academic.oup.com/jimmunol/adv...
Delighted to celebrate @cincyresearch.bsky.social @labwaggoner.bsky.social PhD student Eshana Mukhopadhyay on her Cutting Edge manuscript out today in @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Identification of New Melanoma Epitopes on Melanosomal Proteins Recognized by Tumor Infiltrating T Lymphocytes Restricted by HLA-A1, -A2, and -A3 Alleles url: academic.oup.com/jimmunol/art...
At Osaka University, we also developed scODIN, a tool combining expert knowledge and machine learning to identify immune cell subsets in scRNA-seq data. Out now in Journal of Immunology! github.com/jonasns/scodin academic.oup.com/jimmunol/adv...
NLRC4 deficiency improves host protection during sepsis by regulating macrophage and T-cell responses @jimmunol.bsky.social @lsu.bsky.social academic.oup.com/jimmunol/adv...
p38 signaling enhances short-lived effector cell differentiation and weakens central memory CD8+ T-cell formation @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Review @jimmunol.bsky.social : CD8+ lymphocytes in immunity against tuberculosis @joanneflynn19.bsky.social academic.oup.com/jimmunol/adv...
A lot of peripheral tolerance relies on a cell type called the regulatory T cell. In essence, rather than attacking when activated, regulatory T cells suppress immune responses to curb tissue damage. These were discovered by Nobel winner Shimon Sakaguchi in 1995: academic.oup.com/jimmunol/art...
Sorry about that. Must have been an issue with the link shortener! Here is the link: academic.oup.com/jimmunol/iss...
Foreign epitope–specific naïve Treg cells fine-tune the primary response of Tconv cells specific for the same epitope by curbing the Th1 fate while allowing a robust response @jimmunol.bsky.social @uminnpress.bsky.social academic.oup.com/jimmunol/adv...
MEF2D regulates T-cell function via CD70-CD27 signaling and promotes immune evasion in hepatocellular carcinoma @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Gastrointestinal MAIT cells in chronic HIV-1 infection academic.oup.com/jimmunol/adv... @jimmunol.bsky.social @ucdavis.bsky.social
Germinal centers can override peripheral tolerance, recruiting previously silent autoreactive clones and facilitating diversification of autoantibodies @jimmunol.bsky.social @harvardmed.bsky.social academic.oup.com/jimmunol/adv...
SMI member De’Broski R Herbert and colleagues show TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni in this work from the Journal of Immunology: academic.oup.com/jimmunol/adv... #SMIMemberPaper
academic.oup.com/jimmunol/adv... “Dynamic control of autoreactive B cells from spontaneous germinal centers”
'These findings identify GLP1R as a novel regulator of allogeneic HSC engraftment and suggest that GLP1R agonists, widely used for metabolic disorders, may have therapeutic potential in preventing HSC graft rejection.' #Immunology academic.oup.com/jimmunol/adv...
IL-2 mediates human bystander CD8+ T-cell responses to innate immune signals @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
CD19 and FcγRIIb co-engagement inhibits processes essential to T cell–dependent B-cell responses @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
New from Mark Ruszniak @vubasicsciences.bsky.social An essential role for the GLP-1R in hematopoietic stem cell engraftment academic.oup.com/jimmunol/adv...
Check out our new research on developing a model for tumor infiltrating lymphocyte (TIL) therapy for cholangiocarcinoma (CCA) by the Lesinski and Paulos Labs! @lesinskilab.bsky.social @chrystalpaulos.bsky.social academic.oup.com/jimmunol/adv...
Computing the inducibility of broadly neutralizing antibodies under a context-dependent model of affinity maturation: applications to sequential vaccine design academic.oup.com/jimmunol/adv... (subscription req for full text) #HIV
'We also identified CD4+ T cells & monocytes as key cell subsets in mediating optimal CD8+ T-cell bystander responses. Importantly, our study identified IL-2 as an important mediator in innate bystander activation of CD8+ T cells to IL-15, IFN-α, R848 & CpG.' academic.oup.com/jimmunol/adv...
Granulysin Production and Anticryptococcal Activity Is Dependent upon a Far Upstream Enhancer That Binds STAT5 in Human Peripheral Blood CD4+ T Cells url: academic.oup.com/jimmunol/art... @jimmunol.bsky.social
TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus url: academic.oup.com/jimmunol/art... @jimmunol.bsky.social @innateimmunity.bsky.social
An early burst of cytokine production before the first cell division influences CD8 T cell differentiation @jimmunol.bsky.social #Zajac academic.oup.com/jimmunol/adv...
Transcriptional states of lung cancer microenvironment reveal macrophage subtype dynamics linked to disease progression @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv... New #freshoffthepress from @yeungadventures.bsky.social
Glad to finally have this out. NHP microscopy was not easy with having to validate antibodies. Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection url: academic.oup.com/jimmunol/art... #NewPI @aai.org @jimmunol.bsky.social @weillcornell.bsky.social
Non-hematopoietic tryptophan metabolism is a driver of ineffective T cell responses during secondary pulmonary bacterial infection @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
DOT1L-mediated H3K79me2 directs B-cell repertoire establishment, marginal zone development, and germinal center function @jimmunol.bsky.social @kimljacobson.bsky.social @monashuniversity.bsky.social academic.oup.com/jimmunol/adv...
Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection @jimmunol.bsky.social @weillcornell.bsky.social academic.oup.com/jimmunol/adv...
Dysregulation of complement components associated with inflammation and coagulation in virally suppressed people living with HIV @jimmunol.bsky.social @uhmanoa.bsky.social academic.oup.com/jimmunol/adv...
UTY coordinates with UTX to repress NK cell development and maturation in males @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
In a #Top Read from August, @labwaggoner.bsky.social from @cincyresearch.bsky.social discovered that the transcription factor ASCL2 is required for recruitment of NK cells into the spleen and white pulp providing novel insights into NK cell biology. Read more: academic.oup.com/jimmunol/art...
Lpar5 regulates CD8 T-cell exhaustion through modulation of NK receptor expression, including the CD94/NKG2A inhibitory axis @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
FLT3L neutralization reduces dendritic cell numbers, T Cell activation, and salivary gland lymphocyte infiltration in the NOD.H2h4 Sjögren’s mouse model academic.oup.com/jimmunol/adv... @jimmunol.bsky.social @amgen.bsky.social
CD55hi MAIT cells with elevated cytokine secretion and activation markers serve as potential diagnostic indicators in Sjögren’s disease @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
TGFβ limits proximal CD8+ TCR signaling via PTPN22 following strong and moderate agonism @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social academic.oup.com/jimmunol/adv...
Researchers report that loss of #Parkinsons -associated LRRK2 results in a paradoxical response in microglia: They had a reduction in type I IFN transcripts compared to controls - due to NRF2 redox pathway upregulation in LRRK2 KO microglia academic.oup.com/jimmunol/adv...
Mice lacking the LPA receptor Lpar5 showed stronger antiviral CD8 T cell responses and resisted exhaustion during chronic LCMV infection, suggesting Lpar5 helps enforce T cell exhaustion seen in cancer and persistent viral disease. academic.oup.com/jimmunol/adv...
Natural killer cell–based immunotherapy for cancer : academic.oup.com/jimmunol/art...
Lpar5 regulates the CD8 T-cell response to persistent virus infection by altering exhaustion programming, survival, and NK receptor expression @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
... facilitates the development of safe and efficacious vaccines in humans. Read the full article here: academic.oup.com/jimmunol/art...
Mouse model of Sjögren syndrome–related interstitial lung disease @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Different pattern of CD8 T cell exhaustion in chronic parasite (Toxoplasmosis) infection where stem-like CD8 T cells differentiate into an unconventional intermediate effector memory subset @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Functional role of Kv1.3 localization in chimeric antigen receptor T cells @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
@jimmunol.bsky.social @tajieharris.bsky.social focus: Illuminating immunology through the lens of parasites: A collection on immunoparasitology academic.oup.com/jimmunol/art... collection of 3 reviews
Cell death in the brain during parasitic infections academic.oup.com/jimmunol/art... @tajieharris.bsky.social
Regulatory T cell memory: implications for malaria academic.oup.com/jimmunol/art...
From defense to disease: the multifaceted role of lymphatics during infection academic.oup.com/jimmunol/art...
Transcription factor SP1 in nasal epithelial cells aggravates allergic rhinitis by inducing FOXC1 changes in epithelial barrier integrity @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
IL-2 mutein (SB834Fc) with enhanced affinity for IL-2Rβ subunit induces potent antitumor responses across various mouse tumor models and in healthy human T cells @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Malat1 is a determinant of immune sexual dimorphism by regulating female Th2 cell cytokine expression through controlling early differentiation and response to IL-2 @jimmunol.bsky.social @dimitrislagos.bsky.social academic.oup.com/jimmunol/adv...
ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation @jimmunol.bsky.social @labfehniger.bsky.social @macattacklab.bsky.social academic.oup.com/jimmunol/adv...
1/1 Ziemlich wichtiger Forschungsartikel von @polybiorf.bsky.social und @virusesimmunity.bsky.social - Immunphänotypisierung im Liquor cerebrospinalis zeigt unterschiedliche Immuntypen der myalgischen Enzephalomyelitis/des chronischen Fatigue Syndroms: academic.oup.com/jimmunol/art...
CD20+ NK cells as a functionally distinct lymphocyte subset with enhanced effector capabilities and tissue-homing properties that are enriched in inflammatory disorders @jimmunol.bsky.social @atayvural.bsky.social academic.oup.com/jimmunol/adv...
The transcription factor BCL11B drives NK cell cytotoxicity and antitumor activity @jimmunol.bsky.social academic.oup.com/jimmunol/adv... #Cichocki
Our new review on my favorite topic! #nod2 #tcells #blausyndrome Resolving the field: a role for Nod2 in T cells url: academic.oup.com/jimmunol/art...
'Using the Foxn1lacz model (...) We found that early thymic involution led to aged-like thymic epithelial cells that resulted in aged-like thymocyte phenotypes, with a significant decrease in CD4+ single-positive T cells' #Immunology academic.oup.com/jimmunol/adv...
Review @jimmunol.bsky.social Resolving the field: a role for Nod2 in T cells Implications for Blau syndrome and Crohn’s disease academic.oup.com/jimmunol/adv...
Humanized DRAGA mice are a valuable model to study novel immunotherapies for HIV-1 @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Review @jimmunol.bsky.social Regulation of B-cell development and differentiation by microRNAs during immune response and their implications in immunological disorders academic.oup.com/jimmunol/adv...
CRMP2 expression and function is already validated in human lymphocytes from patients with HTLV1 and MS. Which brings a lot of translational relevance to this manuscript. It's all very exciting academic.oup.com/jimmunol/art... academic.oup.com/jimmunol/art...
Schistosoma manipulates TRPV1+ neuron activation to limit inflammation and reduce pain when piercing the skin during infection academic.oup.com/jimmunol/adv...
Humanized DRAGA mice are a valuable model to study novel immunotherapies for #HIV academic.oup.com/jimmunol/adv... (open access) @jimmunol.bsky.social
NKG2A-mediated immune modulation of NK cells by Staphylococcus aureus @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
CD47-mediated selective accumulation of mature Ly49h+ NK cells to the brain associates with the pathogenesis of cerebral malaria in mice academic.oup.com/jimmunol/adv... @jimmunol.bsky.social
Eomesodermin defines uterine NK cells crucial for pregnancy success in mice #Yokoyama @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunity url: academic.oup.com/jimmunol/art...
Pleased to share our latest paper providing new insights regarding the human MAIT cell response to gastrointestinal bacterial infection (ETEC). @ki.se academic.oup.com/jimmunol/adv...
α7 nicotinic acetylcholine receptor (CHRNA7) is expressed in myeloid immune cells in breast cancer. A agonist of CHRNA7 reduces #tumor growth in pre-clinical mouse models, especially when used in combination with anti-PD-L1 #checkpoint therapy. #ImmunoSky academic.oup.com/jimmunol/art...
U.a. Immunveränderungen, auch des Metabolismus im Gehirn. Und vice versa will ich das Argument der @dgnlt01.bsky.social spiegeln, "es gäbe ja nichts gesichertes". Denn auf der psychologisch/-somatischen Ebene hat man schon viel academic.oup.com/jimmunol/adv... papers.ssrn.com/sol3/papers....
Congrats @lauracanaday.bsky.social @andypedsid.bsky.social @hafeldman17.bsky.social & team on our newest publication @jimmunol.bsky.social Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection academic.oup.com/jimmunol/adv...
IL-23 promotes T cell trafficking in experimental autoimmune myocarditis @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Read the latest #SMIMemberPaper by Susan Kovats and colleagues in The Journal of Immunology on lung-resident conventional dendritic cells during influenza infection. Read more here: academic.oup.com/jimmunol/art...
#ICYMI: Cytokine-induced killer (CIK) cell therapy improved both progression-free and overall survival in patients with #colorectalcancer. CEA serum levels were identified as a biomarker to predict which patients will respond to CIK therapy. Learn more: academic.oup.com/jimmunol/art... #immunosky
The Hippo signaling pathway is important in regulating host immune responses, but have you thought about its role in fish? Scientists revealed the mechanism of the Hippo pathway in the antimicrobial immunity of a pufferfish, Takifugu obscurus. Read now: academic.oup.com/jimmunol/art... #immunosky
#ICYMI: Researchers shared the development of an assay for quantitative assessment by flow cytometry of selective inhibitor effects on peptide trimming, both in the endogenous MHC-I processing pathway and in cross-presentation. Learn more in The JI: academic.oup.com/jimmunol/art...
In a #CuttingEdge article, researchers identified an in-del generated novel neoepitope that elicited in vivo tumor control in models of prophylaxis and therapy. CD8 T cells elicited by this neoepitope showed notably less exhaustion. Learn more: academic.oup.com/jimmunol/art....
www.nature.com/articles/s41... @nature.com journals.aai.org/jimmunol/art... www.frontiersin.org/journals/imm... academic.oup.com/jid/advance-... gupea.ub.gu.se/bitstream/ha...
HIF2α promotes protective Th2 cell responses during intestinal helminth infection @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Just dropped! Complicated impacts of il21 on gc exit to memory. Kudos to @alidvorscek.bsky.social and Jesse Mulder! IL-21 contributes to type 2 memory B cell formation url: academic.oup.com/jimmunol/art...
I don't know if I'd call it beautiful per se but Hozumi and Tonegawa figuring out VDJ recombination was amazing. They had to isolate their own BamHI to do it! Nice commentary in JI as part of their Pillars of Immunology series here: academic.oup.com/jimmunol/art...
Stromal cell–derived chemokines modulate immune cells in inflammation: New findings and future perspectives @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
IL-21 contributes to type 2 memory B cell formation @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
'These results showed that HMGB1 inhibited IFN-γ–induced PD-L1 expression, thereby enhancing the antitumor effects of T cells, and confirmed the role of HMGB1 as a prognostic indicator for lung cancer treated with chimeric antigen receptor T cells.' academic.oup.com/jimmunol/adv...
Can mutations in tumor mitochondrial DNA ( #mtDNA ) generate #neoantigens recognized by T-cells? New report describes mtDNA mutation-specific TCRs. Can mutant mtDNA could be tumor #immunotherapy targets? academic.oup.com/jimmunol/adv...
Review @jimmunol.bsky.social Epigenetic and metabolic regulation of macrophage responsiveness and memory academic.oup.com/jimmunol/adv...
Novel TOX-nanoluciferase-based #reporter mouse that can be used to monitor TOX expression and can be used the screening of molecules that modulate #T-cell #exhaustion. academic.oup.com/jimmunol/art...
Great piece re how to tackle reproducibility/fraud in science. Like many things in life, policing is a blunt tool, we should tackle the underlying causes of these issues. academic.oup.com/jimmunol/art...
LAG3-MHCII interaction induces a tight cell-cell interface at the immunological synapse @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
The role of VISTA engagement in limiting neutrophil-mediated inflammation @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
Distinct expression of CD56 and CD19 marks molecular and functional endotypes of tetanus- versus RBD-specific human bone marrow plasma cells @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
NC410, a bivalent LAIR-2 construct, remodels collagen in the tumor microenvironment and abrogates neutrophil-driven T cell suppression @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
MHC II–restricted presentation of soluble antigen by naïve B cells is impaired upon engagement with membrane-associated antigen: A potential mechanism to mitigate autoreactivity @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
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