May 2009 PMID 19444213

Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions.

Matthew W Powner, Béatrice Gerland, John D Sutherland

Mentions

96
Peak: 6 in Apr 2024
across 5 sources since May 2021

Extended reach

6,758,338
potential audience

Total likes

330

Video views

9,291

Mentions per month

May 2021 – Oct 2025

Where it's discussed

  • News42 articles
  • Blogs27 articles
  • X / Twitter14 posts
  • Facebook11 posts
  • YouTube2 videos

AI synopsis

What people are saying

Overall, the discussions reflect strong interest and moderate engagement, exemplified by comments highlighting the study's significance for understanding prebiotic chemistry, such as mentions of how the synthesis process avoids complex steps and its implications for the RNA world hypothesis, with words like 'major step forward' conveying its potential impact and importance.

AgreementModerate agreement

Most discussions recognize the significance of the study as demonstrating a plausible prebiotic pathway for nucleotide formation, with some explicitly supporting its implications.

InterestHigh interest

Posts show high interest, with commenters discussing the methodology and broader impact on origins of life research.

EngagementModerate engagement

Comments include references to specific studies, critiques, and potential applications, indicating active engagement.

ImpactModerate impact

The discussions suggest the research could influence future experiments and theories related to the origin of RNA and early life chemistry.

Abstract in brief

  • The article discusses a new method for synthesizing activated pyrimidine ribonucleotides that avoids the difficult step of forming free ribose and attaching nucleobases, using simpler prebiotic molecules like cyanamide, cyanoacetylene, glycolaldehyde, glyceraldehyde, and inorganic phosphate.
  • This synthesis occurs through intermediates such as arabinose aminooxazoline and anhydronucleoside, under conditions that could have existed on early Earth, demonstrating a plausible pathway for the origin of RNA components.
  • The presence of inorganic phosphate is crucial throughout the process, as it acts as a catalyst and buffer, highlighting the importance of mixed chemical systems where reactants influence multiple steps in prebiotic reactions.]

Top posts

Most liked on X and Bluesky
Hasan Iessa
@H_iessa · X

لطالما كان نشوء الحياة على سطح الأرض لغزًا وهاجسًا للجميع. البعض ادعى أنه من المستحيل أن تنشأ دون تدخل خارق للطبيعة، ولكن للعلم رأيٌ آخر. في هذه الرووم طرح كامل حول نشأة الحياة مدعّم بالدراسات العلمية موضحًا الأسئلة التي أجابها العلم والتي ما زالت مجهولة. https://t.co/vNw6z63xGw

Apr 10, 2024 · 37 likes · 5 shares · 3,827 followers View post →
The Rejected
@TRej2011 · X

@SDAFS56788141 @SSpence64 @SipkeStorm @1deaman @JustinCPorter @Lilith_Atheist Next study… Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions https://t.co/1z2HoebGCC

Jan 29, 2025 · 1 like · 4,663 followers View post →
Daytime Pub Smell
@DaytimePubSmell · X

@Ofthalmo1 @darwintojesus They DEMONSTRABLY form amino acids and RNA strings, dickhead. Proteins come much, much later after RNA structures are co-opted by more stable DNA. https://t.co/6yg1YTGa1Z

Apr 3, 2025 · 1 like · 2,796 followers View post →
D J Walker
@DJWCymruExile · X

@EricsonAdv @mawson_craig @YorkshirePalaeo @HaggertyTaupier @jesusace_com @Friendof_Darwin @JustinCPorter @NonProphet75 @Dlanorx @TakeThatDarwin @umfpt @jimmynimble @Ah_Science @Call_Me_Emo1 @LtUhura2017 @JakeMondale @Rkreb1 @fmacanadaguy @Nat1Newf @tweettruth2me And linked to you several times. Is it the synthesis of nucleotides your after cos Venter do that too. If you want it under plausible pre-biotic conditions, You need John Sutherland etc. https://t.co/NP3ZilAfKd

May 19, 2021 · 1 like · 2,782 followers View post →
Grok
@grok · X

@BrightlightIris @DarloSince1883 @BitcoinNews21M For nucleotide synthesis: Powner et al., "Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions," Nature, 2009 (DOI: 10.1038/nature08013). For self-replicating RNA: Paul & Joyce, "A self-replicating ligase ribozyme," PNAS, 2002 (DOI:

Oct 10, 2025 · 6,712,683 followers View post →
مازن
@almurtadmazin · X

RT @H_iessa: لطالما كان نشوء الحياة على سطح الأرض لغزًا وهاجسًا للجميع. البعض ادعى أنه من المستحيل أن تنشأ دون تدخل خارق للطبيعة، ولكن للعل…

Apr 10, 2024 · 5 shares · 8,598 followers View post →

All mentions

Grok
@grok · X

@BrightlightIris @DarloSince1883 @BitcoinNews21M For nucleotide synthesis: Powner et al., "Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions," Nature, 2009 (DOI: 10.1038/nature08013). For self-replicating RNA: Paul & Joyce, "A self-replicating ligase ribozyme," PNAS, 2002 (DOI:

Oct 10, 2025 · 6,712,683 followers View post →
arvin15
@the__Arvin_1 · X

@XboxIq31778 @efgrdtfser @S4lT81224 Powner, M. W., Gerland, B., & Sutherland, J. D. (2009). "Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions." Nature, 459(7244), 239-242. تشرح تكون الخليه الاولئ

Apr 27, 2025 · 141 followers View post →
Daytime Pub Smell
@DaytimePubSmell · X

@Ofthalmo1 @darwintojesus They DEMONSTRABLY form amino acids and RNA strings, dickhead. Proteins come much, much later after RNA structures are co-opted by more stable DNA. https://t.co/6yg1YTGa1Z

Apr 3, 2025 · 1 like · 2,796 followers View post →
TimmyT09
@TimmyT099 · X

@SDAFS56788141 @DaytimePubSmell @TheHistoryGuy07 And yes, Sutherland’s 2009 paper: “Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions” (Nature). No enzymes, no templates, just simple molecules + phosphate. A major step forward in RNA-world plausibility. ⬇️

Mar 21, 2025 · 274 followers View post →
The Rejected
@TRej2011 · X

@SDAFS56788141 @SSpence64 @SipkeStorm @1deaman @JustinCPorter @Lilith_Atheist Next study… Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions https://t.co/1z2HoebGCC

Jan 29, 2025 · 1 like · 4,663 followers View post →
jerry john
@jerry_mail · X

Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions | Nature https://t.co/erVoWLVNZl

Aug 29, 2024 · 64 followers View post →
syramio
@syramio · X

@REPENTSINHELL @NotEvolution1 1:https://t.co/KbBklbrWdu 2:https://t.co/YupV5K16Oy 3:https://t.co/vFpARW94Xc 4:https://t.co/6zc58zr18h 5:https://t.co/2GF1A3qmGN 6:https://t.co/Ku5BqAvtS8 7:https://t.co/neBcJn67gp 8:https://t.co/DXpNHAbZTL 9:https://t.co/o1XXF4t0ls 10:https://t.co/TxLXBpdWrI https://t.co/bFWwH6tFgl

Aug 10, 2024 · 105 followers View post →
Ali Al Absi علي العبسي
@AlabsiAl · X

RT @H_iessa: لطالما كان نشوء الحياة على سطح الأرض لغزًا وهاجسًا للجميع. البعض ادعى أنه من المستحيل أن تنشأ دون تدخل خارق للطبيعة، ولكن للعل…

Apr 11, 2024 · 5 shares · 66 followers View post →
more than a goddess
@Clubhouseera · X

RT @H_iessa: لطالما كان نشوء الحياة على سطح الأرض لغزًا وهاجسًا للجميع. البعض ادعى أنه من المستحيل أن تنشأ دون تدخل خارق للطبيعة، ولكن للعل…

Apr 10, 2024 · 5 shares · 5,874 followers View post →
Ali
@aligg_89 · X

RT @H_iessa: لطالما كان نشوء الحياة على سطح الأرض لغزًا وهاجسًا للجميع. البعض ادعى أنه من المستحيل أن تنشأ دون تدخل خارق للطبيعة، ولكن للعل…

Apr 10, 2024 · 5 shares · 2,461 followers View post →
مازن
@almurtadmazin · X

RT @H_iessa: لطالما كان نشوء الحياة على سطح الأرض لغزًا وهاجسًا للجميع. البعض ادعى أنه من المستحيل أن تنشأ دون تدخل خارق للطبيعة، ولكن للعل…

Apr 10, 2024 · 5 shares · 8,598 followers View post →
Hasan Iessa
@H_iessa · X

لطالما كان نشوء الحياة على سطح الأرض لغزًا وهاجسًا للجميع. البعض ادعى أنه من المستحيل أن تنشأ دون تدخل خارق للطبيعة، ولكن للعلم رأيٌ آخر. في هذه الرووم طرح كامل حول نشأة الحياة مدعّم بالدراسات العلمية موضحًا الأسئلة التي أجابها العلم والتي ما زالت مجهولة. https://t.co/vNw6z63xGw

Apr 10, 2024 · 37 likes · 5 shares · 3,827 followers View post →
The Rejected
@TRej2011 · X

@mastrscaron1 Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions https://t.co/1z2HodTxou

Oct 14, 2022 · 4,663 followers View post →
D J Walker
@DJWCymruExile · X

@EricsonAdv @mawson_craig @YorkshirePalaeo @HaggertyTaupier @jesusace_com @Friendof_Darwin @JustinCPorter @NonProphet75 @Dlanorx @TakeThatDarwin @umfpt @jimmynimble @Ah_Science @Call_Me_Emo1 @LtUhura2017 @JakeMondale @Rkreb1 @fmacanadaguy @Nat1Newf @tweettruth2me And linked to you several times. Is it the synthesis of nucleotides your after cos Venter do that too. If you want it under plausible pre-biotic conditions, You need John Sutherland etc. https://t.co/NP3ZilAfKd

May 19, 2021 · 1 like · 2,782 followers View post →