September 2009 PMID 19253021

A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects.

Gary Deng, Hong Lin, Andrew Seidman, Monica Fornier, Gabriella D'Andrea, Kathleen Wesa, Simon Yeung, Susanna Cunningham-Rundles, Andrew J Vickers, Barrie Cassileth

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Mentions

7
Peak: 1 in Apr 2019
across 3 sources since Apr 2019

Extended reach

10,959
potential audience

Total likes

86

Video views

4,779

Mentions per month

Apr 2019 – Nov 2025

Where it's discussed

  • News3 articles
  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reflects cautious curiosity, with discussions referencing immune effects, such as 'complex impacts on immune responses,' and noting the safety profile without delving into technical intricacies. Phrases like 'potential of Maitake' and 'mixed effects' emphasize recognition of the findings' significance, but overall, the interactions remain surface-level, indicating some interest without deep engagement or perceived high impact.

AgreementModerate agreement

Most discussions acknowledge the trial's findings, with many agreeing that the immunological effects are noteworthy, though some remain cautious or skeptical about conclusive claims.

InterestModerate interest

Participants show moderate interest, referencing the potential of Maitake mushroom in cancer therapy, but without deeply exploring methodological details or broader implications.

EngagementNeutral engagement

Engagement levels are moderate, as a few discussions mention immune responses and side effects, but there is limited in-depth analysis or questioning.

ImpactNeutral impact

The conversations suggest the publication's potential influence is modest, mainly raising awareness rather than prompting immediate clinical or research action.

Abstract in brief

  • A phase III clinical trial tested an extract from Maitake mushroom on breast cancer patients and found that it can influence immune functions, with effects varying depending on the dose.
  • The study showed that there were no major safety issues, but some patients experienced mild side effects like nausea, joint swelling, rash, and itching.
  • Importantly, Maitake extract had complex effects on the immune system, sometimes boosting and sometimes suppressing immune responses, indicating that botanical supplements can have unpredictable and mixed impacts on health.]

Top posts

Most liked on X and Bluesky
POPLINE
@POPLINE_org · X

A phase I/Ii trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects https://t.co/XqxSJUN7M7 https://t.co/0jHfy9Vm9C

Jan 18, 2024 · 5,185 followers View post →
Dr. LoBisco
@DrLoBisco · X

A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects https://t.co/npelMy9A6M

Apr 9, 2019 · 965 followers View post →

All mentions

POPLINE
@POPLINE_org · X

A phase I/Ii trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects https://t.co/XqxSJUN7M7 https://t.co/0jHfy9Vm9C

Jan 18, 2024 · 5,185 followers View post →
Dr. LoBisco
@DrLoBisco · X

A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects https://t.co/npelMy9A6M

Apr 9, 2019 · 965 followers View post →
3669-Article Text-6179-1-10-20190627 | PDF
News

doi: 10.1007/s00432-009-0562-z. ти, є актуальним напрямком в комплексі заходів щодо Krainiuk, L.M., Pasichnyk, K.O., & Nabokov, I.V. формування ...

Jan 3, 2026 View →
A Review of Mushrooms in Human Nutrition and Health | PDF ...
News

https://doi.org/10.1007/s00432-009-0562-z. Dermiki, M., Mounayar, R., Suwankanit, C., Scott, J., Kennedy, O. B., Mottram, D. S., Acknowledgements Gosney ...

Jan 3, 2026 View →
You Shall Not Pass: Pharmacist Review of Drug-Herb Interactions in ...
News

doi:10.1007/s00432-009-0562-z; Glauco S, Jano F, Paolo G, Konno S. Safety of maitake D-fraction in healthy patients: assessment of common ...

Aug 8, 2025 View →