FASEB J June 2009 PMID 19383836

Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?

Yu Toyoda, Aki Sakurai, Yasumasa Mitani, Masahiro Nakashima, Koh-ichiro Yoshiura, Hiroshi Nakagawa, Yasuo Sakai, Ikuko Ota, Alexander Lezhava, Yoshihide Hayashizaki, Norio Niikawa, Toshihisa Ishikawa

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Mentions

12
Peak: 7 in Dec 2024
across 3 sources since Jul 2020

Extended reach

13,938
potential audience

Total likes

435

Video views

11,612

Mentions per month

Jul 2020 – Jul 2025

Where it's discussed

  • X / Twitter8 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The collective discussions express strong interest through references to DNA testing and gene functions, with phrases like 'learn more about the ABCC11 gene' and personal examples like 'unboxing my DNA results.' The tone is informative and enthusiastic, emphasizing both scientific facts and personal relevance, which supports the recognition of its moderate but noteworthy societal and health impacts.

AgreementModerate agreement

Most discussions align with the publication's findings, emphasizing the role of the ABCC11 gene in earwax type and body odor, indicating agreement with the scientific conclusions.

InterestHigh interest

Participants show high curiosity by referencing DNA results and mentioning the gene’s broader implications, reflecting strong interest.

EngagementModerate engagement

Comments include references to specific studies, gene functions, and personal DNA testing, demonstrating active engagement and deeper understanding.

ImpactModerate impact

The discussions highlight the significance of genetic testing and health awareness, suggesting a moderate but meaningful impact on public perception and personal health insights.

Abstract in brief

  • The SNP 538GA in the ABCC11 gene influences earwax type, where GG and GA genotypes produce wet earwax, and AA results in dry earwax, with this variation also showing ethnic differences due to human migration.
  • The genetic variation affects the N-linked glycosylation, intracellular trafficking, and degradation of the ABCC11 protein, with the mutant Arg180 form being misfolded and degraded, leading to dry earwax.
  • The study developed a rapid genetic testing method (SmartAmp) to identify the ABCC11 genotype, which could also help assess risks related to axillary odor and breast cancer quickly.

Top posts

Most liked on X and Bluesky
bioZone
@thebiozone · X

Dr Louks is right! ABCC11 is not only involved in body odor but also determines whether you have wet or dry earwax! Learn more about the ABCC11 gene here https://t.co/t4cVlW4QJ6 https://t.co/zKKaoZAU3m https://t.co/QgRfr3V1AS

Dec 31, 2024 · 6 likes · 4 shares · 189 followers View post →
bioZone
@thebiozone · X

unboxing my DNA results

Dec 8, 2024 · 3 likes · 1 share · 189 followers View post →
bioZone
@thebiozone · X

sources: Yoshiura et al. (2006). Nature Genetics. https://t.co/Q47KEAGcMd Toyoda et al. (2009). FASEB. https://t.co/azRFb9VEhf Toyoda et al. (2024). Human Cell. https://t.co/87UCzBvYS6

Dec 8, 2024 · 1 like · 189 followers View post →
April
@sciApril · X

RT @thebiozone: Dr Louks is right! ABCC11 is not only involved in body odor but also determines whether you have wet or dry earwax! Learn…

Dec 31, 2024 · 4 shares · 616 followers View post →
April
@sciApril · X

RT @thebiozone: unboxing my DNA results

Dec 8, 2024 · 1 share · 616 followers View post →
pragya_
@pragyaa_ · X

RT @thebiozone: Dr Louks is right! ABCC11 is not only involved in body odor but also determines whether you have wet or dry earwax! Learn…

Jan 1, 2025 · 4 shares · 175 followers View post →

All mentions

Pax
@CutenessWins · X

RT @thebiozone: Dr Louks is right! ABCC11 is not only involved in body odor but also determines whether you have wet or dry earwax! Learn…

Jul 23, 2025 · 4 shares · 145 followers View post →
pragya_
@pragyaa_ · X

RT @thebiozone: Dr Louks is right! ABCC11 is not only involved in body odor but also determines whether you have wet or dry earwax! Learn…

Jan 1, 2025 · 4 shares · 175 followers View post →
Roshni
@RoshniBhatt3 · X

RT @thebiozone: Dr Louks is right! ABCC11 is not only involved in body odor but also determines whether you have wet or dry earwax! Learn…

Dec 31, 2024 · 4 shares · 144 followers View post →
April
@sciApril · X

RT @thebiozone: Dr Louks is right! ABCC11 is not only involved in body odor but also determines whether you have wet or dry earwax! Learn…

Dec 31, 2024 · 4 shares · 616 followers View post →
bioZone
@thebiozone · X

Dr Louks is right! ABCC11 is not only involved in body odor but also determines whether you have wet or dry earwax! Learn more about the ABCC11 gene here https://t.co/t4cVlW4QJ6 https://t.co/zKKaoZAU3m https://t.co/QgRfr3V1AS

Dec 31, 2024 · 6 likes · 4 shares · 189 followers View post →
April
@sciApril · X

RT @thebiozone: unboxing my DNA results

Dec 8, 2024 · 1 share · 616 followers View post →
bioZone
@thebiozone · X

sources: Yoshiura et al. (2006). Nature Genetics. https://t.co/Q47KEAGcMd Toyoda et al. (2009). FASEB. https://t.co/azRFb9VEhf Toyoda et al. (2024). Human Cell. https://t.co/87UCzBvYS6

Dec 8, 2024 · 1 like · 189 followers View post →
bioZone
@thebiozone · X

unboxing my DNA results

Dec 8, 2024 · 3 likes · 1 share · 189 followers View post →
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https://doi.org/10.1096/fj.09-129098 (2009). 29. Ishikawa, T., Toyoda, Y., Yoshiura, K. & Niikawa, N. Pharmacogenetics of human ABC transporter ABCC11: new ...

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