PubHawk
December 2008 PMID 19052124

Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients.

Kenneth Jamerson, Michael A Weber, George L Bakris, Björn Dahlöf, Bertram Pitt, Victor Shi, Allen Hester, Jitendra Gupte, Marjorie Gatlin, Eric J Velazquez

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Mentions

43
Peak: 7 in Jul 2023
across 5 sources since Sep 2019

Extended reach

147,865
potential audience

Total likes

103

Video views

351

Mentions per month

Sep 2019 – Nov 2025

Where it's discussed

  • X / Twitter27 posts
  • Blogs9 articles
  • News3 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Discussions emphasize the significance of the ACCOMPLISH trial, with references to its methodology and results, such as the noted superior outcomes of ACEi + amlodipine over diuretics, with some posts questioning the current relevance of the study given its age. The tone varies from supportive to critical, especially around insights on trial limitations and historical context, demonstrating active engagement and critical thinking.

AgreementModerate agreement

Most discussions support the findings of the ACCOMPLISH trial, highlighting the superiority of the combination therapy with amlodipine and benazepril.

InterestHigh interest

The group shows high interest by referencing specific trials, discussing implications, and recalling historical studies.

EngagementModerate engagement

Participants actively engage with the topic by mentioning related studies, critique, and personal insights, indicating attentive involvement.

ImpactModerate impact

While the discussions reflect recognition of important clinical evidence, they mainly focus on interpretation rather than immediate practice change, so impact is moderate.

Abstract in brief

  • A study compared two combination therapies for high-risk hypertension patients: benazepril plus amlodipine versus benazepril plus hydrochlorothiazide, focusing on reducing cardiovascular events.
  • Results showed that the benazepril plus amlodipine group had a significantly lower rate of primary cardiovascular events, with an absolute risk reduction of 2.2% and a hazard ratio of 0.80, indicating better outcomes than the hydrochlorothiazide combination.
  • The trial was stopped early after about 3 years because benazepril plus amlodipine proved more effective, and side effects were similar to those expected from the medications used.
Read the full abstract

Top posts

Most liked on X and Bluesky
ACCP Cardiology PRN
@accpcardprn · X

Another #TBThursday

Jul 20, 2023 · 45 likes · 6 shares · 9,309 followers View post →
Cait E. Kulig
@Cait_Centra · X

I learn something new everyday, including some trials I probably should have already heard of in my practice; TIL about the ACCOMPLISH trial that looked at the combo of ACEi + CCB vs ACEi + diuretic and BP efficacy (spoiler alert ACEi+CCB was superior) https://t.co/TNnKVhyb47

Nov 14, 2024 · 15 likes · 1,636 followers View post →
Karun Neupane, MD
@KarunNeupaneMD · X

#MedTwitter, Did you know there is evidence supporting use of CCB+ACEI over ACEI+Diuretic to reduce CVS events in HTNsive pts

Mar 5, 2024 · 6 likes · 1 share · 1,918 followers View post →
Swapnil Hiremath @hswapnil.medsky.social
@hswapnil · X

Q/A @wccushman sez: problem with ACCOMPLISH https://t.co/62RKGDpkD9 that dose of HCTZ of 25 mg or less has *never* been reported to beneficial in clinical trials Agree Might say that also applies to HOPE-3? https://t.co/xkjprNTPaY #Hypertension19

Sep 7, 2019 · 4 likes · 2 shares · 21,707 followers View post →
J. Brian Byrd Lab
@thebyrdlab · X

@JHughesPharmD @DustinGrowick ACCOMPLISH: a very large trial led by my colleague Ken Jamerson Compared benazepril-CCB to benazepril-thiazide diuretic Based on ALLHAT, people expected the latter to lead to better outcomes, but former did Surprising study, perhaps somewhat neglected https://t.co/11Bl24Rh0E

Nov 3, 2019 · 4 likes · 4,584 followers View post →
ガラパゴス伊藤@総合診療医
@galapagos_ito · X

一応根拠としてはARB+CCB vs ARB+サイアザイドでARB+CCBが勝ったらしい。 単剤に関しては4剤の効果に差はないみたいだけど、どうせ2剤以上併用することが多いから、それなら初手はCCBかACE-I/ARBのどっちかがよくない？という理屈。 https://t.co/q0j1BPbD8s

Nov 20, 2022 · 4 likes · 2,393 followers View post →

All mentions

د. محمد المنصور
@123mMohammed · X

Jan 4, 2025 · 1 like · 5,984 followers View post →
Cait E. Kulig
@Cait_Centra · X

I learn something new everyday, including some trials I probably should have already heard of in my practice; TIL about the ACCOMPLISH trial that looked at the combo of ACEi + CCB vs ACEi + diuretic and BP efficacy (spoiler alert ACEi+CCB was superior) https://t.co/TNnKVhyb47

Nov 14, 2024 · 15 likes · 1,636 followers View post →
Jeremiah
@DrJKnapp · X

Blood pressure control in 2024 https://t.co/m7cXhN7WhP via @YouTube My first YouTube video

May 2, 2024 View post →
Chidambara .ML.
@chidambara09 · X

RT @KarunNeupaneMD: #MedTwitter, Did you know there is evidence supporting use of CCB+ACEI over ACEI+Diuretic to reduce CVS events in HTNsi…

Mar 6, 2024 · 1 share · 11,666 followers View post →
Karun Neupane, MD
@KarunNeupaneMD · X

#MedTwitter, Did you know there is evidence supporting use of CCB+ACEI over ACEI+Diuretic to reduce CVS events in HTNsive pts

Mar 5, 2024 · 6 likes · 1 share · 1,918 followers View post →
salih
@chawishli_salih · X

RT @accpcardprn: Another #TBThursday

Jul 22, 2023 · 6 shares · 15 followers View post →
Libby Orzel
@libbysenatide · X

RT @accpcardprn: Another #TBThursday

Jul 21, 2023 · 6 shares · 632 followers View post →
Justin Crespo, PharmD
@medic2pharmd · X

RT @accpcardprn: Another #TBThursday

Jul 20, 2023 · 6 shares · 397 followers View post →
hanis hanum zulkifly
@hanishanum · X

RT @accpcardprn: Another #TBThursday

Jul 20, 2023 · 6 shares · 84 followers View post →
PEY
@peyton_brewster · X

RT @accpcardprn: Another #TBThursday

Jul 20, 2023 · 6 shares · 249 followers View post →
Cait E. Kulig
@Cait_Centra · X

RT @accpcardprn: Another #TBThursday

Jul 20, 2023 · 6 shares · 1,636 followers View post →
ACCP Cardiology PRN
@accpcardprn · X

Another #TBThursday

Jul 20, 2023 · 45 likes · 6 shares · 9,309 followers View post →
ガラパゴス伊藤@総合診療医
@galapagos_ito · X

今回一応動画作成には採用するけど、ハイリスクグループだけ集めて複合エンドポイントでギリギリ有意差出すのセコくない？？とは思っちゃうよね(笑) https://t.co/8eBYUkyEZa

Jan 30, 2023 · 2 likes · 2,393 followers View post →
ガラパゴス伊藤@総合診療医
@galapagos_ito · X

一応根拠としてはARB+CCB vs ARB+サイアザイドでARB+CCBが勝ったらしい。 単剤に関しては4剤の効果に差はないみたいだけど、どうせ2剤以上併用することが多いから、それなら初手はCCBかACE-I/ARBのどっちかがよくない？という理屈。 https://t.co/q0j1BPbD8s

Nov 20, 2022 · 4 likes · 2,393 followers View post →
pinacol
@pinacol · X

https://t.co/YLndLgoMLe

Jun 21, 2022 · 2 likes · 1,678 followers View post →
Dr.Barry UreaAide,Nephrologist,Prof,PI,GirlDad
@KidneyAide · X

Thoroughly enjoyed the @thecurbsiders talk on #Hypertension. @DrWanpen did a great job, love the discussion on combo meds, the Accomplish trial Amlo/Benaz

Feb 3, 2021 · 1 like · 463 followers View post →
Keiko Greenberg MD
@KeikoGNeph · X

Remember the ACCOMPLISH trial and wait for randomized study, says Dr. Chris Wilcox (wonder if I can get him to join Twitter to share his wisdom) https://t.co/V2omox6Hn6 https://t.co/VQwq2Lq0XO https://t.co/Rn8oa0cMnF

Jun 26, 2020 · 1 like · 391 followers View post →
Venk Murthy MD PhD
@venkmurthy · X

@ChristosArgyrop @anish_koka @hswapnil @mikejohansenmd Btw, this is from a large province wide registry in Canada. Not perfect but still hardly a basis to dismiss the drug when you also have data like this: https://t.co/hjP9eOlMhw

May 22, 2020 · 22,892 followers View post →
Juan Senior
@jsenior64 · X

@lugocastle De acuerdo! https://t.co/FQcp1i1YXl

Apr 24, 2020 · 11,089 followers View post →
TILRx
@TIL_Rx · X

In patients with HTN and at high risk of CVD, ACE+amlodipine lowers the risk of CVD complications compared to ACE+HCTZ DOI: 10.1056/NEJMoa0806182

Jan 29, 2020 · 3 likes · 61 followers View post →
aminfilm39.6 ♡
@aminfilm936 · X

Jamerson K, Weber MA, Bakris GL, et al; ACCOMPLISH Trial Investigators. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008;359(23):2417-2428. doi: 10.1056/NEJMoa0806182.[PubMed 19052124]

Jan 9, 2020 · 105 followers View post →
Swapnil Hiremath @hswapnil.medsky.social
@hswapnil · X

Hmm ACCOMPLISH presented at ACC in 2008? I think it was published over a decade ago as well https://t.co/62RKGDpkD9 Guess slide made in early 2008? This talk has no citations after 2009 (except for 1 cursory SPRINT reference) Hey @ASNKidney - time for some fresh blood! https://t.co/VhR2BVIuvs

Nov 10, 2019 · 1 like · 21,707 followers View post →
J. Brian Byrd Lab
@thebyrdlab · X

@JHughesPharmD @DustinGrowick ACCOMPLISH: a very large trial led by my colleague Ken Jamerson Compared benazepril-CCB to benazepril-thiazide diuretic Based on ALLHAT, people expected the latter to lead to better outcomes, but former did Surprising study, perhaps somewhat neglected https://t.co/11Bl24Rh0E

Nov 3, 2019 · 4 likes · 4,584 followers View post →
Venk Murthy MD PhD
@venkmurthy · X

@bogdienache @ADAlthousePhD @ChristosArgyrop I also think ACCOMPLISH suggests contrary to this. RCT vs. big data. Cc: @thebyrdlab https://t.co/hjP9eOlMhw

Oct 30, 2019 · 3 likes · 22,892 followers View post →
Nicolas Renna, MD PhD ISHF FESC
@nicolasrennamd · X

RT @hswapnil: Q/A @wccushman sez: problem with ACCOMPLISH https://t.co/62RKGDpkD9 that dose of HCTZ of 25 mg or less has *never* been repor…

Sep 7, 2019 · 2 shares · 933 followers View post →
Marcelo Tavares
@pednephrol · X

RT @hswapnil: Q/A @wccushman sez: problem with ACCOMPLISH https://t.co/62RKGDpkD9 that dose of HCTZ of 25 mg or less has *never* been repor…

Sep 7, 2019 · 2 shares · 600 followers View post →
Swapnil Hiremath @hswapnil.medsky.social
@hswapnil · X

Q/A @wccushman sez: problem with ACCOMPLISH https://t.co/62RKGDpkD9 that dose of HCTZ of 25 mg or less has *never* been reported to beneficial in clinical trials Agree Might say that also applies to HOPE-3? https://t.co/xkjprNTPaY #Hypertension19

Sep 7, 2019 · 4 likes · 2 shares · 21,707 followers View post →