PubHawk
October 1991 PMID 1911707

Lesion-derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophage degradation.

H F Hoff, J O'Neil

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Mentions

3
Peak: 1 in Jul 2023
across 2 sources since Jul 2023

Extended reach

368,663
potential audience

Total likes

11,303

Video views

340,443

Mentions per month

Jul 2023 – Jun 2025

Where it's discussed

  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

The discussions reveal a balanced interest, with posts supporting the importance of LDL modifications in plaques while also debating points such as the presence of different LDL sizes in plaques, exemplified by questions like 'doesn't the observation of both small and large LDLs in plaque rule out this idea.' The tone varies from supportive to curious, reflecting a collective recognition of the research's significance but also ongoing questions about its broader implications.

AgreementModerate agreement

Most discussions show support for the findings, with some questioning specific aspects like the role of LDL sizes in plaque formation.

InterestNeutral interest

The social discussions appear somewhat neutral in interest, with some posters engaging more deeply but others merely acknowledging the topic.

EngagementModerate engagement

Several posters reference the methodology and implications, indicating a moderate level of engagement, especially around the physiological processes involved.

ImpactModerate impact

Participants generally view the research as potentially influential, particularly regarding understanding atherosclerosis and LDL's role.

Abstract in brief

  • The study compares LDL derived from atherosclerotic plaques (ALDL) to artificially oxidized LDL (OxLDL) and finds they share similar structural features, such as increased mobility, cholesterol-to-protein ratio, and recognition by specific antibodies.
  • Both ALDL and OxLDL show increased fragmentation of apolipoprotein B, enhanced recognition by macrophage scavenger receptors, and tendencies to aggregate and become more unstable when concentrated, leading to increased uptake by macrophages through phagocytosis.
  • The results suggest that oxidation is a key process modifying LDL in plaques, potentially causing lipid buildup in macrophages through phagocytosis of aggregated LDL particles, which may contribute to the development of atherosclerosis.]
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Top posts

Most liked on X and Bluesky
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@drpablocorral @soonergise @lipo_fan @JohnKastelein @Drlipid @lipiddoc @society_eas @LipidosSal @alavallecobo @lschreier1 @realDaveFeldman doesn't the observation of both small and large LDLs in plaque rule out this idea that large LDLs can't penetrate and are harmless? https://t.co/Q9BcG35o8E

Jul 2, 2023 · 8 likes · 28,221 followers View post →

All mentions

Gil Carvalho MD PhD
@NutritionMadeS3 · X

@drpablocorral @soonergise @lipo_fan @JohnKastelein @Drlipid @lipiddoc @society_eas @LipidosSal @alavallecobo @lschreier1 @realDaveFeldman doesn't the observation of both small and large LDLs in plaque rule out this idea that large LDLs can't penetrate and are harmless? https://t.co/Q9BcG35o8E

Jul 2, 2023 · 8 likes · 28,221 followers View post →